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Works (1066)

21. Silk-Derived 3D-Bioprinted Scaffolds for Neural Repair and Nerve Regeneration: A Comprehensive Review

Title Tesim:: Silk-Derived 3D-Bioprinted Scaffolds for Neural Repair and Nerve Regeneration: A Comprehensive Review
Creator:: Challa, Sanjana, Beltz, Isabella, Thomas, Charlotte, Choudry, Umar, Schonebaum, Dorien I., Yan, Cynthia, Shariati, Kaavian, Foppiani, Jose A., Lin, Samuel J., Hunt, Jocelyn, Adams, Alynah J., and Kambol, Alexa
Date of publication:: 2026
Abstract Tesim:: Traumatic injuries often result in nerve tissue damage and functional deficits due to limited regeneration. Silk fibroin, a biopolymer with inherent biocompatibility and tunable properties, is a promising material for 3D-bioprinted neural tissue scaffolds. This review highlights recent advancements in silk-derived composite scaffolds, often incorporating additional materials like collagen or conductive polymers to enhance their performance. This review examines how material composition, scaffold architecture, and fabrication strategy influence biological response and functional recovery. This comprehensive review follows PRISMA guidelines and uses comprehensive searches of PubMed, MEDLINE, Embase, Web of Science, Cochrane Central, and ClinicalTrials.gov for studies published through 2025. Studies were screened for eligibility based on substance type, mechanical properties, production methods, and outcomes. Findings were synthesized qualitatively. Twelve studies were included, comprising rat (50%), canine (8.3%), and in vitro (41.7%) models. Analysis reveals that silk fibroin acts as a highly adaptable mechanical backbone. It can consistently integrate with bioactive additives (collagen, dECM) or conductive polymers (Polypyrrole, MXene) to meet specific therapeutic demands. For spinal cord injuries, composites reached a compressive modulus capable of resisting physiological pressures and preventing scaffold collapse. In soft tissue applications, silk–hydrogel blends provided localized release of exosomes and small molecules during the acute injury phase, reducing neuroinflammatory markers. Additionally, adding conductive materials allowed the scaffolds to bridge electrical gaps and promote Schwann cell proliferation and neuronal differentiation. Furthermore, 3D bioprinting enabled the creation of defined microchannels that replicate native fascicular architecture. In vivo outcomes consistently showed superior axonal regeneration, myelination, and synaptic reconnection compared to controls, correlating with significant improvements in electrophysiological and motor function. This review highlights the clinical potential of silk fibroin-based 3D-printed biomaterials for nerve regeneration, including neural repair and neural tissue engineering. More recent studies place greater emphasis on integrating mechanical, architectural, and biological considerations into scaffold design, resulting in increasingly multifunctional scaffold systems. Despite promising efficacy, the heterogeneity of fabrication methods and the predominance of rodent models highlight the need for standardized protocols and evaluations in relevant models to facilitate clinical translation.
Resource type:: Article
Affiliation Label Tesim:: School of Medicine
DOI:: https://doi.org/10.17615/zpbp-0604
Edition:: Publisher
Identifier:: https://doi.org/10.3390/life16060892
ISSN:: 2075-1729
Journal Issue:: 6
Journal Title:: Life
Journal Volume:: 16
Keyword:: mechanical properties, neural repair, nerve guidance conduits, tissue engineering, nerve regeneration, 3D bioprinting, silk bioink, and silk fibroin
License Label:: Attribution 4.0 International
Other Affiliation:: Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Medical College of Wisconsin, School of Medicine, Milwaukee, WI, Division of Plastic and Reconstructive Surgery, University of Minnesota, Minneapolis, MN, and
Page Start:: 892
Person:: Challa, Sanjana, Beltz, Isabella, Thomas, Charlotte, Choudry, Umar, Schonebaum, Dorien I., Yan, Cynthia, Shariati, Kaavian, Foppiani, Jose A., Lin, Samuel J., Hunt, Jocelyn, Adams, Alynah J., and Kambol, Alexa
Publisher:: Multidisciplinary Digital Publishing Institute
Rights Statement Label:: In Copyright
Source:: 13faf055-7c44-4152-b498-fe5f9697d9e7

22. Prior Adversity and Current Functioning Difficulties Predict Likelihood of Meeting the Criteria for Post-Traumatic Stress Disorder and Scoring Above the Cutoff for Post-Traumatic Growth

Title Tesim:: Prior Adversity and Current Functioning Difficulties Predict Likelihood of Meeting the Criteria for Post-Traumatic Stress Disorder and Scoring Above the Cutoff for Post-Traumatic Growth
Creator:: Schroeder, Kourtney L., Cuffe, Steven P., Heath, Erin R., Dana, Audrey N., Dale, Lourdes P., Alexander, Laren M., and Porges, Stephen W.
Date of publication:: 2026
Abstract Tesim:: Background/Objectives: Given that post-traumatic stress disorder (PTSD) and post-traumatic growth (PTG) are separate constructs that can co-occur following adversity, we examined how prior adversity and current functioning difficulties may relate to the likelihood of meeting criteria for PTSD and scoring above the cutoff for PTG among individuals who reported being impacted by their prior adversity. Methods: Participants (n = 2112) in this international sample completed online measures assessing their adversity history, current functioning difficulties (i.e., negative world assumptions and autonomic reactivity), PTSD symptomatology, and PTG. Results: Chi square analyses suggested a trend toward an association between meeting criteria for PTSD and scoring above the cutoff for PTG, although not statistically significant (p = 0.061). Multivariable logistic regression analysis found that individuals most impacted by caregiver abuse and certain specific adversities (i.e., parent with a mental health problem, caregiver and non-caregiver sexual abuse, and being held captive) were more likely to meet the criteria for PTSD. Whereas those most impacted by life-threatening situations and the specific adversities of being impacted by a life-threatening illnesses or injury, were more likely to meet the criteria for PTG. However, the strongest predictor of the likelihood of PTSD was increased autonomic reactivity, and the strongest predictor of the likelihood of PTG was fewer negative world assumptions. Conclusions: Our research suggests the need to assess the perceived impact of adversity history, as well as the potential negative consequences of autonomic reactivity and negative world assumptions, as these may be associated with PTSD symptomatology and PTG.
Resource type:: Article
Affiliation Label Tesim:: School of Medicine and Department of Psychiatry
DOI:: https://doi.org/10.17615/ddqs-4a18
Edition:: Publisher
Identifier:: https://doi.org/10.3390/healthcare14101402
ISSN:: 2227-9032
Journal Issue:: 10
Journal Title:: Healthcare
Journal Volume:: 14
Keyword:: autonomic reactivity, negative world assumptions, post-traumatic growth, PTSD, trauma, and adversity
License Label:: Attribution 4.0 International
Other Affiliation:: Department of Psychiatry, University of Florida College of Medicine—Jacksonville, Jacksonville, FL, Department of Psychology, University of North Florida, Jacksonville, FL, and
Page Start:: 1402
Person:: Schroeder, Kourtney L., Cuffe, Steven P., Heath, Erin R., Dana, Audrey N., Dale, Lourdes P., Alexander, Laren M., and Porges, Stephen W.
Publisher:: Multidisciplinary Digital Publishing Institute
Rights Statement Label:: In Copyright
Source:: b54ea2a9-cb8f-48cd-bb32-6d84e94ddc1e

23. A Novel Mechanism for Autoantigenicity: Condensate Conformational Change

Title Tesim:: A Novel Mechanism for Autoantigenicity: Condensate Conformational Change
Creator:: Carl, Philip L. and Fried, Howard M.
Date of publication:: 2026
Abstract Tesim:: Autoantigens, targets of B cell antibodies, account for ~10% of the human proteome. It is not well understood why or how particular self-proteins become autoantigens. Prominent theories posit that failures of the immune system at various levels or exposure of aberrant proteins to the immune system are responsible for autoantigenicity. In contrast, we propose a completely unrelated mechanism of autoantigenicity that is based on normal cell functioning. We suggest that, when a protein associates with one of the ~100 types of biomolecular condensates, protein–protein interaction therein causes changes in protein structure or conformation that signal an untolerized state to the immune system. This proposal is derived from the fact that many macromolecules are more concentrated within condensates than in the extra-condensate environment. Thus, the propensity for macromolecular interaction may be greater in condensates compared with the non-condensate environment. In support of this proposal, we present examples of predicted conformational differences, with and without accompanying secondary structure differences, between proteins in known condensate heteromeric complexes and in their free monomer forms. In each case, the differences correlated with predicted B-cell binding, supporting our model. Further, from a compilation of ~1900 autoantigens, we estimate that autoantigens are twice as prevalent in condensates compared with the entire human proteome (Chi squared p < 0.0001), further suggesting that a property of condensates, e.g., protein conformational change, may contribute to autoantigenicity.
Resource type:: Article
Affiliation Label Tesim:: School of Medicine, Department of Pharmacology, and Department of Biochemistry and Biophysics
DOI:: https://doi.org/10.17615/y1qb-5q44
Edition:: Publisher
Identifier:: https://doi.org/10.3390/biom16060803
ISSN:: 2218-273X
Journal Issue:: 6
Journal Title:: Biomolecules
Journal Volume:: 16
Keyword:: immune system, biomolecular condensate, autoantigenicity, protein–protein interaction, protein structure, epitope, protein dynamics, and B cell recognition
License Label:: Attribution 4.0 International
Other Affiliation:
Page Start:: 803
Person:: Carl, Philip L. and Fried, Howard M.
Publisher:: Multidisciplinary Digital Publishing Institute
Rights Statement Label:: In Copyright
Source:: 8557d954-85b4-4f7f-a34f-ce0941b692e2

