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1011. An Amine-Reactive Phenazine Ethosulfate (arPES)—A Novel Redox Probe for Electrochemical Aptamer-Based Sensor

Title Tesim:
An Amine-Reactive Phenazine Ethosulfate (arPES)—A Novel Redox Probe for Electrochemical Aptamer-Based Sensor
Creator:
Ikebukuro, Kazunori, Sode, Koji, Lee, Jinhee, Nagata, Madoka, and Henley, Stephen
Date of publication:
2022
Abstract Tesim:
Electrochemical aptamer-based biosensors (E-ABs) are attractive candidates for use in biomarker detection systems due to their sensitivity, rapid response, and design flexibility. There are only several redox probes that were employed previously for this application, and a combination of redox probes affords some advantages in target detection. Thus, it would be advantageous to study new redox probes in an E-AB system. In this study, we report the use of amine-reactive phenazine ethosulfate (arPES) for E-AB through its conjugation to the terminus of thrombin-binding aptamer. The constructed E-AB can detect thrombin by square-wave voltammetry (SWV), showing peak current at −0.15 V vs. Ag/AgCl at pH 7, which differs from redox probes used previously for E-ABs. We also compared the characteristics of PES as a redox probe for E-AB to methylene blue (MB), which is widely used. arPES showed stable signal at physiological pH. Moreover, the pH profile of arPES modified thrombin-binding aptamer revealed the potential application of arPES for a simultaneous multianalyte detection system. This could be achieved using different aptamers with several redox probes in tandem that harbor various electrochemical peak potentials. Our findings present a great opportunity to improve the current standard of biological fluid monitoring using E-AB.
Resource type:
Article
Affiliation Label Tesim:
School of Medicine and Joint Department of Biomedical Engineering
DOI:
https://doi.org/10.17615/2beq-p456
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/s22051760
ISSN:
1424-8220
Journal Issue:
5
Journal Title:
Sensors
Journal Volume:
22
Keyword:
electrochemical sensor, amine-reactive phenazine ethosulfate, aptamer, and redox probe
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
Tokyo University of Agriculture and Technology
Page Start:
1760
Person:
Ikebukuro, Kazunori, Sode, Koji, Lee, Jinhee, Nagata, Madoka, and Henley, Stephen
Rights Statement Label:
In Copyright
Source:
mdpi_backfiles_11

1012. Mapping Forest Aboveground Biomass Using Multisource Remotely Sensed Data

Title Tesim:
Mapping Forest Aboveground Biomass Using Multisource Remotely Sensed Data
Creator:
Ehlers, Dekker, Wang, Chao, Song, Conghe, Woodcock, Curtis, Frankenberg, Elizabeth, Zhang, Yulong, Coulston, John, and Pavelsky, Tamlin
Date of publication:
2022
Abstract Tesim:
The majority of the aboveground biomass on the Earth’s land surface is stored in forests. Thus, forest biomass plays a critical role in the global carbon cycle. Yet accurate estimate of forest aboveground biomass (FAGB) remains elusive. This study proposed a new conceptual model to map FAGB using remotely sensed data from multiple sensors. The conceptual model, which provides guidance for selecting remotely sensed data, is based on the principle of estimating FAGB on the ground using allometry, which needs species, diameter at breast height (DBH), and tree height as inputs. Based on the conceptual model, we used multiseasonal Landsat images to provide information about species composition for the forests in the study area, LiDAR data for canopy height, and the image texture and image texture ratio at two spatial resolutions for tree crown size, which is related to DBH. Moreover, we added RaDAR data to provide canopy volume information to the model. All the data layers were fed to a Random Forest (RF) regression model. The study was carried out in eastern North Carolina. We used biomass from the USFS Forest Inventory and Analysis plots to train and test the model performance. The best model achieved an R2 of 0.625 with a root mean squared error (RMSE) of 18.8 Mg/ha (47.6%) with the “out-of-bag” samples at 30 × 30 m spatial resolution. The top five most important variables include the 95th, 85th, 75th, and 50th percentile heights of the LiDAR points and their standard deviations of 85th heights. Numerous features from multiseasonal Sentinel-1 C-Band SAR, multiseasonal Landsat 8 imagery along with image texture features from very high-resolution imagery were selected. But the importance of the height metrics dwarfed all other variables. More tests of the conceptual model in places with a broader range of biomass and more diverse species composition are needed to evaluate the importance of other input variables.
Resource type:
Article
Affiliation Label Tesim:
College of Arts and Sciences and Department of Geography
DOI:
https://doi.org/10.17615/wbf8-5d33
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/rs14051115
ISSN:
2072-4292
Journal Issue:
5
Journal Title:
Remote Sensing
Journal Volume:
14
Keyword:
forest aboveground biomass, optical remote sensing, random forest, LiDAR, and RaDAR
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
Boston University, Carolina Population Center, University of Tennessee at Knoxville, and USDA Forest Service
Page Start:
1115
Person:
Ehlers, Dekker, Wang, Chao, Song, Conghe, Woodcock, Curtis, Frankenberg, Elizabeth, Zhang, Yulong, Coulston, John, and Pavelsky, Tamlin
Rights Statement Label:
In Copyright
Source:
mdpi_backfiles_10

