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Works (442)
101. Trajectories of Meat Intake and Risk of Type 2 Diabetes: Findings from the China Health and Nutrition Survey (1997–2018)
- Title Tesim:
- Trajectories of Meat Intake and Risk of Type 2 Diabetes: Findings from the China Health and Nutrition Survey (1997–2018)
- Creator:
- Ding, Gangqiang, Wang, Qi, Jiao, Yingying, Liu, Mengran, Du, Shufa, Wang, Huijun, Zhang, Bing, and Su, Chang
- Date of publication:
- 2023
- Abstract Tesim:
- Few articles have investigated the impact of long-term meat intake trends and their changes during follow-up on the risk of type 2 diabetes (T2D). We aimed to explore the long-term trajectories of meat intake and determine its association with T2D risk in Chinese adults. This study used seven rounds of data from the China Health and Nutrition Survey (1997, 2000, 2004, 2006, 2009, 2015, and 2018), and 4464 adults aged 18 years or older were analyzed. The group-based trajectory modeling was used to identify meat intake trajectories over 21 years. Multivariate Cox proportional hazard and restricted cubic spline models were used to analyze the association and dose–response relationship between meat intake and T2D. Four trajectory groups were identified: “low-increase intake group” (Group 1), “moderate-increase intake group” (Group 2), “medium-stable intake group” (Group 3), and “high intake group” (Group 4). Compared with Group 2, Group 4 was associated with a higher risk of developing T2D (hazard ratio 2.37 [95% CI 1.41–3.98]). After adjusting for demographic characteristics, lifestyle, total energy intake, waist circumference, and systolic blood pressure, and using the third quintile as a reference, the risk of T2D was increased by 46% in the lowest quintile with meat intake (hazard ratio 1.46 [95% CI 1.07–2.01]) and by 41% in the highest quintile with meat intake (HR 1.41 [95% CI 1.03–1.94]). A U-shape was observed between meat intake and T2D risk (p for nonlinear < 0.001). When the intake was lower than 75 g/day, the risk of T2D was negatively correlated with meat intake, while the risk of T2D was positively correlated with meat intake when the intake was higher than 165 g/day. We identified four trajectory groups of meat intake from 1997 to 2018, which were associated with different risks of developing T2D. A U-shaped association was observed between meat intake and T2D in Chinese adults.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Nutrition
- DOI:
- https://doi.org/10.17615/ee76-1v32
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/nu15143277
- ISSN:
- 2072-6643
- Journal Issue:
- 14
- Journal Title:
- Nutrients
- Journal Volume:
- 15
- Keyword:
- type 2 diabetes, dose–response relationship, trajectories, Chinese adults, and meat intake
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Chinese Center for Disease Control and Prevention and
- Page Start:
- 3277
- Person:
- Ding, Gangqiang, Wang, Qi, Jiao, Yingying, Liu, Mengran, Du, Shufa, Wang, Huijun, Zhang, Bing, and Su, Chang
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- bce9dd22-6894-42e1-a9ae-8a5597cd323a
102. The Current Landscape of Glioblastoma Biomarkers in Body Fluids
- Title Tesim:
- The Current Landscape of Glioblastoma Biomarkers in Body Fluids
- Creator:
- Farjadian, Fatemeh, Benhabbour, Soumya Rahima, Doroudian, Mohammad, Zanganeh, Saba, Esmaelizad, Nazanin, and Abbasgholinejad, Elham
- Date of publication:
- 2023
- Abstract Tesim:
- Glioblastoma (GBM) is a highly aggressive and lethal primary brain cancer that necessitates early detection and accurate diagnosis for effective treatment and improved patient outcomes. Traditional diagnostic methods, such as imaging techniques and tissue biopsies, have limitations in providing real-time information and distinguishing treatment-related changes from tumor progression. Liquid biopsies, used to analyze biomarkers in body fluids, offer a non-invasive and dynamic approach to detecting and monitoring GBM. This article provides an overview of GBM biomarkers in body fluids, including circulating tumor cells (CTCs), cell-free DNA (cfDNA), cell-free RNA (cfRNA), microRNA (miRNA), and extracellular vesicles. It explores the clinical utility of these biomarkers for GBM detection, monitoring, and prognosis. Challenges and limitations in implementing liquid biopsy strategies in clinical practice are also discussed. The article highlights the potential of liquid biopsies as valuable tools for personalized GBM management but underscores the need for standardized protocols and further research to optimize their clinical utility.
