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UNC-authored articles published by MDPI
Works (441)
141. Gardening in Childcare Centers: A Randomized Controlled Trial Examining the Effects of a Garden Intervention on Physical Activity among Children Aged 3–5 Years in North Carolina
- Title Tesim:
- Gardening in Childcare Centers: A Randomized Controlled Trial Examining the Effects of a Garden Intervention on Physical Activity among Children Aged 3–5 Years in North Carolina
- Creator:
- Monsur, Muntazar, Wells, Nancy M., Moore, Robin C., Cosco, Nilda Graciela, and Hales, Derek
- Date of publication:
- 2023
- Abstract Tesim:
- This study examined the effects of a childcare gardening intervention on children’s physical activity (PA). Eligible childcare centers were randomly assigned to: (1) garden intervention (n = 5; year 1); (2) waitlist control (n = 5; control year 1, intervention year 2); or (3) control (n = 5; year 2 only) groups. Across the two-year study, PA was measured for 3 days at four data collection periods using Actigraph GT3X+ accelerometers. The intervention comprised 6 raised fruit and vegetable garden beds and a gardening guide with age-appropriate learning activities. The sample included a total of 321 3–5-year-olds enrolled in childcare centers in Wake County, North Carolina, with n = 293 possessing PA data for at least one time point. The analyses employed repeated measures linear mixed models (SAS v 9.4 PROC MIXED), accounting for clustering of the children within the center and relevant covariates (e.g., cohort, weather, outside days, accelerometer wear). A significant intervention effect was found for MVPA (p < 0.0001) and SED minutes (p = 0.0004), with children at intervention centers acquiring approximately 6 min more MVPA and 14 min less sedentary time each day. The effects were moderated by sex and age, with a stronger impact for boys and the youngest children. The results suggest that childcare gardening has potential as a PA intervention.
- Resource type:
- Article
- Affiliation Label Tesim:
- UNC Center for Health Promotion and Disease Prevention
- DOI:
- https://doi.org/10.17615/enbn-hp51
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/ijerph20115939
- ISSN:
- 1660-4601
- Journal Issue:
- 11
- Journal Title:
- International Journal of Environmental Research and Public Health
- Journal Volume:
- 20
- Keyword:
- childcare, randomized controlled trial, accelerometry, physical activity, children, and gardening
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Texas Tech University, Cornell University, North Carolina State University, and
- Page Start:
- 5939
- Person:
- Monsur, Muntazar, Wells, Nancy M., Moore, Robin C., Cosco, Nilda Graciela, and Hales, Derek
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 3c4d4840-906c-43bd-8600-22380b48d53b
142. Extracellular Vesicles Released by Genetically Modified Macrophages Activate Autophagy and Produce Potent Neuroprotection in Mouse Model of Lysosomal Storage Disorder, Batten Disease
- Title Tesim:
- Extracellular Vesicles Released by Genetically Modified Macrophages Activate Autophagy and Produce Potent Neuroprotection in Mouse Model of Lysosomal Storage Disorder, Batten Disease
- Creator:
- Yuan, Hong, Wu, Zhanhong, Zhao, Yuling, Swain, Carson J., Rodriguez, Myosotys, Haney, Matthew J., El-Hage, Nazira, Batrakova, Elena V., and Liu, Mori
- Date of publication:
- 2023
- Abstract Tesim:
- Over the recent decades, the use of extracellular vesicles (EVs) has attracted considerable attention. Herein, we report the development of a novel EV-based drug delivery system for the transport of the lysosomal enzyme tripeptidyl peptidase-1 (TPP1) to treat Batten disease (BD). Endogenous loading of macrophage-derived EVs was achieved through transfection of parent cells with TPP1-encoding pDNA. More than 20% ID/g was detected in the brain following a single intrathecal injection of EVs in a mouse model of BD, ceroid lipofuscinosis neuronal type 2 (CLN2) mice. Furthermore, the cumulative effect of EVs repetitive administrations in the brain was demonstrated. TPP1-loaded EVs (EV-TPP1) produced potent therapeutic effects, resulting in efficient elimination of