18F-fluorodeoxyglucose uptake of stimulated brown adipose tissue in mice with functional and impaired brown adipose tissue thermogenesis

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Brown adipose tissue (BAT) is a fat tissue present in most mammals, which is specialized in non-shivering thermogenesis. Thermogenic activity in BAT is commonly detected by PET/CT imaging with 18F-FDG, a glucose analog, in both rodents and humans. Increased uptake of the 18F-FDG within regions of BAT is interpreted as an indicator of increased thermogenic activity within the tissue. Despite its prevalence, recent studies have begun to question the use of 18F-FDG PET/CT for the detection of BAT thermogenesis, casting doubt on the direct relationship between glucose uptake and the degree of thermogenic activity. To this end, this study aims...

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