24. Cost-Effectiveness of a Lifestyle and Behavioral Care Model Targeting Cardiometabolic Disease Progression

Title Tesim:: Cost-Effectiveness of a Lifestyle and Behavioral Care Model Targeting Cardiometabolic Disease Progression
Creator:: Alencar, Michelle, Sauls, Rachel, and Whetten, Justin
Date of publication:: 2026
Abstract Tesim:: Highlights Public health relevance—How does this work relate to a public health issue? <ul> <li>Chronic cardiometabolic diseases—major drivers of U.S. morbidity, mortality, and healthcare spending—are directly addressed through a scalable telehealth behavioral care model.</li> <li>The study evaluates an intervention that targets lifestyle-related risk factors, a central population-level lever for reducing chronic disease burden.</li> </ul> Public health significance—Why is this work of significance to public health? <ul> <li>The program demonstrates substantial cost savings ($6403 per member; $28.6 M population savings) and health gains (0.1 QALY), showing that behavioral interventions can yield meaningful, measurable health improvements.</li> <li>The high ROI (6.53) provides rare evidence that prevention-focused behavioral care models can be both clinically effective and economically sustainable at scale.</li> </ul> Public health implications—What are the key implications or messages for practitioners, policy makers and/or researchers in public health? <ul> <li>Employers and health systems can integrate telehealth-enabled behavioral care into benefit designs to reduce long-term healthcare costs while improving employee health outcomes.</li> <li>Policymakers and researchers may use the provided modeling framework as a reproducible method for evaluating cost-effectiveness and ROI of lifestyle and chronic disease interventions. </li> </ul> and Chronic diseases drive healthcare costs, and employers seek scalable strategies to improve health outcomes and control expenses. Telehealth behavioral care shows promise for managing chronic conditions, but its long-term economic value in employer populations is still unclear. We assessed the cost-effectiveness and ROI of a behavioral care (LBC) model using a Markov model in a custom analytic tool. The model simulated disease progression, healthcare utilization, and QALYs over five years from the employer perspective. Transition probabilities, costs, and mortality risks were obtained from the InHealth program, national sources, and published literature. Employees in the behavioral care model were compared with a control group receiving usual care. Among 4461 employees aged 40, intervention participants had five-year costs of $41,431, versus $47,834 for controls, saving $6403 per member and $28.6 million overall. Treated members gained 4.7 QALYs compared to 4.6 in controls, equivalent to 36.5 extra days of full health. The program had a ROI of 6.53, showing significant cost savings. Telehealth behavioral care is a cost-effective way to improve health outcomes and provide financial benefits to employers. These results support incorporating behavioral care into value-based benefits and highlight potential long-term savings through prevention and management of lifestyle-related chronic diseases.
Resource type:: Article
Affiliation Label Tesim:: Gillings School of Global Public Health and Department of Nutrition
Type:: http://purl.org/dc/dcmitype/Text
DOI:: https://doi.org/10.17615/frjx-8y22
Edition:: Publisher
Identifier:: DOI: https://dx.doi.org/10.3390/ijerph23040526, PMCID: PMC13115628, and PMID: 42074463
ISSN:: 1660-4601
Journal Issue:: 4
Journal Title:: International Journal of Environmental Research and Public Health
Journal Volume:: 23
Keyword:: apoptosis, wellness, electronic medical records (EMRs), Thailand, Y2Si2O7, harm reduction, health behaviors, iPSC-CM high-throughput screening, mesenchymal, endurance sport, loneliness, texture, universal health coverage, maraging steel, foetal uteri, caspase 3, CRISPR/Cas12a, immunohistochemistry, DEGs, gaseous, Ki67, single-cell proteomics, urban design, sleep, postoperative pulmonary complications (PPCs), teleradiology, executive function, informal caregiver, honey, prednisone, early-age shrinkage, fatty acids, pillar–backfill composite materials (PBCM), work grit, pedometer, Ang II, stress, biodegradation, adiposity, tumor microenvironment, non-melanoma skin cancer, circulating tumor cells, public space, long-term care, timing of maternal infection, remote work, Ganoderma lucidum, emotional, IL-15, Nepal, gut microbiome, drought stress, adsorption isotherms, rumen fermentation, valaciclovir, DNA methylation, somatic mutation, obesity, cochlea, family system unit stress theory, probiotic, myometrium, alkali activator, flavonoid, nursing care, hydrophilic, pure nickel, plasma-induced cell death mechanisms, maximum growth rate, the whole-genome level, osteoclast differentiation, PFGE, bioethics, chronic kidney disease, ultrasound-assisted extraction, β-tricalcium phosphate, pediatric otology, crushing degree, recovery failure index, mitochondrial stress, overtraining syndrome, drugs, titers and classes, endothelial permeability, genome-wide identification, proteoglycans, convolutional neural network, non-covalent interaction, GLB1, novel metabolic modulators in heart disease, pathogenesis, short-term longitudinal design (time-lagged design), Young’s modulus, sintering behavior, microstructure, autosomal recessive disorders, implementation science, weight maintenance, circRNA, organ-on-a-chip, differential coexpression, hydrophobic, phosphate flotation, systematic review, migrant health, forest therapy, ambulance, artificial intelligence (AI), necrotizing enterocolitis (NEC), laser powder bed fusion, self-tolerance, cardiovascular diseases, structural phase transition, amino acids, jujube, models, in silico toxicity, population genomics, shear resistance, job satisfaction, minority community, cementitious properties, polyradiculoneuritis, eating behavior, colorectal cancer, Bayley-III, reinforcing factors, tooth loss, N-A-S-H gel, sedation, astringency, flax fibers, GM1-gangliosidosis, neuroplasticity, molecular dynamics simulation, TFAP2D, maternal psychophysiological stress, myosteatosis, non-muscle-invasive bladder cancer, Aliivibrio fischeri, soluble dietary fiber, oncolytic virus, cinnamaldehyde/β-cyclodextrin inclusion complex, lysosomal storage disorders, differential scanning calorimetry, return on investment, thermal shock resistance, optical properties, body mass index, kinetic chain, ankle strength, epigenetic regulation, drill pipe, Cabernet Sauvignon wine, regional distribution, corrosion, pediatric, mycelium bio-composites, osteosarcoma, platinum sensitivity status, spatial heterogeneity, ACE inhibitory peptides, breast cancer, morphometric analysis, lipidomics-guided precision medicine, ketamine, soy protein isolate, personalized exercise medicine, ovarian cancer, cardiotoxicity, precision medicine, Listeria monocytogenes, molecular dynamics, substrate depletion, CJD-related neuropathy, molecular docking, immune checkpoint inhibitors, fieldwork education, school streets, surgical training, human development of salivary glands, angiogenesis, sarcopenic obesity, low-q scattering, β-amyloid, brain health, rapid detection, wastewater, nanoparticles, meso-mechanics, sleep surgery, enabling factors, medium-gluten wheat flour, sepsis, AI Modelling, ecotoxicity, political economy, dark-induced senescence, women’s health, BMI, intermittent fasting, LC-MS/MS, green advocacy, fibrosis, prediction, workforce, bitterness, cyberbullying, ROS, microphysiological system, CCM, MRI images, age-related decline, virtual reality, diabetic kidney disease, non-small-cell lung cancer, mechanical degradation, Bacopa monnieri, deep learning, NK-92, progression-free survival, SHAP, intra/interindividual variability, universal health care, ceramics, liver transplantation, non-Smad signaling, sealant, PEG 200, Hericium erinaceus, MAPK, RAS, cancer metabolism, disulfide bond formation, hemodialysis, PD-L1, aroma compounds, ectopic ACTH syndrome, drying shrinkage, multi-omics biomarkers, mitogen-activated protein kinase (MAPK), VEGF/VEGFR, disease burden, cell type annotation, internet use, flax, cholesterol efflux pathway inhibitors, chitosan, social participation, IL-18, shared decision-making, ready-to-eat food, magnetic resonance imaging, antioxidant, low-pass whole genome sequencing, nitrogen metabolism, antioxidant stability, biomarker panels, working from home, 3D printing, bronchial asthma, cytokine genes, Cd(II) adsorption, anchovy, egg quality, sustainable waste management, surgical simulation, stromal layer, Saudi Arabia, hematopoietic stem cell, hand exercises, absorbed components, Arabidopsis, digital model, monogenic kidney disorders, doping, women, reflection, health, osteogenesis, testis, microRNAs, electron beam evaporation, functional overreaching, dopamine, criminal justice, RTE, locomotor activity, photocatalysis, personalized medicine, sulfide minerals, expanded disability status scale (EDSS), alcoholic liver disease, circulating tumor DNA, resilience, enterovirus, benzimidazole, metabolic reprogramming, hepatocellular carcinoma, VUCA environments, Thai youth, untargeted metabolomics, trans-cinnamic acid, family caregiver, motive inference, rapid screening, L-Theanine, risk modeling, polyphenol, anti-A and anti-B isohemagglutinins, human serum albumin, Biogenic amines, syngeneic murine model, solvent optimization, exposome, resource utilization, protein misfolding, cylindrical metamaterial, sensory analysis, S-nitrosylation, children, early cognitive development, adaptive decision making, estimated daily intake, targeted therapy, healthcare experience, autotetraploid, health literacy, digital literacy, sport performance, toxicological risk, microscopic morphology, bone marrow, fetal salivary glands, intimate image offences, uncooperative children, pharmacological chaperone, GLP-1/GIP receptor agonists, bud sport, serotonin, mass spectrometry, network pharmacology, hydrogen nitride (TiN), TGF-β, antimicrobial susceptibility, twice-exceptionality, optical property inversion, nutraceuticals, cognitive stimulation, relapse rate, natural compounds, additive manufacturing, testicular dysfunction, health resources, sports genetics, mussel shell waste, nicotinic cholinergic receptor, heat transfer coefficient, disc perforation, electrocardiography interpretation, brain metastasis, virtual reality surgical simulation, tracked vehicle, SLC7A11, orally disintegrating film, geospatial analysis, genetic differentiation, workload, electrical equivalent circuit modeling, reinfection, top-down mass spectrometry, antioxidants, jasmine tea, crack, exploratory factor analysis, DAZL protein, finite element analysis, corundum–mullite, hybrid work, drug delivery systems, fibrolytic enzymes, hyperplasia/hypertrophy, complications, lung cancer, moderation analysis, preterm infants, self-control, dense granule protein, atomic force microscopy, hydration mechanism, GC-MS, interactive model, CAMK2A, PEG 400, carnitine, Tricholoma terreum, rheology, IPSS resolution, smoking, social media addiction, nootropics, gene amplifications and deletions, cerebral palsy, endemic transition, post-transcriptional regulation, environmental factors, autoimmune diseases, student well-being, fresh wet noodles, microsatellite stable, starvation, PD-L1 expression, home remedy, determinants, menopause, childhood trauma, trimethylamine-N-oxide (TMAO), proteomics, muscle function, disability, health inequality, PI3K, oxidative stress, Ethiopia, maceration time, PIWI proteins, microvascular dysfunction, glioblastoma, annealing, urinary toxicity prediction, CO2 emission, chromatin compartments, military professionals, AI, deadly gap, family nursing, genotype–phenotype correlations, active mobility, athletic monitoring, men’s health, LRG1, neurogenomics, lignocellulosic fibers, adverse childhood experiences, feasibility, experiential processing, sustainability consciousness, septic arthritis, Digital Game-Based Learning Environment (DGBLE), transcriptional remodeling, obstructive sleep apnea, uniaxial compression test, 5xFAD mice, metabolomics, motion, expression patterns, low-carbon steel, socioeconomic factors, Jordan, isorhamnetin, OIC countries, GRA12, critical size defect, composite surimi, Ambiol, optical coherence tomography angiography, sleep quality, neurogenesis, coping, XGBoost, psychological resilience, rabbit calvaria, safety, Microcystis novacekii, suicide prevention, MCF-7 cells, structural preprocessing, participatory methods, reward learning, RA, joint effusion, total hip arthroplasty, flow cytometry, forced degradation, toddler language development, hyperthermic intraperitoneal chemotherapy, tumor-associated macrophages, xanthan gum, LIPI-1, extracellular vesicles, grape seed extract, allograft rejection, bacterial β-barrel pore-forming toxins, Cu(II) adsorption, CXADR, keloid, PVD coating, age-related diseases, affective dynamics, taste, fruit bruise discrimination, malignancy, health insurance, stable vibration isolation performance, rural health disparities, rabies, immunity, tumor detection, Sendai virus, radiofrequency-assisted uvulopalatoplasty, biomarker discovery, Hla, proteoform biomarkers, phospholipid transfer protein modulators, Band 3, in silico, gliflozins, recycled foam concrete aggregate, transcriptome analysis, cholesterol metabolism, family stress, overweight, diagnosis, relationship quality, bone, ZnO, ligandability, residual cancer burden, laminar flow, transitioning servicemembers/veterans, life expectancy, senescence, white tea micro-nanoparticles, cardiomyocyte lipid metabolism drug targets, receptor activator of nuclear factor kappa-B ligand (RANKL), NICU, criminal victimization, QZS, dopaminergic synapse, fortification, leukocytes, anterior palatoplasty, hydraulic braking system, One Health, caregivers, small-angle neutron scattering, thermal insulation tiles, brain metastases, pediatric hip, dyslexia, multimodal intervention, street medicine, high pressure, plasma mediated gene delivery, behavioral model, bone morphogenetic protein-2, dendritic cell vaccines, extracellular matrix (ECM), perceived value, CG, intra-articular injection, mithramycin A, growth potential, structural equation modeling, cognitive function, meat quality, technology-facilitated sexual violence, functional measurement, cytokines, shot peening, fisetin, behavioral loyalty, degradation products, pheochromocytoma, TNFα, role ambiguity, lymph node metastases, osteoarthritis, developmental adenomyosis, nomogram, quality control, laminated glass, rheumatoid arthritis, muscle quality, organoid, genome-wide association studies (GWAS), single-cell RNA sequencing, quality of life, behavior therapy, rare CJD phenotype, neurodevelopmental outcomes, mitochondrial variants, beta-galactosidase, cost, diabetes mellitus, preeclampsia, campus well-being, rumen microbiota, health and wellness coaching, failure mode, myofibrillar protein microgel particles, Moran’s index, spatial frequency domain imaging, meta-regression, Artemia salina, COVID-19, compressive strength, Freesurfer, scale validation, emotional mapping, soccer kicking, neuropsychiatry, ZTE, clonogenic survival, LPO, decision support systems, maternal phubbing, white matter plasticity, recombinase polymerase amplification, neuron–glia communication, home health care, genetics, miRNA, temporomandibular disorders (TMDs), bifacial photovoltaic module, bioinformatics, spinal cord, mRNA, erythrocyte, waste from decoration, nurses cannulation failure, cement-stabilized macadam, cancer, sexual and reproductive health, numbness, alternative overlap syndrome, grain boundaries, behavior management, biosensors, reproductive genetic carrier screening, nephrocalcinosis, thromboinflammation, mineral metabolism, RNA-seq transcriptomics, CSF liquid biopsy, oligodendrocyte lineage cells, older adults, risk factors, program feasibility, pickering emulsion stability, nanocolloids, low-frequency disturbance, neuroimaging, lung squamous cell carcinoma, physical therapy, discrete element method, SARS-CoV-2, social determinants, hydrogen permeation, expense, ambulance services, rehabilitation services, precise tumor detection, victim support services, hemoglobin, surface profile correction, choline, Taiwan, temporal bone, chemical composition, emerging markets, Gd2Ce2O7, gel properties, immunosuppression, ABO antigens, musculoskeletal injury susceptibility, challenge test, bougainvillea, salivary cortisol, mathematics education, motor rehabilitation, physicochemical properties, meta-analysis, paresthesia, peripheral nerve injury, ABCA1/PLTP axis in cardiac therapy, austenitic stainless steels, site-directed enzyme enhancement therapy (SEE-Tx), ball speed, continuous electric furnace, Alzheimer’s disease, mitochondria, Philippines, mouse model, aqueous-phase dispersion characteristics, experience-dependent brain remodeling, washout interval, nanomaterials, chronic obstructive pulmonary disease, mitochondrial dysfunction therapeutics, cholangiocarcinoma, neutrophil percentage-to-albumin ratio, Parkinson’s disease, MASLD, HDL function enhancers, enzymatic inhibition, LEV14, cerebrospinal fluid, topic modeling, clinical, ACE2, transcriptomics, thrombosis, gallium (Ga), cell spacing, psychometrics, coordination, furcation involvement, structural, monozygotic twins’ (MZ), anxiety, neuroinflammation, exogenous proteins, ROC analysis, aerobic capacity, weight loss, community-based intervention, bovine blood, structurally targeted allosteric regulators (STARs), immune tolerance induction, sarcopenia, brain tumor, polysomnography, clinical characteristics, sustainable healthcare, Non-small cell lung cancer, temporomandibular joint osteoarthritis, peer support, spiritual, graft loss, structure–activity relationship, Al2O3 doping, psychiatry, retention, neuropsychiatric conditions, T cell receptor, clinical profiling, lipid nanoparticles, spatial dose distribution, regulatory screening, monoclonal antibodies, mixture design, chronic care, immunotherapy, metabolic abnormalities, LC–MS/MS, IL-12, perspectives, circular bioeconomy, anterior cruciate ligament (ACL), disparity, cell-cycle checkpoint, reading profiles, PLA biocomposites, corporate reputation, 316 L, perceived stress, nurses, validity, basic psychological need satisfaction, microhardness, nuclear factor κB (NF-κB), student mental health, mental health services, pesticide residues, health services accessibility, balance, epilepsy, trauma-informed practice, mitochondrial metabolism, neurorehabilitation, psychological well-being, transcription factors, positive allosteric modulator (PAM), heart failure, overall survival, disinfection, dexmedetomidine, prenatal antiviral therapy, peptide–MHC complexes, machine learning, multiple myeloma, mental, anticancer, measurable residual disease, force chain network, fatigue, inflammatory markers, FMOD, environmental sustainability, bornyl acetate, strength profiling, surface modification, economy, Coxsackievirus B5, ketogenic diet, geographic detector, Ti3O5, toddler social development, parenting stress, psychiatrist, functional polymorphisms, regenerative cardiology drug discovery, dental anxiety, HSF, Magellan platform, antimicrobial, GMFCS IV, parental school involvement, lipidomics, HNSCC, green synthesis, mobile health, phenolic compounds, ozone, cardioncology, invertebrate model, developmental stage, physical, neurodiversity, multiple sclerosis, lactate, bone resorption, optical coherence tomography, comparative extraction, gifted with learning disabilities, TGFβ, braking performance, caloric restriction, employee well-being, infant temperament, renal failure, polyphenols, NF-κB signaling pathway, red blood cell, breastfeeding, nitric oxide, distribution rules of 6-mer spectra, Apis mellifera, evaluation, artificial intelligence, decision curve analysis, online gender-based violence, hyperglycemia, TiO2 films, upcycling, handgrip strength, food production, prostate cancer, bioactive peptides, infant sleep, materials performance, prognosis, mechanical reliability, online social support, food safety, inflammation, stability, betaine, influencing factor, selection signal, SF-36, hemolytic activity, spatial agglomeration, chromatin regulation, polysaccharide–metal ions complex, recognition-primed decision making, adsorption, higher-order aberration, periodontitis, coronaviruses, data processing, pediatric dentistry, health-related quality of life, drilling fluid, mutation burden analysis, radiomics, neonatal brain MRI, therapeutic playgroups, interlayer bond strength, microbiome, volatile organic compounds (VOCs), periprosthetic joint infection, RNA therapeutics, dyadic intervention, multispectral, phylogenetic relationships, Toxoplasma gondii, adolescents, aging, body fat percentage, selective transfer, section modulus, ACAN, AP-2δ, Bayesian optimization, composite activator, activity-dependent myelination, adaptations, MRI, psychology, aqueous, family, CFIR, adult salivary glands, corrosion resistance, hyperthermia, the rare earth C-type structure, population, congenital cytomegalovirus, validation, highland barley, food, THZ1, consumer behavior, miRNAs, lung adenocarcinoma, lipid metabolism mechanism, acidity, tooth mobility, monetary reimbursement, social support, pain, biomarkers, fundamental movement skills, Bacillus subtilis, workforce distribution, religion, high power impulse magnetron sputtering (HIPIMS), temporomandibular joint (TMJ), prostate LDR, accessibility services, digital image correlation (DIC), EHR-based study, TOPSIS, AI emotion recognition, hearing loss, mechanical properties, Amomum villosum Lour, platelets, MDA, blood–brain barrier, astrocyte, neoadjuvant chemotherapy, essential oil, medicine, BDNF, surface chemistry, smoot muscle, masters athlete, hyperparameter, reflexive thematic analysis, age at onset, genetic polymorphism, CJD atypical presentation, genotyping-by-sequencing (GBS), haemostasis, multi-spectroscopic analysis, adults, social determinants of health, e-cigarettes, epigenetic, repeated loading, fish, acoustic emission (AE), chitin, hydrodynamic cavitation, occupational therapy, drying process, antibacterial activity, LY3200882, lemon by-products, screen time, cell-free DNA, cognitive enhancement, inflammaging, composite action, hemorrhage, data simulation, live yeast, Adventist spirituality, molecular simulation, NK cells, adenomyosis, tubular transport defects, multi-omics, higher education, siponimod, oryzanol, depression, epigenetics, Gossypium herbaceum, CG-specific selection mode, androgen deprivation therapy, transcriptional regulation, CML, palliative performance scale, Medial Olivocochlear (MOC) system, emotional intelligence, ultra-high-performance concrete, diagnostic, nutrient deprivation, health promoting campus, vaping cessation, Cu@Ag core–shell nanoparticle, physical activity, hemorheology, keratoconus, JAZs, HlyII, prognostic indicators, cognitive, multiple sclerosis severity score (MSSS), preventive behaviors, osteoporosis, CytK-2, oral pathogenic bacteria, anterior disc displacement, magnetic resonance imaging (MRI), antigen-specific immunotherapy, pathogenic variants, calcium lactate, bioelectrical impedance analysis, whole genome conserved domains, couple-based screening, leaf senescence, health professionals, non-functional overreaching, cognitive profiles, intersectionality, parental support, scenting process, gradation design, neuroprotection, aversive, interfacial adhesion, Yanbian yellow cattle, vascular remodeling, revision, bridging therapy, health policy, Artemia franciscana, and Prosopis laevigata
License Label:: Attribution 4.0 International
ORCID:: https://orcid.org/0000-0002-9879-9660, , and https://orcid.org/0000-0002-1430-2187
Other Affiliation:: Department of Kinesiology, California State University Long Beach, Long Beach, CA, , and Medical Economics, University of New Mexico Health System, Albuquerque, NM
Person:: Alencar, Michelle, Sauls, Rachel, and Whetten, Justin
Publisher:: Multidisciplinary Digital Publishing Institute (MDPI)
Rights Statement Label:: In Copyright

