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UNC-authored articles published by MDPI
Works (1066)
1031. How overweight and obesity relate to the development of functional limitations among filipino women
- Title Tesim:
- How overweight and obesity relate to the development of functional limitations among filipino women
- Creator:
- Adair, L.S., Borja, J.B., and Duazo, P.
- Date of publication:
- 2018
- Abstract Tesim:
- As life expectancy and obesity increase in low and middle-income countries, the relationship of weight status to functional outcomes in older adults in these settings requires attention. We examined how overweight (BMI > 25 kg/m2), obesity (BMI > 30 kg/m2), and high waist circumference (WC > 80 cm) related to grip strength, timed up-and-go, and development of limitations in mobility, activities of daily living (ADL), and instrumental activities of daily living (IADL) among Filipino women. We analyzed data from seven rounds of the Cebu Longitudinal Health and Nutrition Survey (1994, n = 2279 to 2015, n = 1568, age 49-78 years) to examine how women's reports of functional limitations related to their prior WC, and how their grip strength and timed up-and-go related to concurrently measured overweight and obesity, adjusted for age, socioeconomic status, and urbanicity. High WC was associated with higher odds of subsequent mobility and IADL limitations. Chronic disease morbidity (sum of self-reported arthritis, high blood pressure, heart disease, diabetes, and cancer) fully mediated the association of high WC with ADL and IADL limitations, but not physical/mobility limitations. Longer up-and-go times, and higher grip strength were related to overweight and obesity. Results emphasize the need for obesity prevention to reduce chronic diseases and maintain good functional status as women age.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health and Department of Nutrition
- DOI:
- https://doi.org/10.17615/epmb-d746
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/geriatrics3040063
- ISSN:
- 2308-3417
- Journal Issue:
- 4
- Journal Title:
- Geriatrics
- Journal Volume:
- 3
- Keyword:
- Timed up-and-go, Philippines, Activities of daily living, Obesity, Instrumental activities of daily living, Mobility limitations, Grip strength, and Functional limitations
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- University of San Carlos
- Person:
- Adair, L.S., Borja, J.B., and Duazo, P.
- Publisher:
- MDPI Multidisciplinary Digital Publishing Institute
- Rights Statement Label:
- In Copyright
- Source:
- linda_adair_20
1032. Determinants of successful aging in a cohort of Filipino women
- Title Tesim:
- Determinants of successful aging in a cohort of Filipino women
- Creator:
- Adair, L.S., Avila, J., and Tzioumis, E.
- Date of publication:
- 2019
- Abstract Tesim:
- This study describes a multidimensional measure of successful aging (SA) and examines the relationship with chronic disease status and self-reported health. Using data from the 2015 Cebu Longitudinal Health and Nutrition Survey of 1568 Filipino women, we created a four domainmeasure of SA (physiological, mental health, cognitive, sociological). We explored age-stratified associations of each domain and total SA with various health behaviors, chronic disease status, and correlations with self-reported health measures. Both age groups reported aging well, but younger women had higher mean SA scores. Association patterns between domain and total SA and sociodemographic and health behaviors were similar across age groups. Physiological score was associated with hypertension for all ages, and with diabetes in younger women. Total SA was moderately correlated with self-reported health measures. Participants reported aging successfully despite chronic disease status. Future studies should use a multidimensional definition of SA which incorporates elders' perspective.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health and Department of Nutrition
- DOI:
- https://doi.org/10.17615/gyc7-5m83
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/geriatrics4010012
- ISSN:
- 2308-3417
- Journal Issue:
- 1
- Journal Title:
- Geriatrics
- Journal Volume:
- 4
- Keyword:
- Low- and middle-income countries, Self-rated health, Women, and Successful aging
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- University of San Carlos
- Person:
- Adair, L.S., Avila, J., and Tzioumis, E.
- Publisher:
- MDPI Multidisciplinary Digital Publishing Institute
- Rights Statement Label:
- In Copyright
- Source:
- linda_adair_16
1033. Identification of novel candidate genes and variants for hearing loss and temporal bone anomalies
- Title Tesim:
- Identification of novel candidate genes and variants for hearing loss and temporal bone anomalies
- Creator:
- Perez, M.E.C., Reyes-Quintos, M.R.T., Chiong, C.M., Chan, A.L., Lee, N.R., Bootpetch, T.C., Tantoco, M.L.C., Mohlke, K.L., Yarza, T.K.L., Cutiongco-De la Paz, E.M., Cruz, T.L.G., Tobias-Grasso, C.A.M., and Santos-Cortez, R.L.P.
