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601. Möbius-strip-like columnar functional connections are revealed in somato-sensory receptive field centroids

Title Tesim:
Möbius-strip-like columnar functional connections are revealed in somato-sensory receptive field centroids
Creator:
Bourke, Paul D., Wright, James J., and Favorov, Oleg Vyachesslavovich
Date of publication:
2014
Abstract Tesim:
Receptive fields of neurons in the forelimb region of areas 3b and 1 of primary somatosensory cortex, in cats and monkeys, were mapped using extracellular recordings obtained sequentially from nearly radial penetrations. Locations of the field centroids indicated the presence of a functional system in which cortical homotypic representations of the limb surfaces are entwined in three-dimensional Möbius-strip-like patterns of synaptic connections. Boundaries of somatosensory receptive field in nested groups irregularly overlie the centroid order, and are interpreted as arising from the superposition of learned connections upon the embryonic order. Since the theory of embryonic synaptic self-organization used to model these results was devised and earlier used to explain findings in primary visual cortex, the present findings suggest the theory may be of general application throughout cortex and may reveal a modular functional synaptic system, which, only in some parts of the cortex, and in some species, is manifest as anatomical ordering into columns.
Resource type:
Article
Deposit Record:
http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/f8/ca/d5/63/f8cad563-9b67-4053-a6f6-f544764d92b7
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/7tne-9196
Identifier:
PMID: 25400552, PMCID: PMC4215792, Onescience id: 574a29d7bad0bacc08b359b5f1bec5275154a083, and Publisher DOI: https://doi.org/10.3389/fnana.2014.00119
ISSN:
1662-5129
Journal Title:
Frontiers in Neuroanatomy
Journal Volume:
8
Keyword:
S1 segregates., S1 segregates, Human anatomy, QM1-695, Cortical development, neuromicrocircuitry, Neuroscience, cortical response properties, cortical development, synaptic organization, RC321-571, Original Research Article, cortical column, and Neurosciences. Biological psychiatry. Neuropsychiatry
Language Label:
English
Person:
Bourke, Paul D., Wright, James J., and Favorov, Oleg Vyachesslavovich
Rights Statement Label:
In Copyright
Source:
0r967b13m

602. Spatial organization of excitatory synaptic inputs to layer 4 neurons in mouse primary auditory cortex

Title Tesim:
Spatial organization of excitatory synaptic inputs to layer 4 neurons in mouse primary auditory cortex
Creator:
Manis, Paul B. and Kratz, Megan B.
Date of publication:
2015
Abstract Tesim:
Layer 4 (L4) of primary auditory cortex (A1) receives a tonotopically organized projection from the medial geniculate nucleus of the thalamus. However, individual neurons in A1 respond to a wider range of sound frequencies than would be predicted by their thalamic input, which suggests the existence of cross-frequency intracortical networks. We used laser scanning photostimulation and uncaging of glutamate in brain slices of mouse A1 to characterize the spatial organization of intracortical inputs to L4 neurons. Slices were prepared to include the entire tonotopic extent of A1. We find that L4 neurons receive local vertically organized (columnar) excitation from layers 2 through 6 (L6) and horizontally organized excitation primarily from L4 and L6 neurons in regions centered ~300–500 μm caudal and/or rostral to the cell. Excitatory horizontal synaptic connections from layers 2 and 3 were sparse. The origins of horizontal projections from L4 and L6 correspond to regions in the tonotopic map that are approximately an octave away from the target cell location. Such spatially organized lateral connections may contribute to the detection and processing of auditory objects with specific spectral structures.
Resource type:
Article
Deposit Record:
http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/f8/ca/d5/63/f8cad563-9b67-4053-a6f6-f544764d92b7
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/fx3a-e841
Identifier:
PMCID: PMC4413692, PMID: 25972787, Publisher DOI: https://doi.org/10.3389/fncir.2015.00017, and Onescience id: bd3b237349396b9aa29f17f19a8be5673c727b02
ISSN:
1662-5110
Journal Title:
Frontiers in Neural Circuits
Journal Volume:
9
Keyword:
Patch-Clamp Techniques, Neurons, Auditory Pathways, patch clamp, Animals, brain slice, Algorithms, thalamocortical recipient neurons, glutamate uncaging, Brain Mapping, spectral integration, Mice, intracortical circuits, neocortical circuits, Excitatory Postsynaptic Potentials, and Auditory Cortex
Language Label:
English
Person:
Manis, Paul B. and Kratz, Megan B.
Rights Statement Label:
In Copyright
Source:
000006032

