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UNC-authored articles published by Frontiers
Works (707)
21. Dietary fatty acids improve perceived sleep quality, stress, and health in migraine: a secondary analysis of a randomized controlled trial
- Title Tesim:
- Dietary fatty acids improve perceived sleep quality, stress, and health in migraine: a secondary analysis of a randomized controlled trial
- Creator:
- Mann, J. Douglas, Zamora, Daisy, Domeniciello, Anthony, Faurot, Keturah R., Ramsden, Christopher E., Palsson, Olafur, Lynch, Chanee E., Gaylord, Susan A., Horowitz, Mark, MacIntosh, Beth A., Honvoh, Gilson, Miller, Vanessa, and Park, Jinyoung
- Date of publication:
- 2023
- Abstract Tesim:
- BackgroundMigraine is a prevalent disabling condition often associated with comorbid physical and psychological symptoms that contribute to impaired quality of life and disability. Studies suggest that increasing dietary omega-3 fatty acid is associated with headache reduction, but less is known about the effects on quality of life in migraine.MethodsAfter a 4-week run-in, 182 adults with 5–20 migraine days per month were randomized to one of the 3 arms for sixteen weeks. Dietary arms included: H3L6 (a high omega-3, low omega-6 diet), H3 (a high omega-3, an average omega-6 diet), or a control diet (average intakes of omega-3 and omega-6 fatty acids). Prespecified secondary endpoints included daily diary measures (stress perception, sleep quality, and perceived health), Patient-Reported Outcome Measurement Information System Version 1.0 ([PROMIS©) measures and the Migraine Disability Assessment (MIDAS). Analyses used linear mixed effects models to control for repeated measures.ResultsThe H3L6 diet was associated with significant improvements in stress perception [adjusted mean difference (aMD): −1.5 (95% confidence interval: −1.7 to −1.2)], sleep quality [aMD: 0.2 (95% CI:0.1–0.2)], and perceived health [aMD: 0.2 (0.2–0.3)] compared to the control. Similarly, the H3 diet was associated with significant improvements in stress perception [aMD: −0.8 (−1.1 to −0.5)], sleep quality [aMD: 0.2 (0.1, 0.3)], and perceived health [aMD: 0.3 (0.2, 0.3)] compared to the control. MIDAS scores improved substantially in the intervention groups compared with the control (H3L6 aMD: −11.8 [−25.1, 1.5] and H3 aMD: −10.7 [−24.0, 2.7]). Among the PROMIS-29 assessments, the biggest impact was on pain interference [H3L6 MD: −1.8 (−4.4, 0.7) and H3 aMD: −3.2 (−5.9, −0.5)] and pain intensity [H3L6 MD: −0.6 (−1.3, 0.1) and H3 aMD: −0.6 (−1.4, 0.1)].DiscussionThe diary measures, with their increased power, supported our hypothesis that symptoms associated with migraine attacks could be responsive to specific dietary fatty acid manipulations. Changes in the PROMIS© measures reflected improvements in non-headache pain as well as physical and psychological function, largely in the expected directions. These findings suggest that increasing omega-3 with or without decreasing omega-6 in the diet may represent a reasonable adjunctive approach to reducing symptoms associated with migraine attacks. Trial Registration: ClinicalTrials.gov NCT02012790.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Neurology, Department of Physical Medicine and Rehabilitation, Department of Medicine, and UNC Medical Center
- DOI:
- https://doi.org/10.17615/2q0e-h937
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fpain.2023.1231054
- ISSN:
- 2673-561X
- Journal Title:
- Frontiers in Pain Research
- Journal Volume:
- 4
- Keyword:
- stress, quality of life, migraine, fatty acids, sleep quality, perceived health, and dietary intervention
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- and National Institute on Aging
- Person:
- Mann, J. Douglas, Zamora, Daisy, Domeniciello, Anthony, Faurot, Keturah R., Ramsden, Christopher E., Palsson, Olafur, Lynch, Chanee E., Gaylord, Susan A., Horowitz, Mark, MacIntosh, Beth A., Honvoh, Gilson, Miller, Vanessa, and Park, Jinyoung
- Publisher:
- Frontiers Media
- Source:
- 5c04a797-a3ac-4054-a453-18f7c0fdf592
22. Crowd-sourced investigation of a potential relationship between Bartonella-associated cutaneous lesions and neuropsychiatric symptoms
- Title Tesim:
- Crowd-sourced investigation of a potential relationship between Bartonella-associated cutaneous lesions and neuropsychiatric symptoms
- Creator:
- Frohlich, Flavio, Stewart, Zachary, and Korsapathy, Sanvi