- Date of publication:
- 2021
- Abstract Tesim:
- Background: Hearing loss remains an important global health problem that is potentially addressed through early identification of a genetic etiology, which helps to predict outcomes of hearing rehabilitation such as cochlear implantation and also to mitigate the long-term effects of comorbidities. The identification of variants for hearing loss and detailed descriptions of clinical phenotypes in patients from various populations are needed to improve the utility of clinical genetic screening for hearing loss. Methods: Clinical and exome data from 15 children with hearing loss were reviewed. Standard tools for annotating variants were used and rare, putatively deleterious variants were selected from the exome data. Results: In 15 children, 21 rare damaging variants in 17 genes were identified, including: 14 known hearing loss or neurodevelopmental genes, 11 of which had novel variants; and three candidate genes IST1, CBLN3 and GDPD5, two of which were identified in children with both hearing loss and enlarged vestibular aqueducts. Patients with variants within IST1 and MYO18B had poorer outcomes after cochlear implantation. Conclusion: Our findings highlight the importance of identifying novel variants and genes in ethnic groups that are understudied for hearing loss.
- Resource type:
- Article
- Affiliation Label Tesim:
- School of Medicine and Department of Genetics
- DOI:
- https://doi.org/10.17615/jezj-d859
- Edition:
- Publisher
- Identifier:
- PMID 33924653 and https://dx.doi.org/10.3390/genes12040566
- ISSN:
- 2073-4425
- Journal Issue:
- 4
- Journal Title:
- Genes
- Journal Volume:
- 12
- Keyword:
- Hearing loss, Anomalies, Malformations, CBLN3, IST1, Temporal bone, Genetic testing, Inner ear, GDPD5, Enlarged vestibular aqueduct, and Cochlear implant
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- ORCID:
- Other Affiliation:
- University of the Philippines Manila, University of San Carlos, University of Colorado, , and MED-EL
- Person:
- Perez, M.E.C., Reyes-Quintos, M.R.T., Chiong, C.M., Chan, A.L., Lee, N.R., Bootpetch, T.C., Tantoco, M.L.C., Mohlke, K.L., Yarza, T.K.L., Cutiongco-De la Paz, E.M., Cruz, T.L.G., Tobias-Grasso, C.A.M., and Santos-Cortez, R.L.P.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- karen_mohlke_3
1034. Low-Level ionizing radiation induces selective killing of HIV-1-infected cells with reversal of cytokine induction using mtor inhibitors
- Title Tesim:
- Low-Level ionizing radiation induces selective killing of HIV-1-infected cells with reversal of cytokine induction using mtor inhibitors
- Creator:
- Batrakova, E.V., Pinto, D.O., Kashanchi, F., Noren Hooten, N., Evans, M.K., Heredia, A., Vo, T.T., Cowen, M., DeMarino, C., Kim, Y., Barclay, R.A., Pleet, M.L., and Iordanskiy, S.
- Date of publication:
- 2020
- Abstract Tesim:
- HIV-1 infects 39.5 million people worldwide, and cART is effective in preventing viral spread by reducing HIV-1 plasma viral loads to undetectable levels. However, viral reservoirs persist by mechanisms, including the inhibition of autophagy by HIV-1 proteins (i.e., Nef and Tat). HIV-1 reservoirs can be targeted by the “shock and kill” strategy, which utilizes latency-reversing agents (LRAs) to activate latent proviruses and immunotarget the virus-producing cells. Yet, limitations include reduced LRA permeability across anatomical barriers and immune hyper-activation. Ionizing radiation (IR) induces effective viral activation across anatomical barriers. Like other LRAs, IR may cause inflammation and modulate the secretion of extracellular vesicles (EVs). We and others have shown that cells may secrete cytokines and viral proteins in EVs and, therefore, LRAs may contribute to inflammatory EVs. In the present study, we mitigated the effects of IR-induced inflammatory EVs (i.e., TNF-α), through the use of mTOR inhibitors (mTORi; Rapamycin and INK128). Further, mTORi were found to enhance the selective killing of HIV-1-infected myeloid and T-cell reservoirs at the exclusion of uninfected cells, potentially via inhibition of viral transcription/translation and induction of autophagy. Collectively, the proposed regimen using cART, IR, and mTORi presents a novel approach allowing for the targeting of viral reservoirs, prevention of immune hyper-activation, and selectively killing latently infected HIV-1 cells.