25. Intravenous and Subcutaneous Pharmacokinetic Modeling to Support the Development of Long-Acting Multipurpose Prevention Technology for HIV and Pregnancy

Title Tesim:: Intravenous and Subcutaneous Pharmacokinetic Modeling to Support the Development of Long-Acting Multipurpose Prevention Technology for HIV and Pregnancy
Creator:: King, Jasmine L., Oliveira, Daniel, Benhabbour, Soumya Rahima, Le, Thy, Cottrell, Mackenzie, Sykes, Craig, Engel, Nathan, and Schauer, Amanda P.
Date of publication:: April 10, 2026
Abstract Tesim:: Background/Objectives: Women and girls, particularly in sub-Saharan Africa, face high risks for both HIV and unintended pregnancy. Inconsistent condom use underscores the need for new multipurpose prevention technologies (MPTs) that combine HIV pre-exposure prophylaxis (PrEP) and contraception. Long-acting (LA) injectables are especially promising. To this end, an LA cabotegravir (CAB)/medroxyprogesterone acetate (MPA) in situ-forming implant (ISFI) has been developed. We report pharmacokinetic (PK) modeling to characterize CAB and MPA disposition and absorption to support the development of the MPT ISFI. Methods: Female BALB/c mice received single intravenous (IV) or subcutaneous (SQ) bolus doses of CAB or MPA. Sparse plasma samples were collected (~3 mice/timepoint) for PK analysis by LC-MS/MS. Noncompartmental analysis assessed SQ bioavailability. Macroparameterized compartmental PK models were fit to IV data to derive unit impulse responses (UIRs) for each drug. Results: CAB and MPA exhibited 61% and 42% bioavailability, respectively. CAB IV PK was best described by a two-compartment model with macroconstant parameters: A = 16,621 ng/mL, α = 4.52 h−1, B = 30,206 ng/mL, and β = 0.053 h−1. MPA IV PK was also best described by a two-compartment model, with A = 2506 ng/mL, α = 10.5 h−1, B = 439 ng/mL, and β = 0.65 h−1. These values define the UIR for CAB and MPA. Conclusions: Our IV PK modeling framework fully characterizes CAB/MPA disposition in mouse, enabling downstream deconvolution-based estimation of absorption from controlled-release formulations. This provides a foundation for in vitro–in vivo correlation, facilitating preclinical evaluation of long-acting formulations such as ISFIs.
Resource type:: Article
Affiliation Label Tesim:: School of Medicine, UNC/NCSU Joint Department of Biomedical Engineering, Eshelman School of Pharmacy, and Division of Pharmacotherapy and Experimental Therapeutics
Type:: http://purl.org/dc/dcmitype/Text
DOI:: https://doi.org/10.17615/v1kj-mr46
Edition:: Publisher
Identifier:: DOI: https://dx.doi.org/10.3390/biomedicines14040873, PMID: 42072413, and PMCID: PMC13114243
ISSN:: 2227-9059
Journal Issue:: 4
Journal Title:: Biomedicines
Journal Volume:: 14
Keyword:: toxicology, dysbiosis, IGF2, calcium–phosphorus product, mycotoxins, synergistic adulticides, antisense oligonucleotide, Tie2, gaseous emissions, supramolecular hydrogels, radial tear, EPA, probiotics, pH-responsive nanoprodrug, federated learning, thermal stress, cartilage tissue engineering, hypermetamorphosis, wildlife tourism ethics, helminth parasites, endometrial intraepithelial neoplasia, allergies, dairy cattle, Aspen Plus® simulation, football, oxidative stress, droplet microfluidics, mitochondrial dysfunction, game meat, myeloid-derived suppressor cells (MDSCs), hierarchical variance partitioning, low-protein diet, tuberculosis, empathic response, biodegradable materials, Eublepharis macularius, vector-quantized variational autoencoders, comminuted fractures of the distal humerus, ribosomal intergenic spacer marker (rIGS-ID800), DNA viruses, contamination, inflammatory modulation, spatial variables, mild cognitive impairment, extremophile, hepatic health, periotest, bariatric surgery, exosomes, testosterone, stress reduction, PRM, SII, open quantum systems, pre-addiction, PsSTT3B, cascading failures, tablet-based cognitive screening, Alzheimer’s disease, altitude sickness, transcriptional profile, sea ice, comparative genomics, hospitalized patients, signaling rewiring, mitochondrial membrane, Citrus medica var. sarcodactylis, aging, oxaliplatin, captive dolphin, Bombyx mori, socioeconomic factors, population-based mortality study, size-dependent effects, bibliometric analysis, mesenchymal stem cells, RT-qPCR, human-induced pluripotent stem cells, lipid-rich tissues, bone tissue engineering, infancy, gender disparities, endosymbiotic Chlorella, star anise + geranial, antimicrobial peptides, endophytic fungi, eye contact, piglets, behavioral repeatability, breeding method, marine, CTLA-4, eggshell membrane, rheumatoid arthritis, autophagy, Falhas de mercado, astrocyte proliferation, methane, immune melanization, Cr substitution, mitochondria-specific monoclonal antibody, peak frequency, visual attention, sporotrichosis, monocytes, biomarkers, machine learning, Long COVID, Locus Coeruleus, AI medical conversational agents, congenital infection, polyamines, ribonucleobase oxidation, Helicobacter pylori, stress distribution, avian pathogenic Escherichia coli (APEC), PARB clade, growth habit, metastability, eclampsia, reproductive structure abortion, manganese dioxide, skeletal muscle satellite cells, carbon tetrachloride, human papillomavirus, testis, Canada, community structure, pipeline, quality of care, subjective cognitive decline, metastatic calcification, Cretaceous, hepatotoxicity, oral supplementation, block-matching and 3D filtering, intraspinal schwannomas, negative self-image, conservation, virtual reality, tolerance, circular food system, Transnasal advancement flap, defects, patient safety, ewe, mpox Clade II, video recommendation, multiscale entropy, B cells, male reproductive function, antibiotic susceptibility, HPLC, surgical techniques, human embryonic stem cells, spatiotemporal analysis, Dirac quantization, Post-COVID, hesperidin, autoregressive transformer, foods and feeds, community participation, type 1 diabetes, phenoloxidase, normal maps, cognitive ability, metal-ion doping, mental health, in vitro larval rearing method, shelter capacity, stimuli-responsive materials, prevention, appearance anthropomorphism, meiotic spindle, non-target honeybee, temperature–humidity index, Testudo graeca, functional medicine, conservative management, MPXV, CKD, nanofibers, Litopenaeus vannamei, ammonia, nano-assisted EOR, protein C, antibiofilm, early intervention, cardiac tissue engineering, veterinary science, nerve tissue engineering, oxyphilic adenoma, screening test evaluation, SIRIUS, Health economics, survival assay, c-Abl, prednisolone, chitosan, cannabidiol, Democratic Republic of the Congo, precision medicine, feline coronavirus FCoV, joint-preserving surgery, co-occurrence network, long-term memory, AQI prediction, SARS-CoV-2, CNS, screening panel, eotaxin, osteosarcoma, oligosaccharyltransferase, PUFAs, epigenetic regulation, secreted proteins, personalized medicine, near-infrared spectroscopy, electron transfer, periodontal index, product inhibition, exercise test, anterior cruciate ligament, market state awareness, remdesivir, rivers, inflammation, gelatin, beef cattle, dental tissue engineering, S-PRG, relaxing music, PV membrane, nanoparticles (NPs), ventricular tachycardia, fibrillation, inflammatory bowel disease, longevity, digital literacy, cecum, mitotempo, citizen science, bibliometric, perfluorononanoic acid (PFNA), anti-coagulants, Phaseolus vulgaris, aperture adjustment, mild cognitive impairment (MCI), assessment, perfluorooctanoic acid (PFOA), peritalar instability, neurotoxicity, Política de saúde, mass spectrometry, diagnostic potential, scientometric, weaned piglets, climate change, social hypernetwork, TRP channels, flatfish, automatic detection, feed supplementation, spontaneous neural data, bone substitutes, development, Nocardia seriolae strain JXMa251025, oxidized cellulose, chest radiography, endometrial cancer, ion channels, forecasting platform, Coleoptera, telerehabilitation, immunotherapy, resonance frequency analysis, positive self-image, contrast-induced nephropathy, phage diversity, follicle-stimulating hormone, reaction time, reptile cognition, CuCoAl catalysts, antioxidant activity, microbiome, monkeypox, RNA-seq, blood indices, Astragaloside IV, internal brace, cognitive frailty, transcript, ischemic stroke, hematology, calcium, electrospinning, nephrotoxicity, noradrenaline, Uro-CT, two-phase design, mental health problems, flavonoid quantification, bias correction, subject-wise validation, inbreeding, GC376, lipid content, cetacean, neurodegeneration, macrophages, human papillomavirus (HPV) and cervical cancer, psychosocial factors, SHAP, hnRNPA1, doping, Bider marking, risk factor, outbreak, Explainable AI (XAI) for aerospace, silica nanoparticles, path integrals, central sensitization inventory score, Roux-en-Y gastric bypass (RYGB), multiplex polymerase chain reaction, cellular crosstalk, hypothalamus, sol–gel, scaling, pituitary, monoaminergic system, social rejection, nobiletin, immunogenicity, goose, Chinese rice-field eels (Monopterus albus), multipurpose prevention technologies, AP sites, growth performance, insulin resistance, sustainable materials, pomace, mental disorders, mannan-rich fraction, Cantharidae, amyotrophic lateral sclerosis, commodification, United States, statistical aggregation, EPR measurements, biomechanical testing, ethnozoology, sustainability, data-driven rehabilitation, Economia da saúde, functional dyspepsia, Lang Son Province, FIP, viral coinfection, information propagation, severe hypertension, captive breeding, tissue engineering (TE), Hylurgus ligniperda, fertility potential, composite, curriculum development, mycorrhizal colonization (MC), bone-mimetic microspheres, chronic endometritis, untargeted metabolomics, One Health, non-verbal communication, GS-441524, mineral, atrial natriuretic peptide (ANP), medical vision question answering, Posterior Reversible Encephalopathy Syndrome, early onset sepsis, amino acid, BODIPY FL C5-ceramide, DNA methylation, body composition, lithium–sulfur batteries, pedigree analysis, appearance, brain–machine interface, tissue engineering, collagen hydrogel, posterior acoustic shadowing, earthworms, Bayesian analysis, mpox Clade I, synergistic effect, brain, consultation length, hypodomanergia, PRRSV, HPV vaccination status, flexible contact-pressure sensor, chronic intestinal inflammation, Vietnam, histological examination, glycyrrhizic acid, Neopestalotiopsis, decidual–ovular material, traumatic brain injury, pigmentation, DNA damage, spatial–temporal graph, hemostatic biomaterials, HPV DNA clearance, Scaptotrigona postica, stress resilience, heavy oil, substance use disorder, remote monitoring, broiler chickens, functional group doping, bile acids, cryptic species descriptions, home-based therapy, TEK, collaborative governance, Eocene, CCL5/RANTES, 6-minute walk test, power-law scaling, voles, cinnamaldehyde, carioca type bean, α-tocopherol, water-clear cell parathyroid adenoma (WCCA), hydrogel, fetal alcohol spectrum disorders, body condition scoring, psychological well-being, virus–cancer awareness, fouling, drug, antiviral, extraterrestrial, pig welfare monitoring, Parkinson’s disease, cardiorespiratory fitness, osteochondral fragments, bile acid synthesis pathway, polystyrene microplastics, neuroimaging burden, cold-active cellobiohydrolase, short-term prophylaxis, antifungal immunotherapy, antiaging, mechanism, bee keeping, antibacterial, partial multi-label feature selection, Metarhizium parapingshaense, physical frailty (J-CHS criteria), Ecuador, veterinary education, team sports, in vitro antioxidant activity, immune checkpoint modulation, CXCL1/GROa, calgranulins, FIN, velocity based training, medical systems, healthcommunication, DHA, age, adrenal gland, precision livestock farming, climate health, colorectal cancer (CRC), Strasser grading, EEG, joint biomechanics, fruit exploitation, parental cognitive ability, risk assessment, periodontitis, relaxation dynamics, menisci tear, detoxification, microbial resilience, fatigue, total variation, transcriptome, Wistar rat model, parathyroid hormone (PTH), surface analysis, insect diet, Oculoplastic surgery, olfactory sensory neurons, pseudarthrosis, Syngnathidae, metabolic bariatric surgery, iterative reconstruction, rule-based image analysis, glucuronolactone, exotic pet trade, Madagascar, public health, cabotegravir, sheltering conditions, laryngopharyngeal reflux disease, neuropsychological test, targeted therapy, dental implants, allografts, specular reflection, nutrient digestion, trade network analysis, stochastic cell fate, reptiles, catalyst, mouse, virulence, wavelet entropy, entropy-based fusion, calprotectin (S100A8/A9), substrate size, antifungal, computed tomography, industrial inspection, Mongolian horse, serum, children, graphene-enhanced hydrogel, DRC and neighboring countries, mixture model, natural feed additives, rumen microbiome, older adults, wasp-plant interactions, CB1 receptor, muscle mass, hydrothermal vent, evolutionary mechanisms, chest X-ray, monitoring, vaccine safety, depression, classical mechanics, dual-task assessment, microbiota, students’ choices, pre-eclampsia, Phytophthora sojae, virulence factors, Saudi Arabia, LabGym, viscosity reduction, per- and polyfluoroalkyl substances (PFAS), serpentine, climate resilience, metabolic syndrome, critical thinking, Elateroidea, invasive forest pests, mice, Pilates, age-standardized mortality rate, Burmese amber, FUS, functional raw material, kidney and gallbladder stones, Inula salicina, Market failures, finite element analysis, parathyroid lipoadenoma, placental infection, RIF, GPCR signaling, ISFI, animal science, PEM, hypothalamic–pituitary–adrenal axis, MetFrag, trust, xenografts, cardiovascular disease, Medial canthal reconstruction, neonicotinoids, percutaneous cannulated paravertebral approach, lamb, hemorrhagic stroke, hydrothermal synthesis, actin cap, semi-restrictive elbow prosthesis, child health, agricultural pest, mitophagy, HIV infections, curcumin, biodiversity, immunomodulatory, sparse regression, molnupiravir, three-dimensional cell culture, stock price prediction, subtalar arthroereisis, traumatic arthritis, tumor microenvironment, maxillary sinus augmentation, bioacoustics, carbon capture adsorbents, Polish sport horse, task performance and analysis, orthopoxvirus, lung-targeted delivery, short peptides, gold nanoparticles, adaptive feedback, biocide, cannabinoids, resistance exercise, long-acting, gene regulation, traumatic retroperitoneal urinoma, deep learning, vertical sleeve gastrectomy, spatiotemporal regulation, microbiota gut-brain axis, computer-aided detection (CAD), pediatric cancer patients, athlete monitoring, middle age, review, railway equipment, type I interferons, cloud motion forecasting, CCL2/MCP-1, edge computing, autism spectrum disorder, far-field, hypoxic, biomarker discovery, placenta-derived mesenchymal stem cells, alternative charge separation pathway, growth, label distribution learning, surveillance and control strategies, amyloid-β, restriction fragment length polymorphism, protein, microbiota-targeted therapy, interfacial regulation, Megaloptera, flywheel, human hepatocytes, wound healing, equine, citrus peel-derived materials, organoids, XRD, neurodevelopmental disorders, healthy aging, object detection, Gaucher disease, intestinal barrier, ME/CFS, mortality, pulmonary function, lipid metabolism, ethogram, siloxane matrices, Al-lizardite, vitamin, toxicological profiling, miscarriage, near-field, Arthrex NanoNeedle, growth factors, nirmatrelvir, lifestyle medicine, respiratory syncytial virus, pediatric infectious diseases, spatial learning, myogenesis, species diversity, Lactobacillus, α-synuclein, NLR, viscoelastic relaxation, Chinese mitten crab, one health, injury risk, core stability, systemic risk, RPL, small ruminant, lipophilic fluoroquinolones, mitochondria, podcasting, spacecraft anomaly detection, hunting, atrial tachycardia, capacity for care, hyperparathyroidism, oxidative damage protection, therapeutic targeting, EO binary mixture, self-healing materials, stereology, intestinal microbiota, athletes, pathogenesis, quantum action, doped metal ions, insulator, satellite telemetry data mining, molecular diagnostics, single-case design, biomaterial, pulmonary tuberculosis, attitude to mental health, SSPE, omnipolar technology, methyl-keto (acetyl) group, spermidine, dopa decarboxylase, menstrual migraine, pharmacokinetics, ovary, antioxidants, Basal cell carcinoma, pathogenicity, eye mask, augmented reality, desalination, risk stratification, acetylcholinesterase (AChE), behaviour categorization, metal–organic frameworks, anti-inflammatory, CTCF, spontaneous pregnancy loss, amphibians, elderly, self-powering, diagnostic PCR, photosynthetic reaction center, metal ions, Metarhizium pingshaense sensu lato, volatile fatty acids, nursing, high-altitude pulmonary edema, functional mobility, thiamethoxam, chromosome conformation capture, therapy resistance, proinflammatory process, cancer vaccine, 16S rRNA, cat, 3-dimensional, in vitro tumor model, carrying capacity, thyroid gland, Morris water maze, higher alcohol synthesis, psoriasis, NF-κB/MAPK signaling cascade, Optical Coherence Elastography, PCV10-SII pneumococcal conjugate vaccines, Metarhizium anisopliae sensu lato, progressive collapsing foot deformity, hydrogels, biorefinery, bone regeneration, HIV PrEP, intelligence development, Arvicola scherman, MassFrontier, alveolar–capillary barrier, parathyroid oncocytic adenoma, invasive species, systematic review, hypobaric hypoxia, mTORC1, mixed effects model analysis, hair loss, asymmetry, Determinantes comerciais, fetal programming, chlorogenic acid, nursing education, vascular calcification, DSS-induced colitis, paracetamol, quantum field theories, epidemiology, Musca domestica, quantum time, pharmaceutical, tissue randomization, screening and triage, critical isthmus, collagenase-induced osteoarthritis, endocrinology, reactive astrocytes, dementia, biological activity, parathyroid adenoma, acetaminophen, rice, length of stay, minimally invasive surgery, palmitoylethanolamide, single-marker phylogeny, directed hypergraph, water velocity, rhinovirus, progesterone, cognitive ontogeny, stingless bees, drying methods, volumetric modulated arc therapy, animal sheltering, MS-FINDER, mycotoxin co-occurrence, Kihon Checklist (KCL), secretome, oxidized RNA protein binding, regenerative medicine, motor decoding, enolase vaccine, Tau, host defense peptides, leaf spot, pain, skin elasticity, Commercial determinants, saccharification, interpretability, neutrophils, evaporation-induced self-assembly, phageome, pest management, multi-scale neighborhood granular, histamine N-methyltransferase gene, mpox virus, cross-modal attention, cervical cytology, mouse brain, prophylactic nebulized hUC-MSC-EVs, CNN-LSTM, estradiol, cyclodextrin host–guest chemistry, gamification, population genetic, meta-analysis, TDP-43, perceived infection risk, standardized reconstruction, liver tissue engineering, intestinal morphology, screening, abortion, social stigma, prenatal care, dual-branch architecture, reward deficiency, muscle strength, virus, environmental adaptation, Hymenoptera, late onset sepsis, RNA oxidation, rabbit production, compressed sensing, neurological rehabilitation, ureteral reimplantation, stillbirth, cross-reactivity, uremic cardiomyopathy, chronic care, fruit rot, feature enhancement, vaccine, adipose, artificial intelligence, second quantization, measurement method, piezodielectric effect, oxidized RNA degradation, primary percutaneous coronary intervention, trench, sea, cancer prevention, PI3K pathway, hippocampus, narrative review, skin, trap measurements, tooth mobility, polymer–nanoparticle hybrid gels, hornets, quantum Mpemba effect, gut microbiota, antioxidant/ROS, biotic and abiotic factors, symptoms, precision chemoprevention, endometrial microbiome, γH2AX in-cell western assay, apple orchards, socioeconomic status, shape memory, reversible cognitive frailty, head lice, ureteroscopy, atrial fibrillation, urban network structure, transcriptome sequencing, alopecia, antiphotoaging, eccentric, preclinical, endoreduplication, calcium nitrate, liver, animal adoption, immunohistochemistry, MPA, chorioamnionitis, food insecurity, adults, ultrasound image, polylysine, soccer players, Metarhizium hybridum, surface normal vectors, post-exertional malaise, selenium nanoparticles, Sprague-Dawley rats, maternal supplementation, Melipona scutellaris, CCL7/MCP-3, neuroactives, reproductive hormones, neonatal stem cells, infertility, cadmium, in silico annotation, Health policy, laser interferometric elastography, bacteriochlorophyll, pediatric hospitalization, atypical PRES, RNA 8-oxoG, CCD-RSM optimisation, patient engagement, amesite, S100 proteins, mechanisms, evodiamine, chronic kidney disease, supply chain vulnerability, uncertainty-aware prediction, polygenic score, sport horse breeding, biosecurity, molecular stratification, profound sudden deafness, directed hypernetwork, pectoral muscle quality, biomedicines, phycocyanin, EIDD-1931, seasonality, straw application (SP), RNA, body condition, modification, amyloids, noninvasive glucose detection, immunopathogenesis, EIDD-2801, fracture, sperm quality, mitochondria–PV membrane complex, ordered mesoporous materials, urban agglomerations, lysosomal storage disorders, neotropical brown stink bug, cold exposure, temperature, skin diseases, prematurity, pharmacology, resistance training, skin tissue engineering, olfactory epithelium, learnable fusion layer, pterostilbene, phytophagous insect, phenomenological renormalization group, pediculosis, antioxidant, aquaculture, CXCL12/SDF-1a, distal radius fractures, wearable devices, thiol-containing compounds, chitin, wildlife health, RIPK3, transmission electron microscopy, gut–brain axis, metabolic amplification, ophthalmic tissue engineering, grain type, synergistic effects, MRI, exercise, differentially expressed genes, hydralazine, fibrosis, immunization programs, phytosynthesis, hospital stay, operation, cross-border exchanges of mycotoxins, sulfur, emerging virus, sequencing-independent species identification, Yimeng Black goats, diabetic retinopathy, GOS, CB2 receptor, genetic diversity, arthroscopy, plant extract, biomolecular condensates, pyeloureteral duplication, neuroinflammation, strawberry, Paramecium bursaria, redox dysregulation, early-life programming, metagenomics, ground-based sky imaging, stem cell therapy, greenhouse gas, human papillomavirus (HPV), measles, deep hemostasis, 3D-printed, cardioprotection, antioxidant capacity, mpox, multi-prompt learning, activated carbon, AKI, whole-genome sequencing, quadruple therapy, Kastamonu, reactive oxygen species, Drosophila melanogaster, athletic performance, environmental footprint, standing arthroscopy, Stroop-like task, phylogeny, echocardiography, low-level light therapy, pressurised hydroethanol extraction, guppy, weightlifting, PEG hydrogels, photoacoustic spectroscopy, signs, nanotechnology, oogenesis, lung cancer, transition levels, controlled release, edible crickets, rumen fermentation, hearing recovery, anxiety, family and community nurse, regional integration, and membrane distillation
License Label:: Attribution 4.0 International
ORCID:: , https://orcid.org/0000-0002-4738-5871, https://orcid.org/0000-0002-0291-5111, and https://orcid.org/0000-0002-7026-7224
Other Affiliation:
Person:: King, Jasmine L., Oliveira, Daniel, Benhabbour, Soumya Rahima, Le, Thy, Cottrell, Mackenzie, Sykes, Craig, Engel, Nathan, and Schauer, Amanda P.
Publisher:: Multidisciplinary Digital Publishing Institute (MDPI)
Rights Statement Label:: In Copyright

