In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact
Creator:
Razvi, Hassan, Filler, Guido, Jain, Nina, Gilleskie, Donna, Gilliland, Jason, Hatch, Joseph E., Coulson, Sherry, Burton, Jeremy, Ross, Sherry, Bjazevic, Jennifer, Diaz-Gonzalez de Ferris, Maria E., Fearrington, Loretta, Bhayana, Vipin, Dave, Sumit, Viprakasit, Davis, Denstedt, John, Wang, Peter, Sultan, Nabil, McClure, J. Andrew, Ritter, Victor, and Lin, Feng-Chang
Date of publication:
2023
Abstract Tesim:
Background Urinary stone disease (USD) historically has affected older men, but studies suggest recent increases in women, leading to a near identical sex incidence ratio. USD incidence has doubled every 10 years, with disproportionate increases amongst children, adolescent, and young adult (AYA) women. USD stone composition in women is frequently apatite (calcium phosphate), which forms in a higher urine pH, low urinary citrate, and an abundance of urinary uric acid, while men produce more calcium oxalate stones. The reasons for this epidemiological trend are unknown. Methods This perspective presents the extent of USD with data from a Canadian Province and a North American institution, explanations for these findings and offers potential solutions to decrease this trend. We describe the economic impact of USD. Findings There was a significant increase of 46% in overall surgical interventions for USD in Ontario. The incidence rose from 47.0/100,000 in 2002 to 68.7/100,000 population in 2016. In a single United States institution, the overall USD annual unique patient count rose from 10,612 to 17,706 from 2015 to 2019, and the proportion of women with USD was much higher than expected. In the 10–17-year-old patients, 50.1% were girls; with 57.5% in the 18–34 age group and 53.6% in the 35–44 age group. The roles of obesity, diet, hormones, environmental factors, infections, and antibiotics, as well as the economic impact, are discussed. Interpretation We confirm the significant increase in USD among women. We offer potential explanations for this sex disparity, including microbiological and pathophysiological aspects. We also outline innovative solutions – that may require steps beyond typical preventive and treatment recommendations.
Resource type:
Article
Affiliation Label Tesim:
Department of Pediatrics, Department of Economics, Department of Urology, North Carolina Translational and Clinical Sciences Institute, and Department of Biostatistics
DOI:
https://doi.org/10.17615/29f7-mw45
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fmed.2023.1272900
ISSN:
2296-858X
Journal Title:
Frontiers in Medicine
Journal Volume:
10
Keyword:
hormones, population-based epidemiology, obesity, environmental factors, sex differences, urinary stone disease, diet, and urinary phthalates
Language Label:
English
License Label:
Attribution 4.0 International
ORCID:
Other Affiliation:
Western University and
Person:
Razvi, Hassan, Filler, Guido, Jain, Nina, Gilleskie, Donna, Gilliland, Jason, Hatch, Joseph E., Coulson, Sherry, Burton, Jeremy, Ross, Sherry, Bjazevic, Jennifer, Diaz-Gonzalez de Ferris, Maria E., Fearrington, Loretta, Bhayana, Vipin, Dave, Sumit, Viprakasit, Davis, Denstedt, John, Wang, Peter, Sultan, Nabil, McClure, J. Andrew, Ritter, Victor, and Lin, Feng-Chang
Epidemiology of neurocognitive disorders in adults from urban-marginalized areas: a door-to-door population-based study in Puente Piedra, Lima, Peru
Creator:
Chang, Alexandra, Villafuerte, Mirla, Custodio, Nilton, Herrera-Perez, Eder, Diaz, Monica, Lanata, Serggio, and Montesinos, Rosa
Date of publication:
2023
Abstract Tesim:
BackgroundIn Latin America (LA), the prevalence of dementia is expected to triple to 150 million people by 2050. The 2020 Lancet Commission report identified several modifiable dementia risk factors, yet few social and environmental factors, most relevant to vulnerable regions of LA, were highlighted in this report. We sought to assess the epidemiology of neurocognitive disorders (NCD) in Puente Piedra, one of the most socially and economically vulnerable districts of Lima, the capital of Peru.MethodologyThis was a cross-sectional door-to-door observational study that used two-stage household sampling. One young adult (30–59 years) and one older adult (>60 years) per household were enrolled. We collected demographic, clinical, and neurocognitive data. Addenbrooke’s Cognitive Examination (young adults) and the RUDAS-PE (older adults) were used, classifying participants as cognitively normal, possible mild NCD, or possible major NCD.ResultsWe enrolled 247 participants (median age 46 years; 67% female). One-fourth had not completed secondary school and more than 50% completed only secondary school. Most participants were housewives (46%) and 21% did not have health insurance. The overall prevalence of possible NCD was 30% (25.6 and 41.8% among younger adults and older adults, respectively). Among younger adults, those ages 55–59 years more frequently had NCD (70%) compared to younger age ranges. Among older adults, only 3 subjects (4.5%) had major NCD.ConclusionWe found a high frequency of possible NCDs in a socially and economically vulnerable community in Lima, Peru, with younger adults showing levels of NCD higher than expected. Our findings support the need for health systems to incorporate cognitive screenings programs for NCD in younger ages. Future research on NCD would include younger populations, particularly in vulnerable communities.