- Resource type:
- Article
- Affiliation Label Tesim:
- School of Medicine and Department of Medicine
- DOI:
- https://doi.org/10.17615/kwcv-g557
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/v12080885 and PMID 32823598
- ISSN:
- 1999-4915
- Journal Issue:
- 8
- Journal Title:
- Viruses
- Journal Volume:
- 12
- Keyword:
- Ionizing radiation, MTOR inhibition, HIV-1, Shock and kill, Inflammation, Cell death, Latency reversal, Extracellular vesicles, HIV-1 therapy, and Autophagy
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- George Mason University, National Institutes of Health, University of Maryland, Baltimore, and Uniformed Services University of the Health Sciences
- Person:
- Batrakova, E.V., Pinto, D.O., Kashanchi, F., Noren Hooten, N., Evans, M.K., Heredia, A., Vo, T.T., Cowen, M., DeMarino, C., Kim, Y., Barclay, R.A., Pleet, M.L., and Iordanskiy, S.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- elena_batrakova_8
1035. Extracellular vesicle-based therapeutics: Preclinical and clinical investigations
- Title Tesim:
- Extracellular vesicle-based therapeutics: Preclinical and clinical investigations
- Creator:
- Li, S.M., Batrakova, E.V., Gololobova, O.A., Klyachko, N.L., and Arzt, C.J.
- Date of publication:
- 2020
- Abstract Tesim:
- Drug nanoformulations hold remarkable promise for the efficient delivery of therapeutics to a disease site. Unfortunately, artificial nanocarriers, mostly liposomes and polymeric nanoparticles, show limited applications due to the unfavorable pharmacokinetics and rapid clearance from the blood circulation by the reticuloendothelial system (RES). Besides, many of them have high cytotoxicity, low biodegradability, and the inability to cross biological barriers, including the blood brain barrier. Extracellular vesicles (EVs) are novel candidates for drug delivery systems with high bioavailability, exceptional biocompatibility, and low immunogenicity. They provide a means for intercellular communication and the transmission of bioactive compounds to targeted tissues, cells, and organs. These features have made them increasingly attractive as a therapeutic platform in recent years. However, there are many obstacles to designing EV-based therapeutics. In this review, we will outline the main hurdles and limitations for therapeutic and clinical applications of drug loaded EV formulations and describe various attempts to solve these problems.
- Resource type:
- Article
- Affiliation Label Tesim:
- Eshelman School of Pharmacy and Center for Nanotechnology in Drug Delivery
- DOI:
- https://doi.org/10.17615/gkde-7912
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/pharmaceutics12121171
- ISSN:
- 1999-4923
- Journal Issue:
- 12
- Journal Title:
- Pharmaceutics
- Journal Volume:
- 12
- Keyword:
- Drug delivery, Clinical applications, and Extracellular vesicles
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Page End:
- 26
- Page Start:
- 1
- Person:
- Li, S.M., Batrakova, E.V., Gololobova, O.A., Klyachko, N.L., and Arzt, C.J.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- elena_batrakova_6
1036. Targeting beclin1 as an adjunctive therapy against hiv using mannosylated polyethylenimine nanoparticles
- Title Tesim:
- Targeting beclin1 as an adjunctive therapy against hiv using mannosylated polyethylenimine nanoparticles
- Creator:
- Rodriguez, M., Zhao, Y., El-Hage, N., Batrakova, E.V., Karuppan, M.K.M., and Soler, Y.