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction Preliminary studies suggest that infection with Bartonella bacteria can not only cause a characteristic rash, headache, fever, and fatigue but also neuropsychiatric symptoms. To date, this association has only been reported in case studies, and it remains unclear if this association generalizes to larger samples. Methods We used Amazon's Mechanical Turk (MTurk) to crowdsource a large sample (N = 996) of individuals to ascertain the extent to which the presence of participant-identified Bartonella-associated cutaneous lesions (BACL) was associated with self-reported measures of anxiety, depression, and schizotypy. Participants were asked to select images of cutaneous lesions they had seen on their own bodies and complete a battery of self-report questionnaires to assess psychiatric symptoms. Participants were not informed that the focus of the study was on potential dermatological lesions associated with Bartonella. Point-biserial correlations were used to determine the potential relationship between selecting a BACL image and the severity of self-reported psychiatric symptoms. Results Scores of anxiety, depression, and schizotypy were positively and significantly correlated with selecting a BACL image. Furthermore, self-report scores of 10 or higher on the GAD-7 and PHQ-9, which represent the suggested clinical cutoffs for meeting criteria for a depressive or anxiety-related disorder, were also significantly associated with selecting a BACL image. Non-Bartonella-associated cutaneous legions were also significantly associated with self-reported measures of psychiatric symptoms. Discussion The current study broadens the link between the presence of BACL and the presence of psychiatric symptoms of anxiety, depression, and schizotypy and extends a potential relationship beyond the small sample sizes of previous case studies and case series. Further investigation is recommended to address limitations and expand on these findings.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Psychiatry
- DOI:
- https://doi.org/10.17615/e746-tw18
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fpsyt.2023.1244121
- ISSN:
- 1664-0640
- Journal Title:
- Frontiers in Psychiatry
- Journal Volume:
- 14
- Keyword:
- Bartonella, schizotypy, depression, anxiety, and MTurk
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Person:
- Frohlich, Flavio, Stewart, Zachary, and Korsapathy, Sanvi
- Publisher:
- Frontiers Media
- Source:
- caa9e6c0-a2f4-4f5b-afcf-a698a0826055
23. Candidate composite biomarker to inform drug treatments for diabetic kidney disease
- Title Tesim:
- Candidate composite biomarker to inform drug treatments for diabetic kidney disease
- Creator:
- Abebe, Seyum, Slanzi, Debora, Poli, Irene, Mayer, Gert, Jones, Roger D., Silvestri, Claudio, and Distefano, Veronica
- Date of publication:
- 2023
- Abstract Tesim:
- IntroductionCurrent guidelines recommend renin angiotensin system inhibitors (RASi) as key components of treatment of diabetic kidney disease (DKD). Additional options include sodium-glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide 1 receptor agonists (GLP1a), and mineralocorticoid receptor antagonists (MCRa). The identification of the optimum drug combination for an individual is difficult because of the inter-, and longitudinal intra-individual heterogeneity of response to therapy.ResultsUsing data from a large observational study (PROVALID), we identified a set of parameters that can be combined into a meaningful composite biomarker that appears to be able to identify which of the various treatment options is clinically beneficial for an individual. It uses machine-earning techniques to estimate under what conditions a treatment of RASi plus an additional treatment is different from the treatment with RASi alone. The measure of difference is the annual percent change (ΔeGFR) in the estimated glomerular filtration rate (ΔeGFR). The 1eGFR is estimated for both the RASi-alone treatment and the add-on treatment.DiscussionHigher estimated increase of eGFR for add-on patients compared with RASi-alone patients indicates that prognosis may be improved with the add-on treatment. The personalized biomarker value thus identifies which patients may benefit from the additional treatment.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Biology
- DOI:
- https://doi.org/10.17615/p3s5-q060
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fmed.2023.1271407
- ISSN:
- 2296-858X
- Journal Title:
- Frontiers in Medicine
- Journal Volume:
- 10
- Keyword:
- biomarkers, RASi, clinical data, MCRa, SGLT2i, precision medicine, and diabetic kidney disease
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Ca’ Foscari University of Venice, Medical University Innsbruck, and
- Person:
- Abebe, Seyum, Slanzi, Debora, Poli, Irene, Mayer, Gert, Jones, Roger D., Silvestri, Claudio, and Distefano, Veronica
- Publisher:
- Frontiers Media SA
- Source:
- ca5516fe-5b66-4236-af89-6a1f3dd0f566
24. Assessing the pre-implementation context for financial navigation in rural and non-rural oncology clinics
- Title Tesim:
- Assessing the pre-implementation context for financial navigation in rural and non-rural oncology clinics
- Creator:
- Planey, Arrianna Marie, Biddell, Caitlin B., Petermann, Victoria M., Bell, Ronny A., Cabarrus, Kendrel, Deal, Allison M., Reeder-Hayes, Katherine, Birken, Sarah A., Samuel-Ryals, Cleo A., Padilla, Neda, Gellin, Mindy, Manning, Michelle, Rosenstein, Donald L., Strom, Carla, Vestal, Derek, Wheeler, Stephanie B., Leutner, Brian, King, Sherry, Young, Tiffany H., and Spees, Lisa P.
