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UNC-authored articles published by Frontiers
Works (762)
71. Interpreting growth hormone and IGF-I results using modern assays and reference ranges for the monitoring of treatment effectiveness in acromegaly
- Title Tesim:
- Interpreting growth hormone and IGF-I results using modern assays and reference ranges for the monitoring of treatment effectiveness in acromegaly
- Creator:
- Clemmons, David R. and Bidlingmaier, Martin
- Date of publication:
- 2023
- Abstract Tesim:
- Standard treatment for acromegaly focuses on the achievement of target absolute levels of growth hormone (GH) and insulin-like growth factor (IGF-I). The appropriateness of these targets when measured using modern assay methods is not well defined. This paper reviews biochemical status assessed using methods available at the time and associated clinical outcomes. GH measurements were shown to provide an indication of changes in tumor size, and failure of GH suppression after glucose stimulation is associated with tumor recurrence. IGF-I levels were more closely associated with changes in symptoms and signs. Reduced GH and IGF-I concentrations were shown to be associated with increased longevity, although the degree of increase has only been analyzed for GH. Lowering of GH and IGF-I has consistently been associated with improved outcomes; however, absolute levels reported in previous studies were based on results from methods and reference ranges that are now obsolete. Applying previously described absolute thresholds as targets (e.g. “normal” IGF-I level) when using current methods are best applied to those with active acromegaly symptoms who could benefit from further lowering of biochemical markers. In asymptomatic individuals with mild IGF-I or GH elevations, targeting biochemical “normalization” would result in the need for combination pharmacotherapy in many patients without proven benefit. Measurement of both GH and IGF-I remains an essential component of diagnosis and monitoring the effectiveness of treatment in acromegaly; however, treatment goals based only on previously identified absolute thresholds are not appropriate without taking into account the assay and reference ranges being employed. Treatment goals should be individualized considering biochemical improvement from an untreated baseline, symptoms of disease, risks, burdens and costs of complex treatment regimens, comorbidities, and quality of life.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Medicine
- DOI:
- https://doi.org/10.17615/dm1f-je35
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fendo.2023.1266339
- ISSN:
- 1664-2392
- Journal Title:
- Frontiers in Endocrinology
- Journal Volume:
- 14
- Keyword:
- therapy, IGF-I, biochemical markers, treatment response, acromegaly, and growth hormone
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- and Klinikum der Universität München
- Person:
- Clemmons, David R. and Bidlingmaier, Martin
- Publisher:
- Frontiers Media
- Source:
- b94ba737-22bc-4c4f-80a1-a2f698435fb3
72. In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact
- Title Tesim:
- In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact
- Creator:
- Razvi, Hassan, Filler, Guido, Jain, Nina, Gilleskie, Donna, Gilliland, Jason, Hatch, Joseph E., Coulson, Sherry, Burton, Jeremy, Ross, Sherry, Bjazevic, Jennifer, Diaz-Gonzalez de Ferris, Maria E., Fearrington, Loretta, Bhayana, Vipin, Dave, Sumit, Viprakasit, Davis, Denstedt, John, Wang, Peter, Sultan, Nabil, McClure, J. Andrew, Ritter, Victor, and Lin, Feng-Chang
- Date of publication:
- 2023
- Abstract Tesim:
- Background Urinary stone disease (USD) historically has affected older men, but studies suggest recent increases in women, leading to a near identical sex incidence ratio. USD incidence has doubled every 10 years, with disproportionate increases amongst children, adolescent, and young adult (AYA) women. USD stone composition in women is frequently apatite (calcium phosphate), which forms in a higher urine pH, low urinary citrate, and an abundance of urinary uric acid, while men produce more calcium oxalate stones. The reasons for this epidemiological trend are unknown. Methods This perspective presents the extent of USD with data from a Canadian Province and a North American institution, explanations for these findings and offers potential solutions to decrease this trend. We describe the economic impact of USD. Findings There was a significant increase of 46% in overall surgical interventions for USD in Ontario. The incidence rose from 47.0/100,000 in 2002 to 68.7/100,000 population in 2016. In a single United States institution, the overall USD annual unique patient count rose from 10,612 to 17,706 from 2015 to 2019, and the proportion of women with USD was much higher than expected. In the 10–17-year-old patients, 50.1% were girls; with 57.5% in the 18–34 age group and 53.6% in the 35–44 age group. The roles of obesity, diet, hormones, environmental factors, infections, and antibiotics, as well as the economic impact, are discussed. Interpretation We confirm the significant increase in USD among women. We offer potential explanations for this sex disparity, including microbiological and pathophysiological aspects. We also outline innovative solutions – that may require steps beyond typical preventive and treatment recommendations.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Pediatrics, Department of Economics, Department of Urology, North Carolina Translational and Clinical Sciences Institute, and Department of Biostatistics