Resource type:
Article
Affiliation Label Tesim:
Department of Neurology
DOI:
https://doi.org/10.17615/rkn9-9652
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fpubh.2023.1228008
ISSN:
2296-2565
Journal Title:
Frontiers in Public Health
Journal Volume:
11
Keyword:
door-to-door study, mild neurocognitive disorder, cognitive impairment, neuroepidemiology, major neurocognitive disorder, mild cognitive impairment, and dementia
Language Label:
English
License Label:
Attribution 4.0 International
ORCID:
Other Affiliation:
Universidad Peruana de Ciencias Aplicadas, Edgardo Rebagliati Martins National Hospital, Instituto Peruano de Neurociencias, Universidad San Ignacio de Loyola, , and University of California, San Francisco
Person:
Chang, Alexandra, Villafuerte, Mirla, Custodio, Nilton, Herrera-Perez, Eder, Diaz, Monica, Lanata, Serggio, and Montesinos, Rosa
Taking stock of the contributions to the “Insights in extreme microbiology: 2022” Research Topic again reveals the extraordinary breadth that exists within the field of Extreme Microbiology.
Resource type:
Article
Affiliation Label Tesim:
Department of Earth, Marine and Environmental Sciences
DOI:
https://doi.org/10.17615/8565-6158
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fmicb.2023.1324080
ISSN:
1664-302X
Journal Title:
Frontiers in Microbiology
Journal Volume:
14
Keyword:
insights, microbiology, 2022, Research Topic, and microbial community
Editorial: Global excellence in inflammation pharmacology
Creator:
Saha, Sukanya and Ghosh, Shatadal
Date of publication:
2023
Abstract Tesim:
In our day-to-day life, acute inflammation occurs commonly as a part of the body’s regular healing process post an injury or infection and is usually short term in nature. The problem arises when this inflammation becomes chronic, due to the failure in resolving itself, leading to a spectrum of diseases which explicitly contributes to more than 50% of worldwide mortality (GBD, 2017 Causes of Death Collaborators, 2018; Furman et al., 2019) Thus, prolonged inflammation is emerging as a serious threat to the global population and socioeconomic sustainability. Advancements in effective anti-inflammatory therapies have been significantly evolving, but challenges persist (Netea et al., 2017). Hence, scientists globally or in global alliance, with varied scientific perspectives, are actively working on finding out pharmacological interventions against inflammation associated pathogenesis and diseases. A major part of the research is also focused on scientific advancements of evolving therapeutic strategies by identifying the central signaling molecules or cascades involved in the onset and progression of chronic inflammation. This special edition Research Topic Global Excellence in Inflammation Pharmacology aims in emphasizing on the recent progress made in these fields, highlighting the diversified research performed across the entire breadth of Inflammation Pharmacology and providing insights to it. This Research Topic comprises of four extensive literature reviews discussing the potential pharmacological interventions and their allied risk in inflammation associated diseases.
