Frontiers

User Collection Public
UNC logo

UNC-authored articles published by Frontiers

Works (775)

View results as:
List List Masonry Masonry Slideshow Slideshow
Sort the listing of items  

481. Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases

Title Tesim:
Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases
Creator:
Roberts, J., Lopez Quezada, L., Lupoli, T.J., Schoenen, F.J., Edoo, Z., Li, X., Aubé, J., Gold, B., Ling, Y., Nguyen, Q., Smith, R., Hugonnet, J.-E., Sacchettini, J.C., Arthur, M., Nathan, C., Li, K., and Park, S.W.
Date of publication:
2020
Abstract Tesim:
As β-lactams are reconsidered for the treatment of tuberculosis (TB), their targets are assumed to be peptidoglycan transpeptidases, as verified by adduct formation and kinetic inhibition of Mycobacterium tuberculosis (Mtb) transpeptidases by carbapenems active against replicating Mtb. Here, we investigated the targets of recently described cephalosporins that are selectively active against non-replicating (NR) Mtb. NR-active cephalosporins failed to inhibit recombinant Mtb transpeptidases. Accordingly, we used alkyne analogs of NR-active cephalosporins to pull down potential targets through unbiased activity-based protein profiling and identified over 30 protein binders. None was a transpeptidase. Several of the target candidates are plausibly related to Mtb’s survival in an NR state. However, biochemical tests and studies of loss of function mutants did not identify a unique target that accounts for the bactericidal activity of these beta-lactams against NR Mtb. Instead, NR-active cephalosporins appear to kill Mtb by collective action on multiple targets. These results highlight the ability of these β-lactams to target diverse classes of proteins.
Resource type:
Article
Affiliation Label Tesim:
Division of Chemical Biology and Medicinal Chemistry
DOI:
https://doi.org/10.17615/vg5m-j221
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fmicb.2020.01248
ISSN:
1664-302X
Journal Title:
Frontiers in Microbiology
Journal Volume:
11
Keyword:
M. tuberculosis, cephalosporin, β-lactams, click chemistry, ABPP, and non-replicating
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
Weill Cornell Medical College, University of Kansas, Université de Paris, and Texas A&M University
Person:
Roberts, J., Lopez Quezada, L., Lupoli, T.J., Schoenen, F.J., Edoo, Z., Li, X., Aubé, J., Gold, B., Ling, Y., Nguyen, Q., Smith, R., Hugonnet, J.-E., Sacchettini, J.C., Arthur, M., Nathan, C., Li, K., and Park, S.W.
Publisher:
Frontiers Media S.A.
Rights Statement Label:
In Copyright
Source:
jeffrey_aube_14

482. Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria

Title Tesim:
Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria
Creator:
Miao, Edward A. and Harvest, Carissa K.
Date of publication:
2022
Abstract Tesim:
Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol-invasive Burkholderia and Shigella species by lysing the infected cell via pyroptosis. However, recent evidence has shown caspase-11 and gasdermin D activation can result in two different outcomes: pyroptosis and autophagy. Burkholderia cepacia complex has the ability invade the cytosol but is unable to inhibit caspase-11 and gasdermin D. Yet instead of activating pyroptosis during infection with these bacteria, the autophagy pathway is stimulated through caspases and gasdermin D. In contrast, Burkholderia thailandensis can invade the cytosol where caspasae-11 and gasdermin D is activated but the result is pyroptosis of the infected cell. In this review we propose a hypothetical model to explain why autophagy would be the solution to kill one type of Burkholderia species, but another Burkholderia species is killed by pyroptosis. For pathogens with high virulence, pyroptosis is the only solution to kill bacteria. This explains why some pathogens, such as Shigella have evolved methods to inhibit caspase-11 and gasdermin D as well as autophagy. We also discuss similar regulatory steps that affect caspase-1 that may permit the cell to forbear undergoing pyroptosis after caspase-1 activates in response to bacteria with partially effective virulence factors.
Resource type:
Article
Affiliation Label Tesim:
Department of Microbiology and Immunology
DOI:
https://doi.org/10.17615/27ph-tr21
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fimmu.2022.871190
ISSN:
1664-3224
Journal Title:
Frontiers in Immunology
Journal Volume:
13
Keyword:
caspase-1, caspase-11, Shigella, autophagy, Burkholderia, and pyroptosis
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
Duke University
Person:
Miao, Edward A. and Harvest, Carissa K.
Rights Statement Label:
In Copyright
Source:
covid_OA_2022-04_13