- Date of publication:
- 2021
- Abstract Tesim:
- Using nanoparticle-based RNA interference (RNAi), we have previously shown that silenc-ing the host autophagic protein, Beclin1, in HIV-infected human microglia and astrocytes restricts HIV replication and its viral-associated inflammatory responses. Here, we confirmed the efficacy of Beclin1 small interfering RNA (siBeclin1) as an adjunctive antiviral and anti-inflammatory therapy in myeloid human microglia and primary human astrocytes infected with HIV, both with and without exposure to combined antiretroviral (cART) drugs. To specifically target human microglia and human astrocytes, we used a nanoparticle (NP) comprised of linear cationic polyethylenimine (PEI) conjugated with mannose (Man) and encapsulated with siBeclin1. The target specificity of the PEI-Man NP was confirmed in vitro using human neuronal and glial cells transfected with the NP encapsulated with fluorescein isothiocyanate (FITC). PEI-Man-siBeclin1 NPs were intranasally deliv-ered to healthy C57BL/6 mice in order to report the biodistribution of siBeclin1 in different areas of the brain, measured using stem-loop RT-PCR. Postmortem brains recovered at 1–48 h post-treatment with the PEI-Man-siRNA NP showed no significant changes in the secretion of the chemokines regulated on activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein-1 (MCP-1) and showed significant decreases in the secretion of the cytokines interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) when compared to phosphate-buffered saline (PBS)-treated brains. Nissl staining showed minimal differences between the neuronal structures when compared to PBS-treated brains, which correlated with no adverse behavioral affects. To confirm the brain and peripheral organ distribution of PEI-siBeclin1 in living mice, we used the In vivo Imaging System (IVIS) and demonstrated a significant brain accumulation of siBeclin1 through intranasal administration.
- Resource type:
- Article
- Affiliation Label Tesim:
- Eshelman School of Pharmacy
- DOI:
- https://doi.org/10.17615/wz7c-5p21
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/pharmaceutics13020223
- ISSN:
- 1999-4923
- Journal Issue:
- 2
- Journal Title:
- Pharmaceutics
- Journal Volume:
- 13
- Keyword:
- HIV, In vivo imaging system, Polyethylenimine nanoparticle, Beclin1, and Intranasal delivery
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- Florida International University
- Page End:
- 17
- Page Start:
- 1
- Person:
- Rodriguez, M., Zhao, Y., El-Hage, N., Batrakova, E.V., Karuppan, M.K.M., and Soler, Y.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- elena_batrakova_2
1037. Transcriptome-wide association study of blood cell traits in african ancestry and hispanic/latino populations
- Title Tesim:
- Transcriptome-wide association study of blood cell traits in african ancestry and hispanic/latino populations
- Creator:
- Jorgenson, E., Li, Y., Liu, Y., Qian, H., Hodonsky, C.J., Fornage, M., Wang, T., Sun, Q., Chen, J., Buyske, S., Yin, J., Xie, M., North, K.E., Raffield, L.M., Smith, J.A., Kowalski, M.H., Bien, S.A., Rowland, B., Reiner, A.P., Rich, S.S., Rotter, J.I., Tapia, A.L., Argos, M., Young, K.L., Choquet, H., Zhao, W., Avery, C.L., Zhou, X., Kooperberg, C., Wen, J., Loos, R.J.F., Rosen, J.D., Graff, M., Moon, J.-Y., Shang, L., and Shan, Y.
- Date of publication:
- 2021
- Abstract Tesim:
- Background: Thousands of genetic variants have been associated with hematological traits, though target genes remain unknown at most loci. Moreover, limited analyses have been conducted in African ancestry and Hispanic/Latino populations; hematological trait associated variants more common in these populations have likely been missed. Methods: To derive gene expression prediction models, we used ancestry-stratified datasets from the Multi-Ethnic Study of Atherosclerosis (MESA, including n = 229 African American and n = 381 Hispanic/Latino participants, monocytes) and the Depression Genes and Networks study (DGN, n = 922 European ancestry participants, whole blood). We then performed a transcriptome-wide association study (TWAS) for platelet count, hemoglobin, hematocrit, and white blood cell count in African (n = 27,955) and Hispanic/Latino (n = 28,324) ancestry participants. Results: Our results revealed 24 suggestive signals (p < 1 × 10−4 ) that were conditionally distinct from known GWAS identified variants and successfully replicated these signals in European ancestry subjects from UK Biobank. We found modestly improved correlation of predicted and measured gene expression in an independent African American cohort (the Genetic Epidemiology Network of Arteriopathy (GENOA) study (n = 802), lymphoblastoid cell lines) using the larger DGN reference panel; however, some genes were well predicted using MESA but not DGN. Conclusions: These analyses demonstrate the importance of performing TWAS and other genetic analyses across diverse populations and of balancing sample size and ancestry background matching when selecting a TWAS reference panel.
