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UNC-authored articles published by Frontiers
Works (698)
41. Plasma phosphorylated tau181 as a biomarker of mild traumatic brain injury: findings from THINC and NCAA-DoD CARE Consortium prospective cohorts
- Title Tesim:
- Plasma phosphorylated tau181 as a biomarker of mild traumatic brain injury: findings from THINC and NCAA-DoD CARE Consortium prospective cohorts
- Creator:
- Broglio, Steven P., Giza, Christopher C., Meier, Timothy B., Devoto, Christina, Huber, Daniel, Cameron, Kenneth L., Brooks, Alison, Pasquina, Paul, Jackson, Jonathan, Rowson, Steven, McAllister, Thomas, Lai, Chen, Duma, Stefan, Vorn, Rany, Gill, Jessica M., CARE Consortium Investigators, Mithani, Sara, Turtzo, Christine, Latour, Lawrence, Guskiewicz, Kevin, Nelson, Lindsay D., Harezlak, Jaroslaw, Mihalik, Jason P., McGinty, Gerald, and McCrea, Michael A.
- Date of publication:
- 2023
- Abstract Tesim:
- Objective The aim of this study was to investigate phosphorylated tau (p-tau181) protein in plasma in a cohort of mild traumatic brain injury (mTBI) patients and a cohort of concussed athletes. Methods This pilot study comprised two independent cohorts. The first cohort—part of a Traumatic Head Injury Neuroimaging Classification (THINC) study—with a mean age of 46 years was composed of uninjured controls (UIC, n = 30) and mTBI patients (n = 288) recruited from the emergency department with clinical computed tomography (CT) and research magnetic resonance imaging (MRI) findings. The second cohort—with a mean age of 19 years—comprised 133 collegiate athletes with (n = 112) and without (n = 21) concussions. The participants enrolled in the second cohort were a part of a multicenter, prospective, case-control study conducted by the NCAA-DoD Concussion Assessment, Research and Education (CARE) Consortium at six CARE Advanced Research Core (ARC) sites between 2015 and 2019. Blood was collected within 48 h of injury for both cohorts. Plasma concentration (pg/ml) of p-tau181 was measured using the Single Molecule Array ultrasensitive assay. Results Concentrations of plasma p-tau181 in both cohorts were significantly elevated compared to controls within 48 h of injury, with the highest concentrations of p-tau181 within 18 h of injury, with an area under the curve (AUC) of 0.690–0.748, respectively, in distinguishing mTBI patients and concussed athletes from controls. Among the mTBI patients, the levels of plasma p-tau181 were significantly higher in patients with positive neuroimaging (either CT+/MRI+, n = 74 or CT−/MRI+, n = 89) compared to mTBI patients with negative neuroimaging (CT−/MRI−, n = 111) findings and UIC (P-values < 0.05). Conclusion These findings indicate that plasma p-tau181 concentrations likely relate to brain injury, with the highest levels in patients with neuroimaging evidence of injury. Future research is needed to replicate and validate this protein assay's performance as a possible early diagnostic biomarker for mTBI/concussions.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Exercise and Sport Science
- DOI:
- https://doi.org/10.17615/vazw-bm79
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fneur.2023.1202967
- ISSN:
- 1664-2295
- Journal Issue:
- 8
- Journal Title:
- Frontiers in Neurology
- Journal Volume:
- 2
- Keyword:
- concussion, sports related concussion, mTBI, p-tau181, brain trauma, and mild traumatic brain injury
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University of Michigan, University of California, Los Angeles, Medical College of Wisconsin, Henry M. Jackson Foundation for the Advancement of Military Medicine, Keller Army Hospital, University of Wisconsin, Madison, Uniformed Services University and Health Science, United States Air Force Academy, Virginia Tech, Indiana University School of Medicine, National Institutes of Health, Johns Hopkins University, , University of Texas Health at San Antonio, and Indiana University, Bloomington
- Page Start:
- e0000152
- Person:
- Broglio, Steven P., Giza, Christopher C., Meier, Timothy B., Devoto, Christina, Huber, Daniel, Cameron, Kenneth L., Brooks, Alison, Pasquina, Paul, Jackson, Jonathan, Rowson, Steven, McAllister, Thomas, Lai, Chen, Duma, Stefan, Vorn, Rany, Gill, Jessica M., CARE Consortium Investigators, Mithani, Sara, Turtzo, Christine, Latour, Lawrence, Guskiewicz, Kevin, Nelson, Lindsay D., Harezlak, Jaroslaw, Mihalik, Jason P., McGinty, Gerald, and McCrea, Michael A.
