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UNC-authored articles published by Frontiers
Works (762)
111. Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders
- Title Tesim:
- Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders
- Creator:
- McLarnan S.M., Zhang S., Baker B.H., Pearson B.L., Simon J.M., and Chung W.K.
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction: De novo mutations contribute to a large proportion of sporadic psychiatric and developmental disorders, yet the potential role of environmental carcinogens as drivers of causal de novo mutations in neurodevelopmental disorders is poorly studied. Methods: To explore environmental mutation vulnerability of disease-associated gene sets, we analyzed publicly available whole genome sequencing datasets of mutations in human induced pluripotent stem cell clonal lines exposed to 12 classes of environmental carcinogens, and human lung cancers from individuals living in highly polluted regions. We compared observed rates of exposure-induced mutations in disease-related gene sets with the expected rates of mutations based on control genes randomly sampled from the genome using exact binomial tests. To explore the role of sequence characteristics in mutation vulnerability, we modeled the effects of sequence length, gene expression, and percent GC content on mutation rates of entire genes and gene coding sequences using multivariate Quasi-Poisson regressions. Results: We demonstrate that several mutagens, including radiation and polycyclic aromatic hydrocarbons, disproportionately mutate genes related to neurodevelopmental disorders including autism spectrum disorders, schizophrenia, and attention deficit hyperactivity disorder. Other disease genes including amyotrophic lateral sclerosis, Alzheimer’s disease, congenital heart disease, orofacial clefts, and coronary artery disease were generally not mutated more than expected. Longer sequence length was more strongly associated with elevated mutations in entire genes compared with mutations in coding sequences. Increased expression was associated with decreased coding sequence mutation rate, but not with the mutability of entire genes. Increased GC content was associated with increased coding sequence mutation rates but decreased mutation rates in entire genes. Discussion: Our findings support the possibility that neurodevelopmental disorder genetic etiology is partially driven by a contribution of environment-induced germ line and somatic mutations.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Genetics
- DOI:
- https://doi.org/10.17615/ddh0-kr31
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fnins.2023.1106573
- ISSN:
- 1662-4548
- Journal Title:
- Frontiers in Neuroscience
- Journal Volume:
- 17
- Keyword:
- carcinogen, autism, neurodevelopmental disorders, de novo mutation, somatic mutation, and mutagenesis
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Columbia University and
- Person:
- McLarnan S.M., Zhang S., Baker B.H., Pearson B.L., Simon J.M., and Chung W.K.
- Publisher:
- Frontiers Media SA
- Source:
- 26e2514d-f5bf-4f86-992a-021e70ad79b9
112. Efficacy of social cognition and interaction training in outpatients with schizophrenia spectrum disorders: randomized controlled trial
- Title Tesim:
- Efficacy of social cognition and interaction training in outpatients with schizophrenia spectrum disorders: randomized controlled trial
- Creator:
- Davidson C.A., Roberts D.L., Fiszdon J.M., Penn D.L., Dixon H.D., and Bell M.D.
- Date of publication:
- 2023
- Abstract Tesim:
- Given the relationship between social cognition and functional outcome in schizophrenia, a number of social cognitive interventions have been developed, including Social Cognition Interaction Training (SCIT), a group-based, comprehensive, manualized intervention. In the current trial, we examined SCIT efficacy as well as potential moderators of treatment effects. Fifty-one outpatients were randomized to SCIT or a wait-list-control (WLC), with assessments of social cognition, neurocognition, self-report, symptoms, and functioning conducted at baseline and end of the active phase. Relative to WLC, we did not find significant improvements for SCIT on neurocognition, social cognition, self-report, or symptoms, though there was a trend-level, medium effect favoring the SCIT condition on interpersonal and instrumental role function. Post-hoc analyses indicated that baseline neurocognition did not impact degree of social cognitive or functional change. Shorter duration of illness was significantly associated with better post-training neurocognition and self-esteem and, at trend-level with better symptoms and social functioning. We discuss the importance of outcome measure selection and the need for continued evaluation of potential treatment moderators in order to better match people to existing treatments. Clinical trial registration: Clinicaltrials.gov, Identifier NCT00587561.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Psychology and Neuroscience
- DOI:
- https://doi.org/10.17615/dk3n-q982
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fpsyt.2023.1217735
- ISSN:
- 1664-0640
- Journal Title:
- Frontiers in Psychiatry
- Journal Volume:
- 14
- Keyword:
- training, psychosis, rehabilitation, social cognition, schizophrenia, and randomized controlled trial
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Emory University, University of Texas Health Science Center, Yale University, , and Mercer University
- Person:
- Davidson C.A., Roberts D.L., Fiszdon J.M., Penn D.L., Dixon H.D., and Bell M.D.