483. Harnessing the Anti-Tumor Mediators in Mast Cells as a New Strategy for Adoptive Cell Transfer for Cancer

Title Tesim:
Harnessing the Anti-Tumor Mediators in Mast Cells as a New Strategy for Adoptive Cell Transfer for Cancer
Creator:
Ahani, Elnaz, Dellinger, Kristen, Motaghed, Mona, Kepley, Christopher L., Fereydouni, Mohammad, Metcalfe, Dean D., and Kafri, Tal
Date of publication:
2022
Abstract Tesim:
The emergence of cancer immunotherapies utilizing adoptive cell transfer (ACT) continues to be one of the most promising strategies for cancer treatment. Mast cells (MCs) which occur throughout vascularized tissues, are most commonly associated with Type I hypersensitivity, bind immunoglobin E (IgE) with high affinity, produce anti-cancer mediators such as tumor necrosis factor alpha (TNF-α) and granulocyte macrophage colony-stimulating factor (GM-CSF), and generally populate the tumor microenvironments. Yet, the role of MCs in cancer pathologies remains controversial with evidence for both anti-tumor and pro-tumor effects. Here, we review the studies examining the role of MCs in multiple forms of cancer, provide an alternative, MC-based hypothesis underlying the mechanism of therapeutic tumor IgE efficacy in clinical trials, and propose a novel strategy for using tumor-targeted, IgE-sensitized MCs as a platform for developing new cellular cancer immunotherapies. This autologous MC cancer immunotherapy could have several advantages over current cell-based cancer immunotherapies and provide new mechanistic strategies for cancer therapeutics alone or in combination with current approaches.
Resource type:
Article
Affiliation Label Tesim:
Department of Microbiology and Immunology
DOI:
https://doi.org/10.17615/4bqj-tx32
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fonc.2022.830199
ISSN:
2234-943X
Journal Title:
Frontiers in Oncology
Journal Volume:
12
Keyword:
FceRI, mast cells, IgE, cancer immunotherapy, and adoptive cell transfer
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
North Carolina A&T State University, Liberty University, University of North Carolina Greensboro, and National Institutes of Health
Person:
Ahani, Elnaz, Dellinger, Kristen, Motaghed, Mona, Kepley, Christopher L., Fereydouni, Mohammad, Metcalfe, Dean D., and Kafri, Tal
Rights Statement Label:
In Copyright
Source:
covid_OA_2022-04_12

484. Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer

Title Tesim:
Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer
Creator:
Lee, Jacqueline, Repka, Michael C., Forsthoefel, Matthew, Obayomi-Davies, Olusola, Lischalk, Jonathan W., Creswell, Michael, Carrasquilla, Michael, Aghdam, Nima, Kataria, Shaan, Hankins, Ryan A., Collins, Brian T., Suy, Simeng, Lei, Siyuan, and Collins, Sean P.
Date of publication:
2022
Abstract Tesim:
In this review we outline the current evidence for the use of hydrogel rectal spacers in the treatment paradigm for prostate cancer with external beam radiation therapy. We review their development, summarize clinical evidence, risk of adverse events, best practices for placement, treatment planning considerations and finally we outline a framework and rationale for the utilization of rectal spacers when treating unfavorable risk prostate cancer with dose escalated Stereotactic Body Radiation Therapy (SBRT).
Resource type:
Article
Affiliation Label Tesim:
Department of Radiation Oncology
DOI:
https://doi.org/10.17615/2a2s-hp13
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fonc.2022.860848
ISSN:
2234-943X
Journal Title:
Frontiers in Oncology
Journal Volume:
12
Keyword:
prostate, rectal spacer, hydrogel, SBRT, radiation therapy, and radiotherapy
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
Georgetown University School of Medicine, Radiotherapy Centers of Kentuckiana, Wellstar Kennestone Hospital, New York University, MedStar Georgetown University Hospital, Beth Israel Deaconess Medical Center, and Arlington & Reston Radiation Oncology
Person:
Lee, Jacqueline, Repka, Michael C., Forsthoefel, Matthew, Obayomi-Davies, Olusola, Lischalk, Jonathan W., Creswell, Michael, Carrasquilla, Michael, Aghdam, Nima, Kataria, Shaan, Hankins, Ryan A., Collins, Brian T., Suy, Simeng, Lei, Siyuan, and Collins, Sean P.
Rights Statement Label:
In Copyright
Source:
covid_OA_2022-04_11