Resource type:
Article
Affiliation Label Tesim:
Department of Medicine
DOI:
https://doi.org/10.17615/gw8d-0732
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fphar.2023.1307503
ISSN:
1663-9812
Journal Title:
Frontiers in Pharmacology
Journal Volume:
14
Keyword:
global alliance, inflammation, therapeutics, diseases, and pharmacological interventions
Dietary fatty acids improve perceived sleep quality, stress, and health in migraine: a secondary analysis of a randomized controlled trial
Creator:
Mann, J. Douglas, Zamora, Daisy, Domeniciello, Anthony, Faurot, Keturah R., Ramsden, Christopher E., Palsson, Olafur, Lynch, Chanee E., Gaylord, Susan A., Horowitz, Mark, MacIntosh, Beth A., Honvoh, Gilson, Miller, Vanessa, and Park, Jinyoung
Department of Neurology, Department of Physical Medicine and Rehabilitation, Department of Medicine, and UNC Medical Center
DOI:
https://doi.org/10.17615/2q0e-h937
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fpain.2023.1231054
ISSN:
2673-561X
Journal Title:
Frontiers in Pain Research
Journal Volume:
4
Keyword:
stress, quality of life, migraine, fatty acids, sleep quality, perceived health, and dietary intervention
Language Label:
English
License Label:
Attribution 4.0 International
ORCID:
Other Affiliation:
and National Institute on Aging
Person:
Mann, J. Douglas, Zamora, Daisy, Domeniciello, Anthony, Faurot, Keturah R., Ramsden, Christopher E., Palsson, Olafur, Lynch, Chanee E., Gaylord, Susan A., Horowitz, Mark, MacIntosh, Beth A., Honvoh, Gilson, Miller, Vanessa, and Park, Jinyoung
Crowd-sourced investigation of a potential relationship between Bartonella-associated cutaneous lesions and neuropsychiatric symptoms
Creator:
Frohlich, Flavio, Stewart, Zachary, and Korsapathy, Sanvi
Date of publication:
2023
Abstract Tesim:
Introduction Preliminary studies suggest that infection with Bartonella bacteria can not only cause a characteristic rash, headache, fever, and fatigue but also neuropsychiatric symptoms. To date, this association has only been reported in case studies, and it remains unclear if this association generalizes to larger samples. Methods We used Amazon's Mechanical Turk (MTurk) to crowdsource a large sample (N = 996) of individuals to ascertain the extent to which the presence of participant-identified Bartonella-associated cutaneous lesions (BACL) was associated with self-reported measures of anxiety, depression, and schizotypy. Participants were asked to select images of cutaneous lesions they had seen on their own bodies and complete a battery of self-report questionnaires to assess psychiatric symptoms. Participants were not informed that the focus of the study was on potential dermatological lesions associated with Bartonella. Point-biserial correlations were used to determine the potential relationship between selecting a BACL image and the severity of self-reported psychiatric symptoms. Results Scores of anxiety, depression, and schizotypy were positively and significantly correlated with selecting a BACL image. Furthermore, self-report scores of 10 or higher on the GAD-7 and PHQ-9, which represent the suggested clinical cutoffs for meeting criteria for a depressive or anxiety-related disorder, were also significantly associated with selecting a BACL image. Non-Bartonella-associated cutaneous legions were also significantly associated with self-reported measures of psychiatric symptoms. Discussion The current study broadens the link between the presence of BACL and the presence of psychiatric symptoms of anxiety, depression, and schizotypy and extends a potential relationship beyond the small sample sizes of previous case studies and case series. Further investigation is recommended to address limitations and expand on these findings.
Resource type:
Article
Affiliation Label Tesim:
Department of Psychiatry
DOI:
https://doi.org/10.17615/e746-tw18
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fpsyt.2023.1244121
ISSN:
1664-0640
Journal Title:
Frontiers in Psychiatry
Journal Volume:
14
Keyword:
Bartonella, schizotypy, depression, anxiety, and MTurk
Language Label:
English
License Label:
Attribution 4.0 International
ORCID:
Other Affiliation:
Person:
Frohlich, Flavio, Stewart, Zachary, and Korsapathy, Sanvi
Candidate composite biomarker to inform drug treatments for diabetic kidney disease
Creator:
Abebe, Seyum, Slanzi, Debora, Poli, Irene, Mayer, Gert, Jones, Roger D., Silvestri, Claudio, and Distefano, Veronica
Date of publication:
2023
Abstract Tesim:
IntroductionCurrent guidelines recommend renin angiotensin system inhibitors (RASi) as key components of treatment of diabetic kidney disease (DKD). Additional options include sodium-glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide 1 receptor agonists (GLP1a), and mineralocorticoid receptor antagonists (MCRa). The identification of the optimum drug combination for an individual is difficult because of the inter-, and longitudinal intra-individual heterogeneity of response to therapy.ResultsUsing data from a large observational study (PROVALID), we identified a set of parameters that can be combined into a meaningful composite biomarker that appears to be able to identify which of the various treatment options is clinically beneficial for an individual. It uses machine-earning techniques to estimate under what conditions a treatment of RASi plus an additional treatment is different from the treatment with RASi alone. The measure of difference is the annual percent change (ΔeGFR) in the estimated glomerular filtration rate (ΔeGFR). The 1eGFR is estimated for both the RASi-alone treatment and the add-on treatment.DiscussionHigher estimated increase of eGFR for add-on patients compared with RASi-alone patients indicates that prognosis may be improved with the add-on treatment. The personalized biomarker value thus identifies which patients may benefit from the additional treatment.