- Resource type:
- Article
- Affiliation Label Tesim:
- Joint Department of Biomedical Engineering
- DOI:
- https://doi.org/10.17615/fqka-fr93
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/cancers15153804
- ISSN:
- 2072-6694
- Journal Issue:
- 15
- Journal Title:
- Cancers
- Journal Volume:
- 15
- Keyword:
- body fluids, cell-free DNA (cfDNA), biomarkers, cell-free RNA (cfRNA), microRNA (miRNA), extracellular vesicles (EV), exosomes, glioblastoma, and circulating tumor cells (CTCs)
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Shiraz University of Medical Sciences, , and Kharazmi University
- Page Start:
- 3804
- Person:
- Farjadian, Fatemeh, Benhabbour, Soumya Rahima, Doroudian, Mohammad, Zanganeh, Saba, Esmaelizad, Nazanin, and Abbasgholinejad, Elham
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 306a0187-9b11-49c1-ab0a-3e2fddee5932
103. Self-Compassion and Depressive Symptoms as Determinants of Sensitive Parenting: Associations with Sociodemographic Characteristics in a Sample of Mothers and Toddlers
- Title Tesim:
- Self-Compassion and Depressive Symptoms as Determinants of Sensitive Parenting: Associations with Sociodemographic Characteristics in a Sample of Mothers and Toddlers
- Creator:
- Zvara, Bharathi J., Andridge, Rebecca, Keim, Sarah A., and Anderson, Sarah E.
- Date of publication:
- 2023
- Abstract Tesim:
- Parenting that is sensitive and responsive to children’s needs has been shown to support children’s optimal growth and development in many cultural contexts. Numerous studies suggest that self-compassion is positively related to sensitive parenting. Despite growing research interest linking self-compassion to responsive parenting, there are considerable gaps in the literature. The current study examined the associations between self-compassion, depressive symptoms, socioeconomic status, and sensitive parenting. Data was obtained from a cohort study of 300 families in central Ohio enrolled when children were a mean (SD) calendar age of 18.2 (0.7) months. Children of all gestational ages at birth are included, and 37% were born preterm (<37 weeks’ gestation). Observational protocols were used to determine maternal sensitivity in a semi-structured play setting. Self-compassion was assessed with the Self-Compassion Scale when children were 24 months old. Self-compassion was not associated with sociodemographic characteristics including maternal education, household income, child sex and gestational age. In unadjusted regression models, depressive symptoms were related to sensitive parenting (B = −0.036, SE = 0.016, p = 0.03), but self-compassion was not a statistically significant predictor (p = 0.35) of sensitivity, and neither self-compassion nor depressive symptoms were statistically significant predictors of sensitive parenting after adjustment for covariates. Considerations for future studies are discussed.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Maternal and Child Health
- DOI:
- https://doi.org/10.17615/cpcx-2v10
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/children10081284
- ISSN:
- 2227-9067
- Journal Issue:
- 8
- Journal Title:
- Children
- Journal Volume:
- 10
- Keyword:
- toddler, sensitive parenting, self-compassion, and depressive symptoms
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- and The Ohio State University
- Page Start:
- 1284
- Person:
- Zvara, Bharathi J., Andridge, Rebecca, Keim, Sarah A., and Anderson, Sarah E.
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 4dc6ca64-596e-487c-89a0-d9921f8b3754
104. Observational Implications of OJ 287’s Predicted 2022 Disk Impact in the Black Hole Binary Model
- Title Tesim:
- Observational Implications of OJ 287’s Predicted 2022 Disk Impact in the Black Hole Binary Model
- Creator:
- Gupta, Alok C., Valtonen, Mauri J., Imazawa, Ryo, Mugrauer, Markus, Štrobl, Jan, Gomez, Jose L., Uemura, Makoto, Pursimo, Tapio, Matsumoto, Katsura, Berdyugin, Andrei V., Jelínek, Martin, Knudstrup, Emil, Ciprini, Stefano, Gopakumar, Achamveedu, Sadun, Alberto, Zejmo, Michal, Tornikoski, Merja, Drozdz, Marek, Hudec, Rene, Nilsson, Kari, Dey, Lankeswar, Lehto, Harry J., Reichart, Daniel E., Lähteenmäki, Anne, Zola, Staszek, Sillanpää, Aimo, and Kouprianov, Vladimir V.