485. MiRKAT-MC: A Distance-Based Microbiome Kernel Association Test With Multi-Categorical Outcomes

Title Tesim:
MiRKAT-MC: A Distance-Based Microbiome Kernel Association Test With Multi-Categorical Outcomes
Creator:
Jiang, Zhiwen, Chen, Jun, Zhao, Ni, Zhan, Xiang, and He, Mengyu
Date of publication:
2022
Abstract Tesim:
Increasing evidence has elucidated that the microbiome plays a critical role in many human diseases. Apart from continuous and binary traits that measure the extent or presence of a disease, multi-categorical outcomes including variations/subtypes of a disease or ordinal levels of disease severity are commonly seen in clinical studies. On top of that, studies with clustered design (i.e., family-based and longitudinal studies) are popular alternatives to population-based ones as they are able to identify characteristics on both individual and population levels and to investigate the trajectory of traits of interest over time. However, existing methods for microbiome association analysis are inadequate to handle multi-categorical outcomes, neither independent nor clustered data. We propose a microbiome kernel association test with multi-categorical outcomes (MiRKAT-MC). Our method is versatile to deal with both nominal and ordinal outcomes for independent and clustered data. In addition, it incorporates multiple ecological distances to allow for different association patterns between outcomes and microbiome compositions to be incorporated. A computationally efficient pseudo-permutation strategy is used to evaluate the statistical significance. Comprehensive simulations show that MiRKAT-MC preserves the nominal type I error and increases statistical powers under various scenarios and data types. We also apply MiRKAT-MC to real data sets with nominal and ordinal outcomes to gain biological insights. MiRKAT-MC is easy to implement, and freely available via an R package at https://github.com/Zhiwen-Owen-Jiang/MiRKATMC with a Graphical User Interface through R Shinny also available.
Resource type:
Article
Affiliation Label Tesim:
Department of Biostatistics
DOI:
https://doi.org/10.17615/1bqp-wm74
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fgene.2022.841764
ISSN:
1664-8021
Journal Title:
Frontiers in Genetics
Journal Volume:
13
Keyword:
microbiome association analysis, longitudinal studies, kernel association test, multi-categorical outcomes, and beta-diversity
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
Mayo Clinic, Johns Hopkins University, Peking University, and Emory University
Person:
Jiang, Zhiwen, Chen, Jun, Zhao, Ni, Zhan, Xiang, and He, Mengyu
Rights Statement Label:
In Copyright
Source:
covid_OA_2022-04_10