- DOI:
- https://doi.org/10.17615/29f7-mw45
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fmed.2023.1272900
- ISSN:
- 2296-858X
- Journal Title:
- Frontiers in Medicine
- Journal Volume:
- 10
- Keyword:
- hormones, population-based epidemiology, obesity, environmental factors, sex differences, urinary stone disease, diet, and urinary phthalates
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Western University and
- Person:
- Razvi, Hassan, Filler, Guido, Jain, Nina, Gilleskie, Donna, Gilliland, Jason, Hatch, Joseph E., Coulson, Sherry, Burton, Jeremy, Ross, Sherry, Bjazevic, Jennifer, Diaz-Gonzalez de Ferris, Maria E., Fearrington, Loretta, Bhayana, Vipin, Dave, Sumit, Viprakasit, Davis, Denstedt, John, Wang, Peter, Sultan, Nabil, McClure, J. Andrew, Ritter, Victor, and Lin, Feng-Chang
- Publisher:
- Frontiers Media
- Source:
- 50578623-f486-45ed-9776-5156df960f65
73. Epidemiology of neurocognitive disorders in adults from urban-marginalized areas: a door-to-door population-based study in Puente Piedra, Lima, Peru
- Title Tesim:
- Epidemiology of neurocognitive disorders in adults from urban-marginalized areas: a door-to-door population-based study in Puente Piedra, Lima, Peru
- Creator:
- Chang, Alexandra, Villafuerte, Mirla, Custodio, Nilton, Herrera-Perez, Eder, Diaz, Monica, Lanata, Serggio, and Montesinos, Rosa
- Date of publication:
- 2023
- Abstract Tesim:
- BackgroundIn Latin America (LA), the prevalence of dementia is expected to triple to 150 million people by 2050. The 2020 Lancet Commission report identified several modifiable dementia risk factors, yet few social and environmental factors, most relevant to vulnerable regions of LA, were highlighted in this report. We sought to assess the epidemiology of neurocognitive disorders (NCD) in Puente Piedra, one of the most socially and economically vulnerable districts of Lima, the capital of Peru.MethodologyThis was a cross-sectional door-to-door observational study that used two-stage household sampling. One young adult (30–59 years) and one older adult (>60 years) per household were enrolled. We collected demographic, clinical, and neurocognitive data. Addenbrooke’s Cognitive Examination (young adults) and the RUDAS-PE (older adults) were used, classifying participants as cognitively normal, possible mild NCD, or possible major NCD.ResultsWe enrolled 247 participants (median age 46 years; 67% female). One-fourth had not completed secondary school and more than 50% completed only secondary school. Most participants were housewives (46%) and 21% did not have health insurance. The overall prevalence of possible NCD was 30% (25.6 and 41.8% among younger adults and older adults, respectively). Among younger adults, those ages 55–59 years more frequently had NCD (70%) compared to younger age ranges. Among older adults, only 3 subjects (4.5%) had major NCD.ConclusionWe found a high frequency of possible NCDs in a socially and economically vulnerable community in Lima, Peru, with younger adults showing levels of NCD higher than expected. Our findings support the need for health systems to incorporate cognitive screenings programs for NCD in younger ages. Future research on NCD would include younger populations, particularly in vulnerable communities.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Neurology
- DOI:
- https://doi.org/10.17615/rkn9-9652
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fpubh.2023.1228008
- ISSN:
- 2296-2565
- Journal Title:
- Frontiers in Public Health
- Journal Volume:
- 11
- Keyword:
- door-to-door study, mild neurocognitive disorder, cognitive impairment, neuroepidemiology, major neurocognitive disorder, mild cognitive impairment, and dementia
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Universidad Peruana de Ciencias Aplicadas, Edgardo Rebagliati Martins National Hospital, Instituto Peruano de Neurociencias, Universidad San Ignacio de Loyola, , and University of California, San Francisco
- Person:
- Chang, Alexandra, Villafuerte, Mirla, Custodio, Nilton, Herrera-Perez, Eder, Diaz, Monica, Lanata, Serggio, and Montesinos, Rosa
- Publisher:
- Frontiers Media
- Source:
- 41df8fbe-a475-49d4-b90e-437c0ab8c4f1
74. Editorial: Insights in extreme microbiology: 2022
- Title Tesim:
- Editorial: Insights in extreme microbiology: 2022
- Creator:
- Teske, Andreas P. and Edgcomb, Virginia P.