1013. Environmental Health Literacy as Knowing, Feeling, and Believing: Analyzing Linkages between Race, Ethnicity, and Socioeconomic Status and Willingness to Engage in Protective Behaviors against Health Threats

Title Tesim:
Environmental Health Literacy as Knowing, Feeling, and Believing: Analyzing Linkages between Race, Ethnicity, and Socioeconomic Status and Willingness to Engage in Protective Behaviors against Health Threats
Creator:
Carlsten, Elise, May, Katlyn, Binder, Andrew R., Murphy, John, and Gross, Anna
Date of publication:
2022
Abstract Tesim:
This study investigates the relationships between environmental health literacy, the characteristics of people (race, ethnicity, and socioeconomic status) associated with health disparities, and people’s willingness to engage in protective behaviors against environmental health threats. Environmental health literacy is a framework for capturing the continuum between the knowledge of environmental impacts on public health, and the skills and decisions needed to take health-protective actions. We pay particular attention to three dimensions of environmental health literacy: factual knowledge (knowing the facts), knowledge sufficiency (feeling ready to decide what to do), and response efficacy (believing that protective behaviors work). In June 2020, we collected survey data from North Carolina residents on two topics: the viral infection COVID-19 and industrial contaminants called per- and polyfluoroalkyl substances (PFAS). We used their responses to test stepwise regression models with willingness to engage in protective behaviors as a dependent variable and other characteristics as independent variables, including environmental health literacy. For both topics, our results indicated that no disparities emerged according to socioeconomic factors (level of education, household income, or renting one’s residence). We observed disparities in willingness according to race, comparing Black to White participants, but not when comparing White to American Indian, Alaska Native, Asian, Native Hawaiian, or Pacific Islander participants nor Hispanic to non-Hispanic participants. The disparities in willingness between Black and White participants persisted until we introduced the variables of environmental health literacy, when the difference between these groups was no longer significant in the final regression models. The findings suggest that focusing on environmental health literacy could bridge a gap in willingness to protect oneself based on factors such as race/ethnicity and socioeconomic status, which have been identified in the environmental health literature as resulting in health disparities.
Resource type:
Article
DOI:
https://doi.org/10.17615/mhd0-9h87
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijerph19052701
ISSN:
1660-4601
Journal Issue:
5
Journal Title:
International Journal of Environmental Research and Public Health
Journal Volume:
19
Keyword:
factual knowledge, efficacy, socioeconomic status, race and ethnicity, environmental health literacy, PFAS, knowledge sufficiency, COVID-19, and health disparities
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
North Carolina State University
Page Start:
2701
Person:
Carlsten, Elise, May, Katlyn, Binder, Andrew R., Murphy, John, and Gross, Anna
Rights Statement Label:
In Copyright
Source:
mdpi_backfiles_9