- Date of publication:
- 2023
- Abstract Tesim:
- BackgroundFinancial navigation (FN) is an evidence-based intervention designed to address financial toxicity for cancer patients. FN's success depends on organizations' readiness to implement and other factors that may hinder or support implementation. Tailored implementation strategies can support practice change but must be matched to the implementation context. We assessed perceptions of readiness and perceived barriers and facilitators to successful implementation among staff at nine cancer care organizations (5 rural, 4 non-rural) recruited to participate in the scale-up of a FN intervention. To understand differences in the pre-implementation context and inform modifications to implementation strategies, we compared findings between rural and non-rural organizations.MethodsWe conducted surveys (n = 78) and in-depth interviews (n = 73) with staff at each organization. We assessed perceptions of readiness using the Organizational Readiness for Implementing Change (ORIC) scale. In-depth interviews elicited perceived barriers and facilitators to implementing FN in each context. We used descriptive statistics to analyze ORIC results and deductive thematic analysis, employing a codebook guided by the Consolidated Framework for Implementation Research (CFIR), to synthesize themes in barriers and facilitators across sites, and by rurality.ResultsResults from the ORIC scale indicated strong perceptions of organizational readiness across all sites. Staff from rural areas reported greater confidence in their ability to manage the politics of change (87% rural, 76% non-rural) and in their organization's ability to support staff adjusting to the change (96% rural, 75% non-rural). Staff at both rural and non-rural sites highlighted factors reflective of the Intervention Characteristics (relative advantage) and Implementation Climate (compatibility and tension for change) domains as facilitators. Although few barriers to implementation were reported, differences arose between rural and non-rural sites in these perceived barriers, with non-rural staff more often raising concerns about resistance to change and compatibility with existing work processes and rural staff more often raising concerns about competing time demands and limited resources.ConclusionsStaff across both rural and non-rural settings identified few, but different, barriers to implementing a novel FN intervention that they perceived as important and responsive to patients' needs. These findings can inform how strategies are tailored to support FN in diverse oncology practices.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Health Policy and Management, School of Nursing, UNC Lineberger Comprehensive Cancer Center, and Department of Psychiatry
- DOI:
- https://doi.org/10.17615/p1w4-j415
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/frhs.2023.1148887
- ISSN:
- 2813-0146
- Journal Title:
- Frontiers in Health Services
- Journal Volume:
- 3
- Keyword:
- cancer, rural, implementation science, financial navigation, financial toxicity, and organizational readiness framework for advancing implementation science
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- , Wake Forest University, Division of Oncology, UNC Lenoir Health Care, Pardee UNC Health Care, Carteret Health Care Cancer Center, and Novant Health Cancer Institute
- Person:
- Planey, Arrianna Marie, Biddell, Caitlin B., Petermann, Victoria M., Bell, Ronny A., Cabarrus, Kendrel, Deal, Allison M., Reeder-Hayes, Katherine, Birken, Sarah A., Samuel-Ryals, Cleo A., Padilla, Neda, Gellin, Mindy, Manning, Michelle, Rosenstein, Donald L., Strom, Carla, Vestal, Derek, Wheeler, Stephanie B., Leutner, Brian, King, Sherry, Young, Tiffany H., and Spees, Lisa P.