26. Circadian Controlled Transcription in Brain and Peripheral Organs of Juvenile and Adult Mice

Title Tesim:: Circadian Controlled Transcription in Brain and Peripheral Organs of Juvenile and Adult Mice
Creator:: Sancar, Aziz, Kose, Cansu, Akyel, Yasemin Kubra, and Arslan, Kaan
Date of publication:: 2026
Abstract Tesim:: Circadian clocks generate daily rhythms of gene expression that influence physiology, disease, and responses to therapeutics, yet how circadian transcription differs between juvenile and adult organisms remains unresolved. Here, we used genome-wide eXcision Repair sequencing (XR-seq) to quantify transcription-coupled repair as an indirect, high-sensitivity measure of transcription. We profiled the brain, liver, kidney, and testis from juvenile and adult C57BL6/J mice across a 24 h cycle and show that XR-seq enables sensitive circadian transcription mapping. In all organs except the testis, rhythmic transcription phases clustered near dawn and dusk. While core clock gene rhythms are largely preserved between juveniles and adults, rhythms of many clock-controlled genes differ markedly by age. Rhythmic genes are strongly organ-specific yet their overlap between ages is limited, indicating substantial developmental changes in circadian control. Together, these data provide a multi-organ map of juvenile versus adult circadian transcription and indicate that adult therapeutic schedules may not translate to juveniles.
Resource type:: Article
Affiliation Label Tesim:: School of Medicine and Department of Biochemistry and Biophysics
Type:: http://purl.org/dc/dcmitype/Text
DOI:: https://doi.org/10.17615/w5ax-nv32
Edition:: Publisher
Identifier:: PMID: 42074050, PMCID: PMC13116229, and DOI: https://dx.doi.org/10.3390/ijms27083408
ISSN:: 1422-0067
Journal Issue:: 8
Journal Title:: International Journal of Molecular Sciences
Journal Volume:: 27
Keyword:: dihydroartemisinin, bio-guided fractionation, soybean productivity, biliary leakage, juvenile dermatomyositis, obesity paradox, healthcare quality improvement, health education, central retinal arteriolar equivalent, regional anesthesia, electroretinography, systematic review, alcohol intake, non-variceal upper gastrointestinal bleeding (NVUGIB), ECG, preterm infant, anatomical anomalies, episcleral vein aqueous column, virus clearance, E1 enzymes, Rgg-family regulator, Cunninghamia lanceolata, adiponectin, abscisic acid, diabetic neuropathy, plant mitochondria, whole-genome sequencing, community-based participatory research, coumarins, microtiter plate, rhizosphere hypoxia, substantia nigra pars reticulata, diversity, isoquercitrin, cardiogenic shock, retrospective cohort study, respiratory disease, pregnancy, GRADE, Parkinson’s disease, colorectal carcinoma, European black elderberry fruit extract, estrogen receptor β, magnesium sulfate, sexual consent, bacterial communities, alpine meadow, bridge nodes, nonlinear phenomenological viscoelastic model, comorbidity, periodontal diseases, daily food rations, musculoskeletal complications, urine cytology, central obesity, single-cell perturbation, oral intake, water deficit, ST-segment elevation myocardial infarction, Young’s modulus, colorectal cancer, glucose metabolism, whisker tracking, Angelica pancicii Vandas ex. Velen., management strategies, database searching, polyphenols, hospital accreditation, saline soil reclamation, thromboembolic risk, primary care, risk factors, linear symmetry, fibromyalgia, diagnostic challenges, risk assessment, leaf color, event recorder, E3 enzymes, amyopathic dermatomyositis, G-quadruplex, vitamin K, cellular stress, deep infiltrating endometriosis, multimorbidity, ventricular septal rupture, SYNTAX score, serious mental illness, bioelectronic, gas-phase continuity, intensive care unit, maxilla, photosynthesis, Pediococcus lactis, Tobago, inflammation-based indices, polyphenol, ankle foot orthosis, endometriosis, KNOX, sleep deprivation, Diffuse Large B-Cell Lymphoma, safety assessment, dysphagia, inborn errors of immunity, ClHsf8, mechanisms, virus neutralization, pulsed electric field, reproduction, diet quality, Rho kinase inhibitor, endothelial dysfunction, simulation study, rutin, global health, process analytical technology, pain, downstream purification, inflammation-associated metastasis, tezepelumab, Cleistocalyx nervosum var. paniala, dietary patterns, chromosome-level analysis, idiopathic inflammatory myopathies, female, culturally responsive care, MASH, overall survival (OS), breastfeeding intensity, pacemakers, surface free energy, independent living, leaf hydraulic properties, skin rash, psychological distress, MASLD, cancer cell migration, molecular phylogeny, HIF1, anatomical sanctuary, molecular modeling, neuromodulation, lipid metabolism, conventional aqueous outflow, biomarker, Sjögren’s disease, Spanish-speaking communities, ACE inhibitors, Diabetic Retinopathy, racial disparities, enteric viruses, influenza A virus, sun-overexposure, Na+/K+ balance, microbiome, bronchiectasis, tension-type headache, neovascular age-related macular degeneration, titanium dioxide, renal cyst-ultrasound, L-lactic acid, Geoclemys hamiltonii, autoantibody, exercise therapy, radiotherapy, immune system, n-3 fatty acid, A549 lung adenocarcinoma, anti-thyroperoxidase, potassium silicate, pharmacological effects, phytochemistry, pancreatic surgery, lumbar vertebrae, opioid receptor, molecular subtypes, connective tissue disease, gene mentions, physiotherapy, intensity gradient, velvet LAE1/VEL1, mortality, smartwatch, dermatology, molecular pathways, high-resolution computed tomography, HIV reservoir, meteosensitivity, Verbenaceae, EUS-hepaticogastrostomy, cytokinin oxidase/dehydrogenase, hydrogen peroxide, Latine health, development, nucleocapsid, renal cyst-Bosniak classification, Rasch, Paget’s disease of bone, bladder urothelial carcinoma (BUC), livestock AMR transmission, drug penetration, transcriptomics, rheumatologic diseases, mitochondrial respiration, whole human milk, orthotic tuning, first 1000 days of life, in vitro confrontation, asthma, pneumothorax, classification, 3D systems, genetic polymorphism, machine learning model, unconfined compression, adrenalectomy, eating disorders, cigarette smoking, calcium metabolism, polyphasic approach, oral health, exercise recovery, salt stress, Fusarium graminearum, awareness, soil nutrients, health care use, inflammatory skin disease, grain filling, isometric exercise, viral RNA synthesis, environmental exposure, speckle-tracking echocardiography, gas exchange, agro-pastoral ecotone zone, aged, systemic sclerosis, prosthetic joint infection, gene silencing, crop varieties, expression patterns, deconvolution, case series, bacterial superinfection, nonfat dry milk, microhaplotype, free fatty acids, breastfeeding, achene, pulmonary rehabilitation, antioxidant, AFO–footwear combination, mouse, PROM, neuromuscular impairment, EUS-radiofrequency ablation, suicidal ideation, Trichostatin A (TSA), nutritional impact symptoms, pediatric obesity, amputation, photosynthetic efficiency, meta-analysis, Nigeria, Glycine max, antiparallel TERRA, Armillaria, complication, staging, primary prevention, social work, osteocalcin, sports performance, zygotic embryo, Hsf, steatosis, wheat production, infertility, gene family, potassium-sodium homeostasis, acute pain, degradation, systems biology, myocardial deformation, malignant ascites, NDPK, anaerobes, xerostomia, TSLP, K18-hACE2 mice, DHA, soft rice, xanthine oxidase, fecal-oral route, HepG2, airborne ARGs, tryptophan hydroxylase 2, circadian rhythms, pigments, RNA encapsidation, energy limitation, delirium, failure to rescue, Afro-Caribbean, obsessive compulsive disorder, EMSA, scoping review, soil respiration, iota-carrageenan, bioelectrical impedance analysis, co-culture, porphyrin and nucleic acid interactions, genetic risk factors, body composition, cardiac protection, KIF1C, soil fertility, Spain, HCoV-OC43, targeted therapy, apple tree, Haemophilus parainfluenzae, appetite-regulating hormones, risk factor, salinity stress, probabilistic genotyping, aneurysm, outpatient care, oxalate, uracil misincorporation, histopathology, brain, network pharmacology, intraocular pressure, chronic obstructive pulmonary disease, healthy eating, gene editing, apoptosis, whole genome sequencing, tumor metastasis, pigmented black rice, IVIVE, 6-hydroxydopamine, prenatal diagnosis, outcome, intravenous lidocaine, gene profiling, pyrazole derivatives, blood pressure, oxidative stress, NAFLD, pharmacodynamics, filamentous cyanobacteria, VAP, end-stage kidney disease, PubMed, fungi, brain morphology, osteoarthritis, children and adolescents, term breastfed infants, gene duplication, rat model, waist circumference, follow-up, overall survival, dentition status, doubling time, clinical psychology, myocardial infarction, cellular structural features, Fe(II) tris(1-pyrazolyl)methane complex, digital health, spinal cord injury, Fitzpatrick skin tone, anxiety, cognition, metastatic non-small cell lung cancer, institutional trust, flavonoids, Franche-Comté, transcriptome, ubiquitination, capsid protein, logistic regression, C3-epimer, site-directed mutagenesis, endocrine system, computed tomography, disease control, coenzyme Q10, women’s cardiovascular health, GLP-1, accessibility, sepsis, sap flux density, 16S–23S ITS rRNA, gender-based violence, articular cartilage, palatal expansion technique, acute anterior non-infectious uveitis, sex differences, molecular surveillance, comparative genomic analysis, hypertension, MetALD, LCPUFA, antimicrobial resistance, microbial fertilizer, lipotoxicity, non-coding RNA, oncogenic driver mutations, hair follicle cycle and regeneration, SOD1, epidemiology, A549, hyperfluorescence, antibody, critical quality attributes, Western Greece, JAK/STAT signaling, OXPHOS pathway, deficiency, resistant hypertension, rate controlling medical treatment, static culture, miRNAs, plant–endophyte interactions, insect herbivory, adverse outcomes, calcium oxalate, fibrosis, sequence analysis, cognitive dysfunction, human astroviruses, vitamins, postbiotics, tree height prediction, metagenomics livestock dust, metabolism, optical coherence tomography, personalized medicine, folate, C-reactive protein, globus pallidus internus, chlorogenic acid, proGCG, plant lectins, surgical management, three-way admixture, IFN-γ pathway, rural older adults, cyclosporin A, abiotic stress tolerance, probiotics, autograft, creatine, light-energy use efficiency, LC–MS/MS, surgical planning, central retinal venular equivalent, phenolic compounds, soil amendment, aging, inter-rater reliability, health equity, arsenic, postoperative complications, timing, childhood obesity, oral toxicity, morphology, endangered turtles, endometrial cancer, LC–MS, chemical fertilizer, regeneration system, antidiabetic activity, DNA mixture, fortification strategies, human coronavirus HCoV-229E, molecular dynamics simulation, renin–angiotensin system, population structure, demolition dust, spheroids, ROS, WGCNA, social determinants of health, inverse probability weighting, ripening transition, phenylpropanoid pathway, polysomnography, gut microbiota, physical health, network-based polygenic risk score, waterlogging stress, NMDA receptor, balance disorders, Catalpa ovata, chronic kidney disease, hemodialysis, malocclusion, respiratory syncytial virus (RSV), evaporated skim milk, post-acute sequelae of COVID-19, maternal hypoxia, functionality, customer satisfaction, mental health, Sclerotinia sclerotiorum, vitamin D, turmeric, vascular protection, autoimmune diseases, laryngeal cancer, text mining, quality-adjusted life-years (QALYs), subthalamic nucleus, meta-analysis as topic, diet, psychometric validation, liver fibrosis, neutrophil percentage-to-albumin ratio (NPAR), acute pancreatitis, dryness, Hepatitis E virus (HEV), Bifidobacterium, IOP, malignant biliary obstruction, solar UV, NAC transcription factor, docking simulation, difficulties, amyotrophic lateral sclerosis, Berlin