1014. Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms

Title Tesim:
Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms
Creator:
Nath, Bhupendra, Niphakis, Micah J., Xu, Callie, Mukhopadhyay, Somnath, Lichtman, Aron H., Fitting, Sylvia, Ignatowska-Jankowska, Bogna M., Cravatt, Benjamin F., Xu, Changqing, Jiang, Wei, Yadav-Samudrala, Barkha J., and Mistry, Twisha
Date of publication:
2022
Abstract Tesim:
(1) Background. The endocannabinoid (eCB) system, which regulates physiological and cognitive processes, presents a promising therapeutic target for treating HIV-associated neurocognitive disorders (HAND). Here we examine whether upregulating eCB tone has potential protective effects against HIV-1 Tat (a key HIV transactivator of transcription) protein-induced alterations in synaptic activity. (2) Methods. Whole-cell patch-clamp recordings were performed to assess inhibitory GABAergic neurotransmission in prefrontal cortex slices of Tat transgenic male and female mice, in the presence and absence of the fatty acid amide hydrolase (FAAH) enzyme inhibitor PF3845. Western blot and mass spectrometry analyses assessed alterations of cannabinoid receptor and enzyme protein expression as well as endogenous ligands, respectively, to determine the impact of Tat exposure on the eCB system. (3) Results. GABAergic activity was significantly altered upon Tat exposure based on sex, whereas the effectiveness of PF3845 to suppress GABAergic activity in Tat transgenic mice was not altered by Tat or sex and involved CB1R-related mechanisms that depended on calcium signaling. Additionally, our data indicated sex-dependent changes for AEA and related non-eCB lipids based on Tat induction. (4) Conclusion. Results highlight sex- and/or Tat-dependent alterations of GABAergic activity and eCB signaling in the prefrontal cortex of Tat transgenic mice and further increase our understanding about the role of FAAH inhibition in neuroHIV.
Resource type:
Article
Affiliation Label Tesim:
College of Arts and Sciences and Department of Psychology and Neuroscience
DOI:
https://doi.org/10.17615/41fa-mc54
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/cells11050857
ISSN:
2073-4409
Journal Issue:
5
Journal Title:
Cells
Journal Volume:
11
Keyword:
endocannabinoid enzyme inhibitor, inhibitory postsynaptic potentials, neuroHIV, fatty acid amide hydrolase, anandamide, Tat transgenic mice, non-eCB lipids, PF3845, cannabinoid type 1 receptor, and endocannabinoids
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
North Carolina Central University, Scripps Research Institute, Virginia Commonwealth University, Okinawa Institute of Science and Technology, and Medical University of South Carolina
Page Start:
857
Person:
Nath, Bhupendra, Niphakis, Micah J., Xu, Callie, Mukhopadhyay, Somnath, Lichtman, Aron H., Fitting, Sylvia, Ignatowska-Jankowska, Bogna M., Cravatt, Benjamin F., Xu, Changqing, Jiang, Wei, Yadav-Samudrala, Barkha J., and Mistry, Twisha
Rights Statement Label:
In Copyright
Source:
mdpi_backfiles_8

1015. Designing Environmental Messages to Discourage Red Meat Consumption: An Online Experiment

Title Tesim:
Designing Environmental Messages to Discourage Red Meat Consumption: An Online Experiment
Creator:
Hall, Marissa G., Wistar, Alice, Taillie, Lindsey Smith, and Bercholz, Maxime
Date of publication:
2022
Abstract Tesim:
Reducing red meat consumption in high-consuming countries is critical for mitigating climate change and preventing chronic disease. This study tested the effectiveness of messages conveying the worsening or reduction of environmental harms at discouraging red meat consumption. 1078 U.S. adults viewed seven messages in an online survey highlighting the reduction or worsening of environmental harms associated with eating red meat (between-subjects factor) and rated the messages on how much they discouraged them from wanting to buy beef. Each message highlighted a different environmental harm: deforestation, climate change, water shortages, biodiversity loss, carbon footprint, greenhouse gas emissions, or environment (within-subjects factor). No statistically significant difference was found between the reduction and worsening of environmental harms conditions for most topics, though the worsening of harms frame slightly outperformed the reduction of harms frame for the ‘environment’ topic. ‘Environment’ was also the message topic that elicited the strongest response from participants overall. Latino participants, those with more than a high school degree, and those who consume beef once a week or less rated messages as more effective than non-Latino participants, those who completed high school or less, and those who consumed beef more than once a week. Future research should explore the effect of messages on behavioral outcomes.
Resource type:
Article
Affiliation Label Tesim:
Gillings School of Global Public Health, Department of Health Behavior, and Carolina Population Center
DOI:
https://doi.org/10.17615/msne-qb79
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijerph19052919
ISSN:
1660-4601
Journal Issue:
5
Journal Title:
International Journal of Environmental Research and Public Health
Journal Volume:
19
Keyword:
sustainability, goal framing, environmental behavior, vegetarianism, meat consumption, emphasis framing, and health communication
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
Princeton University
Page Start:
2919
Person:
Hall, Marissa G., Wistar, Alice, Taillie, Lindsey Smith, and Bercholz, Maxime
Rights Statement Label:
In Copyright
Source:
mdpi_backfiles_7

1016. Trends in the Management of Headache Disorders in US Emergency Departments: Analysis of 2007–2018 National Hospital Ambulatory Medical Care Survey Data