lipofuscin aggregates in lysosomes, decreased inflammation, and improved neuronal survival in CLN2 mice. In terms of mechanism, EV-TPP1 treatments caused significant activation of the autophagy pathway, including altered expression of the autophagy-related proteins LC3 and P62, in the CLN2 mouse brain. We hypothesized that along with TPP1 delivery to the brain, EV-based formulations can enhance host cellular homeostasis, causing degradation of lipofuscin aggregates through the autophagy–lysosomal pathway. Overall, continued research into new and effective therapies for BD is crucial for improving the lives of those affected by this condition.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Radiology, Center for Nanotechnology in Drug Delivery, and Eshelman School of Pharmacy
- DOI:
- https://doi.org/10.17615/qe5q-zr76
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/cells12111497
- ISSN:
- 2073-4409
- Journal Issue:
- 11
- Journal Title:
- Cells
- Journal Volume:
- 12
- Keyword:
- Batten disease, autophagy, drug delivery, extracellular vesicles, neuroprotection, and lysosomal storage disorders
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- and Florida International University
- Page Start:
- 1497
- Person:
- Yuan, Hong, Wu, Zhanhong, Zhao, Yuling, Swain, Carson J., Rodriguez, Myosotys, Haney, Matthew J., El-Hage, Nazira, Batrakova, Elena V., and Liu, Mori
- Rights Statement Label:
- In Copyright
- Source:
- 3ec5ec10-8d86-43aa-b5e6-5d2a26aa1b15
143. Dose-Ranging Plasma and Genital Tissue Pharmacokinetics and Biodegradation of Ultra-Long-Acting Cabotegravir In Situ Forming Implant
- Title Tesim:
- Dose-Ranging Plasma and Genital Tissue Pharmacokinetics and Biodegradation of Ultra-Long-Acting Cabotegravir In Situ Forming Implant
- Creator:
- Kashuba, Angela D. M., Benhabbour, Soumya Rahima, Sykes, Craig, Cottrell, Mackenzie L., Thorson, Allison L., Shrivastava, Roopali, Young, Isabella C., and Schauer, Amanda P.
- Date of publication:
- 2023
- Abstract Tesim:
- HIV continues to affect millions of men and women worldwide. The development of long-acting injectables for HIV prevention can overcome adherence challenges with daily oral prevention regimens by reducing dosing frequency and stigma. We previously developed an ultra-long-acting injectable, biodegradable, and removeable in situ forming implant (ISFI) with cabotegravir (CAB) that demonstrated protection after multiple rectal SHIV challenges in female macaques. Here, we sought to further characterize CAB ISFI pharmacokinetics (PK) in mice by assessing the effect of dose and number of injections on CAB PK, time to completion of CAB release and polymer degradation, long-term genital tissue PK, and CAB PK tail after implant removal. CAB concentrations in plasma were above the benchmark for protection for 11–12 months with proportionality between dose and drug exposure. CAB ISFI exhibited high concentrations in vaginal, cervical, and rectal tissues for up to 180 days. Furthermore, depots were easily retrievable up to 180 days post-administration with up to 34% residual CAB and near complete (85%) polymer degradation quantified in depots ex vivo. After depot removal, results demonstrated a median 11-fold decline in CAB plasma concentrations across all doses. Ultimately, this study provided critical PK information for the CAB ISFI formulation that could aid in its future translation to clinical studies.
- Resource type:
- Article
- Affiliation Label Tesim:
- Division of Pharmacotherapy and Experimental Therapeutics, Division of Pharmacoengineering and Molecular Pharmaceutics, and Joint Department of Biomedical Engineering
- DOI:
- https://doi.org/10.17615/1vek-6988
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/pharmaceutics15051487
- ISSN:
- 1999-4923
- Journal Issue:
- 5
- Journal Title:
- Pharmaceutics
- Journal Volume:
- 15
- Keyword:
- pharmacokinetics, biodegradable, injectable, polymer, long acting, and HIV
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Page Start:
- 1487
- Person:
- Kashuba, Angela D. M., Benhabbour, Soumya Rahima, Sykes, Craig, Cottrell, Mackenzie L., Thorson, Allison L., Shrivastava, Roopali, Young, Isabella C., and Schauer, Amanda P.