603. Optical suppression of drug-evoked phasic dopamine release

Title Tesim:
Optical suppression of drug-evoked phasic dopamine release
Creator:
Deisseroth, Karl, Sinon, Christopher G., Fortin, Samantha M., Kantak, Pranish A., Roitman, Mitchell F., Witten, Ilana B., Stuber, Garret D., McCutcheon, James E., and Cone, Jackson J.
Date of publication:
2014
Abstract Tesim:
Brief fluctuations in dopamine concentration (dopamine transients) play a key role in behavior towards rewards, including drugs of abuse. Drug-evoked dopamine transients may result from actions at both dopamine cell bodies and dopamine terminals. Inhibitory opsins can be targeted to dopamine neurons permitting their firing activity to be suppressed. However, as dopamine transients can become uncoupled from firing, it is unknown whether optogenetic hyperpolarization at the level of the soma is able to suppress dopamine transients. Here, we used in vivo fast-scan cyclic voltammetry to record transients evoked by cocaine and raclopride in nucleus accumbens (NAc) of urethane-anesthetized rats. We targeted halorhodopsin (NpHR) specifically to dopamine cells by injecting Cre-inducible virus into ventral tegmental area (VTA) of transgenic rats that expressed Cre recombinase under control of the tyrosine hydroxylase promoter (TH-Cre+ rats). Consistent with previous work, co-administration of cocaine and raclopride led to the generation of dopamine transients in NAc shell. Illumination of VTA with laser strongly suppressed the frequency of transients in NpHR-expressing rats, but not in control rats. Laser did not have any effect on amplitude of transients. Thus, optogenetics can effectively reduce the occurrence of drug-evoked transients and is therefore a suitable approach for studying the functional role of such transients in drug-associated behavior.
Resource type:
Article
Deposit Record:
http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/f8/ca/d5/63/f8cad563-9b67-4053-a6f6-f544764d92b7
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/azpd-rn98
Identifier:
PMCID: PMC4166314, Onescience id: 39be1395547615f081bb7732e01a437604f15aac, Publisher DOI: https://doi.org/10.3389/fncir.2014.00114, and PMID: 25278845
ISSN:
1662-5110
Journal Title:
Frontiers in Neural Circuits
Journal Volume:
8
Keyword:
Opsins, TH-Cre, Neurons, dopamine transients, Recombinases, Cell Body, Dopamine, Lasers, Cells, Halorhodopsins, Nucleus Accumbens, Ventral Tegmental Area, optogenetics, Carisoprodol, Urethane, rat, Th, Optogenetics, TH, Dopamine Agents, Tyrosine 3-Monooxygenase, Fast-Scan Cyclic voltammetry, Street Drugs, Cocaine, Rattus norvegicus, and Raclopride
Language Label:
English
Person:
Deisseroth, Karl, Sinon, Christopher G., Fortin, Samantha M., Kantak, Pranish A., Roitman, Mitchell F., Witten, Ilana B., Stuber, Garret D., McCutcheon, James E., and Cone, Jackson J.
Rights Statement Label:
In Copyright
Source:
zc77sx59n

604. GABAergic and glycinergic inhibitory synaptic transmission in the ventral cochlear nucleus studied in VGAT channelrhodopsin-2 mice