486. Entactogens: How the Name for a Novel Class of Psychoactive Agents Originated

Title Tesim:
Entactogens: How the Name for a Novel Class of Psychoactive Agents Originated
Creator:
Nichols, David E.
Date of publication:
2022
Abstract Tesim:
At first glance, it appears there is little difference between the molecular structures of methylenedioxymethamphetamine (MDMA), which has an N-methyl attached to its amino group, and methylenedioxyamphetamine (MDA), a primary amine that is recognized to have hallucinogenic activity. It is known from studies with other hallucinogenic amphetamines that N-methylation of hallucinogenic amphetamines attenuates or abolishes hallucinogenic activity. Nevertheless, MDMA is biologically active and has a potency only slightly less than its MDA parent. Importantly, it is the Ievo-isomer of hallucinogenic phenethylamines that is more biologically active, whereas it is the dextro isomer of MDMA that is more active. This reversal of stereochemistry for the activity of two very closely related molecules is a very powerful clue that their mechanisms of action differ. Finally, extension of the alpha-methyl of hallucinogenic amphetamines to an alpha-ethyl moiety completely abolishes their hallucinogenic activity. Ultimately, we extended the alpha-methyl group of MDMA to an alpha-ethyl to afford a molecule we named (N-Methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB) that retained significant MDMA-like psychoactivity. Hence, there are three structural features that distinguish MDMA from the hallucinogenic amphetamines: (1) the N-methyl on the basic nitrogen, (2) the reversal of stereochemistry and, (3) tolerance of an alpha-ethyl moiety as contrasted with the alpha-methyl of hallucinogenic phenethylamines. Clearly, MDMA is distinct from classical hallucinogenic phenethylamines in its structure, and its psychopharmacology is also unique. Thus, in 1986 I proposed the name “Entactogen” for the pharmacological class of drugs that includes 3,4-methylenedioxymethamphetamine (MDMA) and other substances with a similar psychopharmacological effect. The name is derived from roots that indicate that entactogens produce a “touching within.” Rather than having significant psychostimulant, or hallucinogenic effects, MDMA powerfully promotes affiliative social behavior, has acute anxiolytic effects, and can lead to profound states of introspection and personal reflection. Its mechanism of action is now established as involving transport of MDMA by the neuronal serotonin reuptake carrier followed by carrier-mediated release of stored neuronal serotonin.
Resource type:
Article
Affiliation Label Tesim:
Division of Chemical Biology and Medicinal Chemistry
DOI:
https://doi.org/10.17615/wh97-gq35
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fpsyt.2022.863088
ISSN:
1664-0640
Journal Title:
Frontiers in Psychiatry
Journal Volume:
13
Keyword:
MBDB, entactogen, serotonin transporter, MDMA, and serotonin
Language Label:
English
License Label:
Attribution 4.0 International
Person:
Nichols, David E.
Rights Statement Label:
In Copyright
Source:
frontiers_backfiles_40

487. Parental Guidance Suggested: Engaging Parents as Partners in Research Studies of Genomic Screening for a Pediatric Population

Title Tesim:
Parental Guidance Suggested: Engaging Parents as Partners in Research Studies of Genomic Screening for a Pediatric Population
Creator:
Milko, Laura V., Owens, Thomas H., Osborne, Heather, Bennetone, Ashley, Powell, Sabrina N., O'Daniel, Julianne, James-Crook, Erin R., Byfield, Grace, Harrison, Langston K., Shaw, Jonathan L., and Frantz, Annabelle M.
Date of publication:
2022
Abstract Tesim:
Recent advances in genomic sequencing and genomic medicine are reshaping the landscape of clinical care. As a screening modality, genetic sequencing has the potential to dramatically expand the clinical utility of newborn screening (NBS), though significant barriers remain regarding ethical, legal, and social implications (ELSI) and technical and evidentiary challenges. Stakeholder-informed implementation research is poised to grapple with many of these barriers, and parents are crucial stakeholders in this process. We describe the formation and activities of a Community Research Board (CRB) composed of parents with diverse backgrounds assembled to participate in an ongoing research partnership with genomic and public health researchers at the University of North Carolina. The mission of the CRB is to provide insight into parental perspectives regarding the prospect of adding genomic sequencing to NBS and collaboratively develop strategies to ensure its equitable uptake. We describe how these contributions can improve the accessibility of research and recruitment methods and promote trust and inclusivity within diverse communities to maximize the societal benefit of population genomic screening in healthy children.
Resource type:
Article
Affiliation Label Tesim:
Department of Genetics
DOI:
https://doi.org/10.17615/wpvb-yq89
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fgene.2022.867030
ISSN:
1664-8021
Journal Title:
Frontiers in Genetics
Journal Volume:
13
Keyword:
accessibility, public health, community research board, genomic sequencing, engaging parents, equity, newborn screening, and stakeholders
Language Label:
English
License Label:
Attribution 4.0 International
Person:
Milko, Laura V., Owens, Thomas H., Osborne, Heather, Bennetone, Ashley, Powell, Sabrina N., O'Daniel, Julianne, James-Crook, Erin R., Byfield, Grace, Harrison, Langston K., Shaw, Jonathan L., and Frantz, Annabelle M.
Rights Statement Label:
In Copyright
Source:
frontiers_backfiles_39