- Publisher:
- Frontiers Media SA
- Source:
- 3d072112-cd06-457b-a689-9c058078c895
25. A cross-sectional study confirms temporary post-COVID-19 vaccine menstrual irregularity and the associated physiological changes among vaccinated women in Jordan
- Title Tesim:
- A cross-sectional study confirms temporary post-COVID-19 vaccine menstrual irregularity and the associated physiological changes among vaccinated women in Jordan
- Creator:
- Hajjo R., Al-Momany A., Sabbah D.A., Almomani E.Y., and Qablan A.
- Date of publication:
- 2023
- Abstract Tesim:
- Background: COVID-19 vaccines continue to save people’s lives around the world; however, some vaccine adverse events have been a major concern which slowed down vaccination campaigns. Anecdotal evidence pointed to the vaccine effect on menstruation but evidence from the adverse event reporting systems and the biomedical literature was lacking. This study aimed to investigate the physiological changes in women during menstruation amid the COVID-19 vaccination. Methods: A cross-sectional online survey was distributed to COVID-19 vaccinated women from Nov 2021 to Jan 2022. The results were analyzed using the SPSS software. Results: Among the 564 vaccinated women, 52% experienced significant menstrual irregularities post-vaccination compared to before regardless of the vaccine type. The kind of menstrual irregularity varied among the vaccinated women, for example, 33% had earlier menstruation, while 35% reported delayed menstruation. About 31% experienced heavier menstruation, whereas 24% had lighter menstrual flow. About 29% had menstruation last longer, but 13% had it shorter than usual. Noteworthy, the menstrual irregularities were more frequent after the second vaccine shot, and they disappeared within 3 months on average. Interestingly, 24% of the vaccinated women reported these irregularities to their gynecologist. Conclusion: The COVID-19 vaccine may cause physiological disturbances during menstruation. Luckily, these irregularities were short-termed and should not be a reason for vaccine hesitancy in women. Further studies are encouraged to unravel the COVID-19 vaccine adverse effect on women’s health.
- Resource type:
- Article
- Affiliation Label Tesim:
- Division of Chemical Biology and Medicinal Chemistry
- DOI:
- https://doi.org/10.17615/djdj-px95
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fmed.2023.1211283
- ISSN:
- 2296-858X
- Journal Title:
- Frontiers in Medicine
- Journal Volume:
- 10
- Keyword:
- COVID-19 vaccine, adverse events, menstrual cycle irregularity, vaccinated women, and Jordan
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- , University of Jordan, Al-Zaytoonah University of Jordan, Al-Balqa Applied University, and United Arab Emirates University
- Person:
- Hajjo R., Al-Momany A., Sabbah D.A., Almomani E.Y., and Qablan A.
- Publisher:
- Frontiers Media SA
- Source:
- 9899aca4-8587-4aa7-9c37-9aa96e4bd4cb
26. Vibrio gazogenes-dependent disruption of aflatoxin biosynthesis in Aspergillus flavus: the connection with endosomal uptake and hyphal morphogenesis
- Title Tesim:
- Vibrio gazogenes-dependent disruption of aflatoxin biosynthesis in Aspergillus flavus: the connection with endosomal uptake and hyphal morphogenesis
- Creator:
- Cary J.W., Keller N.P., Basu P., Lebar M.D., Decho A.W., Gummadidala P.M., Dias T., Chandler S., Chanda A., Jesmin R., and Majumdar R.