- Publisher:
- Frontiers Media SA
- Source:
- 33dd0b9c-03ac-45d0-b5c3-adce27721f5c
113. Editorial: Advances in brain imaging and stimulation methods for cognitive function investigation
- Title Tesim:
- Editorial: Advances in brain imaging and stimulation methods for cognitive function investigation
- Creator:
- Yuan, Zhen, Palm, Ulrich, Boettiger, Charlotte A., and Assenza, Giovanni
- Date of publication:
- 2023
- Abstract Tesim:
- The Research Topic “Advances in brain imaging and stimulation methods for cognitive function investigation” gathers basic research and clinical results of experimental brain imaging and stimulation techniques which are used to investigate mechanisms of cognitive function and dysfunction.
- Resource type:
- Article
- DOI:
- https://doi.org/10.17615/pk3z-a082
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fnhum.2023.1280782
- ISSN:
- 1662-5161
- Journal Title:
- Frontiers in Human Neuroscience
- Journal Volume:
- 14
- Keyword:
- brain stimulation, neuropsychology, clinical application, transcranial magnetic stimulation, and brain imaging
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University of Macau, Klinikum der Universität München, , and University of Rome
- Person:
- Yuan, Zhen, Palm, Ulrich, Boettiger, Charlotte A., and Assenza, Giovanni
- Publisher:
- Frontiers Media SA
- Source:
- 972d5cf6-a79f-40b7-9239-36f20d5ee81b
114. Cognitive phenotypes in late-onset epilepsy: results from the atherosclerosis risk in communities study
- Title Tesim:
- Cognitive phenotypes in late-onset epilepsy: results from the atherosclerosis risk in communities study
- Creator:
- Schneider, Andrea L. C., Reyes, Anny, McDonald, Carrie R., Johnson, Emily L., Gottesman, Rebecca F., and Kucharska-Newton, Anna M.