Questionnaire, tobacco use, drought stress, prognostic factors, E2 enzymes, bacteriocin, vitamin D deficiency, drug-induced dermatomyositis, heat stress, congenital heart disease, Apnea–Hypopnea Index, Y chromosome, porcine epidemic diarrhea virus, musculoskeletal fitness, RSM modeling, medicine, tumor microenvironment, autotrophic respiration, docosahexaenoic acid, melatonin, splenic transcriptome, drug delivery systems, functional enrichment, CiHsf10, Bangia fuscopurpurea, adaxial, effect modification, HLA locus, ubiquitin, glycation, fission yeast, HFSCs, carbon and nitrogen metabolism, visual tracking, systematic reviews as topic, curcumin, combination therapy, cyanidin-3-O-glucoside, Streptococcus parauberis, XDR-TB, deubiquitination, TERRA, jujube, sports nutrition, frailty, SGLT2 inhibitors, next-generation sequencing, artificial intelligence, winter wheat, biomass, IL-6, supramolecular interactions, anxiety disorders, chronic hepatitis B, dermatomyositis, psychiatric interventions, bioactive components, Aeromonas hydrophila, lipase, emodin, cross-species comparison, neuritogenesis, hairy roots, quality of life, gene expression, phosphatidylglycerol biosynthesis, phylogenetic relationship, receptacle, IAV, Romania, human milk, molecular targets, non-typhoidal Salmonella, planar development, reactive oxygen species (ROS), clinical implementation, anti-thyroglobulin, structural equation modeling, growth rate, adolescents, disease-specific survival (DSS), multifocal electroretinography, single-cell isolation, polymorphisms, cardiovascular risk, biologics, yield, mononuclear stem cells, proteinopathy, blunt abdominal trauma, low-temperature stress, laminar growth, Firth correction, indocyanine green angiography, cancer, hypothyroidism, HSP47, phytochemicals, multidisciplinary counseling, neurological rehabilitation, redox homeostasis, k-fold cross-validation, biochanin A, rheumatoid arthritis, infrared-based device, postmenopausal women, synaptogenesis, photosynthetic heterogeneity, metabolic health, interventional angiography, mitochondrial genome, long COVID, follow-up injury incidence, survival, β-catenin, global longitudinal strain, teledermatology, shank–to–vertical angle, cardiac surgery, PBPK, cognitive performance, drug-resistant tuberculosis, osteoporotic fractures, perioperative analgesia, AMPK/Nrf2/GSH pathway, antiviral activity, soil hydrothermal environment, genotype specificity, soil recovery, Lactiplantibacillus plantarum, photoinhibition, progression free survival, immune microenvironment, Schinus terebinthifolia, Wnt signaling, elevated liver enzymes, rehabilitation, Sinojackia xylocarpa, deep brain stimulation, upper-lobe fibrosis, cytoskeleton, atrial fibrillation, sex-specific effects, pediatric allergic diseases, public health, transcriptional regulation, estrogen dependence, cotton, tissue heterogeneity, recombinant forms, Eastern Cape, proteomic analysis, prognostic marker, 16S rRNA gene, cancer therapy, environmental resistome, vascular inflammation, anthocyanins, co-expression network, esophageal, maize, celiac disease, antioxidant activity, topography, coronary artery disease, treatment response, early childhood, sports injuries, enucleation, anticancer agents, XR-seq, Trichoderma, hepaticojejunostomy insufficiency, neuropsychiatric manifestations, visceral injury, histomorphometry, intra-aortic balloon pump, rule-based extraction, children, framework-based proficiency, NPFSCs, tumor suppressor, VLPs, catboost, left ventricular hypertrophy, aortic stenosis, psychometrics, asthma phenotypes, body mass index, reference values, antioxidant defense, obstructive sleep apnea, soybean, sodium intake, ovarian cancer, phylogenetic analysis, average acceleration, pharmacokinetics, TAVI, vestibular dysfunction, regulatory factors, antifungal activity, athletes, medlar fruit, AMD, Naples Prognostic Score, cardiorenal syndrome, MACE, arrhythmia in children, facial nerve, osteoporosis, leptin, genotoxicity, superior and inferior grains, peripheral nerve stimulation, viral latency, arterial erosion, childhood, LC-MS profiling, drip fertigation, KRIT1, brain fog, neuroimmune mechanisms, N-acetylcysteine, hemoglobin video imaging, sleep disorder, hypothetical secondary structures, reaction centers, structure–activity relationship, preparatory exercise, Ulmus pumila, plant colonization, human coronavirus HCoV-OC43, multifrequency bioimpedance analysis, lime and gypsum incorporation, manual therapy, paraplegia, ubiquitin–proteasome system, KardiaMobile, stress echocardiography, head and neck squamous cell carcinoma, medicinal chemistry, single-cell RNA sequencing, transient elastography, diagnostic threshold, genome-wide association study, spinal fusion, cost-effectiveness analysis, viscoelastic modeling, head and neck cancer, DNA methylation, heat shock proteins, health care utilization, sleep quality, Rockall score, ITS, plant development, somatic embryogenesis, stress, chronic inflammation, cardiovascular disease, public health nutrition, chlorophyll fluorescence, antiviral, mucin 2, excess, NSCs, hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase (HCT/HQT), mimetic antibacterial membrane, portable electrocardiograph, precision medicine, meteoropathy, folic acid, circular dichroism, enzyme inhibitory activity, neurodevelopment, EPR spectroscopy, step-up approach, particulate matter, photosynthetic characteristics, weather, nail growth and digit regeneration, type 2 diabetes, feedback device, postpartum depression, AIMS65, edinburgh postnatal depression scale, exacerbation, MVC, cardiopulmonary resuscitation, vaginal infection, digital sexual consent, MDR-TB, pancreatic beta cells, subarachnoid hemorrhage, human amniotic membrane, singlet oxygen, electronic health records, orthorexia nervosa, fascicular turnover flap, vulvovaginal candidiasis, hypomyopatic dermatomyositis, fluorescence in situ hybridization (FISH), type 1 diabetes mellitus, LP28, protein–protein interaction, exponential phase, therapeutic approaches, end-stage renal disease, reactive oxygen species, United Arab Emirates, universities, clinical practice, drug repurposing, orthodontic appliances, ELISA, tibiofemoral joint, resource use efficiency, COVID-19, visceral artery, stroke prevention, pathogenicity, immunity, diagnostic performance, neoplasm, HIV co-infection, sunburn, COPD, postoperative delirium, preserved network between blood and brain, peptaibols, elite athletes, risk stratification, transcriptome reprogramming, food access, bacteriocins, acute myocardial infarction, chest compression quality, chromatography, network analysis, biomechanical properties, Malus sieversii, public health campaigns, Joint Commission International (JCI), SARS-CoV-2, sub-saturating light, survival analysis, Hijdra scale, Cordyceps militaris, comparative immunology, overweight, environmental pollutants, late onset prosthetic joint infection, sexual violence, thyroid elastography, appearance quality, getah virus, antibiotic stewardship, casein micelle, seroprevalence, cells, biopolymers, 25(OH)D, quorum sensing, benign paroxysmal positional vertigo, Endophytes, time lag, temporary housing, depression, extracts, IL18, mice, adults, dialysis, diastolic dysfunction, hub proteins, proteasome, differential gene expression, vestibular assessment, community mental health, ascorbic acid, pregnant adolescents, peripheral artery disease, anticancer, kidney transplantation, cardiac aging, pleuroparenchymal fibroelastosis, severe uncontrolled asthma, accidental falls, negative strand RNA virus, double hidden-layer neural network, transgenerational effect, Fusarium ear rot, lettuce, admission, renal cyst-contrast-enhanced ultrasound, adrenal metastasis, energy absorption, functional food, transcription-coupled repair, artemisinin, glycosylation sites, social model of disability, interstitial lung disease, general obesity, organ-on-a-chip, kidney disease, non-photochemical quenching, microvascular complications, fibroelastosis, lumbar microdiscectomy, 16S rRNA amplicon sequencing, DLCO, exercise safety incidents, patient-derived organoids, pandemic preparedness, butyrylcholinesterase, food fortification policy, metabolomics, cross-sectional studies, assisted reproductive techniques, Haemophilus influenzae, healthcare personnel, disease incidence, Achillea santolina, peripheral nerve regeneration, gut health, 2D monocultures, postoperative pain, HD-ZIP II transcription factors, hybrid compounds, non-mineral antioxidants, retinal inflammation, interleukin-8, genetic diversity, EUS-choledochoduodenostomy, schwannoma, fatigue, protein–protein interactions, laccase, EPS, single nucleotide polymorphism, Chrysanthemum indicum, obesity, heart failure, insulin resistance, antioxidants, postpancreatectomy hemorrhage, genetic ancestry, inflammation, community forum, cardiovascular risk factors, sulfated polymer, CRISPR/Cas system, anthropometry, opioid use, re-emergence, predictors, atherosclerosis, EUS-gallbladder drainage, rural health, prognosis, earthquake, multimodal large language model, Video-Assisted Retroperitoneal Debridement (VARD), topology modulation, recombination, EUS-gastroenterostomy, biological nitrogen fixation, ZnTCPPSpm4, diabetic retinopathy, early postpartum, fertilization in vitro, genetic variants, mixed-effects model, PCSK1, esophagectomy, transmission electron microscopy, One Health, carcinoembryonic antigen (CEA), TRV, adolescence, cross-sectional study, protein structure, thyroid, cognition-related traits, Ecuador, hepatocellular carcinoma, metagenomic analysis, general practitioners, emergency department, acetylcholinesterase, levothyroxine, porcine, Fisher scale, ultra-processed foods, autoimmune, pathways, therapeutic endoscopic ultrasound, CLCrV, giant cell arteritis, microbiota, activity, web-based applications, angle class III, monocots, poultry production, pachydrusen, pharmacy, AGCES (American & Global College of Endometriosis Specialists), nutritional intervention, implantable cardioverter defibrillators, lignin biosynthesis, AsA-GSH cycle, strawberry, treatment outcomes, tobacco cessation, molecular docking, angiotensin receptor blockers, film mulching drip irrigation, anthocyanin, evolution, Malus domestica, community-based rehabilitation, individual spike productivity, plant density optimization, sports injury, pediatric nutrition, robotic surgery, phylloclades, restless legs syndrome, Lippia origanoides Kunth essential oil, HSP90, heterotrophic respiration, tissue regeneration, α-glucosidase, biomarkers, European countries, natural substance, newborn, termination of pregnancy, biosynthesis mechanism, Ruscus aculeatus, steatotic liver disease, benign biliary disease, endovascular, hearing loss, TDP-43, TGF-β1, mitochondrial DNA, catalytic mechanism, analgesia, health impact, Alzheimer’s disease, lactation, spectroscopy, cardiovascular diseases, chiral analysis, nutritional risk, misclassification, Liquidambar formosana Hance, semi-rational design, thermostability, macular function, thermal stability, Schizosaccharomyces pombe, upper tract urothelial carcinoma (UTUC), single nucleotide polymorphisms, Thailand, physical functional performance, rehabilitation period, neurological disorder, gestational weight gain, skin homeostasis and regeneration, rehospitalization, intracytoplasmic sperm injections, ERIC-PCR, fecal microbiota transplantation, epigenetics, therapeutic exercise, Aflatoxin B1, ripasudil hydrochloride hydrate–brimonidine tartrate fixed-dose combination, molecular evolution, deubiquitinase, tyrosinase, ion channels, birth weight, oxygen desaturation index, abaxial, and adenomyosis
License Label:: Attribution 4.0 International
ORCID:: https://orcid.org/0000-0001-6469-4900, , https://orcid.org/0000-0002-1734-8340, and https://orcid.org/0000-0002-5122-2880
Other Affiliation:
Person:: Sancar, Aziz, Kose, Cansu, Akyel, Yasemin Kubra, and Arslan, Kaan
Publisher:: Multidisciplinary Digital Publishing Institute (MDPI)
Rights Statement Label:: In Copyright