- Resource type:
- Article
- Affiliation Label Tesim:
- School of Medicine, Department of Genetics, College of Arts and Sciences, Department of Statistics and Operations Research, Gillings School of Global Public Health, Department of Biostatistics, and Department of Epidemiology
- DOI:
- https://doi.org/10.17615/x9y4-pk77
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/genes12071049
- ISSN:
- 2073-4425
- Journal Issue:
- 7
- Journal Title:
- Genes
- Journal Volume:
- 12
- Keyword:
- Expression analysis, Non-European populations, Ancestry, and TWAS (transcriptome-wide association study)
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- ORCID:
- Other Affiliation:
- Regeneron Genetics Center, , Duke University, University of Virginia, The University of Texas Health Science Center, Albert Einstein College of Medicine, Rutgers University, Kaiser Permanente Northern California, University of Michigan, Fred Hutchinson Cancer Research Center, University of Washington, Harbor-UCLA Medical Center, University of Illinois at Chicago, and Icahn School of Medicine at Mount Sinai
- Person:
- Jorgenson, E., Li, Y., Liu, Y., Qian, H., Hodonsky, C.J., Fornage, M., Wang, T., Sun, Q., Chen, J., Buyske, S., Yin, J., Xie, M., North, K.E., Raffield, L.M., Smith, J.A., Kowalski, M.H., Bien, S.A., Rowland, B., Reiner, A.P., Rich, S.S., Rotter, J.I., Tapia, A.L., Argos, M., Young, K.L., Choquet, H., Zhao, W., Avery, C.L., Zhou, X., Kooperberg, C., Wen, J., Loos, R.J.F., Rosen, J.D., Graff, M., Moon, J.-Y., Shang, L., and Shan, Y.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- yun_li_3
1038. Expressheart: Web portal to visualize transcriptome profiles of non-cardiomyocyte cells
- Title Tesim:
- Expressheart: Web portal to visualize transcriptome profiles of non-cardiomyocyte cells
- Creator:
- Qian, L., Dong, Y., Zentz, S.C., Roach, J., Luan, C., Yang, Y., Zelt, R., Li, G., Xie, Y., Liu, J., and Li, Y.
- Date of publication:
- 2021
- Abstract Tesim:
- Unveiling the molecular features in the heart is essential for the study of heart diseases. Non-cardiomyocytes (nonCMs) play critical roles in providing structural and mechanical support to the working myocardium. There is an increasing amount of single-cell RNA-sequencing (scRNA-seq) data characterizing the transcriptomic profiles of nonCM cells. However, no tool allows researchers to easily access the information. Thus, in this study, we develop an open-access web portal, Express-Heart, to visualize scRNA-seq data of nonCMs from five laboratories encompassing three species. ExpressHeart enables comprehensive visualization of major cell types and subtypes in each study; visualizes gene expression in each cell type/subtype in various ways; and facilitates identifying cell-type-specific and species-specific marker genes. ExpressHeart also provides an interface to directly combine information across datasets, for example, generating lists of high confidence DEGs by taking the intersection across different datasets. Moreover, ExpressHeart performs comparisons across datasets. We show that some homolog genes (e.g., Mmp14 in mice and mmp14b in zebrafish) are expressed in different cell types between mice and zebrafish, suggesting different functions across species. We expect ExpressHeart to serve as a valuable portal for investigators, shedding light on the roles of genes on heart development in nonCM cells.
- Resource type:
- Article
- Affiliation Label Tesim:
- School of Medicine, Department of Pathology and Laboratory Medicine, Gillings School of Global Public Health, Department of Biostatistics, Information Technology Services, Department of Research Computing, College of Arts and Sciences, and Department of Statistics and Operations Research
- DOI:
- https://doi.org/10.17615/wgg2-9c06
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/ijms22168943
- ISSN:
- 1661-6596
- Journal Issue:
- 16
- Journal Title:
- International Journal of Molecular Sciences
- Journal Volume:
- 22
- Keyword:
- Cross-species comparison, R Shiny, Non-cardiomyocytes, Single-cell RNA-sequencing, Expressheart, Visualization, and Differentially expressed genes
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- ORCID:
- Other Affiliation:
- Person:
- Qian, L., Dong, Y., Zentz, S.C., Roach, J., Luan, C., Yang, Y., Zelt, R., Li, G., Xie, Y., Liu, J., and Li, Y.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- yun_li_2
1039. One-year follow-up examination of the impact of the North Carolina healthy food small retailer program on healthy food availability, purchases, and consumption
- Title Tesim:
- One-year follow-up examination of the impact of the North Carolina healthy food small retailer program on healthy food availability, purchases, and consumption
- Creator:
- Laska, M.N., Ammerman, A., Truesdale, K.P., Pitts, S.B.J., McGuirt, J.T., Bell, R., Haynes-Maslow, L., and Wu, Q.