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction Cognitive phenotyping is a widely used approach to characterize the heterogeneity of deficits in patients with a range of neurological disorders but has only recently been applied to patients with epilepsy. In this study, we identify cognitive phenotypes in older adults with late-onset epilepsy (LOE) and examine their demographic, clinical, and vascular profiles. Further, we examine whether specific phenotypes pose an increased risk for progressive cognitive decline. Methods Participants were part of the Atherosclerosis Risk in Communities Study (ARIC), a prospective longitudinal community-based cohort study of 15,792 individuals initially enrolled in 1987–1989. LOE was identified from linked Centers for Medicare and Medicaid Services claims data. Ninety-one participants with LOE completed comprehensive testing either prior to or after seizure onset as part of a larger cohort in the ARIC Neurocognitive Study in either 2011–2013 or 2016–2017 (follow-up mean = 4.9 years). Cognitive phenotypes in individuals with LOE were derived by calculating test-level impairments for each participant (i.e., ≤1 SD below cognitively normal participants on measures of language, memory, and executive function/processing speed); and then assigning participants to phenotypes if they were impaired on at least two tests within a domain. The total number of impaired domains was used to determine the cognitive phenotypes (i.e., Minimal/No Impairment, Single Domain, or Multidomain). Results At our baseline (Visit 5), 36.3% met criteria for Minimal/No Impairment, 35% for Single Domain Impairment (with executive functioning/ processing speed impaired in 53.6%), and 28.7% for Multidomain Impairment. The Minimal/No Impairment group had higher education and occupational complexity. There were no differences in clinical or vascular risk factors across phenotypes. Of those participants with longitudinal data (Visit 6; n = 24), 62.5% declined (i.e., progressed to a more impaired phenotype) and 37.5% remained stable. Those who remained stable were more highly educated compared to those that declined. Discussion Our results demonstrate the presence of identifiable cognitive phenotypes in older adults with LOE. These results also highlight the high prevalence of cognitive impairments across domains, with deficits in executive function/processing speed the most common isolated impairment. We also demonstrate that higher education was associated with a Minimal/No Impairment phenotype and lower risk for cognitive decline over time.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- DOI:
- https://doi.org/10.17615/86r1-6f66
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fneur.2023.1230368
- ISSN:
- 1664-2295
- Journal Title:
- Frontiers in Neurology
- Journal Volume:
- 17
- Keyword:
- phenotypes, dementia, cognition, aging, and epilepsy
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University of Pennsylvania, University of California, San Diego, Johns Hopkins University School of Medicine, National Institute of Neurological Disorders and Stroke Intramural Research Program, and
- Person:
- Schneider, Andrea L. C., Reyes, Anny, McDonald, Carrie R., Johnson, Emily L., Gottesman, Rebecca F., and Kucharska-Newton, Anna M.
- Publisher:
- Frontiers Media SA
- Source:
- a54f46a6-0670-4c41-aa77-78a4d48fed05
115. Characterizing host-pathogen interactions between Zostera marina and Labyrinthula zosterae
- Title Tesim:
- Characterizing host-pathogen interactions between Zostera marina and Labyrinthula zosterae
- Creator:
- Burge, Colleen A., Crandall, Grace, Loeher, Malina M., Van Alstyne, Kathryn L., Alidoost Salimi, Mahsa, Swanger, Megan, Eisenlord, Morgan E., Lee, James Sanghyun, Groner, Maya L., Dayal, Sukanya, Stoops, Mark, Shore, Amanda, Venkataraman, Yaamini R., and Fast, Mark D.
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction Seagrass meadows serve as an integral component of coastal ecosystems but are declining rapidly due to numerous anthropogenic stressors including climate change. Eelgrass wasting disease, caused by opportunistic Labyrinthula spp., is an increasing concern with rising seawater temperature. To better understand the host-pathogen interaction, we paired whole organism physiological assays with dual transcriptomic analysis of the infected host and parasite. Methods Eelgrass (Zostera marina) shoots were placed in one of two temperature treatments, 11° C or 18° C, acclimated for 10 days, and exposed to a waterborne inoculation containing infectious Labyrinthula zosterae (Lz) or sterile seawater. At two- and five-days post-exposure, pathogen load, visible disease signs, whole leaf phenolic content, and both host- and pathogen- transcriptomes were characterized. Results Two days after exposure, more than 90% of plants had visible lesions and Lz DNA was detectable in 100% percent of sampled plants in the Lz exposed treatment. Concentrations of total phenolic compounds were lower after 5 days of combined exposure to warmer temperatures and Lz, but were unaffected in other treatments. Concentrations of condensed tannins were not affected by Lz or temperature, and did not change over time. Analysis of the eelgrass transcriptome revealed 540 differentially expressed genes in response to Lz exposure, but not temperature. Lz-exposed plants had gene expression patterns consistent with increased defense responses through altered regulation of phytohormone biosynthesis, stress response, and immune function pathways. Analysis of the pathogen transcriptome revealed up-regulation of genes potentially involved in breakdown of host defense, chemotaxis, phagocytosis, and metabolism. Discussion The lack of a significant temperature signal was unexpected but suggests a more pronounced physiological response to Lz infection as compared to temperature. Pre-acclimation of eelgrass plants to the temperature treatments may have contributed to the limited physiological responses to temperature. Collectively, these data characterize a widespread physiological response to pathogen attack and demonstrate the value of paired transcriptomics to understand infections in a host-pathogen system.