Title Tesim:
GABAergic and glycinergic inhibitory synaptic transmission in the ventral cochlear nucleus studied in VGAT channelrhodopsin-2 mice
Creator:
Manis, Paul B. and Xie, Ruili
Date of publication:
2014
Abstract Tesim:
Both glycine and GABA mediate inhibitory synaptic transmission in the ventral cochlear nucleus (VCN). In mice, the time course of glycinergic inhibition is slow in bushy cells and fast in multipolar (stellate) cells, and is proposed to contribute to the processing of temporal cues in both cell types. Much less is known about GABAergic synaptic transmission in this circuit. Electrical stimulation of the auditory nerve or the tuberculoventral pathway evokes little GABAergic synaptic current in brain slice preparations, and spontaneous GABAergic miniature synaptic currents occur infrequently. To investigate synaptic currents carried by GABA receptors in bushy and multipolar cells, we used transgenic mice in which channelrhodopsin-2 and EYFP is driven by the vesicular GABA transporter (VGAT-ChR2-EYFP) and is expressed in both GABAergic and glycinergic neurons. Light stimulation evoked action potentials in EYFP-expressing presynaptic cells, and evoked inhibitory postsynaptic potentials (IPSPs) in non-expressing bushy and planar multipolar cells. Less than 10% of the IPSP amplitude in bushy cells arose from GABAergic synapses, whereas 40% of the IPSP in multipolar neurons was GABAergic. In voltage clamp, glycinergic IPSCs were significantly slower in bushy neurons than in multipolar neurons, whereas there was little difference in the kinetics of the GABAergic IPSCs between two cell types. During prolonged stimulation, the ratio of steady state vs. peak IPSC amplitude was significantly lower for glycinergic IPSCs. Surprisingly, the reversal potentials of GABAergic IPSCs were negative to those of glycinergic IPSCs in both bushy and multipolar neurons. In the absence of receptor blockers, repetitive light stimulation was only able to effectively evoke IPSCs up to 20 Hz in both bushy and multipolar neurons. We conclude that local GABAergic release within the VCN can differentially influence bushy and multipolar cells.
Resource type:
Article
Deposit Record:
http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/f8/ca/d5/63/f8cad563-9b67-4053-a6f6-f544764d92b7
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/p7r1-ah33
Identifier:
Publisher DOI: https://doi.org/10.3389/fncir.2014.00084, Onescience id: 4affc24007700f90f76dbffbfcfb42e71adc9def, PMID: 25104925, and PMCID: PMC4109614
ISSN:
1662-5110
Journal Title:
Frontiers in Neural Circuits
Journal Volume:
8
Keyword:
Cochlear Nucleus, Mice, Channelrhodopsins, GABA Antagonists, Inhibitory Postsynaptic Potentials, Nerve Net, target-specific inhibition, IPSC, Animals, Glycine, bushy, Glycine Agents, Excitatory Amino Acid Antagonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, multipolar, Mice, Inbred C57BL, stellate, and Mice, Transgenic
Language Label:
English
Person:
Manis, Paul B. and Xie, Ruili
Rights Statement Label:
In Copyright
Source:
jh344083w

605. Biology of adeno-associated viral vectors in the central nervous system

Title Tesim:
Biology of adeno-associated viral vectors in the central nervous system
Creator:
Asokan, Aravind, Samulski, Richard J., and Murlidharan, Giridhar
Date of publication:
2014
Abstract Tesim:
Gene therapy is a promising approach for treating a spectrum of neurological and neurodegenerative disorders by delivering corrective genes to the central nervous system (CNS). In particular, adeno-associated viruses (AAVs) have emerged as promising tools for clinical gene transfer in a broad range of genetic disorders with neurological manifestations. In the current review, we have attempted to bridge our understanding of the biology of different AAV strains with their transduction profiles, cellular tropisms, and transport mechanisms within the CNS. Continued efforts to dissect AAV-host interactions within the brain are likely to aid in the development of improved vectors for CNS-directed gene transfer applications in the clinic.
Resource type:
Article
Deposit Record:
http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/f8/ca/d5/63/f8cad563-9b67-4053-a6f6-f544764d92b7
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/gvx8-7082
Identifier:
Publisher DOI: https://doi.org/10.3389/fnmol.2014.00076, Onescience id: 4603fdd86988b78a9d95739d6a8835d692a59055, PMID: 25285067, and PMCID: PMC4168676
ISSN:
1662-5099
Journal Title:
Frontiers in Molecular Neuroscience
Journal Volume:
7
Keyword:
Gene Therapy, neurological disorders, viral vectors, adeno-associated virus (AAV), and Neurodegenerative Diseases
Language Label:
English
Person:
Asokan, Aravind, Samulski, Richard J., and Murlidharan, Giridhar
Rights Statement Label:
In Copyright
Source:
tx31qr166