- Date of publication:
- 2023
- Abstract Tesim:
- We present a summary of the results of the OJ 287 observational campaign, which was carried out during the 2021/2022 observational season. This season is special in the binary model because the major axis of the precessing binary happens to lie almost exactly in the plane of the accretion disc of the primary. This leads to pairs of almost identical impacts between the secondary black hole and the accretion disk in 2005 and 2022. In 2005, a special flare called “blue flash” was observed 35 days after the disk impact, which should have also been verifiable in 2022. We did observe a similar flash and were able to obtain more details of its properties. We describe this in the framework of expanding cloud models. In addition, we were able to identify the flare arising exactly at the time of the disc crossing from its photo-polarimetric and gamma-ray properties. This is an important identification, as it directly confirms the orbit model. Moreover, we saw a huge flare that lasted only one day. We may understand this as the lighting up of the jet of the secondary black hole when its Roche lobe is suddenly flooded by the gas from the primary disk. Therefore, this may be the first time we directly observed the secondary black hole in the OJ 287 binary system.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Physics and Astronomy
- DOI:
- https://doi.org/10.17615/m8g4-cs33
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/galaxies11040082
- ISSN:
- 2075-4434
- Journal Issue:
- 4
- Journal Title:
- Galaxies
- Journal Volume:
- 11
- Keyword:
- accretion discs, accretion, gravitational waves, quasars: supermassive black holes, BL Lacertae objects: individual: OJ 287, and galaxies: jets
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Shanghai Astronomical Observatory, University of Turku, Hiroshima University, Astrophysical Institute and University Observatory, Astronomical Institute (ASU CAS),, The Institute of Astrophysics of Andalusia—CSIC, Nordic Optical Telescope, Osaka Kyoiku University, National Institute of Nuclear Physics, Tata Institute of Fundamental Research, University of Colorado, University of Zielona Gora, Aalto University, Mt. Suhora Observatory, Czech Technical University, , and Jagiellonian University
- Page Start:
- 82
- Person:
- Gupta, Alok C., Valtonen, Mauri J., Imazawa, Ryo, Mugrauer, Markus, Štrobl, Jan, Gomez, Jose L., Uemura, Makoto, Pursimo, Tapio, Matsumoto, Katsura, Berdyugin, Andrei V., Jelínek, Martin, Knudstrup, Emil, Ciprini, Stefano, Gopakumar, Achamveedu, Sadun, Alberto, Zejmo, Michal, Tornikoski, Merja, Drozdz, Marek, Hudec, Rene, Nilsson, Kari, Dey, Lankeswar, Lehto, Harry J., Reichart, Daniel E., Lähteenmäki, Anne, Zola, Staszek, Sillanpää, Aimo, and Kouprianov, Vladimir V.
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 0f2c0611-bfe2-4d7d-951f-5402bdd578a4
105. New Concepts in Therapeutic Manipulation of HIV-1 Transcription and Latency: Latency Reversal versus Latency Prevention
- Title Tesim:
- New Concepts in Therapeutic Manipulation of HIV-1 Transcription and Latency: Latency Reversal versus Latency Prevention
- Creator:
- Browne, Edward P., Margolis, David M., and Lewis, Catherine A.