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- c78aa4d3-7c74-489b-8393-85724e7874d1
144. COVID-19-Related Testing, Knowledge and Behaviors among Severe and Chronic Non-Communicable Disease Patients in Neno District, Malawi: A Prospective Cohort Study
- Title Tesim:
- COVID-19-Related Testing, Knowledge and Behaviors among Severe and Chronic Non-Communicable Disease Patients in Neno District, Malawi: A Prospective Cohort Study
- Creator:
- Vrkljan, Kaylin, Aron, Moses Banda, Nyirongo, Revelation, Dullie, Luckson, Mailosi, Bright, Zaniku, Haules Robbins, Ruderman, Todd, Munyaneza, Fabien, Barnhart, Dale A., Banda, Gladys Mtalimanja, Connolly, Emilia, Ndambo, Myness Kasanda, Tyagi, Kartik, Mphande, Isaac, and Talama, George
- Date of publication:
- 2023
- Abstract Tesim:
- COVID-19-related knowledge and behaviors remain essential for controlling the spread of disease, especially among vulnerable patients with advanced, chronic diseases. We prospectively assessed changes over 11 months in COVID-19-related testing, knowledge, and behaviors among patients with non-communicable diseases in rural Malawi using four rounds of telephone interviews between November 2020 to October 2021. The most commonly reported COVID-19-related risks among patients included visiting health facilities (35–49%), attending mass gatherings (33–36%), and travelling outside the district (14–19%). Patients reporting having experienced COVID-like symptoms increased from 30% in December 2020 to 41% in October 2021. However, only 13% of patients had ever received a COVID-19 test by the end of the study period. Respondents answered 67–70% of the COVID-19 knowledge questions correctly, with no significant changes over time. Hand washing, wearing face masks and maintaining a safe distance were the most frequently reported strategies to prevent the spreading of COVID-19. Wearing face masks significantly improved over time (p < 0.001). Although the majority reported accurate knowledge about COVID-19 and enhanced adherence to infection prevention measures over time, patients commonly visited locations where they could be exposed to COVID-19. Government and other stakeholders should increase COVID-19 testing accessibility to primary and secondary facilities.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health
- DOI:
- https://doi.org/10.17615/8tge-ca02
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/ijerph20105877
- ISSN:
- 1660-4601
- Journal Issue:
- 10
- Journal Title:
- International Journal of Environmental Research and Public Health
- Journal Volume:
- 20
- Keyword:
- Malawi, noncommunicable diseases, chronic disease, COVID-19, and COVID-19 testing
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Harvard University, Partners In Health/Abwenzi Pa za Umoyo, Kamuzu University of Health Sciences, Partners in Health/Inshuti Mu Buzima, Ministry of Health, Malawi, Malawi Epidemiology and Intervention Research Unit, , and Partners in Hope
- Page Start:
- 5877
- Person:
- Vrkljan, Kaylin, Aron, Moses Banda, Nyirongo, Revelation, Dullie, Luckson, Mailosi, Bright, Zaniku, Haules Robbins, Ruderman, Todd, Munyaneza, Fabien, Barnhart, Dale A., Banda, Gladys Mtalimanja, Connolly, Emilia, Ndambo, Myness Kasanda, Tyagi, Kartik, Mphande, Isaac, and Talama, George
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 2708f098-bc49-4c42-b63b-6bcbaa90bab1
145. CC-Chemokine Receptor-2 Expression in Osteoblasts Contributes to Cartilage and Bone Damage during Post-Traumatic Osteoarthritis
- Title Tesim:
- CC-Chemokine Receptor-2 Expression in Osteoblasts Contributes to Cartilage and Bone Damage during Post-Traumatic Osteoarthritis
- Creator:
- Valdés-Fernández, José, Arbeeva, Liubov, Granero-Moltó, Froilán, Prósper, Felipe, Willcockson, Helen, Musawwir, Layla, Ozkan, Huseyin, Hooper, Lola B., Mucahit, Esra, and Longobardi, Lara
- Date of publication:
- 2023
- Abstract Tesim:
- In osteoarthritis (OA), bone changes are radiological hallmarks and are considered important for disease progression. The C-C chemokine receptor-2 (CCR2) has been shown to play an important role in bone physiology. In this study, we investigated whether Ccr2 osteoblast-specific inactivation at different times during post-traumatic OA (PTOA) progression improves joint structures, bone parameters, and pain. We used a tamoxifen-inducible Ccr2 inactivation in Collagen1α-expressing cells to obtain osteoblasts lacking Ccr2 (CCR2-Col1αKO). We stimulated PTOA changes in CCR2-Col1αKO and CCR2+/+ mice using the destabilization of the meniscus model (DMM), inducing recombination before or after DMM (early- vs. late-inactivation). Joint damage was evaluated at two, four, eight, and twelve weeks post-DMM using multiple scores: articular-cartilage structure (ACS), Safranin-O, histomorphometry, osteophyte size/maturity, subchondral bone thickness and synovial hyperplasia. Spontaneous and evoked pain were assessed for up to 20 weeks. We found that early osteoblast-Ccr2 inactivation delayed articular cartilage damage and matrix degeneration compared to CCR2+/+, as well as DMM-induced bone thickness. Osteophyte formation and maturation were only minimally affected. Late Collagen1α-Ccr2 deletion led to less evident improvements. Osteoblast-Ccr2 deletion also improved static measures of pain, while evoked pain did not change. Our study demonstrates that Ccr2 expression in osteoblasts contributes to PTOA disease progression and pain by affecting both cartilage and bone tissues.
- Resource type:
- Article
- Affiliation Label Tesim:
- Division of Rheumatology, Allergy and Immunology
- DOI:
- https://doi.org/10.17615/zsdk-6a53
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/biom13060891
- ISSN:
- 2218-273X
- Journal Issue:
- 6
- Journal Title:
- Biomolecules
- Journal Volume:
- 13
- Keyword:
- osteoarthritis, bone, and chemokines
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Universidad de Navarra and
- Page Start:
- 891
- Person:
- Valdés-Fernández, José, Arbeeva, Liubov, Granero-Moltó, Froilán, Prósper, Felipe, Willcockson, Helen, Musawwir, Layla, Ozkan, Huseyin, Hooper, Lola B., Mucahit, Esra, and Longobardi, Lara
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- a707b595-1517-478a-a218-cd4d8c431c85
146. Biochar and Its Potential Application for the Improvement of the Anaerobic Digestion Process: A Critical Review
- Title Tesim:
- Biochar and Its Potential Application for the Improvement of the Anaerobic Digestion Process: A Critical Review
- Creator:
- Semiyaga, Swaib, Boutikos, Panagiotis, Muoghalu, Chimdi C., Aragón-Briceño, Christian, Manga, Musa, and Olabinjo, Omotunde
- Date of publication:
- 2023
- Abstract Tesim:
- Poor management of organic waste is a key environmental and public health issue as it contributes to environmental contamination and the spread of diseases. Anaerobic digestion (AD) presents an efficient method for organic waste management while generating energy and nutrient-rich digestate. However, the AD process is limited by key factors, which include process inefficiencies from substrate-induced instability, poor quality digestate, and poor management of effluent and emissions. Lately, there has been more interest in the use of biochar for improving anaerobic digestion. Biochar can improve methane production by speeding up the methanogenesis stage, protecting microorganisms from toxic shocks, and reducing inhibition from ammonia and volatile fatty acids. It can be applied for in situ cleanup of biogas to remove carbon dioxide. Applying biochar in AD is undergoing intensive research and development; however, there are still unresolved factors and challenges, such as the influence of feedstock source and pyrolysis on the performance of biochar when it is added to the AD process. In light of these considerations, this review sheds more light on various potential uses of biochar to complement or improve the AD process. This review also considers the mechanisms through which biochar enhances methane production rate, biochar’s influence on the resulting digestate, and areas for future research.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Environmental Sciences and Engineering
- DOI:
- https://doi.org/10.17615/26aw-0468
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/en16104051
- ISSN:
- 1996-1073
- Journal Issue:
- 10
- Journal Title:
- Energies
- Journal Volume:
- 16