- Publisher:
- Frontiers Media SA
- Source:
- 68b294e4-489a-4616-8983-cfaab1ffb7ce
42. Orlistat exerts anti-obesity and anti-tumorigenic effects in a transgenic mouse model of endometrial cancer
- Title Tesim:
- Orlistat exerts anti-obesity and anti-tumorigenic effects in a transgenic mouse model of endometrial cancer
- Creator:
- Wysham W.Z., Roque D.R., Fang Z., Deng B., Yin Y., Bae-Jump V., Zhou C., Xu G., Zhao Z., Sun W., and Shen X.
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction: Among all cancers, endometrial cancer is most strongly associated with obesity, with more than 65% of endometrial cancers attributable to obesity and being overweight. Fatty acid synthase (FAS), a key lipogenic enzyme, is expressed in endometrial cancer tumors and is associated with a worse prognosis for this disease. Orlistat, an FAS inhibitor, is an FDA-approved weight loss medication that has demonstrated anti-tumor activity in a variety of preclinical cancer models. Methods: In this study, the Lkb1fl/flp53fl/fl mouse model of endometroid endometrial cancer was exposed to three diet interventions, including a high fat diet (obese), a low fat diet (lean) and switch from a high fat to a low fat diet, and then exposed to orlistat or placebo. Results: The mice fed a high-fat diet had significantly increased body weight and tumor weight compared to mice fed a low-fat diet. Switching from a high-fat diet to a low fat diet led to a reduction in mouse weight and suppressed tumor growth, as compared to both the high fat diet and low fat diet groups. Orlistat effectively decreased body weight in obese mice and inhibited tumor growth in obese, lean, and the high fat diet switch to low fat diet mouse groups through induction of apoptosis. Orlistat also showed anti-proliferative activity in nine of 11 primary cultures of human endometrial cancer. Discussion: Our findings provide strong evidence that dietary intervention and orlistat have anti-tumor activity in vivo and supports further investigation of orlistat in combination with dietary interventions for the prevention and treatment of endometrial cancer.
- Resource type:
- Article
- Affiliation Label Tesim:
- University of North Carolina at Chapel Hill and UNC Lineberger Comprehensive Cancer Center
- DOI:
- https://doi.org/10.17615/3yaj-8991
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fonc.2023.1219923
- ISSN:
- 2234-943X
- Journal Title:
- Frontiers in Oncology
- Journal Volume:
- 13
- Keyword:
- orlistat, dietary intervention, endometrial cancer, apoptosis, and obesity
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Legacy Medical Group, Northwestern University Feinberg School of Medicine, and
- Person:
- Wysham W.Z., Roque D.R., Fang Z., Deng B., Yin Y., Bae-Jump V., Zhou C., Xu G., Zhao Z., Sun W., and Shen X.