488. B Cell Receptor Signaling and Protein Kinase D2 Support Regulatory B Cell Function in Pancreatic Cancer

Title Tesim:
B Cell Receptor Signaling and Protein Kinase D2 Support Regulatory B Cell Function in Pancreatic Cancer
Creator:
Mirlekar, Bhalchandra, Pylayeva-Gupta, Yuliya, Steward, Colleen, Bishop, Gail, and Michaud, Daniel
Date of publication:
2022
Abstract Tesim:
B cells can act as potent suppressors of anti-tumor T cell immunity, presenting a mechanism of resistance to immunotherapy. In pancreatic ductal adenocarcinoma, B cells can display a T cell-suppressive or regulatory phenotype centered on the expression of the cytokine Interleukin 35 (IL-35). While B cell-mediated immunosuppression presents a barrier to anti-tumorigenic T cell function, it is not clear how regulatory B cell function could be targeted, and the signals that promote this suppressive phenotype in B cells are not well understood. Here we use a novel IL-35 reporter model to understand which signaling pathways are important for immunosuppressive properties in B cells. In vitro analysis of IL-35 reporter B cells revealed a synergy between the BCR and TLR4 signaling pathways is sufficient to induce IL-35 expression. However, in vivo, B cell receptor activation, as opposed to MyD88 signaling in B cells, is central to B cell-mediated suppression and promotion of pancreatic cancer growth. Further analysis identified protein kinase D2 (PKD2) as being a key downstream regulator of IL-35 expression in B cells. Regulatory B cells with an inactivating mutation in PKD2 failed to produce IL-35 or fully suppress effector T cell function in vitro. Furthermore, inhibition of PKD in B cells decreased tumor growth and promoted effector T cell function upon adoptive transfer into B cell-deficient mice. Collectively, these data provide insight into how regulatory B cell function is promoted in pancreatic cancer and identify potential therapeutic targets to restrain this function.
Resource type:
Article
Affiliation Label Tesim:
UNC Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, and Department of Cell Biology and Physiology
DOI:
https://doi.org/10.17615/7289-tg26
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fimmu.2021.745873
ISSN:
1664-3224
Journal Title:
Frontiers in Immunology
Journal Volume:
12
Keyword:
pancreatic cancer, BCR, PKD, regulatory B cell, and IL-35
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
University of Iowa
Person:
Mirlekar, Bhalchandra, Pylayeva-Gupta, Yuliya, Steward, Colleen, Bishop, Gail, and Michaud, Daniel
Rights Statement Label:
In Copyright
Source:
frontiers_backfiles_38

489. What Factors Predict the Adoption of Type 2 Diabetes Patients to Wearable Activity Trackers—Application of Diffusion of Innovation Theory