- Keyword:
- biomass, contaminant removal, pyrolysis, adsorption, greywater, and biochar
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Makerere University, Center for Research and Technology—Hellas, , CIRCE-Research Centre for Energy Resources and Consumption, and Obafemi Awolowo University
- Page Start:
- 4051
- Person:
- Semiyaga, Swaib, Boutikos, Panagiotis, Muoghalu, Chimdi C., Aragón-Briceño, Christian, Manga, Musa, and Olabinjo, Omotunde
- Rights Statement Label:
- In Copyright
- Source:
- 6d0a0a56-8ee6-4fdf-abb4-7ad8666080e2
147. Associations between Plasma Lipid Mediators and Chronic Daily Headache Outcomes in Patients Randomized to a Low Linoleic Acid Diet with or without Added Omega-3 Fatty Acids
- Title Tesim:
- Associations between Plasma Lipid Mediators and Chronic Daily Headache Outcomes in Patients Randomized to a Low Linoleic Acid Diet with or without Added Omega-3 Fatty Acids
- Creator:
- Mann, J. Douglas, Zamora, Daisy, Faurot, Keturah R., Ramsden, Christopher E., Horowitz, Mark, Shen, Qing, Yang, Jun, Taha, Ameer Y., MacIntosh, Beth A., and Hammock, Bruce D.
- Date of publication:
- 2023
- Abstract Tesim:
- A previous report showed that 12-week lowering of dietary omega-6 linoleic acid (LA) coupled with increased omega-3 polyunsaturated fatty acid (PUFA) intake (H3-L6 diet) reduced headache frequency and improved quality of life in patients with chronic daily headaches (CDHs) compared to dietary LA reduction alone (L6 diet). The trial also showed that targeted dietary manipulation alters PUFA-derived lipid mediators and endocannabinoids. However, several additional classes of lipid mediators associated with pain in preclinical models were not measured. The current secondary analysis investigated whether the clinical benefits of the H3-L6 diet were related to changes in plasma unesterified PUFA-derived lipid mediators known to be involved in nociception, including prostanoids. Lipid mediators were measured by ultra-high-pressure liquid chromatography coupled with tandem mass-spectrometry. Compared to baseline, dietary LA lowering with or without added omega-3 fatty acids did not alter unesterified n-6 PUFA-derived lipid mediators, although several species derived from LA, di-homo-gamma-linolenic acid, and arachidonic acid were positively associated with headache frequency and intensity, as well as mental health burden. Alpha-linolenic acid (ALA)-derived metabolites were also associated with increased headache frequency and intensity, although they did not change from the baseline in either dietary group. Compared to baseline, docosahexaenoic acid (DHA)-derived epoxides were more elevated in the H3-L6 group compared to the L6 group. Diet-induced elevations in plasma DHA-epoxides were associated with reduced headache frequency, better physical and mental health, and improved quality of life (p < 0.05). Prostanoids were not detected, except for PGF2-alpha, which was not associated with any outcomes. This study demonstrates that diet-induced changes in DHA-epoxides were associated with pain reduction in patients with chronic headaches, whereas n-6 PUFA and ALA metabolites were associated with nociception. Lipid mediator associations with mental health and quality of life paralleled pain management outcomes in this population. The findings point to a network of multiple diet-modifiable lipid mediator targets for pain management in individuals with CDHs.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Neurology, Department of Psychiatry, and Department of Physical Medicine and Rehabilitation
- DOI:
- https://doi.org/10.17615/4qmp-2s61
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/metabo13060690
- ISSN:
- 2218-1989
- Journal Issue:
- 6
- Journal Title:
- Metabolites
- Journal Volume:
- 13
- Keyword:
- lipids, diet, quality of life, fish, pain, and psychological distress
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- , National Institute on Aging, and University of California, Davis
- Page Start:
- 690
- Person:
- Mann, J. Douglas, Zamora, Daisy, Faurot, Keturah R., Ramsden, Christopher E., Horowitz, Mark, Shen, Qing, Yang, Jun, Taha, Ameer Y., MacIntosh, Beth A., and Hammock, Bruce D.