- Publisher:
- Frontiers Media SA
- Source:
- 4a28b871-0b1f-4c71-b637-bb687c8b483b
43. NeuroBridge: a prototype platform for discovery of the long-tail neuroimaging data
- Title Tesim:
- NeuroBridge: a prototype platform for discovery of the long-tail neuroimaging data
- Creator:
- Moore, Stephen M., Sahoo, Satya S., Wang, Yue, Wang, Lei, Kogan, Alex, Ambite, José Luis, Turner, Jessica A., Dockes, Jerome, Lander, Howard, Poline, Jean-Baptiste, Appaji, Abhishek, Turner, Matthew D., Herrick, Rick, Marcus, Daniel, Rajasekar, Arcot, Bijsterbosch, Janine, and Wang, Xiaochen
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction Open science initiatives have enabled sharing of large amounts of already collected data. However, significant gaps remain regarding how to find appropriate data, including underutilized data that exist in the long tail of science. We demonstrate the NeuroBridge prototype and its ability to search PubMed Central full-text papers for information relevant to neuroimaging data collected from schizophrenia and addiction studies. Methods The NeuroBridge architecture contained the following components: (1) Extensible ontology for modeling study metadata: subject population, imaging techniques, and relevant behavioral, cognitive, or clinical data. Details are described in the companion paper in this special issue; (2) A natural-language based document processor that leveraged pre-trained deep-learning models on a small-sample document corpus to establish efficient representations for each article as a collection of machine-recognized ontological terms; (3) Integrated search using ontology-driven similarity to query PubMed Central and NeuroQuery, which provides fMRI activation maps along with PubMed source articles. Results The NeuroBridge prototype contains a corpus of 356 papers from 2018 to 2021 describing schizophrenia and addiction neuroimaging studies, of which 186 were annotated with the NeuroBridge ontology. The search portal on the NeuroBridge website https://neurobridges.org/ provides an interactive Query Builder, where the user builds queries by selecting NeuroBridge ontology terms to preserve the ontology tree structure. For each return entry, links to the PubMed abstract as well as to the PMC full-text article, if available, are presented. For each of the returned articles, we provide a list of clinical assessments described in the Section “Methods” of the article. Articles returned from NeuroQuery based on the same search are also presented. Conclusion The NeuroBridge prototype combines ontology-based search with natural-language text-mining approaches to demonstrate that papers relevant to a user’s research question can be identified. The NeuroBridge prototype takes a first step toward identifying potential neuroimaging data described in full-text papers. Toward the overall goal of discovering “enough data of the right kind,” ongoing work includes validating the document processor with a larger corpus, extending the ontology to include detailed imaging data, and extracting information regarding data availability from the returned publications and incorporating XNAT-based neuroimaging databases to enhance data accessibility.
- Resource type:
- Article
- Affiliation Label Tesim:
- School of Information and Library Science and Renaissance Computing Institute
- DOI:
- https://doi.org/10.17615/an5d-3y88
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fninf.2023.1215261
- ISSN:
- 1662-5196
- Journal Issue:
- 17
- Journal Title:
- Frontiers in Neuroinformatics
- Journal Volume:
- 24
- Keyword:
- ontology, MRI, schizophrenia, experimental design, addiction, metadata, and text-mining
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Washington University in St. Louis, Case Western Reserve University, , Ohio State University Wexner Medical Center, University of Southern California, The Ohio State University Wexner Medical Center, McGill University, BMS College of Engineering, and Pennsylvania State University
- Page Start:
- 13242
- Person:
- Moore, Stephen M., Sahoo, Satya S., Wang, Yue, Wang, Lei, Kogan, Alex, Ambite, José Luis, Turner, Jessica A., Dockes, Jerome, Lander, Howard, Poline, Jean-Baptiste, Appaji, Abhishek, Turner, Matthew D., Herrick, Rick, Marcus, Daniel, Rajasekar, Arcot, Bijsterbosch, Janine, and Wang, Xiaochen
- Publisher:
- Frontiers Media SA
- Source:
- 1222a449-7622-4af2-8658-ce1eb3a92348
44. Mindshift in autism: a call to professionals in research, clinical, and educational settings
- Title Tesim:
- Mindshift in autism: a call to professionals in research, clinical, and educational settings
- Creator:
- Jones, Desiree R., Nicolaidis, Christina, Waisman, T. C., McVey, Alana J., Raymaker, Dora M., and Maddox, Brenna B.
- Date of publication:
- 2023
- Abstract Tesim:
- Autistic people often have poor outcomes over the life course, including in health, education, employment, and community inclusion. Many professionals working with Autistic adults in research, clinical, and educational settings devote their careers to trying to improve such outcomes. However, we maintain that real progress cannot happen without a fundamental mindshift. The status quo for professionals is to view autism as an illness. Instead, the neurodiversity movement encourages us to value and embrace autism as an aspect of human diversity and asks us to view Autistic people as a marginalized group that experiences significant disparities. While some professionals may be adopting language and concepts from the neurodiversity movement, we argue that making this mindshift fundamentally changes our practice across research, clinical, and educational settings. In this perspective, we call on professionals to embrace this mindshift to reduce discrimination and stigma, halt the spread of harmful ideologies, and help Autistic adults live fulfilling lives.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Psychiatry
- DOI:
- https://doi.org/10.17615/ej7e-aj58
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fpsyt.2023.1251058
- ISSN:
- 1664-0640
- Journal Title:
- Frontiers in Psychiatry
- Keyword:
- neurodiversity, disability justice, stigma, discrimination, and autism
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University of Texas at Dallas, Portland State University, Autism Training Academy, University of Washington, and
- Person:
- Jones, Desiree R., Nicolaidis, Christina, Waisman, T. C., McVey, Alana J., Raymaker, Dora M., and Maddox, Brenna B.