Title Tesim:
Trends in the Management of Headache Disorders in US Emergency Departments: Analysis of 2007–2018 National Hospital Ambulatory Medical Care Survey Data
Creator:
Adkins, Lauren, Wilson, Debbie L., Lipe, Abigale, Park, Haesuk, Orlova, Yulia, Lo-Ciganic, Wei-Hsuan, Yang, Seonkyeong, Hincapie-Castillo, Juan M., Chang, Ching-Yuan, and Boren, Macy
Date of publication:
2022
Abstract Tesim:
We examined trends in management of headache disorders in United States (US) emergency department (ED) visits. We conducted a cross-sectional study using 2007–2018 National Hospital Ambulatory Medical Care Survey data. We included adult patient visits (≥18 years) with a primary ED discharge diagnosis of headache. We classified headache medications by pharmacological group: opioids, butalbital, ergot alkaloids/triptans, acetaminophen/nonsteroidal anti-inflammatory drugs (NSAIDs), antiemetics, diphenhydramine, corticosteroids, and intravenous fluids. To obtain reliable estimates, we aggregated data into three time periods: 2007–2010, 2011–2014, and 2015–2018. Using multivariable logistic regression, we examined medication, neuroimaging, and outpatient referral trends, separately. Among headache-related ED visits, opioid use decreased from 54.1% in 2007–2010 to 28.3% in 2015–2018 (Ptrend < 0.001). There were statistically significant increasing trends in acetaminophen/NSAIDs, diphenhydramine, and corticosteroids use (all Ptrend < 0.001). Changes in butalbital (6.4%), ergot alkaloid/triptan (4.7%), antiemetic (59.2% in 2015–2018), and neuroimaging (37.3%) use over time were insignificant. Headache-related ED visits with outpatient referral for follow-up increased slightly from 73.3% in 2007–2010 to 79.7% in 2015–2018 (Ptrend = 0.02). Reflecting evidence-based guideline recommendations for headache management, opioid use substantially decreased from 2007 to 2018 among US headache-related ED visits. Future studies are warranted to identify strategies to promote evidence-based treatment for headaches (e.g., sumatriptan, dexamethasone) and appropriate outpatient referral and reduce unnecessary neuroimaging orders in EDs.
Resource type:
Article
Affiliation Label Tesim:
Gillings School of Global Public Health and Department of Epidemiology
DOI:
https://doi.org/10.17615/n5q1-jz72
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/jcm11051401
ISSN:
2077-0383
Journal Issue:
5
Journal Title:
Journal of Clinical Medicine
Journal Volume:
11
Keyword:
neuroimaging, headache, primary headache, antiemetic, migraine, NHAMCS, ED visits, triptan, opioid analgesic, and trend
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
University of Florida
Page Start:
1401
Person:
Adkins, Lauren, Wilson, Debbie L., Lipe, Abigale, Park, Haesuk, Orlova, Yulia, Lo-Ciganic, Wei-Hsuan, Yang, Seonkyeong, Hincapie-Castillo, Juan M., Chang, Ching-Yuan, and Boren, Macy
Rights Statement Label:
In Copyright
Source:
mdpi_backfiles_6

1017. Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders

Title Tesim:
Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders
Creator:
Kwan, Sze Ting Cecilia, Mooney, Sandra M., Saini, Nipun, Virdee, Manjot S., Helfrich, Kaylee K., and Smith, Susan M.
Date of publication:
2022
Abstract Tesim:
Prenatal alcohol exposure (PAE) causes fetal growth restrictions. A major driver of fetal growth deficits is maternal metabolic disruption; this is under-investigated following PAE. Untargeted metabolomics on the dam and fetus exposed to alcohol (ALC) revealed that the hepatic metabolome of ALC and control (CON) dams were distinct, whereas that of ALC and CON fetuses were similar. Alcohol reduced maternal hepatic glucose content and enriched essential amino acid (AA) catabolites, N-acetylated AA products, urea content, and free fatty acids. These alterations suggest an attempt to minimize the glucose gap by increasing gluconeogenesis using AA and glycerol. In contrast, ALC fetuses had unchanged glucose and AA levels, suggesting an adequate draw of maternal nutrients, despite intensified stress on ALC dams. Maternal metabolites including glycolytic intermediates, AA catabolites, urea, and one-carbon-related metabolites correlated with fetal liver and brain weights, whereas lipid metabolites correlated with fetal body weight, indicating they may be drivers of fetal weight outcomes. Together, these data suggest that ALC alters maternal hepatic metabolic activity to limit glucose availability, thereby switching to alternate energy sources to meet the high-energy demands of pregnancy. Their correlation with fetal phenotypic outcomes indicates the influence of maternal metabolism on fetal growth and development.
Resource type:
Article
Affiliation Label Tesim:
Nutrition Research Institute
DOI:
https://doi.org/10.17615/sdbd-5544
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/nu14051096
ISSN:
2072-6643
Journal Issue:
5
Journal Title:
Nutrients
Journal Volume:
14
Keyword:
fetal weight, prenatal alcohol exposure, gluconeogenesis, glucose, hepatic metabolism, amino acids, pregnancy, maternal–fetal metabolism, and untargeted metabolomics
Language Label:
English
License Label:
Attribution 3.0 United States
Page Start:
1096
Person:
Kwan, Sze Ting Cecilia, Mooney, Sandra M., Saini, Nipun, Virdee, Manjot S., Helfrich, Kaylee K., and Smith, Susan M.
Rights Statement Label:
In Copyright
Source:
mdpi_backfiles_5