Title Tesim:
What Factors Predict the Adoption of Type 2 Diabetes Patients to Wearable Activity Trackers—Application of Diffusion of Innovation Theory
Creator:
Fisher, Edwin B., Chen, Ping, Shen, Ying, Li, Zeming, Feng, Xing Lin, and Sun, Xinying
Date of publication:
2022
Abstract Tesim:
Background: Globally, diabetes has brought an enormous burden to public health resources, and the situation of disease burden caused by diabetes in China is especially severe. China is currently facing the dual threat of aging and diabetes, and wearable activity trackers could promote elderly diabetic patients' physical activity levels and help them to manage blood glucose control. Therefore, examining the influencing factors of elderly patients' adoption intention is critical as wearing adoption determines actual wearing behaviors.Objective: This study aims to explore the predicting factors of Chinese elderly type 2 diabetic patients' adoption intention to wearable activity trackers and their actual wearing behavior, using diffusion of innovation theory as the theoretical framework. We hope to provide insights into future interventions using wearable activity trackers as tools to improve the outcome of patients.Methods: Wearable activity trackers were freely distributed to type 2 diabetic patients in Beijing, China. A questionnaire survey was conducted to examine predicting factors of adoption intention after a week's try-on. Actual wearing behavior for 3-month was obtained from the exclusive cloud. Data were analyzed with structural equation modeling.Results: A total of 725 patients completed the questionnaire. Patients had a mean age of 60.3 ± 7.6 years old and the educational level was generally lower. The results indicated that observability was the primary influencing factor of patients' adoption intention (β = 0.775, P < 0.001). Relative advantage (β = 0.182, P = 0.014) and perceived social image (β = 0.080, P = 0.039) also had a positive influence while perceived risk (β = −0.148, P < 0.001) exerted a negative influence. In addition, results showed that the more intention led to the better actual wearing behavior (β = 0.127, P = 0.003). Observability (β = 0.103, P = 0.005), perceived ease (β = 0.085, P = 0.004), and relative advantage (β = 0.041, P = 0.009) also indirectly influenced the wearing behavior.Conclusion: The intentions of Chinese elderly type 2 diabetic patients to wearable activity trackers directly influenced the actual wearing behavior. In addition, their adoption intention to wearable activity trackers was mainly influenced by observability, perceived ease to use, relative advantage, perceived risk, and social image.
Resource type:
Article
Affiliation Label Tesim:
Department of Health Behavior and Department of Health Policy and Management
DOI:
https://doi.org/10.17615/q6ba-t098
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fpubh.2021.773293
ISSN:
2296-2565
Journal Title:
Frontiers in Public Health
Journal Volume:
9
Keyword:
type 2 diabetes, wearable activity trackers, elderly patients, physical activity, diffusion of innovation theory, and structural equation modeling
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
Peking University and Beijing Center for Disease Prevention and Control
Person:
Fisher, Edwin B., Chen, Ping, Shen, Ying, Li, Zeming, Feng, Xing Lin, and Sun, Xinying
Rights Statement Label:
In Copyright
Source:
frontiers_backfiles_37

490. Brain Imaging Biomarkers for Chronic Pain

Title Tesim:
Brain Imaging Biomarkers for Chronic Pain
Creator:
Gewandter, Jennifer S., Geha, Paul, and Zhang, Zhengwu
Date of publication:
2022
Abstract Tesim:
The prevalence of chronic pain has reached epidemic levels. In addition to personal suffering chronic pain is associated with psychiatric and medical co-morbidities, notably substance misuse, and a huge a societal cost amounting to hundreds of billions of dollars annually in medical cost, lost wages, and productivity. Chronic pain does not have a cure or quantitative diagnostic or prognostic tools. In this manuscript we provide evidence that this situation is about to change. We first start by summarizing our current understanding of the role of the brain in the pathogenesis of chronic pain. We particularly focus on the concept of learning in the emergence of chronic pain, and the implication of the limbic brain circuitry and dopaminergic signaling, which underly emotional learning and decision making, in this process. Next, we summarize data from our labs and from other groups on the latest brain imaging findings in different chronic pain conditions focusing on results with significant potential for translation into clinical applications. The gaps in the study of chronic pain and brain imaging are highlighted in throughout the overview. Finally, we conclude by discussing the costs and benefits of using brain biomarkers of chronic pain and compare to other potential markers.
Resource type:
Article
Affiliation Label Tesim:
Department of Statistics and Operations Research
DOI:
https://doi.org/10.17615/5rbq-yv05
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fneur.2021.734821
ISSN:
1664-2295
Journal Title:
Frontiers in Neurology
Journal Volume:
12
Keyword:
biomarkers, chronic pain, prognosis, neuroimaging, diagnosis, and limbic brain
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
University of Rochester
Person:
Gewandter, Jennifer S., Geha, Paul, and Zhang, Zhengwu
Rights Statement Label:
In Copyright
Source:
frontiers_backfiles_36