- Publisher:
- Frontiers Media SA
- Source:
- d4a60ea6-50ed-44f5-890e-af39380ee950
45. Male partners’ support and influence on pregnant women’s oral PrEP use and adherence in Malawi
- Title Tesim:
- Male partners’ support and influence on pregnant women’s oral PrEP use and adherence in Malawi
- Creator:
- Young A.M., Chi B.H., Tseka J., Hill L.M., Pearce L.D., Mutale W., Maman S., Golin C.E., Bula A., Saidi F., Mmodzi P., and Phanga T.
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction: Daily oral pre-exposure prophylaxis (PrEP) is a safe and effective HIV prevention method for pregnant and postpartum women, but adherence barriers exist. Understanding the role of male partners in supporting PrEP use may inform strategies to support PrEP adherence among pregnant and breastfeeding women. Methods: To understand male partners’ involvement in women's use of PrEP, we conducted in-depth interviews with pregnant women in Lilongwe, Malawi who had recently decided to use PrEP (n = 30) and their male partners (n = 20) in the context of a PrEP adherence trial. Women were purposively recruited to ensure variation in their partners’ HIV status. Interviews were conducted in Chichewa using a semistructured guide. We followed a thematic approach to analyze the interview data. Results: Most male partners were receptive to women using PrEP during pregnancy because it eased their fears of the woman and baby acquiring HIV. Men often played a key role in women's PrEP adherence by providing daily reminders and encouragement to adhere to their medication. The majority of women appreciated this support from the men as it lessened the burden of remembering to take their medications daily on their own and aided their adherence. However, several women who lacked male partner support spoke of wanting their partners to be more involved. Many men living with HIV found the mutual support beneficial for their antiretroviral therapy adherence, while men without HIV or with status unknown appreciated knowing that the family was protected. While most men were open to women continuing PrEP beyond the current study, some would only support it if women were still at risk for acquiring HIV. Conclusion: In this study, male partners were strongly motivated to support the PrEP adherence of their female partners as a way of ensuring that the pregnant women and unborn babies were protected against HIV. Promoting disclosure and tangible support that arises organically among men may be helpful, but programs to enhance this support and identify ways to support women who do not receive support from their partners or do not wish to disclose their PrEP use to partners may be needed. 2023 Young, Saidi, Phanga, Tseka, Bula, Mmodzi, Pearce, Maman, Golin, Mutale, Chi and Hill.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Maternal and Child Health, Department of Obstetrics and Gynecology, UNC Project-Malawi, Department of Health Behavior, and Department of Sociology
- DOI:
- https://doi.org/10.17615/ef4w-z182
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/frph.2023.1206075
- ISSN:
- 2673-3153
- Journal Title:
- Frontiers in Reproductive Health
- Journal Volume:
- 5
- Keyword:
- pregnant and breastfeeding women, Malawi, HIV, social support, PrEP, and male partners
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- and University of Zambia
- Person:
- Young A.M., Chi B.H., Tseka J., Hill L.M., Pearce L.D., Mutale W., Maman S., Golin C.E., Bula A., Saidi F., Mmodzi P., and Phanga T.