27. Hierarchical YOLO-SAM: A Scalable Pipeline for Automated Segmentation and Morphometric Tracking of Coral Recruits in Time-Series Microscopy

Title Tesim:: Hierarchical YOLO-SAM: A Scalable Pipeline for Automated Segmentation and Morphometric Tracking of Coral Recruits in Time-Series Microscopy
Creator:: Van Horn, Meg, Zhao, Richard S., Fogarty, Nicole D., and Chen, Cuixian
Date of publication:: 2026
Abstract Tesim:: Coral reef ecosystems are declining rapidly due to climate change, disease, and anthropogenic stressors, driving the expansion of land-based coral propagation for reef restoration. A major bottleneck in these efforts is the manual measurement of coral recruit tissue area from microscopy images, which requires 2–7 min per image and limits scalability. We present a hierarchical deep learning pipeline that automates this measurement by integrating YOLO-based detection with Segment Anything Model (SAM) segmentation. YOLO localizes recruits and classifies them by developmental stage; stage-specific fine-tuned SAM models then segment live tissue using bounding box and background point prompts to suppress segmentation leakage and improve boundary precision. Surface area is computed directly from the segmented masks using pixel size extracted from image metadata. The pipeline reduces processing time to approximately 3–5 s per image—a 24–140× speedup over manual tracing. Evaluated on 3668 microscopy images from two national coral research facilities, the system achieves a mean IoU exceeding 95% and an auto-acceptance rate (AAR) of 71.51%, where predicted-to-ground-truth area ratios fall within a ±5% tolerance of expert annotation, substantially reducing manual workload while maintaining measurement reliability across species, developmental stages, and imaging conditions. This workflow addresses a critical bottleneck in restoration research and demonstrates the broader applicability of AI-based image analysis in marine ecology.
Resource type:: Article
Affiliation Label Tesim:: College of Arts and Sciences and Department of Computer Science
Type:: http://purl.org/dc/dcmitype/Text
DOI:: https://doi.org/10.17615/5yae-ym61
Edition:: Publisher
Identifier:: PMCID: PMC13119570, PMID: 42076400, and DOI: https://dx.doi.org/10.3390/s26082291
ISSN:: 1424-8220
Journal Issue:: 8
Journal Title:: Sensors (Basel, Switzerland)
Journal Volume:: 26
Keyword:: warpage, PECT sensor, Acetabulum, esters, coherent detection, earth sciences, fungal-bacterial interactions, parietal cortex, Molecular pathways, PET/CT, thermometry, mental health, avalanche photodiode, C. elegans behavior, coral bleaching, industrial applications, endophytic bacteria, lignocellulosic core, additive manufacturing, radar-satellite fusion, AKR1C, soil nitrogen cycling, wafer-scale sub-micrometer fabrication, SBS modifier, electrospinning, hybrid insulator, alphaherpesvirus, duodenal mucosa, epoxy composites, metagenomics, time-restricted eating, fibromyalgia, VOTC, phylogenetic analysis, wireless sensor networks, bacteriophage delivery, neglected tropical diseases, sensor, fat-free mass index, Russia, capsid protein pE120R, outlier rejection, Ki-67, metabolic risk, Pathophysiology, whole-genome analysis, microbial community structure, succinylated pullulan, Inflammaging, Boolean networks, singlet oxygen, normal pressure hydrocephalus, environment, root-zone nitrogen fertilization, neurodegenerative disorders, One Health, receptor-mediated transcytosis, immunotherapy, radiobiology, hydrogels, k-means cluster analysis, ANCA-associated vasculitis, internode development, repair efficiency, split-conformal calibration, β-glucosidase, RT-qPCR, climate variability, Adventitious roots, ECPR, PI3K-AKT-mTOR, Mental health, weaned piglets, MUSPACC, periodontitis, virtual metrology, vaginal drug delivery, exhaustion, drug administration, acupuncture, Lujo hemorrhagic fever, Becken, molecular docking, obstetric complications, carcass lesions, Posterior urethra, Campylobacter jejuni, taping, immunoglobulin G, hemolytic disease of the fetus and newborn, serology, OHCA, systematic review, false-alarm control, acid stress, temporal stability, quality of life, socioeconomic situation, low temperature curing, process state indicator, neuro-HIV, mutation analysis, aromatase inhibition, root system architecture, ECE1, ES-SCLC, thermostability, antitumor activity, Aedes aegypti, Inflammation, mediation, GI symptoms, collagen, Rhipicephalus microplus, instance segmentation, arsenic tolerance, cardiovascular medicine, L-tryptophan, iceberg indicators, tunable mode-locked laser, breast cancer, angioedema quality of life questionnaire, precision medicine, 3D modelling, stress-intensity factor, passive sensing, systemic mastocytosis, erbium-doped fiber, microscopy imagery, Canals, optical sensors, NAMS, Hair follicle, vehicle instability warning, taxonomic stability, ballistic performance, indirect costs, mental health services, CMOS image sensor, perimenopause, cytotoxicity, LIPI, topical formulation, phosphate toxicity, ATG7, central sensitization, reconstructive spectrometer, framework development, flavor attribute, LAB-starter cultures, large-scale components, ecological model, collaborative robot, PPy, artemisinin derivatives, Fruit Weight 2.2-like (FWL), prevalence, type 2 diabetes, multi-arcs, latency period, performance evaluation, metrology, data visualization, FTIR-ATR, chitosan, digital phenotyping, Nutrients, tobacco-cancer studies, calibration, MT: Special Issue - Advancements in pediatric cancer therapy, organic fertilizer, children and adolescents, RNA-interactome capture, radioisotope, African swine fever virus, clinical guidelines, fat mass index, pharmacological treatments, multimorbidity, OsFWL8, subcutaneous injectables, Bayesian optimization, postbiotics, antioxidants, carbon nanotube saturable absorber, virion, inertial measurement unit (IMU), metatranscriptomics, suspension, viscosity, infrared spectroscopy, particle production, schizophrenia, TiO2 nanotube, mild cognitive impairment, particle enrichment, Intergenerational relationships, complications, risk of bias, large ruminants, co-amorphous solid dispersion, human-recombinant nerve growth factor, Ion composition, metabarcoding, medical countermeasure development, epigenetics, triboelectric nanogenerator, desert plant microbiome, obesity, photodiode, non-equispaced frequencies, post-processing, helicopter load risk test point matrix, mouse model, Spaceflight, oxygenquenching, coral-associated bacteria, prevalence of SRBDs, flight test, stiffness-to-weight efficiency, continuous cropping, psychometrics, innate immunity, Wheatstone bridge, injection molding, [68Ga]Ga-FAPi-46, microbiome resilience, tooth extraction, hot flashes, antioxidant activity, Nephrectomy, 3D mixed reality glasses, PET imaging, Aeromonas piscicola, pulsed eddy current testing, conceptual model, rapid process, multidimensional equal-frequency binning, pose adjustment and positioning, embedded elastomeric mask, evidence-based psychiatry, Gene ontology, border area, essential oils, functional convergence, ticks, phosphorescence, zoonosis, automated assembly, Social drivers of health, tick-borne diseases, fertilization, agromorphological evaluation, QSPR, fibroblast activation protein inhibitor, interleukin-10, limited buffer capacity, cohort studies, runtime safety monitoring, multiparticulate system, molecular crosstalks, proton motive force, experience sampling, confidence, species distribution models, mutual learning, superhydrophobic, surface roughening, object detection, polarization encoding, arbovirus, osteoarthritis, precision nutrition, microbiota, clipping, stokes vector reconstruction, pediatric sleep apnea, ripening stage, ultrafast, inertial navigation system (INS), Life cycle assessment, social functioning, cystocele, Leishmania infantum, endocrinology, antiviral response, predictive models, Salinity, surveillance capacity-building, Momordica balsamina, urinary incontinence, quinalizarin, polycystic ovary syndrome, RNA-binding protein, auger, vaccine, pargeverine, ocular drug delivery, Biscayne Bay, VOCs, outpatient management (OM), Artificial seawater, preservation properties, chiral configuration, bacterial cellulose, GLUT1, PTSD, functional dependence, Post-stroke cognitive impairment, Lung, iron bioavailability, hydroxypinacolone retinoate, PURA, pre-clinical, KNHANES, animal models of infection, probabilistic prediction, normative charts, Lujo virus, hot-melt extrusion, Dose mapping, substance use disorders, Reirradiation, Dose accumulation, gene regulation, Jingangteng capsule, clinical parameters, autophagy, robust estimation, Linum usitatissimum L., mosquito abatement, bottled water, PD-1 immunotherapy, remote sensing, triplet−triplet annihilation upconversion, biofilm carrier, adaptive feedforward control, ROS, Bovistella utriformis, Google Trends, Cerebral small vessel disease, drift compensation, diabetes mellitus, beta, medicine, stability mechanisms, frailty, acoustic vibration analyses, opportunistic routing, Life expectancy, sleep-related breathing disorders, high performance blockchain system, Time estimation, vaccine-induced antibodies, genetic therapies, Shengmai San, prognostic, methodological bias, optical coherence tomography, epidermal/dermal delivery, clinical implementation, transportation, drug discovery, bioadhesion testing, large-scale network models, bioelectrical impedance analysis, traumatic brain injury, dysphagia, climate change, Rigid image registration, mosquito surveillance, QSAR, Pelvis, antispasmodic therapy, epidemic, Molecular biology, furunculosis, B7-H3, outpatient treatment, phenolic compounds, compartmentalization, neurodegenerative diseases, eye movement, tablet formulation, Fairlie decomposition, hemolysis, segment anything model (SAM), alpha, photosensitizer, β-lactam antibiotics, surface passivation, amputee, biosensor, MFSK, Parotid neoplasms, deep learning (DL), Kupffer cells, SQM® Iron, weight management, pain management, food safety, thermal recovery, dendrochronology, measurement/observer bias, controlled release, cerebral arterial flow, mitochondia, lipopolysaccharide, nitrogen transformation, nonsteroidal anti-inflammatory drugs, risk factors, rib-stiffened PVC foam sandwich structures, fetal growth, catastrophizing, viral hemorrhagic fever, total phenolic content, composite patch repair, Well-being, fowl adenovirus serotype 4, Social support, broiler chickens, double object construction, organic−inorganic hybrid polymers, NICE, iron-limited conditions, FAPI, finite element analysis, rhizosphere, films, gaze sequence, growth measurement, college students, Central venous port, EGOFETs, insulin response, abdominal pain, precipitation nowcasting, global health, Weizmannia coagulans BC99, polypharmacy, genomic diagnostics, radiopharmaceutical, fall, myopia diagnosis, pseudorabies virus, vasculature, contamination/cross-contamination bias, non-contact systems, SHAP, multiple probing strategy, high-concentration proteins, Broker mechanism, reinforcing and weakening phases, point-of-care diagnostics, neuroblastoma, Cell biology, clinical translation, in vivo cryotechnique, PECVD silicon dioxide, routine antenatal anti‐D prophylaxis, hiPSC-derived cortical culture, α-glucosidase, serotypes, high-density polyethylene, menopausal hormone therapy, foodborne pathogens, animal welfare, HDAC inhibitor, interface stress, antigen, traditional risk factors, Fc gamma receptor, Robotic arm, mass efficiency, body composition chart, body composition, safety assessment, urbanization, Lyme disease, observational study, climatic suitability, wounds on the body, tree growth, neuroimmunology, [18F]FDG PET/CT, Sebaceous glands, Gaussian regression, Metabolism, Cushing’s disease, optimization, Prevention, slaughterhouse, compounded formulations, road safety barrier, antibacterial, ecological momentary assessment, Bacillus-based probiotics, biochar, treatment-naïve, frequency-domain representation, single-photon avalanche diode (SPAD), symbiotic plasticity, Beiging, Electronic health records, rice, postoperative outcome, menopausal symptoms, functional gastrointestinal disorders, developability, monoclonal antibody, ELISA, forest inventory, data-driven control, diabetic foot, detection performance, loss of complexity, Light, tryptase, semaglutide, preoperative factors, nanoparticles, multimodal sarcasm detection, spring maize, probiotics, Algae, moving bed biofilm reactor, coral recruit, bladder cancer, aging, blood–brain barrier, ALD passivation, marine ecology, mucoadhesive properties, 3D printing, interface engineering, hospital anxiety and depression scale, DNA probes, single-event effect (SEE), transcranial direct current stimulations, multivariate analysis, wound healing, brain pathology, ulcerative colitis, reference values, diabetic cardiomyopathy, trajectory planning, micro-spectrometer, calcium homeostasis, multiscale entropy, HIV, Bacillus velezensis, viral particle, Adipose tissue, explainable AI, candidalysin, side effects, B-cell epitope, Veggie, adverse outcome prediction, near-domain screening, gettering, multi-scale modeling, exogenous amendments, carbohydrate, ear injuries, mosquito, metabolic syndrome, patients and service users, gastro-resistant, microbial functional genes, cardio-kidney-metabolic syndrome, health sciences, sensor error modeling, yields, pharmaceutics, tracking accuracy, co-infection, RNA, hydraulic injection molding machine, dexketoprofen trometamol, mitochondria, α-amylase, Nitrogen isotopes, anti‐D, climate-smart agriculture, angioedema control test, lead prioritization, cardiac arrest, gut–kidney axis, Differentially expressed genes, Multidisciplinary teams, English etymology, depressive symptoms, underutilised crops, transcription factors, Rev, GPS, Bayesian, fungal polysaccharides, phonotactics, nutritional epidemiology, Paramedic, Brassica napus L., energy absorption, Health sciences, spray drying, MD simulations, hybrid polymer–inorganic composites, Flavor biogenesis, computational imaging, non-linear dynamics, basic therapy, PsAAT3, discriminatory ELISA, Culex spp., ACOG, neonatal outcomes, ureasil, procrustes alignment, Aging, quality control, polygenic scores, satisfaction, Lipidomics, colicky abdominal pain, liver, nanofiber inserts, footwear, angiography, soil fertility, hepatology, patient satisfaction, neurogenic bladder, quantitative proteomics, phthalocyanine, Metabolomics, intestinal injury, non-ceruloplasmin-bound copper, Turnera diffusa, gut health, Longitudinal analysis, P100 wave, hereditary angioedema, differential pulse voltammetry, virus, intensive farming, calibration curve, extremophilic microorganisms, early multiple sclerosis, antibody detection, older adults, electrochemical biosensors, DIVA, L. fermentum, liver sinusoidal endothelial cells, Pediatric Sleep Questionnaire, pharmacology, blockchain sharding, AgPs, polymer-modified bitumen, lumbar infusion test, villus height, marine recirculating aquaculture system, bituminous binders, pangenome analysis, gut flora, contact photolithography, bi-directional association, particle size distribution, chronic gingivostomatitis, carotenoids, metabolism, anti-aging, miriti wood, EMAS, liver lesion, confounders, obesity subtypes, point-of-care test, Robotics, DNA probe, triplex PCR, viral pathogenesis, damping performance, microbial diversity, graduated non-convexity, depression, intranasal administration, volume resistivity, Environmental impact and cost, germanium, method of manipulation, clinical biomarker, immunochromatographic test, Population health, WGCNA, home monitoring, CD8 T cells, cultural heritage, clinical nutrition, cardiovascular risk, Biomarkers, intermittent fasting, FMD, preterm premature rupture of membranes (PPROM), sentiment-guided, Suberin, Post-stroke dementia, self-powered sensing, Breast lymphoma, metal homeostasis, metacognition, cell division, histology, wild animals health, artificial intelligence, one health, colonoscopy, anti‐Müllerian hormone, GNSS-denied navigation, mycorrhizosphere, swine, wavelength tuning, canine, microbiome stability, dry band, breast neoplasms/epidemiology, SU-8, phosphodiesterase-5 (PDE5), self-assembled monolayer, apoptosis, P300, manganese, periodontopathogens, amorphous solid dispersion, CAR T cells, skin adaptation, menopause, Mondrian conformal prediction, breast neoplasms/etiology, the tail rotor load, High-resolution ultrasound, mixed reality, yield prediction, screen-printed gold electrodes (SPAuEs), crypt depth, Novosibirsk region, holo-2bRAD, Listeria, Storm water, Bayesian learning, personalized medicine, Multilevel or hierarchical models, microbial community, plant-associated microbiome, pollution flashover, Breast ultrasound, functional prediction, refugees, sarcopenic obesity, diagnosis, remission, selective laser melting, alloimmunization, swirling flow, activity dosing, Interprofessional teams, pot life, cost-effective fabrication, menopausal transition, arid ecosystem adaptation, anaphylaxis, immunogenicity, glycemic response, species-specific targets, Sewage, controlled-release minerals, regulatory elements, detector multiplexing, CaMKII, dilute phase flow, longitudinal analysis, oxidative stress, Psychiatry and law, echocardiography, lysine clonixinate, recurrence quantification analysis, psychosis, male BALB/c mice, amorphization, pellets, radionuclide, encapsulated iron, risk factors in children, Goniopora sp., fourier transform infrared spectroscopy (FTIR), berberine, gallium-68, liquid vaccine, abiotic stress, food insecurity, Mastectomy, nitric oxide, functional stability, tail injuries, digital measurement, hysterectomy, whole-genome sequencing, Internal echo pattern, cyclodextrins, chatbot, BLV, trimer, amniotic fluid volume, quinua, heart failure, diagnostics, co-delivery, human cysticercosis, symbol error probability, imbalanced regression, sedimentation, Urethral hemangioma, gut microbiome, watermelon production, Newcastle disease virus, biostimulant, boron neutron capture therapy, self-emulsifying drug delivery systems, Sankey plot, fetal body volume, healthcare, genetic diversity of BLV, Social isolation, necropsies archival record, cancer risk factors, water scarcity, Chemotherapy, Long Short-Term Memory (LSTM), feline, posaconazole, signal processing, rubber, ADMET, fatty liver, infection-derived antibodies, dark current, learnability, antibody–drug conjugate, compound isolation, poultry microbiota, micro–nano structure, survey, Amblyomma mixtum, polymeric micelles, optical communication, crosscorrelation, color, meningitis, immune microenvironment, 3‑D-Mixed-Reality-Brillen, temporal dynamics, vulvovaginal candidiasis, drug hypersensitivity, ERPs, CRISPR, Density, probiotic properties, hologenome, forest vulnerability, magnetic resonance imaging, environmental stress, Epithelial–myoepithelial carcinoma, Vascular cognitive impairment, computational pharmacology, complement cascade, initialization observability, agromorphological characterization, zebrafish model, IoT–blockchain, arenavirus, vaginal vault prolapse, shot-to-shot learning, machine learning, nondestructive testing, skin regeneration, vulnerable populations, interferon-stimulated genes, Inflammatory cytokines, Candida albicans, measurement uncertainty, Campylobacter spp., center of pressure, multi-mode interferometer, soy flour replacement, inside-out tracking, Caregiver stress, Chinese yam, composite roofing tiles, rigid spatial alignment, microbial gene expression, consumer acceptance, pathogen proliferation, Cancer metabolism, cancer therapy, sandwich composites, underwater environment, raffia fiber, recombination analysis, polyphenols, shrinkage, guard ring, stem cell memory, publication bias, in situ hybridization, CysLT1 receptor antagonists, QSAR modeling (2D and 3D), uremic toxins, Deformable image registration, Hematospermia, carnosine, nerve regeneration, FRN, body fat mass, arbovirus testing, Motivation, Thulium fiber laser, organizational behavior, sugar, visual–inertial odometry, metabolome, onboard sensor time series, pharmacovigilance, cognitive insight, multifactorial disease, Secondary kidney neoplasms, BNCT, monitoring, machine learning models, circadian cortisol, feed additives, vesicular stomatitis virus, selection index, fMRI, solid tumor, therapeutics, natural fiber reinforcement, Single-nucleotide polymorphisms, multimodal fusion, single-cell transcriptomic, UHPLC-MS, YOLO, fatigue life, visual evoked potential, diabetes, forestry, automated synthesis, cancer, West Nile virus, analytical approach, phase-contrast MRI, flavonoids, particle properties, Space Crop Production, introspective accuracy, proxy-triggered warning, flexible substrates, Roboterarm, silver conductive adhesive, 16S rRNA, Robotik, latency, Psychological distress, technology computer-aided design (TCAD), stabilizer, reporter assay, antiviral, predictive modeling, molecular diagnostics, theranostics, craniospinal compliance, crack–notch interaction, sliding graft copolymer, chronic kidney disease, fluorescence parameters, Breast biopsy, dietary phosphorus, PARP1, neuroprotection, Desalination, postural sway, nanomaterial, avian influenza, Lignin, bovine leukemia virus, silicon, Hydrophobic coating, hydrophobicity, latent neurotoxicity, serum proteomics, Betulin, heterogeneity, SPAD, brain-targeted drug delivery, salivary biomarkers, gender differences, pre-formulation prediction, complement and coagulation cascades, dynamic simulation, total flavonoid content, antenatal care, green Brazilian propolis, microbial succession, Transcriptome, Time-restricted feeding, legumes, villus length, infrared imaging, transcriptome, Fast Orthogonal Search (FOS), injectability, valvular heart disease, phytotherapy, stroke, Taenia solium, nested cross-validation, selection bias, Fermented fish, peripheral nervous system, carpometacarpal joint, reporting bias, Nanoliposomes, and Shockley–Read–Hall
License Label:: Attribution 4.0 International
ORCID:: https://orcid.org/0009-0004-6666-4472, , and https://orcid.org/0000-0003-0938-8841
Other Affiliation:: Department of Biology and Marine Biology, Center for Marine Science, University of North Carolina Wilmington, Wilmington, NC, , and Department of Mathematics and Statistics, University of North Carolina Wilmington, Wilmington, NC
Person:: Van Horn, Meg, Zhao, Richard S., Fogarty, Nicole D., and Chen, Cuixian
Publisher:: Multidisciplinary Digital Publishing Institute (MDPI)
Rights Statement Label:: In Copyright