1018. Does Venue of HIV Testing and Results Disclosure in the Context of a Research Study Affect Adolescent Health and Behavior? Results from a Study in Western Kenya

Title Tesim:
Does Venue of HIV Testing and Results Disclosure in the Context of a Research Study Affect Adolescent Health and Behavior? Results from a Study in Western Kenya
Creator:
Iritani, Bonita J., Field, Samuel H., Luseno, Winnie Kavulani, Kwaro, Daniel, Rennie, Stuart, and Odongo, Fredrick S.
Date of publication:
2022
Abstract Tesim:
Ethical concerns about risks to minor adolescents participating in HIV prevention research is a barrier to their inclusion. One concern is whether HIV testing and results disclosure venue affects the health and behavior of adolescent participants. We assessed for differential effects on quality of life (QOL), depressive symptoms, and sexual behavior due to (1) testing venue (home or health facility) and (2) test result (HIV-positive, HIV-negative, indeterminate). We collected data at three timepoints (baseline, 2-month follow-up, 12-month follow-up) from 113 Kenyan adolescents aged 15–19 (51% female). We analyzed the data using linear mixed effects models for the QOL and depressive symptoms outcomes and a logistic model for the sexual behavior outcome. Results showed a small mental health benefit for adolescents tested for HIV at a health facility compared with home. There was little evidence that testing venue influenced sexual behavior or that test results moderated the effects of HIV testing across all outcomes. The decision to conduct HIV testing at home or a health facility may not be very consequential for adolescents’ health and behavior. Findings underscore the need to critically examine assumptions about adolescent vulnerability to better promote responsible conduct of HIV prevention research with youth in sub-Saharan Africa.
Resource type:
Article
Affiliation Label Tesim:
School of Medicine and Department of Social Medicine
DOI:
https://doi.org/10.17615/eb0r-kp26
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijerph19063249
ISSN:
1660-4601
Journal Issue:
6
Journal Title:
International Journal of Environmental Research and Public Health
Journal Volume:
19
Keyword:
adolescent research participation, HIV prevention, quality of life, sub-Saharan Africa, HIV testing and results disclosure, depressive symptoms, and sexual risk behavior
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
Pacific Institute for Research and Evaluation and Kenya Medical Research Institute
Page Start:
3249
Person:
Iritani, Bonita J., Field, Samuel H., Luseno, Winnie Kavulani, Kwaro, Daniel, Rennie, Stuart, and Odongo, Fredrick S.
Rights Statement Label:
In Copyright
Source:
mdpi_backfiles_4