- Publisher:
- Frontiers Media SA
- Source:
- ab3ed089-322e-4741-bd1b-b5880fb15a41
46. Infant antibody and B-cell responses following confirmed pediatric GII.17 norovirus infections functionally distinguish GII.17 genetic clusters
- Title Tesim:
- Infant antibody and B-cell responses following confirmed pediatric GII.17 norovirus infections functionally distinguish GII.17 genetic clusters
- Creator:
- Baric, Ralph S., Brewer-Jensen, Paul D., Gonzalez, Fredman, Reyes, Yaoska, Vinjé, Jan, Lindesmith, Lisa C., Montmayeur, Anna M., Costantini, Verónica P., Averill, April M., Bucardo, Filemon, May, Samantha, Mallory, Michael L., Diehl, Sean A., Becker-Dreps, Sylvia, McElvany, Benjamin D., Zepeda, Omar, and Strother, Camilla A.
- Date of publication:
- 2023
- Abstract Tesim:
- Genogroup II (GII) noroviruses are a major cause of diarrheal disease burden in children in both high- and low-income countries. GII.17 noroviruses are composed of distinct genetic clusters (I, II, IIIa, and IIIb) and have shown potential for replacing historically more prevalent GII.4 strains, but the serological basis for GII.17 antigenic diversity has not been studied in children. Utilizing samples from a birth cohort, we investigated antibody and B-cell responses to GII.17 cluster variants in confirmed GII.17 infections in young children as well as demonstrated that the distinct genetic clusters co-circulate. Polyclonal serum antibodies bound multiple clusters but showed cluster-specific blockade activity in a surrogate virus neutralization assay. Antibodies secreted by immortalized memory B cells (MBCs) from an infant GII.17 case were highly specific to GII.17 and exhibited blockade activity against this genotype. We isolated an MBC-derived GII.17-specific Immunoglobulin A (IgA) monoclonal antibody called NVA.1 that potently and selectively blocked GII.17 cluster IIIb and recognized an epitope targeted in serum from cluster IIIb–infected children. These data indicate that multiple antigenically distinct GII.17 variants co-circulate in young children, suggesting retention of cluster diversity alongside potential for immune escape given the existence of antibody-defined cluster-specific epitopes elicited during infection.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- DOI:
- https://doi.org/10.17615/7seq-4x32
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fimmu.2023.1229724
- ISSN:
- 1664-3224
- Journal Title:
- Frontiers in Immunology
- Journal Volume:
- 10
- Keyword:
- memory B cells, blockade antibody, variants of concern, children, human monoclonal antibodies, norovirus, and GII.17
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- , National Autonomous University of Nicaragua, Centers for Disease Control and Prevention, and University of Vermont
- Person:
- Baric, Ralph S., Brewer-Jensen, Paul D., Gonzalez, Fredman, Reyes, Yaoska, Vinjé, Jan, Lindesmith, Lisa C., Montmayeur, Anna M., Costantini, Verónica P., Averill, April M., Bucardo, Filemon, May, Samantha, Mallory, Michael L., Diehl, Sean A., Becker-Dreps, Sylvia, McElvany, Benjamin D., Zepeda, Omar, and Strother, Camilla A.
- Publisher:
- Frontiers Media SA
- Source:
- 414b33ac-87ac-4d57-84ec-161c6f76712d
47. Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders
- Title Tesim:
- Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders
- Creator:
- McLarnan S.M., Zhang S., Baker B.H., Pearson B.L., Simon J.M., and Chung W.K.