606. Neural cell adhesion molecule, NCAM, regulates thalamocortical axon pathfinding and the organization of the cortical somatosensory representation in mouse

Title Tesim:
Neural cell adhesion molecule, NCAM, regulates thalamocortical axon pathfinding and the organization of the cortical somatosensory representation in mouse
Creator:
Brennaman, Leann H., Palazzetti, Cecilia, Fairén, Alfonso, Enriquez-Barreto, Lilian, and Maness, Patricia F.
Date of publication:
2012
Abstract Tesim:
To study the potential role of neural cell adhesion molecule (NCAM) in the development of thalamocortical (TC) axon topography, wild type, and NCAM null mutant mice were analyzed for NCAM expression, projection, and targeting of TC afferents within the somatosensory area of the neocortex. Here we report that NCAM and its α-2,8-linked polysialic acid (PSA) are expressed in developing TC axons during projection to the neocortex. Pathfinding of TC axons in wild type and null mutant mice was mapped using anterograde DiI labeling. At embryonic day E16.5, null mutant mice displayed misguided TC axons in the dorsal telencephalon, but not in the ventral telencephalon, an intermediate target that initially sorts TC axons toward correct neocortical areas. During the early postnatal period, rostrolateral TC axons within the internal capsule along the ventral telencephalon adopted distorted trajectories in the ventral telencephalon and failed to reach the neocortex in NCAM null mutant animals. NCAM null mutants showed abnormal segregation of layer IV barrels in a restricted portion of the somatosensory cortex. As shown by Nissl and cytochrome oxidase staining, barrels of the anterolateral barrel subfield (ALBSF) and the most distal barrels of the posteromedial barrel subfield (PMBSF) did not segregate properly in null mutant mice. These results indicate a novel role for NCAM in axonal pathfinding and topographic sorting of TC axons, which may be important for the function of specific territories of sensory representation in the somatosensory cortex.
Resource type:
Article
Deposit Record:
http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/f8/ca/d5/63/f8cad563-9b67-4053-a6f6-f544764d92b7
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/xth4-1h24
Identifier:
Onescience id: 2aa1b077d9c024a7112a90e9acb141cf03d4c7da, PMCID: PMC3378950, PMID: 22723769, and Publisher DOI: https://doi.org/10.3389/fnmol.2012.00076
ISSN:
1662-5099
Journal Title:
Frontiers in Molecular Neuroscience
Journal Volume:
5
Keyword:
Axonal pathfinding, Axonal tract tracing, NCAM, barrel cortex, Adhesion and signaling molecules, and Thalamocortical axons
Language Label:
English
Person:
Brennaman, Leann H., Palazzetti, Cecilia, Fairén, Alfonso, Enriquez-Barreto, Lilian, and Maness, Patricia F.
Rights Statement Label:
In Copyright
Source:
f7623k97z