28. Determinants of Cochlear Implant Evaluation Completion and Uptake in Children

Title Tesim:: Determinants of Cochlear Implant Evaluation Completion and Uptake in Children
Creator:: Sapp, Caitlin, Culbertson, Shannon R., Woodard, Jennifer S., Turner, Dahvae, Dillon, Margaret T., Park, Lisa R., and Richter, Margaret E.
Date of publication:: 2026
Abstract Tesim:: Background/Objectives: Approximately half of US children who meet traditional cochlear implant (CI) candidacy criteria receive an implant. As candidacy expands to include a broader range of hearing configurations, identifying factors that influence referral completion and CI uptake is increasingly important. This study examined the predictors of CI evaluation completion and surgery among children referred for CI assessment, including both traditional and non-traditional candidates. Methods: The medical records of pediatric patients referred for an initial CI evaluation from 2018 through 2024 were reviewed. Referral outcomes were categorized as evaluation not completed, candidate who declined surgery, or candidate who proceeded with surgery. Two binomial logistic regression models assessed the demographic, audiologic, and contextual predictors of CI evaluation completion and CI uptake, including age at referral, candidate type, insurance, referral year, communication mode, race/ethnicity, unaided thresholds, rurality, and county-level social health determinants. Results: The completion of the CI evaluation was significantly influenced by race/ethnicity, candidate type, referral year, and age. Mixed-race children demonstrated higher completion rates than White children. Completion was lower among children with single-sided deafness (SSD), children referred in 2022, and older children. Among children determined to be candidates, 69% proceeded with surgery. CI uptake showed similar patterns, with lower rates among Hispanic children, children with residual hearing or SSD, children referred in 2022, and older children. Conclusions: CI uptake at this center exceeded national averages but was associated with race/ethnicity, candidate type, age, and year of referral. Targeted counseling and outreach may improve timely referral and informed decision-making.
Resource type:: Article
Affiliation Label Tesim:: School of Medicine and Department of Otolaryngology/Head and Neck Surgery
Type:: http://purl.org/dc/dcmitype/Text
DOI:: https://doi.org/10.17615/8ap8-0a22
Edition:: Publisher
Identifier:: PMCID: PMC13072993, DOI: https://dx.doi.org/10.3390/jcm15072731, and PMID: 41977033
ISSN:: 2077-0383
Journal Issue:: 7
Journal Title:: Journal of Clinical Medicine
Journal Volume:: 15
Keyword:: safflower, lymph node metastasis, MSA, zebrafish, flurbiprofen, medlar (Mespilus germanica L.) fruit, titanium alloys, functional ingredients, school feeding, #ENZIAN classification, chest pain, isofuranodiene, proteomics, Comet assay, red mud, bamboo, arterial stiffness, dynamic convolution, fatigue characteristic, giant hiatal hernia, intracranial atherosclerosis, maternal vascular malperfusion, disease perception outcomes, TiO2, penetrating disease, RPL40, Schiff base crosslinking, soil amendments, chromatin remodeling, organ specification, response surface methodology, agricultural robots, rotator cuff, NAS1, photodynamic therapy, pH conditioning, dual drug-eluting suture, sulfated peptides, 1H NMR, tumor board, multi-objective evolutionary algorithm, fiber reinforcement, echocardiographic gradient, net section failure criterion, methanol content, cricothyrotomy, explantation, tribological properties, referral, enzyme inhibition, multiple myeloma, environmental exposure, Kolmogorov–Arnold network, NMR spectroscopy, Europe, hydroponics, cancer drug discovery, nicotinamide riboside, signaling pathways, lithium dendrites, clinicopathological features, hydrogels, LDA, lung transplantation, TLR4, ADCs, raspberry (Rubus idaeus L.), MRONJ, papillary thyroid carcinoma, thermal stability, cetuximab, dog, heavy load, NAD metabolism, surgical suture, glucose, diet, myopia, liver cancer, grain size, stemness, Hemangioma, pore water pressure, IL-23/IL-17 axis, photosensitizer, sleep hygiene, ultrasound-assisted extraction, fog computing, atezolizumab, uptake, NR2F1, fused deposition modeling, fenvalerate, mechanical property, acceleration, hemostasis, high throughput cell phenotyping, robustness in high-noise environments, Moringa oleifera, ALDH2, sleep quality, divalent metal transporter 1 (DMT1), thyroid hormone, UPLC-Q-TOF-MS/MS, percutaneous drainage, multivariate analysis, WSN, trace elements, ultrastructure, solid waste, Eurotium cristatum, meat product, Helichrysum italicum, SHI/STY family, labyrinth emitter, conservation, AZO, erectile dysfunction, liquefaction, meta-analysis, ionic and osmotic adjustment, new approach methodologies (NAMs), Pinus massoniana, topographic correction, antibiotic, hydroxyl number, safety, human-centric oncology, hybrid vigor, CNN, CRISPR/Cas13, calcium–magnesium ratio, zinc, goat whey, neonatal encephalopathy, micro-CT, protein carbonylation, sensor-based monitoring, resin composite, kratom, S-equol, electrospun nanofibers, nanotechnology, organ-on-a-chip, microglia, ginsenoside Rd, Herschel–Bulkley rheology, biorefinery, hydrolysate, hollow microspheres, T cells, whey beverages, zoo, artificial intelligence, foamed lightweight soil, crispy tilapia, TNF-α, PEG, transvalvular gradient, boundary formation, wound dressing, systemic immune-inflammation index, genetics, environmental remediation, incremental technique, adaptive activation functions, neurooncology, neurodegenerative diseases, ethylene, tryptophan, severe asthma, waterborne polyurethane, Penicillium janthinellum, Petasites japonicus, LINC00702, PIK3CA mutation, topical therapy, KP1019, sarcopenia, risk assessment, fluid-bed granulation, cutaneous T-cell lymphoma, cell fate determination, mechanical properties, long-life judgment, Warner–Bratzler shear force, prognostic stratification, food allergy, BPS, candidacy, monocytes, apoptosis, CSF biomarkers, Eph receptor, swelling capacity, anticancer ruthenium complex, psoriasis, food contaminant, rheological properties, C-reactive protein, airway management, feature reduction, nutraceutical, cinnamon essential oil, cancer surgery, thyroid cancer, antioxidants, dissemination, concentrated sulfuric acid, TALAM1, deep eutectic solvents, alkali-activated geopolymers, anisotropy, acute severe ulcerative colitis, nutrient antagonism, microstructure, xenograft model, NF-κB pathway, unconfined compressive strength, sentinel lymph nodes, lung cancer unit, soil type, orf182, multimodal prediction, paraesophageal hernia repair, soy sauce, load carriage, SRS, hepatotoxicity, ribosomal biogenesis, health care access, biological activities, drug repurposing, perturbation model, calcitonin, deep score-based diffusion model, geoepidemiology, Huntington’s disease, overall survival, multi-scale CNN, Laves phase, surfactants and nanoparticles, taproot development, Italian multicenter study, VSMC phenotypic switching, SNVs, digital twin, hematopoiesis, Docking, Gnaphalium affine D. Don, refractory, suture material, mortality, phylogenetic analysis, micro- and nanoplastics, epigenetic landscape, immunosuppression, infliximab, robotic, thermal analysis, electrochemical activity, hybrid-dimensional coupling strategy, odontogenic infection, facial deformation, endovascular treatment, biopolymers, drought, electrochemical corrosion, phytochemicals, therapy, pyrethroid, diagnostic yield, hyperglycemia, bioaccumulation, transcriptome, transcriptome sequencing, ventilatory thresholds, jujube wine, BDNF, carbon yarn, waterproof and breathable membrane, FAD-linked oxidoreductase protein, oil synthesis, endometriosis, tinea incognito, antioxidant, adaptive Kalman Filter, non-traditional, glioblastoma, hydrate nucleation kinetics, colitis, prognosis, lncRNAs, gluten-free bread, molecular docking, systemic gene expression, tumour-associated inflammation, chitosan–genipin, white mulberry, WGS, muscle strength index, environmental enrichment, ultrasound, cytomegalovirus, uterine malignancy, Ruscus aculeatus L., type I glandular trichomes, medullary thyroid carcinoma, flax, adversarial attacks, nanotoxicology, non-coding RNAs, sentinel lymph node biopsy, lily bulbs, near-infrared spectroscopy, angiogenic biomarkers, CAVI, TAS2R43, single-cell protein, SH-SY5Y, actomyosin contractility, bronchial thermoplasty, signage, secretion process, stiffened panels, minimal erythema dose, antioxidant activity, ANK2–MAVS–IL-8 axis, processing and extraction, traditional, pregnancy, colon, infrared emissivity, hepatoprotection, molecular oncology, cold plasma, thoracotomy, regional anesthesia, auxin response factors (ARFs), rapid access clinic, tenocytes, neohesperidin dihydrochalcone-L-arginine complex, gripping motion, sod-1 gene expression, NF-κB signaling, shellac, miR-92a, jaw cyst, implant, WES, Breslow thickness, fetal growth restriction, smoothing, elevated blood pressure, vulnerable plaque, abiotic stress, binary classification, placental vascular malperfusion, multivariate regression analysis, ECG denoising, pelvic pain, intravenous steroid therapy, Takayasu arteritis, clipping, SVM, virtual reality, tactical populations, bread wheat, narrow passage, transcription factor, UChB rats, random vibration, rectum, liquid biopsy, ncRNA, adjuvant therapy, Olive Quick Decline Syndrome, RNF213 variant, femoral anteversion, antimicrobial peptides (AMPs), FTIR, composition optimization, cytokines, apple, oncologic risk stratification, diagnostic delay, generative adversarial network, hardware acceleration, thrombotic thrombocytopenic purpura, acetabulum, insomnia, solid sodium silicate, ferroptosis, solid-state fermentation, (TiB2 + TiC)/Al composites, NLRP3 inflammasome, tannic acid, PAI-1, risk factors, pathophysiological mechanisms, CADES, immune microenvironment, structural connectome, bioactivity, sesquiterpenes, total hip arthroplasty, amino acid profile, ozone, dynamic stress, Cellina di Nardò (Olea europaea L., Oleaceae), genome assembly, PPARGC1A, pomalidomide, Cedrus atlantica, surgery, flowering, milk yield, lipidomics, global health, iron chelation, N-acetylcysteine, endothelial cells, QRISK3, vacuum ageing, internal void, lipid vesicles, instance segmentation, date palm, spatial multi-omics, femoral rotation angle, insoluble dietary fibers, irregular particle morphology, tapioca starch, functionalized suture, tensile strength, giraffe, postoperative infection, DySnakeConv, biomarkers, lung cancer surgery, prognostic biomarkers, countermovement jump, phytohormone, combination therapy, drug-eluting suture, road cycling, DISHAA, uterine sarcoma, gene regulation, tooth extraction, metabolomics, VPg, drug discovery, cyber-physical security, bio-polyols, α-linolenic acid, mechanism degradation, azatides, usual endocervical adenocarcinoma, cisplatin resistance, bacterial load, structural variation, molecular modelling, drug response, IEC 61373 standard, yeast-shell microcapsules, conductive composites, fast track clinic, generative AI, pH, rASRM classification, corrosion, carrot, lightweight architecture, OsWRKY53, tissue expander, hub genes, soy, kombucha, non-transferrin bound iron (NTBI), bias, CRP-to-albumin ratio, optimization study, dysbiosis, prediction, alcohol, comment, deep learning, public policy, vascular homeostasis, resistance, functional food ingredients, solid tumours, self-healing, micro/nano-scale, separator modification, metastatic breast cancer, physics informed neural networks, tumor microenvironment, germplasm resources, lupin, imiquimod, date fruit by-products, seasonality, resource management, stimuli-responsive dressings, lunar regolith, fresh-cut potatoes, UAV, fulvestrant, endothelial dysfunction, rice (Oryza sativa L.), EGFR, viscosity, ELISA, ELSD-LCMS, pharmacological cardioversion, whey fermentation, macro–mesoscopic strength correlation model, beetroot, melanoma, multivariate statistical