- Resource type:
- Article
- Affiliation Label Tesim:
- Institute of Marine Sciences
- DOI:
- https://doi.org/10.17615/ge2d-fg45
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fmars.2023.1152647
- ISSN:
- 2296-7745
- Journal Title:
- Frontiers in Marine Science
- Journal Volume:
- 11
- Keyword:
- Labyrinthula zosterae, marine disease, host-pathogen interactions, eelgrass wasting disease, Zostera marina, and transcriptomics
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University of Maryland Baltimore County, University of Washington, Virginia Institute of Marine Science, Western Washington University, University of Melbourne, Cornell University Corson Hall, Atlantic Veterinary College-University of Prince Edward Island (AVC-UPEI), , Farmingdale State College, and Woods Hole Oceanographic Institution
- Person:
- Burge, Colleen A., Crandall, Grace, Loeher, Malina M., Van Alstyne, Kathryn L., Alidoost Salimi, Mahsa, Swanger, Megan, Eisenlord, Morgan E., Lee, James Sanghyun, Groner, Maya L., Dayal, Sukanya, Stoops, Mark, Shore, Amanda, Venkataraman, Yaamini R., and Fast, Mark D.
- Publisher:
- Frontiers Media SA
- Source:
- 238958be-b1af-42dc-9f89-787f2eb00685
116. Allele-specific quantification of human leukocyte antigen transcript isoforms by nanopore sequencing
- Title Tesim:
- Allele-specific quantification of human leukocyte antigen transcript isoforms by nanopore sequencing
- Creator:
- Weimer, Eric T., Hughes, Andrew E. O., Montgomery, Maureen C., and Liu, Chang
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction While tens of thousands of HLA alleles have been identified by DNA sequencing, the contribution of alternative splicing to HLA diversity is not well characterized. In this study, we sought to determine if long-read sequencing could be used to accurately quantify allele-specific HLA transcripts in primary human lymphocytes. Methods cDNA libraries were prepared from peripheral blood lymphocytes from 12 donors and sequenced by nanopore long-read sequencing. HLA reads were aligned to donor-specific reference sequences based on the known type of each donor. Allele-specific exon utilization was calculated as the proportion of reads aligning to each allele containing known exons, and transcript isoforms were quantified based on patterns of exon utilization within individual reads. Results Splice variants were rare among class I HLA genes (median exon retention rate 99%–100%), except for several HLA-C alleles with exon 5 spliced out of up to 15% of reads. Splice variants were also rare among class II HLA genes (median exon retention rate 98%–100%), except for HLA-DQB1. Consistent with previous work, exon 5 of HLA-DQB1 was spliced out in alleles with a mutated splice acceptor site at rs28688207. Surprisingly, a 28% loss of exon 5 was also observed in HLA-DQB1 alleles with an intact splice acceptor site at rs28688207. Discussion We describe a simple bioinformatic workflow to quantify allele-specific expression of HLA transcript isoforms. Further studies are warranted to characterize the repertoire of HLA transcripts expressed in different cell types and tissues across diverse populations.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Pathology and Laboratory Medicine and UNC Medical Center
- DOI:
- https://doi.org/10.17615/6tay-mp53
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fimmu.2023.1199618
- ISSN:
- 1664-3224
- Journal Title:
- Frontiers in Immunology
- Journal Volume:
- 14
- Keyword:
- transcript isoforms, human leukocyte antigen (HLA), allele-specific expression, long-read sequencing, and nanopore sequencing
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- and Washington University School of Medicine
- Person:
- Weimer, Eric T., Hughes, Andrew E. O., Montgomery, Maureen C., and Liu, Chang
- Publisher:
- Frontiers Media SA
- Source:
- 904d9768-27fa-4f08-9f2c-841976d2ac2b
117. Association between gestational levels of toxic metals and essential elements and cerebral palsy in children
- Title Tesim:
- Association between gestational levels of toxic metals and essential elements and cerebral palsy in children
- Creator:
- Skogheim, Thea S., Winterton, Adriano, Meltzer, Helle M., Surén, Pål, Villanger, Gro D., Thomsen, Cathrine, Knutsen, Helle K., Engel, Stephanie M., Biele, Guido, Andersen, Guro L., Vik, Torstein, Aase, Heidi, and Weyde, Kjell Vegard F.