Assessing the pre-implementation context for financial navigation in rural and non-rural oncology clinics
Creator:
Planey, Arrianna Marie, Biddell, Caitlin B., Petermann, Victoria M., Bell, Ronny A., Cabarrus, Kendrel, Deal, Allison M., Reeder-Hayes, Katherine, Birken, Sarah A., Samuel-Ryals, Cleo A., Padilla, Neda, Gellin, Mindy, Manning, Michelle, Rosenstein, Donald L., Strom, Carla, Vestal, Derek, Wheeler, Stephanie B., Leutner, Brian, King, Sherry, Young, Tiffany H., and Spees, Lisa P.
Date of publication:
2023
Abstract Tesim:
BackgroundFinancial navigation (FN) is an evidence-based intervention designed to address financial toxicity for cancer patients. FN's success depends on organizations' readiness to implement and other factors that may hinder or support implementation. Tailored implementation strategies can support practice change but must be matched to the implementation context. We assessed perceptions of readiness and perceived barriers and facilitators to successful implementation among staff at nine cancer care organizations (5 rural, 4 non-rural) recruited to participate in the scale-up of a FN intervention. To understand differences in the pre-implementation context and inform modifications to implementation strategies, we compared findings between rural and non-rural organizations.MethodsWe conducted surveys (n = 78) and in-depth interviews (n = 73) with staff at each organization. We assessed perceptions of readiness using the Organizational Readiness for Implementing Change (ORIC) scale. In-depth interviews elicited perceived barriers and facilitators to implementing FN in each context. We used descriptive statistics to analyze ORIC results and deductive thematic analysis, employing a codebook guided by the Consolidated Framework for Implementation Research (CFIR), to synthesize themes in barriers and facilitators across sites, and by rurality.ResultsResults from the ORIC scale indicated strong perceptions of organizational readiness across all sites. Staff from rural areas reported greater confidence in their ability to manage the politics of change (87% rural, 76% non-rural) and in their organization's ability to support staff adjusting to the change (96% rural, 75% non-rural). Staff at both rural and non-rural sites highlighted factors reflective of the Intervention Characteristics (relative advantage) and Implementation Climate (compatibility and tension for change) domains as facilitators. Although few barriers to implementation were reported, differences arose between rural and non-rural sites in these perceived barriers, with non-rural staff more often raising concerns about resistance to change and compatibility with existing work processes and rural staff more often raising concerns about competing time demands and limited resources.ConclusionsStaff across both rural and non-rural settings identified few, but different, barriers to implementing a novel FN intervention that they perceived as important and responsive to patients' needs. These findings can inform how strategies are tailored to support FN in diverse oncology practices.
Resource type:
Article
Affiliation Label Tesim:
Department of Health Policy and Management, School of Nursing, UNC Lineberger Comprehensive Cancer Center, and Department of Psychiatry
DOI:
https://doi.org/10.17615/p1w4-j415
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/frhs.2023.1148887
ISSN:
2813-0146
Journal Title:
Frontiers in Health Services
Journal Volume:
3
Keyword:
cancer, rural, implementation science, financial navigation, financial toxicity, and organizational readiness framework for advancing implementation science
Language Label:
English
License Label:
Attribution 4.0 International
ORCID:
Other Affiliation:
, Wake Forest University, Division of Oncology, UNC Lenoir Health Care, Pardee UNC Health Care, Carteret Health Care Cancer Center, and Novant Health Cancer Institute
Person:
Planey, Arrianna Marie, Biddell, Caitlin B., Petermann, Victoria M., Bell, Ronny A., Cabarrus, Kendrel, Deal, Allison M., Reeder-Hayes, Katherine, Birken, Sarah A., Samuel-Ryals, Cleo A., Padilla, Neda, Gellin, Mindy, Manning, Michelle, Rosenstein, Donald L., Strom, Carla, Vestal, Derek, Wheeler, Stephanie B., Leutner, Brian, King, Sherry, Young, Tiffany H., and Spees, Lisa P.
A cross-sectional study confirms temporary post-COVID-19 vaccine menstrual irregularity and the associated physiological changes among vaccinated women in Jordan
Creator:
Hajjo R., Al-Momany A., Sabbah D.A., Almomani E.Y., and Qablan A.