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction: De novo mutations contribute to a large proportion of sporadic psychiatric and developmental disorders, yet the potential role of environmental carcinogens as drivers of causal de novo mutations in neurodevelopmental disorders is poorly studied. Methods: To explore environmental mutation vulnerability of disease-associated gene sets, we analyzed publicly available whole genome sequencing datasets of mutations in human induced pluripotent stem cell clonal lines exposed to 12 classes of environmental carcinogens, and human lung cancers from individuals living in highly polluted regions. We compared observed rates of exposure-induced mutations in disease-related gene sets with the expected rates of mutations based on control genes randomly sampled from the genome using exact binomial tests. To explore the role of sequence characteristics in mutation vulnerability, we modeled the effects of sequence length, gene expression, and percent GC content on mutation rates of entire genes and gene coding sequences using multivariate Quasi-Poisson regressions. Results: We demonstrate that several mutagens, including radiation and polycyclic aromatic hydrocarbons, disproportionately mutate genes related to neurodevelopmental disorders including autism spectrum disorders, schizophrenia, and attention deficit hyperactivity disorder. Other disease genes including amyotrophic lateral sclerosis, Alzheimer’s disease, congenital heart disease, orofacial clefts, and coronary artery disease were generally not mutated more than expected. Longer sequence length was more strongly associated with elevated mutations in entire genes compared with mutations in coding sequences. Increased expression was associated with decreased coding sequence mutation rate, but not with the mutability of entire genes. Increased GC content was associated with increased coding sequence mutation rates but decreased mutation rates in entire genes. Discussion: Our findings support the possibility that neurodevelopmental disorder genetic etiology is partially driven by a contribution of environment-induced germ line and somatic mutations.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Genetics
- DOI:
- https://doi.org/10.17615/ddh0-kr31
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fnins.2023.1106573
- ISSN:
- 1662-4548
- Journal Title:
- Frontiers in Neuroscience
- Journal Volume:
- 17
- Keyword:
- carcinogen, autism, neurodevelopmental disorders, de novo mutation, somatic mutation, and mutagenesis
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Columbia University and
- Person:
- McLarnan S.M., Zhang S., Baker B.H., Pearson B.L., Simon J.M., and Chung W.K.
- Publisher:
- Frontiers Media SA
- Source:
- 26e2514d-f5bf-4f86-992a-021e70ad79b9
48. Efficacy of social cognition and interaction training in outpatients with schizophrenia spectrum disorders: randomized controlled trial
- Title Tesim:
- Efficacy of social cognition and interaction training in outpatients with schizophrenia spectrum disorders: randomized controlled trial
- Creator:
- Davidson C.A., Roberts D.L., Fiszdon J.M., Penn D.L., Dixon H.D., and Bell M.D.
- Date of publication:
- 2023
- Abstract Tesim:
- Given the relationship between social cognition and functional outcome in schizophrenia, a number of social cognitive interventions have been developed, including Social Cognition Interaction Training (SCIT), a group-based, comprehensive, manualized intervention. In the current trial, we examined SCIT efficacy as well as potential moderators of treatment effects. Fifty-one outpatients were randomized to SCIT or a wait-list-control (WLC), with assessments of social cognition, neurocognition, self-report, symptoms, and functioning conducted at baseline and end of the active phase. Relative to WLC, we did not find significant improvements for SCIT on neurocognition, social cognition, self-report, or symptoms, though there was a trend-level, medium effect favoring the SCIT condition on interpersonal and instrumental role function. Post-hoc analyses indicated that baseline neurocognition did not impact degree of social cognitive or functional change. Shorter duration of illness was significantly associated with better post-training neurocognition and self-esteem and, at trend-level with better symptoms and social functioning. We discuss the importance of outcome measure selection and the need for continued evaluation of potential treatment moderators in order to better match people to existing treatments. Clinical trial registration: Clinicaltrials.gov, Identifier NCT00587561.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Psychology and Neuroscience
- DOI:
- https://doi.org/10.17615/dk3n-q982
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fpsyt.2023.1217735
- ISSN:
- 1664-0640
- Journal Title:
- Frontiers in Psychiatry
- Journal Volume:
- 14
- Keyword:
- training, psychosis, rehabilitation, social cognition, schizophrenia, and randomized controlled trial
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Emory University, University of Texas Health Science Center, Yale University, , and Mercer University
- Person:
- Davidson C.A., Roberts D.L., Fiszdon J.M., Penn D.L., Dixon H.D., and Bell M.D.
- Publisher:
- Frontiers Media SA
- Source:
- 33dd0b9c-03ac-45d0-b5c3-adce27721f5c
49. Editorial: Advances in brain imaging and stimulation methods for cognitive function investigation
- Title Tesim:
- Editorial: Advances in brain imaging and stimulation methods for cognitive function investigation
- Creator:
- Yuan, Zhen, Palm, Ulrich, Boettiger, Charlotte A., and Assenza, Giovanni
- Date of publication:
- 2023
- Abstract Tesim:
- The Research Topic “Advances in brain imaging and stimulation methods for cognitive function investigation” gathers basic research and clinical results of experimental brain imaging and stimulation techniques which are used to investigate mechanisms of cognitive function and dysfunction.