- Date of publication:
- 2018
- Abstract Tesim:
- We examined the short-term impact of the North Carolina Healthy Food Small Retailer Program (HFSRP), a legislatively appropriated bill providing funding up to $25,000 to small food retailers for equipment to stock and promote healthier foods, on store-level availability and purchase of healthy foods and beverages, as well as customer dietary patterns, one year post-policy implementation. We evaluated healthy food availability using a validated audit tool, purchases using customer bag-checks, and diet using self-reported questionnaires and skin carotenoid levels, assessed via Veggie Meter™, a non-invasive tool to objectively measure fruit and vegetable consumption. Difference-in-difference analyses were used to examine changes in HFSRP stores versus control stores after 1 year. There were statistically significant improvements in healthy food supply scores (availability), with the Healthy Food Supply HFS score being −0.44 points lower in control stores and 3.13 points higher in HFSRP stores pre/post HFSRP (p = 0.04). However, there were no statistically significant changes in purchases or self-reported consumption or skin carotenoids among customers in HFSRP versus control stores. Additional time or other supports for retailers (e.g., marketing and promotional materials) may be needed for HFSRP implementation to influence purchase and consumption.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health and Department of Nutrition
- DOI:
- https://doi.org/10.17615/ak7v-4r20
- Edition:
- Publisher
- ISSN:
- 1661-7827
- Journal Issue:
- 12
- Journal Title:
- International Journal of Environmental Research and Public Health
- Journal Volume:
- 15
- Keyword:
- Nutrition policy, Rural populations, Health disparities, and Food deserts
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- University of Minnesota, Minneapolis, East Carolina University, University of North Carolina at Greensboro, and North Carolina State University
- Person:
- Laska, M.N., Ammerman, A., Truesdale, K.P., Pitts, S.B.J., McGuirt, J.T., Bell, R., Haynes-Maslow, L., and Wu, Q.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- kimberly_truesdale_7
1040. Dnmts and impact of cpg content, transcription factors, consensus motifs, lncrnas, and histone marks on dna methylation
- Title Tesim:
- Dnmts and impact of cpg content, transcription factors, consensus motifs, lncrnas, and histone marks on dna methylation
- Creator:
- Hernández-Sotelo, D., Loaeza-Loaeza, J., and Beltran, A.S.
- Date of publication:
- 2020
- Abstract Tesim:
- DNA methyltransferases (DNMTs) play an essential role in DNA methylation and transcriptional regulation in the genome. DNMTs, along with other poorly studied elements, modulate the dynamic DNA methylation patterns of embryonic and adult cells. We summarize the current knowledge on the molecular mechanism of DNMTs’ functional targeting to maintain genome-wide DNA methylation patterns. We focus on DNMTs’ intrinsic characteristics, transcriptional regulation, and post-transcriptional modifications. Furthermore, we focus special attention on the DNMTs’ specificity for target sites, including key cis-regulatory factors such as CpG content, common motifs, transcription factors (TF) binding sites, lncRNAs, and histone marks to regulate DNA methylation. We also review how complexes of DNMTs/TFs or DNMTs/lncRNAs are involved in DNA methylation in specific genome regions. Understanding these processes is essential because the spatiotemporal regulation of DNA methylation modulates gene expression in health and disease.
- Resource type:
- Article
- Affiliation Label Tesim:
- School of Medicine and Department of Pharmacology
- DOI:
- https://doi.org/10.17615/apc7-ma42
- Edition:
- Publisher
- Identifier:
- PMID 33198240 and https://dx.doi.org/10.3390/genes11111336
- ISSN:
- 2073-4425
- Journal Issue:
- 11
- Journal Title:
- Genes
- Journal Volume:
- 11
- Keyword:
- CpG content, Methylation, Consensus motifs, DNMT, and Histone marks and transcription factors
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- Universidad Autónoma de Guerrero
- Page End:
- 19
- Page Start:
- 1
- Person:
- Hernández-Sotelo, D., Loaeza-Loaeza, J., and Beltran, A.S.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- adriana_beltran_2
Collection Details
- Total items
-
1066
- Size
-
unknown
- Date created
-
May 26, 2022