Date of publication:
2023
Abstract Tesim:
Background: COVID-19 vaccines continue to save people’s lives around the world; however, some vaccine adverse events have been a major concern which slowed down vaccination campaigns. Anecdotal evidence pointed to the vaccine effect on menstruation but evidence from the adverse event reporting systems and the biomedical literature was lacking. This study aimed to investigate the physiological changes in women during menstruation amid the COVID-19 vaccination. Methods: A cross-sectional online survey was distributed to COVID-19 vaccinated women from Nov 2021 to Jan 2022. The results were analyzed using the SPSS software. Results: Among the 564 vaccinated women, 52% experienced significant menstrual irregularities post-vaccination compared to before regardless of the vaccine type. The kind of menstrual irregularity varied among the vaccinated women, for example, 33% had earlier menstruation, while 35% reported delayed menstruation. About 31% experienced heavier menstruation, whereas 24% had lighter menstrual flow. About 29% had menstruation last longer, but 13% had it shorter than usual. Noteworthy, the menstrual irregularities were more frequent after the second vaccine shot, and they disappeared within 3 months on average. Interestingly, 24% of the vaccinated women reported these irregularities to their gynecologist. Conclusion: The COVID-19 vaccine may cause physiological disturbances during menstruation. Luckily, these irregularities were short-termed and should not be a reason for vaccine hesitancy in women. Further studies are encouraged to unravel the COVID-19 vaccine adverse effect on women’s health.
Resource type:
Article
Affiliation Label Tesim:
Division of Chemical Biology and Medicinal Chemistry
DOI:
https://doi.org/10.17615/djdj-px95
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fmed.2023.1211283
ISSN:
2296-858X
Journal Title:
Frontiers in Medicine
Journal Volume:
10
Keyword:
COVID-19 vaccine, adverse events, menstrual cycle irregularity, vaccinated women, and Jordan
Language Label:
English
License Label:
Attribution 4.0 International
ORCID:
Other Affiliation:
, University of Jordan, Al-Zaytoonah University of Jordan, Al-Balqa Applied University, and United Arab Emirates University
Person:
Hajjo R., Al-Momany A., Sabbah D.A., Almomani E.Y., and Qablan A.
Vibrio gazogenes-dependent disruption of aflatoxin biosynthesis in Aspergillus flavus: the connection with endosomal uptake and hyphal morphogenesis
Creator:
Cary J.W., Keller N.P., Basu P., Lebar M.D., Decho A.W., Gummadidala P.M., Dias T., Chandler S., Chanda A., Jesmin R., and Majumdar R.
Date of publication:
2023
Abstract Tesim:
Aflatoxins, a family of fungal secondary metabolites, are toxic and carcinogenic compounds that pose an enormous threat to global food safety and agricultural sustainability. Specifically agricultural products in African, Southeast Asian and hot and humid regions of American countries suffer most damage from aflatoxin producing molds due to the ideal climate conditions promoting their growth. Our recent studies suggest that Vibrio gazogenes (Vg), an estuarine bacterium non-pathogenic to plants and humans, can significantly inhibit aflatoxin biosynthesis in the producers. In this study, we investigated the mechanism underlying Vg-dependent aflatoxin inhibition using the prominent aflatoxin producer, Aspergillus flavus. We show that aflatoxin inhibition upon Vg treatment was associated with fungal uptake of Vg-prodigiosin, a red pigment, which was consistently visible inside fungal hyphae during treatment. The association of prodigiosin with aflatoxin inhibition was further evident as Serratia marcescens, another prodigiosin producer, significantly inhibited aflatoxin, while non-producers like Escherichia coli, Staphylococcus aureus, Vibrio harveyi, and Vibrio fischeri did not. Also, pure prodigiosin significantly inhibited aflatoxin biosynthesis. Endocytosis inhibitors, filipin and natamycin, reduced the Vg-prodigiosin uptake by the fungus leading to a significant increase in aflatoxin production, suggesting that uptake is endocytosis-dependent. The Vg treatment also reduced hyphal fusion (>98% inhibition) and branching, which are both endosome-dependent processes. Our results, therefore, collectively support our theory that Vg-associated aflatoxin inhibition is mediated by an endocytosis-dependent uptake of Vg-prodigiosin, which possibly leads to a disruption of normal endosomal functions.
Resource type:
Article
Affiliation Label Tesim:
School of Medicine
DOI:
https://doi.org/10.17615/sdmk-jf26
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3389/fmicb.2023.1208961
ISSN:
1664-302X
Journal Title:
Frontiers in Microbiology
Journal Volume:
14
Keyword:
aflatoxin, Aspergillus flavus, mycotoxin, biocontrol, and endosomes
Language Label:
English
License Label:
Attribution 4.0 International
ORCID:
Other Affiliation:
USDA/ARS, University of Wisconsin-Madison, New York College of Podiatric Medicine, University of South Carolina, , Mycologics LLC, and Northwest Irrigation and Soils Research
Person:
Cary J.W., Keller N.P., Basu P., Lebar M.D., Decho A.W., Gummadidala P.M., Dias T., Chandler S., Chanda A., Jesmin R., and Majumdar R.