- Resource type:
- Article
- DOI:
- https://doi.org/10.17615/pk3z-a082
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fnhum.2023.1280782
- ISSN:
- 1662-5161
- Journal Title:
- Frontiers in Human Neuroscience
- Journal Volume:
- 14
- Keyword:
- brain stimulation, neuropsychology, clinical application, transcranial magnetic stimulation, and brain imaging
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University of Macau, Klinikum der Universität München, , and University of Rome
- Person:
- Yuan, Zhen, Palm, Ulrich, Boettiger, Charlotte A., and Assenza, Giovanni
- Publisher:
- Frontiers Media SA
- Source:
- 972d5cf6-a79f-40b7-9239-36f20d5ee81b
50. Cognitive phenotypes in late-onset epilepsy: results from the atherosclerosis risk in communities study
- Title Tesim:
- Cognitive phenotypes in late-onset epilepsy: results from the atherosclerosis risk in communities study
- Creator:
- Schneider, Andrea L. C., Reyes, Anny, McDonald, Carrie R., Johnson, Emily L., Gottesman, Rebecca F., and Kucharska-Newton, Anna M.
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction Cognitive phenotyping is a widely used approach to characterize the heterogeneity of deficits in patients with a range of neurological disorders but has only recently been applied to patients with epilepsy. In this study, we identify cognitive phenotypes in older adults with late-onset epilepsy (LOE) and examine their demographic, clinical, and vascular profiles. Further, we examine whether specific phenotypes pose an increased risk for progressive cognitive decline. Methods Participants were part of the Atherosclerosis Risk in Communities Study (ARIC), a prospective longitudinal community-based cohort study of 15,792 individuals initially enrolled in 1987–1989. LOE was identified from linked Centers for Medicare and Medicaid Services claims data. Ninety-one participants with LOE completed comprehensive testing either prior to or after seizure onset as part of a larger cohort in the ARIC Neurocognitive Study in either 2011–2013 or 2016–2017 (follow-up mean = 4.9 years). Cognitive phenotypes in individuals with LOE were derived by calculating test-level impairments for each participant (i.e., ≤1 SD below cognitively normal participants on measures of language, memory, and executive function/processing speed); and then assigning participants to phenotypes if they were impaired on at least two tests within a domain. The total number of impaired domains was used to determine the cognitive phenotypes (i.e., Minimal/No Impairment, Single Domain, or Multidomain). Results At our baseline (Visit 5), 36.3% met criteria for Minimal/No Impairment, 35% for Single Domain Impairment (with executive functioning/ processing speed impaired in 53.6%), and 28.7% for Multidomain Impairment. The Minimal/No Impairment group had higher education and occupational complexity. There were no differences in clinical or vascular risk factors across phenotypes. Of those participants with longitudinal data (Visit 6; n = 24), 62.5% declined (i.e., progressed to a more impaired phenotype) and 37.5% remained stable. Those who remained stable were more highly educated compared to those that declined. Discussion Our results demonstrate the presence of identifiable cognitive phenotypes in older adults with LOE. These results also highlight the high prevalence of cognitive impairments across domains, with deficits in executive function/processing speed the most common isolated impairment. We also demonstrate that higher education was associated with a Minimal/No Impairment phenotype and lower risk for cognitive decline over time.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- DOI:
- https://doi.org/10.17615/86r1-6f66
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fneur.2023.1230368
- ISSN:
- 1664-2295
- Journal Title:
- Frontiers in Neurology
- Journal Volume:
- 17
- Keyword:
- phenotypes, dementia, cognition, aging, and epilepsy
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University of Pennsylvania, University of California, San Diego, Johns Hopkins University School of Medicine, National Institute of Neurological Disorders and Stroke Intramural Research Program, and
- Person:
- Schneider, Andrea L. C., Reyes, Anny, McDonald, Carrie R., Johnson, Emily L., Gottesman, Rebecca F., and Kucharska-Newton, Anna M.
- Publisher:
- Frontiers Media SA
- Source:
- a54f46a6-0670-4c41-aa77-78a4d48fed05
Collection Details
- Total items
-
698
- Size
-
unknown
- Date created
-
May 26, 2022