- Date of publication:
- 2023
- Abstract Tesim:
- Aflatoxins, a family of fungal secondary metabolites, are toxic and carcinogenic compounds that pose an enormous threat to global food safety and agricultural sustainability. Specifically agricultural products in African, Southeast Asian and hot and humid regions of American countries suffer most damage from aflatoxin producing molds due to the ideal climate conditions promoting their growth. Our recent studies suggest that Vibrio gazogenes (Vg), an estuarine bacterium non-pathogenic to plants and humans, can significantly inhibit aflatoxin biosynthesis in the producers. In this study, we investigated the mechanism underlying Vg-dependent aflatoxin inhibition using the prominent aflatoxin producer, Aspergillus flavus. We show that aflatoxin inhibition upon Vg treatment was associated with fungal uptake of Vg-prodigiosin, a red pigment, which was consistently visible inside fungal hyphae during treatment. The association of prodigiosin with aflatoxin inhibition was further evident as Serratia marcescens, another prodigiosin producer, significantly inhibited aflatoxin, while non-producers like Escherichia coli, Staphylococcus aureus, Vibrio harveyi, and Vibrio fischeri did not. Also, pure prodigiosin significantly inhibited aflatoxin biosynthesis. Endocytosis inhibitors, filipin and natamycin, reduced the Vg-prodigiosin uptake by the fungus leading to a significant increase in aflatoxin production, suggesting that uptake is endocytosis-dependent. The Vg treatment also reduced hyphal fusion (>98% inhibition) and branching, which are both endosome-dependent processes. Our results, therefore, collectively support our theory that Vg-associated aflatoxin inhibition is mediated by an endocytosis-dependent uptake of Vg-prodigiosin, which possibly leads to a disruption of normal endosomal functions.
- Resource type:
- Article
- Affiliation Label Tesim:
- School of Medicine
- DOI:
- https://doi.org/10.17615/sdmk-jf26
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fmicb.2023.1208961
- ISSN:
- 1664-302X
- Journal Title:
- Frontiers in Microbiology
- Journal Volume:
- 14
- Keyword:
- aflatoxin, Aspergillus flavus, mycotoxin, biocontrol, and endosomes
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- USDA/ARS, University of Wisconsin-Madison, New York College of Podiatric Medicine, University of South Carolina, , Mycologics LLC, and Northwest Irrigation and Soils Research
- Person:
- Cary J.W., Keller N.P., Basu P., Lebar M.D., Decho A.W., Gummadidala P.M., Dias T., Chandler S., Chanda A., Jesmin R., and Majumdar R.
- Publisher:
- Frontiers Media SA
- Source:
- 59c44f88-1673-44b0-a737-cfdf75694a41
27. SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition
- Title Tesim:
- SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition
- Creator:
- Lemaire-Paquette, Samuel, Rexhepi, Fjolla, Premkumar, Lakshmanane, Cantin, André, Namvarpour, Mozhdeh, Lucier, Jean-François, Allard-Chamard, Hugues, Menendez, Alfredo, Chowdhury, Mohammad Mobarak Hussain, Ilangumaran, Subburaj, Piché, Alain, Lévesque, Simon, Nandi, Madhuparna, Dionne, Isabelle J., Quenum, Akouavi Julite Irmine, Durocher, Yves, Rioux-Perreault, Christine, Limoges, Marc-André, Akbari, Sara Ali, and Ramanathan, Sheela
- Date of publication:
- 2023
- Abstract Tesim:
- Background Following SARS-CoV-2 infection a significant proportion of convalescent individuals develop the post-COVID condition (PCC) that is characterized by wide spectrum of symptoms encompassing various organs. Even though the underlying pathophysiology of PCC is not known, detection of viral transcripts and antigens in tissues other than lungs raise the possibility that PCC may be a consequence of aberrant immune response to the viral antigens. To test this hypothesis, we evaluated B cell and antibody responses to the SARS-CoV-2 antigens in PCC patients who experienced mild COVID-19 disease during the pre-vaccination period of COVID-19 pandemic. Methods The study subjects included unvaccinated male and female subjects who developed PCC or not (No-PCC) after clearing RT-PCR confirmed mild COVID-19 infection. SARS-CoV-2 D614G and omicron RBD specific B cell subsets in peripheral circulation were assessed by flow cytometry. IgG, IgG3 and IgA antibody titers toward RBD, spike and nucleocapsid antigens in the plasma were evaluated by ELISA. Results The frequency of the B cells specific to D614G-RBD were comparable in convalescent groups with and without PCC in both males and females. Notably, in females with PCC, the anti-D614G RBD specific double negative (IgD-CD27-) B cells showed significant correlation with the number of symptoms at acute of infection. Anti-spike antibody responses were also higher at 3 months post-infection in females who developed PCC, but not in the male PCC group. On the other hand, the male PCC group also showed consistently high anti-RBD IgG responses compared to all other groups. Conclusions The antibody responses to the spike protein, but not the anti-RBD B cell responses diverge between convalescent males and females who develop PCC. Our findings also suggest that sex-related factors may also be involved in the development of PCC via modulating antibody responses to the SARS-CoV-2 antigens.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Microbiology and Immunology