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction Cerebral palsy (CP) is the most common motor disability in childhood, but its causes are only partly known. Early-life exposure to toxic metals and inadequate or excess amounts of essential elements can adversely affect brain and nervous system development. However, little is still known about these as perinatal risk factors for CP. This study aims to investigate the associations between second trimester maternal blood levels of toxic metals, essential elements, and mixtures thereof, with CP diagnoses in children. Methods In a large, population-based prospective birth cohort (The Norwegian Mother, Father, and Child Cohort Study), children with CP diagnoses were identified through The Norwegian Patient Registry and Cerebral Palsy Registry of Norway. One hundred forty-four children with CP and 1,082 controls were included. The relationship between maternal blood concentrations of five toxic metals and six essential elements and CP diagnoses were investigated using mixture approaches: elastic net with stability selection to identify important metals/elements in the mixture in relation to CP; then logistic regressions of the selected metals/elements to estimate odds ratio (OR) of CP and two-way interactions among metals/elements and with child sex and maternal education. Finally, the joint effects of the mixtures on CP diagnoses were estimated using quantile-based g-computation analyses. Results The essential elements manganese and copper, as well as the toxic metal Hg, were the most important in relation to CP. Elevated maternal levels of copper (OR = 1.40) and manganese (OR = 1.20) were associated with increased risk of CP, while Hg levels were, counterintuitively, inversely related to CP. Metal/element interactions that were associated with CP were observed, and that sex and maternal education influenced the relationships between metals/elements and CP. In the joint mixture approach no significant association between the mixture of metals/elements and CP (OR = 1.00, 95% CI = [0.67, 1.50]) was identified. Conclusion Using mixture approaches, elevated levels of copper and manganese measured in maternal blood during the second trimester could be related to increased risk of CP in children. The inverse associations between maternal Hg and CP could reflect Hg as a marker of maternal fish intake and thus nutrients beneficial for foetal brain development.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health
- DOI:
- https://doi.org/10.17615/rvhk-7a95
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fneur.2023.1124943
- ISSN:
- 1664-2295
- Journal Title:
- Frontiers in Neurology
- Journal Volume:
- 14
- Keyword:
- The Norwegian Mother, Father, and Child Cohort Study (MoBa), Medical Birth Registry of Norway (MBRN), brain development, cerebral palsy (CP), essential element, pregnant women, and toxic metal
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Norwegian Institute of Public Health and
- Person:
- Skogheim, Thea S., Winterton, Adriano, Meltzer, Helle M., Surén, Pål, Villanger, Gro D., Thomsen, Cathrine, Knutsen, Helle K., Engel, Stephanie M., Biele, Guido, Andersen, Guro L., Vik, Torstein, Aase, Heidi, and Weyde, Kjell Vegard F.
