In vivo imaging of BAT vasculature reactivity during adrenergic stimulation of non-shivering thermogenesis in mice

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Brown adipose tissue (BAT) is a fat tissue specialized in heat production (non-shivering thermogenesis) and used by mammals to defend core body temperature when exposed to cold. Several studies have shown that during non-shivering thermogenesis the increase in BAT oxygen demand is met by a local and specific increase in tissue’s blood flow. While the vasculature of BAT has been extensively studied postmortem in rodents using histology, optical and CT imaging techniques, vasculature changes during stimulation of non-shivering thermogenesis have never been directly detected in vivo.
Here, by using computed tomography (CT) angiography with gold nanoparticles we investigate, non-invasively, changes...