- Date of publication:
- 2023
- Abstract Tesim:
- Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, but a cure remains elusive. The largest barrier to a cure is the presence of a long-lived latent reservoir that persists within a heterogenous mix of cell types and anatomical compartments. Efforts to eradicate the latent reservoir have primarily focused on latency reversal strategies. However, new work has demonstrated that the majority of the long-lived latent reservoir is established near the time of ART initiation, suggesting that it may be possible to pair an intervention with ART initiation to prevent the formation of a sizable fraction of the latent reservoir. Subsequent treatment with latency reversal agents, in combination with immune clearance agents, may then be a more tractable strategy for fully clearing the latent reservoir in people newly initiating ART. Here, we summarize molecular mechanisms of latency establishment and maintenance, ongoing efforts to develop effective latency reversal agents, and newer efforts to design latency prevention agents. An improved understanding of the molecular mechanisms involved in both the establishment and maintenance of latency will aid in the development of new latency prevention and reversal approaches to ultimately eradicate the latent reservoir.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Microbiology and Immunology
- DOI:
- https://doi.org/10.17615/99ks-4074
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/v15081677
- ISSN:
- 1999-4915
- Journal Issue:
- 8
- Journal Title:
- Viruses
- Journal Volume:
- 15
- Keyword:
- viral and host transcriptional regulators, HIV-1 latency and reactivation, HIV-1 eradication and cure, mechanisms and therapeutic opportunities, chromatin and epigenetics, and HIV-1 latent reservoir
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Page Start:
- 1677
- Person:
- Browne, Edward P., Margolis, David M., and Lewis, Catherine A.
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 4f795397-d8b6-436b-bd80-7e20657bbc5c
106. Non-Hormonal Contraception
- Title Tesim:
- Non-Hormonal Contraception
- Creator:
- Howard, Sarah Anne and Benhabbour, Soumya Rahima
- Date of publication:
- 2023
- Abstract Tesim:
- While hormonal contraceptives are efficacious and available in several forms for women, perception of safety and concern over side effects are a deterrent for many. Existing non-hormonal contraceptives include permanent sterilization, copper intrauterine devices (IUDs), chemical/physical barriers such as spermicides and condoms, as well as traditional family planning methods including withdrawal and the rhythm method. Individuals who wish to retain their fertility in the future can achieve highest adherence and efficacy with long-acting, reversible contraceptives (LARCs), though there is only one, the copper IUD, that is non-hormonal. As rates of unintended pregnancies remain high with existing contraceptive options, it is becoming increasingly attractive to develop novel pregnancy prevention methods for both women and men. Non-hormonal contraceptives can target a variety of critical reproductive processes discussed here. This review focuses on identified non-hormonal contraceptive targets and subsequent drug candidates in development.
- Resource type:
- Article
- Affiliation Label Tesim:
- Division of Pharmacoengineering and Molecular Pharmaceutics
- DOI:
- https://doi.org/10.17615/v1cy-ns50
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/jcm12144791
- ISSN:
- 2077-0383
- Journal Issue:
- 14
- Journal Title:
- Journal of Clinical Medicine
- Journal Volume:
- 12
- Keyword:
- long-acting, non-hormonal, contraceptive, and reversible
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Page Start:
- 4791
- Person:
- Howard, Sarah Anne and Benhabbour, Soumya Rahima
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 93e4e43e-2dfb-44f2-8e76-49a25e617571
107. Metabolomics Analysis Reveals Altered Metabolic Pathways and Response to Doxorubicin in Drug-Resistant Triple-Negative Breast Cancer Cells
- Title Tesim:
- Metabolomics Analysis Reveals Altered Metabolic Pathways and Response to Doxorubicin in Drug-Resistant Triple-Negative Breast Cancer Cells
- Creator:
- Rushing, Blake R., Sumner, Susan, and Molina, Sabrina
- Date of publication:
- 2023
- Abstract Tesim:
- This study aimed to investigate metabolic changes following the acquisition of resistance to doxorubicin in the triple-negative breast cancer (TNBC) cell line MDA-MB-231. Two drug-resistant cell lines, DOX-RES-50 and DOX-RES-100, were generated by treating MDA-MB-231 cells with doxorubicin for 24 h and allowing them to recover for six weeks. Both drug-resistant cell lines demonstrated an increase in doxorubicin IC50 values, indicating acquired drug resistance. Metabolomics analysis showed clear separation between the parental MDA-MB-231 cell line and the drug-resistant cell lines. Pathway analysis revealed that arginine and proline metabolism, glutathione metabolism, and beta-alanine metabolism were significantly perturbed in the drug-resistant cell lines compared to the parental cell line. After matching signals to an in-house library of reference standards, significant decreases in short- and medium-chain acylcarnitines and significant increases in long-chain acylcarnitines, 5-oxoproline, and 7-ketodeoxycholic acid were observed in the resistant cell lines as compared to the parental MDA-MB-231 cell line. In addition to baseline metabolic differences, we also investigated differences in metabolic responses in resistant cell lines upon a second exposure at multiple concentrations. Results indicate that whereas the parental MDA-MB-231 cell line had many metabolites that responded to doxorubicin in a dose-dependent manner, the two resistant cell lines lost a dose-dependent response for the majority of these metabolites. The study’s findings provide insight into how metabolism is altered during the acquisition of resistance in TNBC cells and how the metabolic response to doxorubicin changes upon repeated treatment. This information can potentially identify novel targets to prevent or reverse multi-drug resistance in TNBC, and also demonstrate the usefulness of metabolomics technology in identifying new mechanisms of drug resistance in cancer and potential drug targets.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Nutrition and Nutrition Research Institute
- DOI:
- https://doi.org/10.17615/9ryy-ff39
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/metabo13070865
- ISSN:
- 2218-1989
- Journal Issue:
- 7
- Journal Title:
- Metabolites
- Journal Volume:
- 13
- Keyword:
- triple-negative breast cancer, drug resistance, metabolomics, doxorubicin, and chemotherapy
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Page Start:
- 865
- Person:
- Rushing, Blake R., Sumner, Susan, and Molina, Sabrina
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 9173a510-daff-466a-9162-8d64d853e81c
108. Learning to Fuse Multiple Brain Functional Networks for Automated Autism Identification
- Title Tesim:
- Learning to Fuse Multiple Brain Functional Networks for Automated Autism Identification
- Creator:
- Zhang, Chaojun, Ma, Yunling, Zhang, Limei, Qiao, Lishan, and Liu, Mingxia
- Date of publication:
- 2023
- Abstract Tesim:
- Functional connectivity network (FCN) has become a popular tool to identify potential biomarkers for brain dysfunction, such as autism spectrum disorder (ASD). Due to its importance, researchers have proposed many methods to estimate FCNs from resting-state functional MRI (rs-fMRI) data. However, the existing FCN estimation methods usually only capture a single relationship between brain regions of interest (ROIs), e.g., linear correlation, nonlinear correlation, or higher-order correlation, thus failing to model the complex interaction among ROIs in the brain. Additionally, such traditional methods estimate FCNs in an unsupervised way, and the estimation process is independent of the downstream tasks, which makes it difficult to guarantee the optimal performance for ASD identification. To address these issues, in this paper, we propose a multi-FCN fusion framework for rs-fMRI-based ASD classification. Specifically, for each subject, we first estimate multiple FCNs using different methods to encode rich interactions among ROIs from different perspectives. Then, we use the label information (ASD vs. healthy control (HC)) to learn a set of fusion weights for measuring the importance/discrimination of those estimated FCNs. Finally, we apply the adaptively weighted fused FCN on the ABIDE dataset to identify subjects with ASD from HCs. The proposed FCN fusion framework is straightforward to implement and can significantly improve diagnostic accuracy compared to traditional and state-of-the-art methods.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Radiology
- DOI:
- https://doi.org/10.17615/81ye-rq17
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/biology12070971
- ISSN:
- 2079-7737
- Journal Issue:
- 7
- Journal Title:
- Biology
- Journal Volume:
- 12
- Keyword:
- autism spectrum disorder, adaptive weighting, functional connectivity network, and multi-FCN fusion
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Liaocheng University, Shandong Jianzhu University, and
- Page Start:
- 971
- Person:
- Zhang, Chaojun, Ma, Yunling, Zhang, Limei, Qiao, Lishan, and Liu, Mingxia
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 605b8b80-aad0-43ac-8f3b-4a5191dbc2e9
109. Local Government Debt and Its Impact on Corporate Underinvestment and ESG Performance: Empirical Evidence from China
- Title Tesim:
- Local Government Debt and Its Impact on Corporate Underinvestment and ESG Performance: Empirical Evidence from China
- Creator:
- Duan, Keyi, Ibrahim, Haslindar, and Cao, Mingyao
- Date of publication:
- 2023