- Publisher:
- Frontiers Media SA
- Source:
- bbd94303-2921-4765-bbe8-6c7a4260547a
118. Framework for a Community Health Observing System for the Gulf of Mexico Region: Preparing for Future Disasters
- Title Tesim:
- Framework for a Community Health Observing System for the Gulf of Mexico Region: Preparing for Future Disasters
- Creator:
- Yehuda, R., Orbach, R., Singer, B., McEwen, B., Hale, C., Kirkpatrick, B., Svendsen, E., Cochran, D., Collier, T., Scott, G., Yoskowitz, D., Rowles, T., Partyka, M., Morris, G., Tincher, T., Ebi, K., Seeman, T., Solo-Gabriele, H., Harville, E., Yip, F., Farrington, J., Prather, A.A., Finucane, M., Hswen, Y., Trtanj, J., Halpern, D., Caffey, R., Engel, L.S., Walker, A.H., Manley, R., Abramson, D., Hart, L., Sandifer, P., Knapp, L., Lichtveld, M., Porter, D., and Palinkas, L.
- Date of publication:
- 2020
- Abstract Tesim:
- The Gulf of Mexico (GoM) region is prone to disasters, including recurrent oil spills, hurricanes, floods, industrial accidents, harmful algal blooms, and the current COVID-19 pandemic. The GoM and other regions of the U.S. lack sufficient baseline health information to identify, attribute, mitigate, and facilitate prevention of major health effects of disasters. Developing capacity to assess adverse human health consequences of future disasters requires establishment of a comprehensive, sustained community health observing system, similar to the extensive and well-established environmental observing systems. We propose a system that combines six levels of health data domains, beginning with three existing, national surveys and studies plus three new nested, longitudinal cohort studies. The latter are the unique and most important parts of the system and are focused on the coastal regions of the five GoM States. A statistically representative sample of participants is proposed for the new cohort studies, stratified to ensure proportional inclusion of urban and rural populations and with additional recruitment as necessary to enroll participants from particularly vulnerable or under-represented groups. Secondary data sources such as syndromic surveillance systems, electronic health records, national community surveys, environmental exposure databases, social media, and remote sensing will inform and augment the collection of primary data. Primary data sources will include participant-provided information via questionnaires, clinical measures of mental and physical health, acquisition of biological specimens, and wearable health monitoring devices. A suite of biomarkers may be derived from biological specimens for use in health assessments, including calculation of allostatic load, a measure of cumulative stress. The framework also addresses data management and sharing, participant retention, and system governance. The observing system is designed to continue indefinitely to ensure that essential pre-, during-, and post-disaster health data are collected and maintained. It could also provide a model/vehicle for effective health observation related to infectious disease pandemics such as COVID-19. To our knowledge, there is no comprehensive, disaster-focused health observing system such as the one proposed here currently in existence or planned elsewhere. Significant strengths of the GoM Community Health Observing System (CHOS) are its longitudinal cohorts and ability to adapt rapidly as needs arise and new technologies develop.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- DOI:
- https://doi.org/10.17615/qy95-cv79
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fpubh.2020.578463
- ISSN:
- 2296-2565
- Journal Title:
- Frontiers in Public Health
- Journal Volume:
- 8
- Keyword:
- cohort studies, stress, disasters, Gulf of Mexico, COVID-19, allostatic load, health surveillance, and health observing system
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Icahn School of Medicine at Mount Sinai, University of Texas, Austin, University of Florida, Rockefeller University, Texas A&M University-Corpus Christi, Texas A&M University, Centers for Disease Control and Prevention, University of Southern Mississippi, Western Washington University, University of South Carolina, National Oceanic and Atmospheric Administration, Mississippi-Alabama Sea Grant Consortium, University of Washington, University of California, Los Angeles, University of Miami, Tulane University, Woods Hole Oceanographic Institution, University of California, San Francisco, Rand Corporation, Scripps Institution of Oceanography, Louisiana State University, , SEA Consulting Group, College of Charleston, New York University, and University of Southern California
- Person:
- Yehuda, R., Orbach, R., Singer, B., McEwen, B., Hale, C., Kirkpatrick, B., Svendsen, E., Cochran, D., Collier, T., Scott, G., Yoskowitz, D., Rowles, T., Partyka, M., Morris, G., Tincher, T., Ebi, K., Seeman, T., Solo-Gabriele, H., Harville, E., Yip, F., Farrington, J., Prather, A.A., Finucane, M., Hswen, Y., Trtanj, J., Halpern, D., Caffey, R., Engel, L.S., Walker, A.H., Manley, R., Abramson, D., Hart, L., Sandifer, P., Knapp, L., Lichtveld, M., Porter, D., and Palinkas, L.