- Date of publication:
- 2023
- Abstract Tesim:
- Taking stock of the contributions to the “Insights in extreme microbiology: 2022” Research Topic again reveals the extraordinary breadth that exists within the field of Extreme Microbiology.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Earth, Marine and Environmental Sciences
- DOI:
- https://doi.org/10.17615/8565-6158
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fmicb.2023.1324080
- ISSN:
- 1664-302X
- Journal Title:
- Frontiers in Microbiology
- Journal Volume:
- 14
- Keyword:
- insights, microbiology, 2022, Research Topic, and microbial community
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- and Woods Hole Oceanographic Institution
- Person:
- Teske, Andreas P. and Edgcomb, Virginia P.
- Publisher:
- Frontiers Media
- Source:
- cd2f2a66-54ec-42ab-be5d-12c2a2ad6ee9
75. Editorial: Global excellence in inflammation pharmacology
- Title Tesim:
- Editorial: Global excellence in inflammation pharmacology
- Creator:
- Saha, Sukanya and Ghosh, Shatadal
- Date of publication:
- 2023
- Abstract Tesim:
- In our day-to-day life, acute inflammation occurs commonly as a part of the body’s regular healing process post an injury or infection and is usually short term in nature. The problem arises when this inflammation becomes chronic, due to the failure in resolving itself, leading to a spectrum of diseases which explicitly contributes to more than 50% of worldwide mortality (GBD, 2017 Causes of Death Collaborators, 2018; Furman et al., 2019) Thus, prolonged inflammation is emerging as a serious threat to the global population and socioeconomic sustainability. Advancements in effective anti-inflammatory therapies have been significantly evolving, but challenges persist (Netea et al., 2017). Hence, scientists globally or in global alliance, with varied scientific perspectives, are actively working on finding out pharmacological interventions against inflammation associated pathogenesis and diseases. A major part of the research is also focused on scientific advancements of evolving therapeutic strategies by identifying the central signaling molecules or cascades involved in the onset and progression of chronic inflammation. This special edition Research Topic Global Excellence in Inflammation Pharmacology aims in emphasizing on the recent progress made in these fields, highlighting the diversified research performed across the entire breadth of Inflammation Pharmacology and providing insights to it. This Research Topic comprises of four extensive literature reviews discussing the potential pharmacological interventions and their allied risk in inflammation associated diseases.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Medicine
- DOI:
- https://doi.org/10.17615/gw8d-0732
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fphar.2023.1307503
- ISSN:
- 1663-9812
- Journal Title:
- Frontiers in Pharmacology
- Journal Volume:
- 14
- Keyword:
- global alliance, inflammation, therapeutics, diseases, and pharmacological interventions
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- National Institutes of Health and
- Person:
- Saha, Sukanya and Ghosh, Shatadal
- Publisher:
- Frontiers Media
- Source:
- 73c2a6a7-1900-4cf5-bc63-c1ccbc4d733c
76. Dietary fatty acids improve perceived sleep quality, stress, and health in migraine: a secondary analysis of a randomized controlled trial
- Title Tesim:
- Dietary fatty acids improve perceived sleep quality, stress, and health in migraine: a secondary analysis of a randomized controlled trial
- Creator:
- Mann, J. Douglas, Zamora, Daisy, Domeniciello, Anthony, Faurot, Keturah R., Ramsden, Christopher E., Palsson, Olafur, Lynch, Chanee E., Gaylord, Susan A., Horowitz, Mark, MacIntosh, Beth A., Honvoh, Gilson, Miller, Vanessa, and Park, Jinyoung
- Date of publication:
- 2023
- Abstract Tesim:
- BackgroundMigraine is a prevalent disabling condition often associated with comorbid physical and psychological symptoms that contribute to impaired quality of life and disability. Studies suggest that increasing dietary omega-3 fatty acid is associated with headache reduction, but less is known about the effects on quality of life in migraine.MethodsAfter a 4-week run-in, 182 adults with 5–20 migraine days per month were randomized to one of the 3 arms for sixteen weeks. Dietary arms included: H3L6 (a high omega-3, low omega-6 diet), H3 (a high omega-3, an average omega-6 diet), or a control diet (average intakes of omega-3 and omega-6 fatty acids). Prespecified secondary endpoints included daily diary measures (stress perception, sleep quality, and perceived health), Patient-Reported Outcome Measurement Information System Version 1.0 ([PROMIS©) measures and the Migraine Disability Assessment (MIDAS). Analyses used linear mixed effects models to control for repeated measures.ResultsThe H3L6 diet was associated with significant improvements in stress perception [adjusted mean difference (aMD): −1.5 (95% confidence interval: −1.7 to −1.2)], sleep quality [aMD: 0.2 (95% CI:0.1–0.2)], and perceived health [aMD: 0.2 (0.2–0.3)] compared to the control. Similarly, the H3 diet was associated with significant improvements in stress perception [aMD: −0.8 (−1.1 to −0.5)], sleep quality [aMD: 0.2 (0.1, 0.3)], and perceived health [aMD: 0.3 (0.2, 0.3)] compared to the control. MIDAS scores improved substantially in the intervention groups compared with the control (H3L6 aMD: −11.8 [−25.1, 1.5] and H3 aMD: −10.7 [−24.0, 2.7]). Among the PROMIS-29 assessments, the biggest impact was on pain interference [H3L6 MD: −1.8 (−4.4, 0.7) and H3 aMD: −3.2 (−5.9, −0.5)] and pain intensity [H3L6 MD: −0.6 (−1.3, 0.1) and H3 aMD: −0.6 (−1.4, 0.1)].DiscussionThe diary measures, with their increased power, supported our hypothesis that symptoms associated with migraine attacks could be responsive to specific dietary fatty acid manipulations. Changes in the PROMIS© measures reflected improvements in non-headache pain as well as physical and psychological function, largely in the expected directions. These findings suggest that increasing omega-3 with or without decreasing omega-6 in the diet may represent a reasonable adjunctive approach to reducing symptoms associated with migraine attacks. Trial Registration: ClinicalTrials.gov NCT02012790.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Neurology, Department of Physical Medicine and Rehabilitation, Department of Medicine, and UNC Medical Center
- DOI:
- https://doi.org/10.17615/2q0e-h937
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fpain.2023.1231054
- ISSN:
- 2673-561X
- Journal Title:
- Frontiers in Pain Research
- Journal Volume:
- 4
- Keyword:
- stress, quality of life, migraine, fatty acids, sleep quality, perceived health, and dietary intervention
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- and National Institute on Aging
- Person:
- Mann, J. Douglas, Zamora, Daisy, Domeniciello, Anthony, Faurot, Keturah R., Ramsden, Christopher E., Palsson, Olafur, Lynch, Chanee E., Gaylord, Susan A., Horowitz, Mark, MacIntosh, Beth A., Honvoh, Gilson, Miller, Vanessa, and Park, Jinyoung
- Publisher:
- Frontiers Media
- Source:
- 5c04a797-a3ac-4054-a453-18f7c0fdf592
77. Crowd-sourced investigation of a potential relationship between Bartonella-associated cutaneous lesions and neuropsychiatric symptoms
- Title Tesim:
- Crowd-sourced investigation of a potential relationship between Bartonella-associated cutaneous lesions and neuropsychiatric symptoms
- Creator:
- Frohlich, Flavio, Stewart, Zachary, and Korsapathy, Sanvi
- Date of publication:
- 2023
- Abstract Tesim:
- Introduction Preliminary studies suggest that infection with Bartonella bacteria can not only cause a characteristic rash, headache, fever, and fatigue but also neuropsychiatric symptoms. To date, this association has only been reported in case studies, and it remains unclear if this association generalizes to larger samples. Methods We used Amazon's Mechanical Turk (MTurk) to crowdsource a large sample (N = 996) of individuals to ascertain the extent to which the presence of participant-identified Bartonella-associated cutaneous lesions (BACL) was associated with self-reported measures of anxiety, depression, and schizotypy. Participants were asked to select images of cutaneous lesions they had seen on their own bodies and complete a battery of self-report questionnaires to assess psychiatric symptoms. Participants were not informed that the focus of the study was on