- Rights Statement Label:
- In Copyright
- Source:
- a672dc28-a3cd-4efe-a82e-341eac919f58
148. Association between Yoga Participation and Arterial Stiffness: A Cross-Sectional Study
- Title Tesim:
- Association between Yoga Participation and Arterial Stiffness: A Cross-Sectional Study
- Creator:
- Paterson, Craig, Raj, Tilak, Hamlin, Michael J., Elliot, Catherine A., Stoner, Lee, and Higgins, Simon
- Date of publication:
- 2023
- Abstract Tesim:
- Background: Yoga may help adults of all fitness levels increase their physical activity and decrease their cardiovascular disease risk. Aim: To determine if arterial stiffness is lower (beneficial) in yoga versus non-yoga participants. Method: This cross-sectional study included 202 yoga (48.4 + 14.1 years, 81% female) and 181 (42.8 + 14.1 years, 44% female) non-yoga participants. The primary outcome was carotid–femoral pulse wave velocity (cfPWV). The two groups were compared using analysis of covariance with adjustments for demographic (age and sex), hemodynamic (mean arterial pressure and heart rate), lifestyle (physical activity levels, sedentary behaviour, smoking status and perceived stress score) and cardiometabolic (waist-to-hip ratio, total cholesterol and fasting glucose) factors. Results: Following adjustments, cfPWV was significantly lower in yoga compared to non-yoga participants with a mean difference: −0.28 m.s−1, (95% CI = −0.55 to 0.08). Conclusion: At a population level, yoga participation may assist with decreasing the risk of cardiovascular disease in adults.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Exercise and Sport Science
- DOI:
- https://doi.org/10.17615/kjk8-f215
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/ijerph20105852
- ISSN:
- 1660-4601
- Journal Issue:
- 10
- Journal Title:
- International Journal of Environmental Research and Public Health
- Journal Volume:
- 20
- Keyword:
- arterial stiffness, pulse wave velocity, blood pressure, heart disease, and physical activity
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- and Lincoln University
- Page Start:
- 5852
- Person:
- Paterson, Craig, Raj, Tilak, Hamlin, Michael J., Elliot, Catherine A., Stoner, Lee, and Higgins, Simon
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 94fb05ac-2068-4347-ad40-7ca272e5ceda
149. An Overview of Diet and Physical Activity for Healthy Weight in Adolescents and Young Adults with Type 1 Diabetes: Lessons Learned from the ACT1ON Consortium
- Title Tesim:
- An Overview of Diet and Physical Activity for Healthy Weight in Adolescents and Young Adults with Type 1 Diabetes: Lessons Learned from the ACT1ON Consortium
- Creator:
- Zaharieva, Dessi P., Mayer-Davis, Elizabeth J., Pratley, Richard E., Maahs, David M., Riddell, Michael C., Muntis, Franklin R., Addala, Ananta, Corbin, Karen D., and Bishop, Franziska K.
- Date of publication:
- 2023
- Abstract Tesim:
- The prevalence of overweight and obesity in young people with type 1 diabetes (T1D) now parallels that of the general population. Excess adiposity increases the risk of cardiovascular disease, which is already elevated up to 10-fold in T1D, underscoring a compelling need to address weight management as part of routine T1D care. Sustainable weight management requires both diet and physical activity (PA). Diet and PA approaches must be optimized towards the underlying metabolic and behavioral challenges unique to T1D to support glycemic control throughout the day. Diet strategies for people with T1D need to take into consideration glycemic management, metabolic status, clinical goals, personal preferences, and sociocultural considerations. A major barrier to weight management in this high-risk population is the challenge of integrating regular PA with day-to-day management of T1D. Specifically, exercise poses a substantial challenge due to the increased risk of hypoglycemia and/or hyperglycemia. Indeed, about two-thirds of individuals with T1D do not engage in the recommended amount of PA. Hypoglycemia presents a serious health risk, yet prevention and treatment often necessitates the consumption of additional calories, which may prohibit weight loss over time. Exercising safely is a concern and challenge with weight management and maintaining cardiometabolic health for individuals living with T1D and many healthcare professionals. Thus, a tremendous opportunity exists to improve exercise participation and cardiometabolic outcomes in this population. This article will review dietary strategies, the role of combined PA and diet for weight management, current resources for PA and glucose management, barriers to PA adherence in adults with T1D, as well as findings and lessons learned from the Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON).