- Publisher:
- Frontiers Media S.A.
- Rights Statement Label:
- In Copyright
- Source:
- 1115af3a-10bb-4630-b1ab-691af4aa6749
119. Periconceptional maternal mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes
- Title Tesim:
- Periconceptional maternal mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes
- Creator:
- Daniels, J.L., Wright, F.A., Hoyo, C., Murphy, S.K., Gonzalez-Nahm, S., Maguire, R.L., Huang, Z., Mendez, M., House, J.S., and Fuemmeler, B.F.
- Date of publication:
- 2018
- Abstract Tesim:
- Background: Maternal diet during pregnancy has been shown to influence the child neuro-developmental outcomes. Studies examining effects of dietary patterns on offspring behavior are sparse. Objective: Determine if maternal adherence to a Mediterranean diet is associated with child behavioral outcomes assessed early in life, and to evaluate the role of differentially methylated regions (DMRs) regulating genomically imprinted genes in these associations. Methods: Among 325 mother/infant pairs, we used regression models to evaluate the association between tertiles of maternal periconceptional Mediterranean diet adherence (MDA) scores derived from a Food Frequency Questionnaire, and social and emotional scores derived from the Infant Toddler Social and Emotional Assessment (ITSEA) questionnaire in the second year of life. Methylation of nine genomically imprinted genes was measured to determine if MDA was associated with CpG methylation. Results: Child depression was inversely associated with maternal MDA (Bonferroni-corrected p = 0.041). While controlling for false-discovery, compared to offspring of women with the lowest MDA tertile, those with MDA scores in middle and high MDA tertiles had decreased odds for atypical behaviors [OR (95% CI) = 0.40 (0.20, 0.78) for middle and 0.40 (0.17, 0.92) for highest tertile], for maladaptive behaviors [0.37 (0.18, 0.72) for middle tertile and 0.42 (0.18, 0.95) for highest tertile] and for an index of autism spectrum disorder behaviors [0.46 (0.23, 0.90) for middle and 0.35 (0.15, 0.80) for highest tertile]. Offspring of women with the highest MDA tertile were less likely to exhibit depressive [OR = 0.28 (0.12, 0.64)] and anxiety [0.42 (0.18, 0.97)] behaviors and increased odds of social relatedness [2.31 (1.04, 5.19)] behaviors when compared to low MDA mothers. Some associations varied by sex. Perinatal MDA score was associated with methylation differences for imprinted control regions of PEG10/SGCE [females: Beta (95% CI) = 1.66 (0.52, 2.80) - Bonferroni-corrected p = 0.048; males: -0.56 (-1.13, -0.00)], as well as both MEG3 and IGF2 in males [0.97 (0.00, 1.94)] and -0.92 (-1.65, -0.19) respectively. Conclusion: In this ethnically diverse cohort, maternal adherence to a Mediterranean diet in early pregnancy was associated with favorable neurobehavioral outcomes in early childhood and with sex-dependent methylation differences of MEG3, IGF2, and SGCE/PEG10 DMRs.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- DOI:
- https://doi.org/10.17615/3zn9-wn72
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fcell.2018.00107
- ISSN:
- 2296-634X
- Journal Issue:
- SEP
- Journal Title:
- Frontiers in Cell and Developmental Biology
- Journal Volume:
- 6
- Keyword:
- Child behavior disorders, Cord-blood methylation, Autism spectrum disorder, Epigenetics, Maternal diet, Imprinted genes, Neuro-development, and ADHD-attention deficit disorder
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- , North Carolina State University, Duke University Medical Center, Johns Hopkins Bloomberg School of Public Health, Duke University School of Medicine, University of Pittsburgh, and Virginia Commonwealth University
- Person:
- Daniels, J.L., Wright, F.A., Hoyo, C., Murphy, S.K., Gonzalez-Nahm, S., Maguire, R.L., Huang, Z., Mendez, M., House, J.S., and Fuemmeler, B.F.