607. Role of GSK3 Signaling in Neuronal Morphogenesis

Title Tesim:
Role of GSK3 Signaling in Neuronal Morphogenesis
Creator:
Snider, William D., Zhou, Feng-Quan, Kim, Yun Tai, and Hur, Eun-Mi
Date of publication:
2011
Abstract Tesim:
Glycogen synthase kinase 3 (GSK3) is emerging as a key regulator of several aspects of neuronal morphogenesis including neuronal polarization, axon growth, and axon branching. Multiple signaling pathways have been identified that control neuronal polarization, including PI3K, Rho-GTPases, Par3/6, TSC–mTOR, and PKA–LKB1. However, how these pathways are coordinated is not clear. As GSK3 signaling exhibits crosstalk with each of these pathways it has the potential to integrate these polarity signals in the control neuronal polarization. After neurons establish polarity, GSK3 acts as an important signaling mediator in the regulation of axon extension and axon branching by transducing upstream signaling to reorganization of the axonal cytoskeleton, especially microtubules. Here we review the roles of GSK3 signaling in neuronal morphogenesis and discuss the underlying molecular mechanisms.
Resource type:
Article
Deposit Record:
http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/f8/ca/d5/63/f8cad563-9b67-4053-a6f6-f544764d92b7
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/sa29-5d42
Identifier:
PMID: 22131966, PMCID: PMC3222852, Publisher DOI: https://doi.org/10.3389/fnmol.2011.00048, and Onescience id: 9e8ef8cd478da5d558a26fb62abe6b95b4782905
ISSN:
1662-5099
Journal Title:
Frontiers in Molecular Neuroscience
Journal Volume:
4
Keyword:
GSK3, Growth cone, microtubule plus end binding proteins, axon growth, Microtubules, Axon branching, Cytoskeleton, and Neuronal polarization
Language Label:
English
Person:
Snider, William D., Zhou, Feng-Quan, Kim, Yun Tai, and Hur, Eun-Mi
Rights Statement Label:
In Copyright
Source:
6m311w259

608. Functions of GSK-3 Signaling in Development of the Nervous System

Title Tesim:
Functions of GSK-3 Signaling in Development of the Nervous System
Creator:
Kim, Woo-Yang and Snider, William D.
Date of publication:
2011
Abstract Tesim:
Glycogen synthase kinase-3 (GSK-3) is central to multiple intracellular pathways including those activated by Wnt/β-catenin, Sonic Hedgehog, Notch, growth factor/RTK, and G protein-coupled receptor signals. All of these signals importantly contribute to neural development. Early attention on GSK-3 signaling in neural development centered on the regulation of neuronal polarity using in vitro paradigms. However, recent creation of appropriate genetic models has demonstrated the importance of GSK-3 to multiple aspects of neural development including neural progenitor self-renewal, neurogenesis, neuronal migration, neural differentiation, and synaptic development.
Resource type:
Article
Deposit Record:
http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/f8/ca/d5/63/f8cad563-9b67-4053-a6f6-f544764d92b7
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/533a-sz03
Identifier:
PMID: 22125510, Publisher DOI: https://doi.org/10.3389/fnmol.2011.00044, Onescience id: 148de122fa5f13c3edda080ce19043334e3e005e, and PMCID: PMC3221276
ISSN:
1662-5099
Journal Title:
Frontiers in Molecular Neuroscience
Journal Volume:
4
Keyword:
GSK-3, synaptic development, Neuroscience, neural differentiation, Review Article, neural progenitor, neuronal migration, and Neural progenitor
Language Label:
English
Person:
Kim, Woo-Yang and Snider, William D.
Rights Statement Label:
In Copyright
Source:
rv0431852

609. Role of MRP transporters in regulating antimicrobial drug inefficacy and oxidative stress-induced pathogenesis during HIV-1 and TB infections