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Nutrition
- DOI:
- https://doi.org/10.17615/8rv4-ee11
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/nu15112500
- ISSN:
- 2072-6643
- Journal Issue:
- 11
- Journal Title:
- Nutrients
- Journal Volume:
- 15
- Keyword:
- glycemic control, overweight, exercise, physical activity, weight maintenance, type 1 diabetes, obesity, and continuous glucose monitoring
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Stanford University, , AdventHealth, and York University
- Page Start:
- 2500
- Person:
- Zaharieva, Dessi P., Mayer-Davis, Elizabeth J., Pratley, Richard E., Maahs, David M., Riddell, Michael C., Muntis, Franklin R., Addala, Ananta, Corbin, Karen D., and Bishop, Franziska K.
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 4102c28c-38ba-470a-9e90-2d1a6341188f
150. Adults’ acceptance of covid-19 vaccine for children in selected lower-and middle-income countries
- Title Tesim:
- Adults’ acceptance of covid-19 vaccine for children in selected lower-and middle-income countries
- Creator:
- Bono, S.A., Ditekemena, J.D., Hosseinipour, M.C., Fodjo, J.N.S., Colebunders, R., Low, W.Y., Hasan, M.T., Pengpid, S., Siau, C.S., Sessou, P., Amodan, B.O., Dolo, H., Chen, W.S., and de Moura Villela, E.F.
- Date of publication:
- 2022
- Abstract Tesim:
- Since emergency approval of COVID-19 vaccines for children aged between 12 and 15 years old was recently obtained in the United States and Europe, we aimed to assess the willingness to vaccinate children with a COVID-19 vaccine in lower-and middle-income countries (LMICs). Therefore, we launched an online cross-sectional survey in several LMICs. Questions relating to socio-demographic information, knowledge of COVID-19, level of fear/worry of being infected with COVID-19, and willingness to vaccinate children with the COVID-19 vaccine at 50%, 75% and 95% effectiveness levels, were asked. Of the 6571 participants (mean age = 39 ± 14 years), 64.0%, 72.6%, and 92.9% were willing to vaccinate children at 50%, 75%, and 95% effectiveness levels, respectively. Respondents who were undergraduates, who were more worried/fearful about COVID-19, had higher knowledge scores regarding COVID-19, and a higher belief that COVID-19 vaccination is important to protect others, were more willing to accept COVID-19 vaccination of children. COVID-19 vaccination of children will limit the spread of the virus, especially in schools; it may decrease the need for school closures which has a negative effect on child development. Findings from this study are useful for health promotion strategies during COVID-19 vaccination implementation among children in LMICs.
- Resource type:
- Article
- Affiliation Label Tesim:
- School of Medicine
- DOI:
- https://doi.org/10.17615/8qbw-sg35
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/vaccines10010011
- ISSN:
- 2076-393X
- Journal Issue:
- 1
- Journal Title:
- Vaccines
- Journal Volume:
- 10
- Keyword:
- Children, Parents, Thailand, Africa, Lower-and middle-income countries, Bangladesh, Malaysia, Brazil, COVID-19 vaccination, and Caretaker
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Universiti Sains Malaysia, University of Kinshasa, , University of Antwerp, Universiti Malaya, University of Liverpool, Mahidol University, Universiti Kebangsaan Malaysia, University of Abomey-Calavi, Uganda Public Health Fellowship Program, University of Sciences, Techniques and Technology of Bamako, Swinburne University of Technology, and Federal University of Goiás
- Person:
- Bono, S.A., Ditekemena, J.D., Hosseinipour, M.C., Fodjo, J.N.S., Colebunders, R., Low, W.Y., Hasan, M.T., Pengpid, S., Siau, C.S., Sessou, P., Amodan, B.O., Dolo, H., Chen, W.S., and de Moura Villela, E.F.
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- 3543295c-4a55-4c66-ad7b-092d5610913e
Collection Details
- Total items
-
441
- Size
-
unknown
- Date created
-
May 26, 2022