- DOI:
- https://doi.org/10.17615/k5vg-sc44
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fimmu.2023.1223936
- ISSN:
- 1664-3224
- Journal Title:
- Frontiers in Immunology
- Journal Volume:
- 14
- Keyword:
- RBD specific B cells, SARS-CoV-2 infection, post covid condition (PCC), anti-RBD antibody titer, and long covid
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Centre de Recherche du CHUS, University of Sherbrooke, , and National Research Council Canada
- Person:
- Lemaire-Paquette, Samuel, Rexhepi, Fjolla, Premkumar, Lakshmanane, Cantin, André, Namvarpour, Mozhdeh, Lucier, Jean-François, Allard-Chamard, Hugues, Menendez, Alfredo, Chowdhury, Mohammad Mobarak Hussain, Ilangumaran, Subburaj, Piché, Alain, Lévesque, Simon, Nandi, Madhuparna, Dionne, Isabelle J., Quenum, Akouavi Julite Irmine, Durocher, Yves, Rioux-Perreault, Christine, Limoges, Marc-André, Akbari, Sara Ali, and Ramanathan, Sheela
- Publisher:
- Frontiers Media SA
- Source:
- da66eaf5-5773-48f8-bd05-37cbffcc7f91
28. Preferred physical characteristics of lidocaine thin film for women with vestibulodynia
- Title Tesim:
- Preferred physical characteristics of lidocaine thin film for women with vestibulodynia
- Creator:
- Rowland, Caroline, Cromeens, Martha Grace, Ogbansiegbe, Joseph A., Silverstein, R. Gina, Mihas, Paul, Benhabbour, S. Rahima, and Carey, Erin T.
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction Vestibulodynia (VBD) is the most common cause of sexual pain in the United States, affecting up to 15% of reproductive-aged women during their lifetime with limited treatment options. The purpose of this study was to describe ideal physical characteristics of a vulvar film designed for insertional sexual pain in sexually active women with VBD. Methods Twenty women were recruited to participant in one of six, semi-structured 60-minute focus group discussions regarding treatment options for VBD. Heterosexual women, aged 18–51 years old with a diagnosis of vulvodynia, vestibulodynia or insertional dyspareunia fit the inclusion criteria. Those who reported no episodes of vaginal intercourse in the prior 18 months were excluded. A new vulvar film technology loaded with 50 mg of 5% lidocaine was introduced to the group. Participants took part in focus groups on a rolling basis depending on availability. Focus group discussions were audio-recorded and transcribed verbatim. Two study investigators coded the transcripts using inductive coding and merged their respective projects to resolve disagreements. We analyzed data related to each code to develop code clusters and higher-level primary topics regarding device preferences. Data related to each of these primary topics was analyzed to assess the range of participant attitudes and preferences and to identify patterns within each primary topic.ResultsOne hundred and sixteen women were recruited, and twenty women were enrolled. The mean age for the participants was 33.3 years. Most women were educated with at least some college (93%), White (78.6%), married (75%), and had income greater than $100,000 (50%). Analysis of the focus group discussions identified five common topics addressed by participants: desired loaded medication, film size, film shape, film flexibility, and ease and accuracy of use. Concerns across topics included comfort, sexual spontaneity, and efficacy. Interest in loading the device with other acceptable medications or combination with lidocaine was independently noted in 2/6 (33%) of the focus groups.DiscussionMucoadhesive vulvar thin films may be an acceptable drug delivery system for insertional sexual pain for women with VBD.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Health Policy and Management, School of Nursing, Department of Obstetrics and Gynecology, Odum Institute for Research in Social Science, and Joint Department of Biomedical Engineering
- DOI:
- https://doi.org/10.17615/6zqt-0c62
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fpain.2023.1217035
- ISSN:
- 2673-561X
- Journal Title:
- Frontiers in Pain Research
- Journal Volume:
- 4
- Keyword:
- lidocaine, localized provoked vulvodynia, vulvodynia, vestibulodynia, and dyspareunia
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Person:
- Rowland, Caroline, Cromeens, Martha Grace, Ogbansiegbe, Joseph A., Silverstein, R. Gina, Mihas, Paul, Benhabbour, S. Rahima, and Carey, Erin T.