- Publisher:
- Frontiers Media S.A.
- Source:
- e39a69a0-551d-4944-953b-0ce722689b07
120. Untargeted metabolomics on first trimester serum implicates metabolic perturbations associated with BMI in development of hypertensive disorders: a discovery study
- Title Tesim:
- Untargeted metabolomics on first trimester serum implicates metabolic perturbations associated with BMI in development of hypertensive disorders: a discovery study
- Creator:
- Pan, Ke, Sumner, Susan C. J., McRitchie, Susan L., Li, Yuanyuan, and Harville, Emily W.
- Date of publication:
- 2023
- Abstract Tesim:
- GoalBody mass index (BMI) in early pregnancy is a critical risk factor for hypertensive disorders of pregnancy (HDP). The pathobiology of the interplay between BMI and HDP is not fully understood and represents the focus of this investigation.MethodsBMI and 1st-trimester serum samples were obtained from the Global Alliance to Prevent Prematurity and Stillbirth repository for 154 women (105 without HDP and 49 with HDP). Metabotyping was conducted using ultra-high-performance liquid-chromatography high-resolution mass spectrometry (UHPLC HR-MS). Multivariable linear regression and logistic models were used to determine metabolites and pathway perturbations associated with BMI in women with and without HDP, and to determine metabolites and pathway perturbations associated with HDP for women in categories of obese, overweight, and normal weight based on the 1st trimester BMI. These outcome-associated signals were identified or annotated by matching against an in-house physical standards library and public database. Pathway analysis was conducted by the Mummichog algorithm in MetaboAnalyst.ResultVitamin D3 and lysine metabolism were enriched to associate with BMI for women with and without HDP. Tryptophan metabolism enrichment was associated with HDP in all the BMI categories. Pregnant women who developed HDP showed more metabolic perturbations with BMI (continuous) than those without HDP in their 1st-trimester serum. The HDP-associated pathways for women with normal weight indicated inflammation and immune responses. In contrast, the HDP-associated pathways for women of overweight and obese BMI indicated metabolic syndromes with disorders in glucose, protein, and amino acid, lipid and bile acid metabolism, and oxidative and inflammatory stress.ConclusionHigh first-trimester BMI indicates underlying metabolic syndromes, which play critical roles in HDP development. Vitamin D3 and tryptophan metabolism may be the targets to guide nutritional interventions to mitigate metabolic and inflammatory stress in pregnancy and reduce the onset of HDP.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Nutrition
- DOI:
- https://doi.org/10.17615/852k-gw25
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fnut.2023.1144131
- ISSN:
- 2296-861X
- Journal Title:
- Frontiers in Nutrition
- Journal Volume:
- 10
- Keyword:
- metabolic perturbation, untargeted metabolomics, 1st-trimester, hypertensive disorders in pregnancy, and BMI
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Tulane University School of Public Health and Tropical Medicine and
- Person:
- Pan, Ke, Sumner, Susan C. J., McRitchie, Susan L., Li, Yuanyuan, and Harville, Emily W.
- Publisher:
- Frontiers Media SA
- Rights Statement Label:
- In Copyright
- Source:
- 09594d77-a0b9-416a-a429-ba957bd82791
Collection Details
- Total items
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762
- Size
-
unknown
- Date created
-
May 26, 2022