1019. Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics

Title Tesim:
Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics
Creator:
Cottrell, Mackenzie L., Shrivastava, Roopali, King, Jasmine L., Kashuba, Angela D. M., Howard, Sarah Anne, Dayton, Paul A., Benhabbour, Soumya Rahima, and Joiner, Jordan B.
Date of publication:
2022
Abstract Tesim:
Due to the versatility of the in situ forming implant (ISFI) drug delivery system, it is crucial to understand the effects of formulation parameters for clinical translation. We utilized ultrasound imaging and pharmacokinetics (PK) in mice to understand the impact of administration route, injection volume, and drug loading on ISFI formation, degradation, and drug release in mice. Placebo ISFIs injected subcutaneously (SQ) with smaller volumes (40 μL) exhibited complete degradation within 30–45 days, compared to larger volumes (80 μL), which completely degraded within 45–60 days. However, all dolutegravir (DTG)-loaded ISFIs along the range of injection volumes tested (20–80 μL) were present at 90 days post-injection, suggesting that DTG can prolong ISFI degradation. Ultrasound imaging showed that intramuscular (IM) ISFIs flattened rapidly post administration compared to SQ, which coincides with the earlier Tmax for drug-loaded IM ISFIs. All mice exhibited DTG plasma concentrations above four times the protein-adjusted 90% inhibitory concentration (PA-IC90) throughout the entire 90 days of the study. ISFI release kinetics best fit to zero order or diffusion-controlled models. When total administered dose was held constant, there was no statistical difference in drug exposure regardless of the route of administration or number of injections.
Resource type:
Article
Affiliation Label Tesim:
School of Medicine, Center for AIDS Research, Joint Department of Biomedical Engineering, Eshelman School of Pharmacy, and Division of Pharmacoengineering and Molecular Pharmaceutics
DOI:
https://doi.org/10.17615/wzrz-ge30
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/pharmaceutics14030615
ISSN:
1999-4923
Journal Issue:
3
Journal Title:
Pharmaceutics
Journal Volume:
14
Keyword:
long-acting, controlled release, implants, PLGA, injectable, pharmacokinetics, in situ, biodegradable, drug delivery, and ultrasound
Language Label:
English
License Label:
Attribution 3.0 United States
Page Start:
615
Person:
Cottrell, Mackenzie L., Shrivastava, Roopali, King, Jasmine L., Kashuba, Angela D. M., Howard, Sarah Anne, Dayton, Paul A., Benhabbour, Soumya Rahima, and Joiner, Jordan B.
Rights Statement Label:
In Copyright
Source:
mdpi_backfiles_3

1020. Pre- and Postnatal Fine Particulate Matter Exposure and Childhood Cognitive and Adaptive Function

Title Tesim:
Pre- and Postnatal Fine Particulate Matter Exposure and Childhood Cognitive and Adaptive Function
Creator:
Windham, Gayle C., Schieve, Laura A., Moody, Eric J., Wiggins, Lisa D., Kasten, Eric, Di, Qian, McGuinn, Laura A., Daniels, Julie L., Volk, Heather E., Wright, Robert O., and Schwartz, Joel
Date of publication:
2022
Abstract Tesim:
Increasing evidence exists for an association between early life fine particulate matter (PM2.5) exposure and several neurodevelopmental outcomes, including autism spectrum disorder (ASD); however, the association between PM2.5 and adaptive and cognitive function remains poorly understood. Participants included 658 children with ASD, 771 with a non-ASD developmental disorder, and 849 population controls from the Study to Explore Early Development. Adaptive functioning was assessed in ASD cases using the Vineland Adaptive Behavior Scales (VABS); cognitive functioning was assessed in all groups using the Mullen Scales of Early Learning (MSEL). A satellite-based model was used to assign PM2.5 exposure averages during pregnancy, each trimester, and the first year of life. Linear regression was used to estimate beta coefficients and 95% confidence intervals, adjusting for maternal age, education, prenatal tobacco use, race-ethnicity, study site, and season of birth. PM2.5 exposure was associated with poorer VABS scores for several domains, including daily living skills and socialization. Associations were present between prenatal PM2.5 and lower MSEL scores for all groups combined; results were most prominent for population controls in stratified analyses. These data suggest that early life PM2.5 exposure is associated with specific aspects of cognitive and adaptive functioning in children with and without ASD.
Resource type:
Article
Affiliation Label Tesim:
Gillings School of Global Public Health and Department of Epidemiology
DOI:
https://doi.org/10.17615/kgpw-9j23
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijerph19073748
ISSN:
1660-4601
Journal Issue:
7
Journal Title:
International Journal of Environmental Research and Public Health
Journal Volume:
19
Keyword:
air pollution, cognitive functioning, and autism
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
California Department of Public Health, Centers for Disease Control and Prevention, University of Wyoming, Michigan State University, Tsinghua University, Icahn School of Medicine at Mount Sinai, Johns Hopkins Bloomberg School of Public Health, and Harvard T.H. Chan School of Public Health
Page Start:
3748
Person:
Windham, Gayle C., Schieve, Laura A., Moody, Eric J., Wiggins, Lisa D., Kasten, Eric, Di, Qian, McGuinn, Laura A., Daniels, Julie L., Volk, Heather E., Wright, Robert O., and Schwartz, Joel
Rights Statement Label:
In Copyright
Source:
mdpi_backfiles_2