- Publisher:
- Frontiers Media SA
- Source:
- e943d434-629c-486a-9964-808b875e97ec
29. Prenatal stress unmasks behavioral phenotypes in genetic mouse models of neurodevelopmental disorders
- Title Tesim:
- Prenatal stress unmasks behavioral phenotypes in genetic mouse models of neurodevelopmental disorders
- Creator:
- Moy, Sheryl S., Harper, Kathryn M., and Harp, Samuel J.
- Date of publication:
- 2023
- Abstract Tesim:
- Neurodevelopmental disorders (NDDs) are complex conditions characterized by heterogeneous clinical profiles and symptoms that arise in infancy and childhood. NDDs are often attributed to a complicated interaction between genetic risk and environmental factors, suggesting a need for preclinical models reflecting the combined impact of heritable susceptibility and environmental effects. A notable advantage of “two-hit” models is the power to reveal underlying vulnerability that may not be detected in studies employing only genetic or environmental alterations. In this review, we summarize existing literature that investigates detrimental interactions between prenatal stress (PNS) and genes associated with NDDs, with a focus on behavioral phenotyping approaches in mouse models. A challenge in determining the overall role of PNS exposure in genetic models is the diversity of approaches for inducing stress, variability in developmental timepoints for exposure, and differences in phenotyping regimens across laboratories. Identification of optimal stress protocols and critical windows for developmental effects would greatly improve the use of PNS in gene × environment mouse models of NDDs.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Psychiatry
- DOI:
- https://doi.org/10.17615/860y-yw71
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fnbeh.2023.1271225
- ISSN:
- 1662-5153
- Journal Title:
- Frontiers in Behavioral Neuroscience
- Journal Volume:
- 17
- Keyword:
- maternal behavior, ASD, memory, anxiety, sociability, and schizophrenia
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Person:
- Moy, Sheryl S., Harper, Kathryn M., and Harp, Samuel J.
- Publisher:
- Frontiers Media SA
- Source:
- 3acee189-a59c-41d3-bae4-d8e938c13f9b
30. Population divergence in nutrient-temperature interactions in Pieris rapae
- Title Tesim:
- Population divergence in nutrient-temperature interactions in Pieris rapae
- Creator:
- Kingsolver, J.G. and Parker A.L.
- Date of publication:
- 2023
- Abstract Tesim:
- The interaction between larval host plant quality and temperature can influence the short-term physiological rates and life-history traits of insect herbivores. These factors can vary locally, resulting in local adaptation in responses to diet and temperature, but the comparison of these interactions between populations is infrequently carried out. In this study, we examine how the macronutrient ratio of an artificial diet determines the larval growth, development, and survival of larval Pieris rapae (Lepidoptera: Pieridae) at different temperatures between two invasive North American populations from different climatic regions. We conducted a fully factorial experiment with three temperature treatments (18°C, 25°C, and 32°C) and three artificial diet treatments varying in terms of the ratio of protein to carbohydrate (low protein, balanced, and high protein). The effects of diet on life-history traits were greater at lower temperatures, but these differed between populations. Larvae from the subtropical population had reduced survival to pupation on the low-protein diet in the cold temperature treatment, whereas larval survival for the temperate population was equally high for all temperature and diet treatments. Overall, both populations performed more poorly (i.e., they showed slower rates of consumption, growth, and development, and had a smaller pupal mass) in the diet with the low protein ratio, but larvae from the temperate population were less sensitive to diet ratio changes at all temperatures. Our results confirm that the physiological and life-history consequences of imbalanced nutrition for insect herbivores may depend on developmental temperatures, and that different geographic populations of P. rapae within North America vary in their sensitivity to nutritional balance and temperature.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Biology
- DOI:
- https://doi.org/10.17615/5tq6-a134
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/finsc.2023.1237624
- ISSN:
- 2673-8600
- Journal Title:
- Frontiers in Insect Science
- Journal Volume:
- 3
- Keyword:
- population differentiation, climate change, phenotypic plasticity, cabbage white butterfly, temperature, and macronutrients
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Person:
- Kingsolver, J.G. and Parker A.L.
- Publisher:
- Frontiers Media SA
- Rights Statement Label:
- In Copyright
- Source:
- 9f3e1648-d8e3-4429-bb97-13d0fcd4d66d
Collection Details
- Total items
-
707
- Size
-
unknown
- Date created
-
May 26, 2022