potential dermatological lesions associated with Bartonella. Point-biserial correlations were used to determine the potential relationship between selecting a BACL image and the severity of self-reported psychiatric symptoms. Results Scores of anxiety, depression, and schizotypy were positively and significantly correlated with selecting a BACL image. Furthermore, self-report scores of 10 or higher on the GAD-7 and PHQ-9, which represent the suggested clinical cutoffs for meeting criteria for a depressive or anxiety-related disorder, were also significantly associated with selecting a BACL image. Non-Bartonella-associated cutaneous legions were also significantly associated with self-reported measures of psychiatric symptoms. Discussion The current study broadens the link between the presence of BACL and the presence of psychiatric symptoms of anxiety, depression, and schizotypy and extends a potential relationship beyond the small sample sizes of previous case studies and case series. Further investigation is recommended to address limitations and expand on these findings.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Psychiatry
- DOI:
- https://doi.org/10.17615/e746-tw18
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fpsyt.2023.1244121
- ISSN:
- 1664-0640
- Journal Title:
- Frontiers in Psychiatry
- Journal Volume:
- 14
- Keyword:
- Bartonella, schizotypy, depression, anxiety, and MTurk
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Person:
- Frohlich, Flavio, Stewart, Zachary, and Korsapathy, Sanvi
- Publisher:
- Frontiers Media
- Source:
- caa9e6c0-a2f4-4f5b-afcf-a698a0826055
78. Candidate composite biomarker to inform drug treatments for diabetic kidney disease
- Title Tesim:
- Candidate composite biomarker to inform drug treatments for diabetic kidney disease
- Creator:
- Abebe, Seyum, Slanzi, Debora, Poli, Irene, Mayer, Gert, Jones, Roger D., Silvestri, Claudio, and Distefano, Veronica
- Date of publication:
- 2023
- Abstract Tesim:
- IntroductionCurrent guidelines recommend renin angiotensin system inhibitors (RASi) as key components of treatment of diabetic kidney disease (DKD). Additional options include sodium-glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide 1 receptor agonists (GLP1a), and mineralocorticoid receptor antagonists (MCRa). The identification of the optimum drug combination for an individual is difficult because of the inter-, and longitudinal intra-individual heterogeneity of response to therapy.ResultsUsing data from a large observational study (PROVALID), we identified a set of parameters that can be combined into a meaningful composite biomarker that appears to be able to identify which of the various treatment options is clinically beneficial for an individual. It uses machine-earning techniques to estimate under what conditions a treatment of RASi plus an additional treatment is different from the treatment with RASi alone. The measure of difference is the annual percent change (ΔeGFR) in the estimated glomerular filtration rate (ΔeGFR). The 1eGFR is estimated for both the RASi-alone treatment and the add-on treatment.DiscussionHigher estimated increase of eGFR for add-on patients compared with RASi-alone patients indicates that prognosis may be improved with the add-on treatment. The personalized biomarker value thus identifies which patients may benefit from the additional treatment.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Biology
- DOI:
- https://doi.org/10.17615/p3s5-q060
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fmed.2023.1271407
- ISSN:
- 2296-858X
- Journal Title:
- Frontiers in Medicine
- Journal Volume:
- 10
- Keyword:
- biomarkers, RASi, clinical data, MCRa, SGLT2i, precision medicine, and diabetic kidney disease
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Ca’ Foscari University of Venice, Medical University Innsbruck, and
- Person:
- Abebe, Seyum, Slanzi, Debora, Poli, Irene, Mayer, Gert, Jones, Roger D., Silvestri, Claudio, and Distefano, Veronica
- Publisher:
- Frontiers Media SA
- Source:
- ca5516fe-5b66-4236-af89-6a1f3dd0f566
79. Assessing the pre-implementation context for financial navigation in rural and non-rural oncology clinics
- Title Tesim:
- Assessing the pre-implementation context for financial navigation in rural and non-rural oncology clinics
- Creator:
- Planey, Arrianna Marie, Biddell, Caitlin B., Petermann, Victoria M., Bell, Ronny A., Cabarrus, Kendrel, Deal, Allison M., Reeder-Hayes, Katherine, Birken, Sarah A., Samuel-Ryals, Cleo A., Padilla, Neda, Gellin, Mindy, Manning, Michelle, Rosenstein, Donald L., Strom, Carla, Vestal, Derek, Wheeler, Stephanie B., Leutner, Brian, King, Sherry, Young, Tiffany H., and Spees, Lisa P.
- Date of publication:
- 2023
- Abstract Tesim:
- BackgroundFinancial navigation (FN) is an evidence-based intervention designed to address financial toxicity for cancer patients. FN's success depends on organizations' readiness to implement and other factors that may hinder or support implementation. Tailored implementation strategies can support practice change but must be matched to the implementation context. We assessed perceptions of readiness and perceived barriers and facilitators to successful implementation among staff at nine cancer care organizations (5 rural, 4 non-rural) recruited to participate in the scale-up of a FN intervention. To understand differences in the pre-implementation context and inform modifications to implementation strategies, we compared findings between rural and non-rural organizations.MethodsWe conducted surveys (n = 78) and in-depth interviews (n = 73) with staff at each organization. We assessed perceptions of readiness using the Organizational Readiness for Implementing Change (ORIC) scale. In-depth interviews elicited perceived barriers and facilitators to implementing FN in each context. We used descriptive statistics to analyze ORIC results and deductive thematic analysis, employing a codebook guided by the Consolidated Framework for Implementation Research (CFIR), to synthesize themes in barriers and facilitators across sites, and by rurality.ResultsResults from the ORIC scale indicated strong perceptions of organizational readiness across all sites. Staff from rural areas reported greater confidence in their ability to manage the politics of change (87% rural, 76% non-rural) and in their organization's ability to support staff adjusting to the change (96% rural, 75% non-rural). Staff at both rural and non-rural sites highlighted factors reflective of the Intervention Characteristics (relative advantage) and Implementation Climate (compatibility and tension for change) domains as facilitators. Although few barriers to implementation were reported, differences arose between rural and non-rural sites in these perceived barriers, with non-rural staff more often raising concerns about resistance to change and compatibility with existing work processes and rural staff more often raising concerns about competing time demands and limited resources.ConclusionsStaff across both rural and non-rural settings identified few, but different, barriers to implementing a novel FN intervention that they perceived as important and responsive to patients' needs. These findings can inform how strategies are tailored to support FN in diverse oncology practices.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Health Policy and Management, School of Nursing, UNC Lineberger Comprehensive Cancer Center, and Department of Psychiatry
- DOI:
- https://doi.org/10.17615/p1w4-j415
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/frhs.2023.1148887
- ISSN:
- 2813-0146
- Journal Title:
- Frontiers in Health Services
- Journal Volume:
- 3
- Keyword:
- cancer, rural, implementation science, financial navigation, financial toxicity, and organizational readiness framework for advancing implementation science
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- , Wake Forest University, Division of Oncology, UNC Lenoir Health Care, Pardee UNC Health Care, Carteret Health Care Cancer Center, and Novant Health Cancer Institute
- Person:
- Planey, Arrianna Marie, Biddell, Caitlin B., Petermann, Victoria M., Bell, Ronny A., Cabarrus, Kendrel, Deal, Allison M., Reeder-Hayes, Katherine, Birken, Sarah A., Samuel-Ryals, Cleo A., Padilla, Neda, Gellin, Mindy, Manning, Michelle, Rosenstein, Donald L., Strom, Carla, Vestal, Derek, Wheeler, Stephanie B., Leutner, Brian, King, Sherry, Young, Tiffany H., and Spees, Lisa P.