Title Tesim:
Role of MRP transporters in regulating antimicrobial drug inefficacy and oxidative stress-induced pathogenesis during HIV-1 and TB infections
Creator:
Tse-Dinh, Yuk-Ching, Nair, Madhavan, Barber, Paul, Mondal, Debasis, Batrakova, Elena V., and Roy, Upal
Date of publication:
2015
Abstract Tesim:
Multi-Drug Resistance Proteins (MRPs) are members of the ATP binding cassette (ABC) drug-efflux transporter superfamily. MRPs are known to regulate the efficacy of a broad range of anti-retroviral drugs (ARV) used in highly active antiretroviral therapy (HAART) and antibacterial agents used in Tuberculus Bacilli (TB) therapy. Due to their role in efflux of glutathione (GSH) conjugated drugs, MRPs can also regulate cellular oxidative stress, which may contribute to both HIV and/or TB pathogenesis. This review focuses on the characteristics, functional expression, and modulation of known members of the MRP family in HIV infected cells exposed to ARV drugs and discusses their known role in drug-inefficacy in HIV/TB-induced dysfunctions. Currently, nine members of the MRP family (MRP1-MRP9) have been identified, with MRP1 and MRP2 being the most extensively studied. Details of the other members of this family have not been known until recently, but differential expression has been documented in inflammatory tissues. Researchers have found that the distribution, function, and reactivity of members of MRP family vary in different types of lymphocytes and macrophages, and are differentially expressed at the basal and apical surfaces of both endothelial and epithelial cells. Therefore, the prime objective of this review is to delineate the role of MRP transporters in HAART and TB therapy and their potential in precipitating cellular dysfunctions manifested in these chronic infectious diseases. We also provide an overview of different available options and novel experimental strategies that are being utilized to overcome the drug resistance and disease pathogenesis mediated by these membrane transporters.
Resource type:
Article
Deposit Record:
http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/f8/ca/d5/63/f8cad563-9b67-4053-a6f6-f544764d92b7
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/nt8c-mj53
Identifier:
PMID: 26441882, Onescience id: 52f429bfd5e253ca5326281e903151cc2a1c9380, PMCID: PMC4585023, and Publisher DOI: https://doi.org/10.3389/fmicb.2015.00948
ISSN:
1664-302X
Journal Title:
Frontiers in Microbiology
Journal Volume:
6
Keyword:
HIV-1, therapeutic strategy, QR1-502, TB, Drug Resistance, MRP, Microbiology, antimicrobials, Oxidative Stress, and Pathogenesis
Language Label:
English
Person:
Tse-Dinh, Yuk-Ching, Nair, Madhavan, Barber, Paul, Mondal, Debasis, Batrakova, Elena V., and Roy, Upal
Rights Statement Label:
In Copyright
Source:
8w32rc83g

610. Primer and platform effects on 16S rRNA tag sequencing

Title Tesim:
Primer and platform effects on 16S rRNA tag sequencing
Creator:
Fern, Alison, Woyke, Tanja, Tringe, Susannah G., Kirton, Edward S., Lee, Janey, Tremblay, Julien, Dangl, Jeffery L., Chen, Feng, He, Shaomei, and Singh, Kanwar
Date of publication:
2015
Abstract Tesim:
Sequencing of 16S rRNA gene tags is a popular method for profiling and comparing microbial communities. The protocols and methods used, however, vary considerably with regard to amplification primers, sequencing primers, sequencing technologies; as well as quality filtering and clustering. How results are affected by these choices, and whether data produced with different protocols can be meaningfully compared, is often unknown. Here we compare results obtained using three different amplification primer sets (targeting V4, V6–V8, and V7–V8) and two sequencing technologies (454 pyrosequencing and Illumina MiSeq) using DNA from a mock community containing a known number of species as well as complex environmental samples whose PCR-independent profiles were estimated using shotgun sequencing. We find that paired-end MiSeq reads produce higher quality data and enabled the use of more aggressive quality control parameters over 454, resulting in a higher retention rate of high quality reads for downstream data analysis. While primer choice considerably influences quantitative abundance estimations, sequencing platform has relatively minor effects when matched primers are used. Beta diversity metrics are surprisingly robust to both primer and sequencing platform biases.
Resource type:
Article
Deposit Record:
http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/f8/ca/d5/63/f8cad563-9b67-4053-a6f6-f544764d92b7
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/wgfs-e050
Identifier:
PMCID: PMC4523815, Publisher DOI: https://doi.org/10.3389/fmicb.2015.00771, PMID: 26300854, and Onescience id: bfea4257013bd0420530c871dd6e810422ca1273
ISSN:
1664-302X
Journal Title:
Frontiers in Microbiology
Journal Volume:
6
Keyword:
CISTI, scientific research, electronic documents, technical reports, technology, Ottawa, NRC, scientific information, science, library, Canada Institute for Scientific and Technical Information, technical literature, National Science Library, research, NSL, NRC-CISTI, and National Research Council Canada
Language Label:
English
Person:
Fern, Alison, Woyke, Tanja, Tringe, Susannah G., Kirton, Edward S., Lee, Janey, Tremblay, Julien, Dangl, Jeffery L., Chen, Feng, He, Shaomei, and Singh, Kanwar
Rights Statement Label:
In Copyright
Source:
5138jn124