- Abstract Tesim:
- ESG ratings are closely linked to corporate resource allocation and overarching macroeconomic constituents. Nevertheless, there is a noticeable lack in the literature investigating the interconnected relationship between the growth of local government debt, corporate underinvestment, and ESG ratings. This study aims to investigate the impact of local government debt on corporate underinvestment and its subsequent effects on corporate ESG performance. To achieve this goal, this study utilizes special bond data from Chinese provinces spanning the period between 2015 and 2021. The findings suggest that as local government debt swells, it imposes financing constraints on local companies, leading to underinvestment, particularly for listed companies with a high proportion of fixed assets and non-state-owned enterprises. A key effect is a “crowding-out effect” in which local government debt absorbs resources that could otherwise be allocated to private corporations and non-investment sectors. This trend illuminates the concealed costs of a debt-reliant growth model extending beyond the financial sector to impact broader corporate behavior and ESG performance. Our research suggests that government debt, corporate financing constraints, and ESG investment are intimately linked. The study concludes with policy implications and recommendations aimed at mitigating the investment gap in Chinese enterprises and promoting sustainable economic growth.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of City and Regional Planning
- DOI:
- https://doi.org/10.17615/5skn-yv64
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/su151411116
- ISSN:
- 2071-1050
- Journal Issue:
- 14
- Journal Title:
- Sustainability
- Journal Volume:
- 15
- Keyword:
- ESG, investment, environmental, sustainability, and corporate finance
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- and Universiti Sains Malaysia
- Page Start:
- 11116
- Person:
- Duan, Keyi, Ibrahim, Haslindar, and Cao, Mingyao
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- b8df7204-6c5e-4f06-a1b9-ed985477953e
110. Integrative Chemical–Biological Grouping of Complex High Production Volume Substances from Lower Olefin Manufacturing Streams
- Title Tesim:
- Integrative Chemical–Biological Grouping of Complex High Production Volume Substances from Lower Olefin Manufacturing Streams
- Creator:
- Klaren, William D., Wright, Fred A., Grimm, Fabian A., Cordova, Alexandra C., Baker, Erin S., Ford, Lucie C., Rusyn, Ivan, and Zhou, Yi-Hui
- Date of publication:
- 2023
- Abstract Tesim:
- Human cell-based test methods can be used to evaluate potential hazards of mixtures and products of petroleum refining (“unknown or variable composition, complex reaction products, or biological materials” substances, UVCBs). Analyses of bioactivity and detailed chemical characterization of petroleum UVCBs were used separately for grouping these substances; a combination of the approaches has not been undertaken. Therefore, we used a case example of representative high production volume categories of petroleum UVCBs, 25 lower olefin substances from low benzene naphtha and resin oils categories, to determine whether existing manufacturing-based category grouping can be supported. We collected two types of data: nontarget ion mobility spectrometry-mass spectrometry of both neat substances and their organic extracts and in vitro bioactivity of the organic extracts in five human cell types: umbilical vein endothelial cells and induced pluripotent stem cell-derived hepatocytes, endothelial cells, neurons, and cardiomyocytes. We found that while similarity in composition and bioactivity can be observed for some substances, existing categories are largely heterogeneous. Strong relationships between composition and bioactivity were observed, and individual constituents that determine these associations were identified. Overall, this study showed a promising approach that combines chemical composition and bioactivity data to better characterize the variability within manufacturing categories of petroleum UVCBs.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Chemistry
- DOI:
- https://doi.org/10.17615/c49x-4b28
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/toxics11070586
- ISSN:
- 2305-6304
- Journal Issue:
- 7
- Journal Title:
- Toxics
- Journal Volume:
- 11
- Keyword:
- regulatory risk assessment, read-across, UVCB, petroleum, and ion mobility spectrometry
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Texas A&M University, North Carolina State University, and
- Page Start:
- 586
- Person:
- Klaren, William D., Wright, Fred A., Grimm, Fabian A., Cordova, Alexandra C., Baker, Erin S., Ford, Lucie C., Rusyn, Ivan, and Zhou, Yi-Hui
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 73125e44-d849-4df6-b4bd-97b39761c8d5
Collection Details
- Total items
-
442
- Size
-
unknown
- Date created
-
May 26, 2022