- Publisher:
- Frontiers Media SA
- Source:
- 3d072112-cd06-457b-a689-9c058078c895
80. A cross-sectional study confirms temporary post-COVID-19 vaccine menstrual irregularity and the associated physiological changes among vaccinated women in Jordan
- Title Tesim:
- A cross-sectional study confirms temporary post-COVID-19 vaccine menstrual irregularity and the associated physiological changes among vaccinated women in Jordan
- Creator:
- Hajjo R., Al-Momany A., Sabbah D.A., Almomani E.Y., and Qablan A.
- Date of publication:
- 2023
- Abstract Tesim:
- Background: COVID-19 vaccines continue to save people’s lives around the world; however, some vaccine adverse events have been a major concern which slowed down vaccination campaigns. Anecdotal evidence pointed to the vaccine effect on menstruation but evidence from the adverse event reporting systems and the biomedical literature was lacking. This study aimed to investigate the physiological changes in women during menstruation amid the COVID-19 vaccination. Methods: A cross-sectional online survey was distributed to COVID-19 vaccinated women from Nov 2021 to Jan 2022. The results were analyzed using the SPSS software. Results: Among the 564 vaccinated women, 52% experienced significant menstrual irregularities post-vaccination compared to before regardless of the vaccine type. The kind of menstrual irregularity varied among the vaccinated women, for example, 33% had earlier menstruation, while 35% reported delayed menstruation. About 31% experienced heavier menstruation, whereas 24% had lighter menstrual flow. About 29% had menstruation last longer, but 13% had it shorter than usual. Noteworthy, the menstrual irregularities were more frequent after the second vaccine shot, and they disappeared within 3 months on average. Interestingly, 24% of the vaccinated women reported these irregularities to their gynecologist. Conclusion: The COVID-19 vaccine may cause physiological disturbances during menstruation. Luckily, these irregularities were short-termed and should not be a reason for vaccine hesitancy in women. Further studies are encouraged to unravel the COVID-19 vaccine adverse effect on women’s health.
- Resource type:
- Article
- Affiliation Label Tesim:
- Division of Chemical Biology and Medicinal Chemistry
- DOI:
- https://doi.org/10.17615/djdj-px95
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3389/fmed.2023.1211283
- ISSN:
- 2296-858X
- Journal Title:
- Frontiers in Medicine
- Journal Volume:
- 10
- Keyword:
- COVID-19 vaccine, adverse events, menstrual cycle irregularity, vaccinated women, and Jordan
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- , University of Jordan, Al-Zaytoonah University of Jordan, Al-Balqa Applied University, and United Arab Emirates University
- Person:
- Hajjo R., Al-Momany A., Sabbah D.A., Almomani E.Y., and Qablan A.
- Publisher:
- Frontiers Media SA
- Source:
- 9899aca4-8587-4aa7-9c37-9aa96e4bd4cb
Collection Details
- Total items
-
762
- Size
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unknown
- Date created
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May 26, 2022