analysis, albumin, Smyrnium olusatrum L., drying methods, nutritional compositions, network toxicology, lithium and strontium, membrane processes, Crohn’s disease, non-conforming discretization, precision agriculture, macro- and trace elements, angiogenesis, SHAP, lung transplantation outcomes, process parameter optimization, refrigerated quality, pembrolizumab, directional solidification, battle damage, solvent-based extraction techniques, exosomes, nerve-gut interactions, impact energy, ADAMTS13, rumination time, klotho, Triptophenolide, fundoplication, wire and arc additive manufacturing, yield stress, headache-related disability, inflammatory marker, colorectal carcinoma, CI, maize–soybean rotation, breast implant, fatty acids, acidosis, hydraulic pressure, rhizosphere, asphalt pavement, mixture design, multi-sensor fusion, aluminum alloy, motor neurons, cochlear implant, antimicrobial activity, thermal degradation, polysaccharide carriers for anticancer drugs, wearable devices, UBQ gene family, high-resolution computed tomography, durum wheat, wild rice, flexion–relaxation phenomenon, canopy texture, PIK3CA-mutant CRC, deaf, hemp flour, Saccharomyces cerevisiae, PC-12 cells, solvothermal method, bread, FT-IR spectroscopy, polyethylene terephthalate microplastics, Alda-1, reaction pathway engineering, peptidomimetics, microstructure refinement, Mott–Schottky, anisotropic gradient tensor, cell segregation, perioperative inflammation, egg, food safety, extended Kalman filter, metal–support interactions, immune checkpoint inhibitor, multiaxial, neurovascular unit (NVU), signet-ring cell, normal tension glaucoma, growth-defense tradeoffs, furcellaran, inflammation, coordinated care, enzymatic treatment, bioconjugate, breast neoplasms, cucumber, regioselective biotransformation, long-term physical activity, episodic migraine, anticancer agents, astaxanthin, enzyme-induced carbonate precipitation, high-value products, foundation model, breast cancer, ozone in saline solution, glycidol, additive manufacturing, Ti2AlC, neurofilament light chain, fish maw, testicular seminoma, photosynthesis, chemical compositions, high-content microscopy, PI3K-AKT signaling pathway, thermoplastic starch, nanoparticles, bitter taste receptors, implant-based breast reconstruction, oxidative stress, cement concrete pavement, indoor-outdoor navigation, biocompatibility, COVID-19, HRAS mutation, mineral composition, improved YOLOv8, traditional applications, derivatization, transcriptional regulation, maturity classification, permeation property, infection control, optimal stem anteversion, skeletal muscle mass, family farming, real-world data, hypertension, epigenetic regulation, iron metabolism, chemometrics, antioxidant defense system, foliar metabolome, soil–plant transfer, IL-6, HPLC-MS/MS, imidazoline I2 receptor ligands, copy number variations, targeted therapies, public health, cell ultrastructure, type II endoleak, arsenic, alternatives to antibiotics, HIV-1, YOLOv11n, cancer stem cells, B cells, phenolic compounds, relapse, difficult airway, personalized medicine, turnaround time, autonomous guided vehicle (AGV), heavy metal, precision oncology, ultrasonic evaluation, moonlight proteins, Fukui functions, recycled fine aggregate, CO2 hydrate slurry, esophageal sphincter, sustainability, ulcerative colitis, fatigue assessment, antigenotoxicity, pH-responsive release, physical unclonable function, anterior iliac approach, dexamethasone, haptic feedback, drug resistance, ibuprofen, perturbation, titanium dioxide, volatile metabolites, patient-derived organoids, nutritional components, mitragynine, advanced AI, end-stage renal disease, fermented chickpea flour, image analysis, child, compressive strength, progressive supranuclear palsy, PC-ABS, ecological adaptation, taste signalling, proliferation, oxidative DNA damage, pomace, dynamic penile Doppler ultrasound, Caenorhabditis elegans, oat (Avena sativa L.), neuroprotection, cognitive dysfunction, invasive gradient, neohesperidin dihydrochalcone, particle gradation, WGCNA, Cavutilide, gastric-type endocervical adenocarcinoma, shear strength, reactive oxygen species, the cascaded group attention mechanism, array-CGH, Potyviridae, HALP score, ear filling, defect detection, delayed diagnosis, supercritical CO2, vitamin C, breed-specific regulatory elements, metabolic reprogramming, animal welfare, genipin, laser shock peening, Cistus incanus L., Oryza rufipogon, therapeutic strategies, polydimethylsiloxane, pulmonary embolism, medico-legal assessment, lymphoid development, education, HPLC, human–infrastructure interaction, essential oil, confocal microscopy, residual strength evaluation, inflorescence development, 1H-NMR, QSAR, neurodegeneration, vacuum-microwave drying, eating time, consumer acceptance, meat colour, pancreatic dysfunction, tea plantation, vascular inflammation, intraluminal thrombus, ANOVA, atrial flutter, chromosomal abnormalities, peach landrace, AI-driven diagnostics, leaf area index, patient-reported outcomes, pine wilt disease, compression osteosynthesis, polyphenolic compounds, review, keratinocyte proliferation, cerebral atrophy, 2D materials, fused quinolines, metal transport, vascular lesion, roadside infrastructure, SMOX, GWAS, titanium dioxide photocatalyst, gastropexy, hemodialysis, CNVs, powder metallurgy, molecular profiling, abdominal abscess, precision medicine, non-small cell lung cancer, CSU, inhibition zone test, molten salt synthesis, subarachnoid hemorrhage, ultraviolet radiation, episodic cluster headache, carbohydrate content, anesthetic technique, low geostatic stress, biomarker, purinergic signaling, multiple system atrophy, reaction mechanism, faba beans, graph-theoretical analysis, gut–liver axis, magnetron sputtering, hemophagocytic lymphohistiocytosis, high-purity powders, motility disorders, chia flour, infective endocarditis, multidisciplinary team, gut microbiota, dysplasia, ephrin ligands, lung cancer, Ht513 aggregates, permeation duration, immunotherapy resistance, amyloid-β, polyelectrolytes, adenosine deaminase, Aβ aggregation, rheumatoid arthritis, CMS, interfacial structuring, vehicle-mounted equipment, regeneration, TGFB1, whey valorization, immunosuppressive therapy, chlorophyll fluorescence, transcription factors, thermal properties, water use efficiency, airborne gravity data, red lentil flour, post mortem ageing, environmental resistome, non-linear models, neurodevelopmental disorder, additives, fracture width estimation, salinity, Doppler velocimetry, single-sided deafness, alternative therapies, JAK–STAT signaling, fermentation conditions, daytime sleepiness, PTTG1, antiresorptive therapy, RNA therapeutics, acetylcholinesterase, mesh, hearing loss, vascular surgery, plant growth-promoting rhizobacteria, neuroblastoma, Alnus glutinosa (L.) Gaertn., colorectal cancer, sulfur fumigation, SEM, cardiovascular risk, depression, panitumumab, immunometabolism, liver, artificial intelligence (AI), disinfectant resistance, encapsulation of 5-Fluorouracil, Alzheimer’s disease, surgical site infection, CD39/CD73 ectonucleotidases, greenhouse agriculture, immune checkpoint inhibitors, sickle cell disease, metabolite component, good agricultural practices, Angelica dahurica, stillbirth, blood collection tourniquets, leaf economic spectrum, machine learning, blood–brain barrier, gut–brain axis, chitosan–vanillin oleogels, neuronal morphogenesis, TAVI procedure, lithium metal batteries, transferrin (Tf), antiferroelectric, sensory evaluation, nuclear lamins, type VI secretion system (T6SS), mechanotransduction, genomic instability, FAERS, drip irrigation, solid–liquid interface, buckwheat flour, drug release system, pain assessment, surface electromyography, methicillin-resistant Staphylococcus aureus (MASA), fish quality, oncology, sustainable food systems, thyroid gland, Bi-LSTM, chronic inflammation, industrial solid wastes, amino acids, anaerobic digestion, game meat, vitamin D, lipid oxidation, current sensor, kidney transplantation, C. elegans models, photocatalysis, alpelisib, authentication, mechanical alloying, vascular access, drought tolerance, nomogram, nutrient solution volume, shunt, extracellular matrix, heavy metal stress, temozolomide, leukocyte adhesion, transfer factors, plaque psoriasis, p-Dimethylaminophenol, liver metastases, homeobox, gastrostomy, GC-MS, Ti–6Al–4V, polyphenols, esophageal motility disorder, targeted therapy, tensile fracture tests, immune profile, personalized treatment, inflammatory, toxicity prediction, mitochondrial stress, cyclophosphamide, laparoscopy, steroid response, tyrosylprotein sulfotransferase (TPST), leiomyoma, JAK/STAT signaling pathway, peritoneum, antibiotic resistance, surgical stress response, children, type I collagen, flexural strength, interstitial lung disease, chlorhexidine, bioactive compounds, sheep whey, sheep, orthopedics, eIF4E, molecular dynamics, vasospasm, Anisakis, case–control study, myeloperoxidase, atrial fibrillation, apigenin, 13C NMR, hematopoietic stem cell, CUMT-1 lunar regolith simulant, seedling-stage weed detection, avian pathogenic Escherichia coli (APEC), VATS, theranostic therapy, lumbar neuromuscular control, ECOSAR, mechanosensation, object optimization, small and medium-sized dairy companies, multi-crop learning, protein quality, poly-(α-aza-amino acids), environmental exposome, mixed-effects modeling, immuno-oncology, ductile damage, COX-2, polyvinyl alcohol fibers, heterogeneity, morcellation risk, cold thermal energy storage (CTES), overweight/obesity, fetal vascular malperfusion, large thickness flexible base layer, exposure–response, preservation, thrombin generation, strain energy density, volatilome, antitumor effect, melatonin, ubiquitin-like protein, quality of care, radiation cooling, lower-dimensional crack, high anterior column fracture, vegetable by-products, light interception, bulk-fill resin composite, Internet of Drones, soil pollution, phenylpropanoid metabolism, bursa-derived cells, hormonal priming, photosynthetically active radiation, path planning, Raman spectroscopy, fruit ripeness, rural health, tenderness, robotics, photobiomodulation therapy, acute coronary syndrome, fungal enzyme cocktails, intelligent transportation systems, core–shell structure, inflammatory biomarker, early-onset colorectal cancer, malignant tumors, pediatric, exosome, perioperative oncology, fluorescence imaging, transcriptomics, waste valorization, mean weight 100 grains, protein content, medicinal plants, calcium carbonate precipitation, POCUS, multicenter analysis, physiological sensing, adsorbent pretreatment, dual-tracer imaging, and DNA damage response
License Label:: Attribution 4.0 International
ORCID:: and https://orcid.org/0000-0001-9804-2425
Other Affiliation:: Department of Audiology, UNC Health, Chapel Hill, NC and
Person:: Sapp, Caitlin, Culbertson, Shannon R., Woodard, Jennifer S., Turner, Dahvae, Dillon, Margaret T., Park, Lisa R., and Richter, Margaret E.
Publisher:: Multidisciplinary Digital Publishing Institute (MDPI)
Rights Statement Label:: In Copyright

29. Effectiveness of Adjunctive Measures to Limit Recurrence and Reoperation After Laparoscopic Repair of Large Paraesophageal Hernias: A Single-Institution Series

Title Tesim:: Effectiveness of Adjunctive Measures to Limit Recurrence and Reoperation After Laparoscopic Repair of Large Paraesophageal Hernias: A Single-Institution Series
Creator:: Kessel, Julia, Higgins, Madeleine, Agala, Chris B., Hsu, Justin, Varvoglis, Dimitrios N., Hodges, Maggie M., Cook, Lauren M., Feeney, Timothy, and Farrell, Timothy M.
Date of publication:: 2026
Abstract Tesim:: Background: Despite surgical repair, large paraesophageal hernias (PEHs) often recur. To minimize recurrence, adjunctive measures, such as mesh and gastropexy, have been explored, but their impact on recurrence and reoperation rates remains unclear. Therefore, we analyzed our single-institution case series, where absorbable hiatal overlay mesh and percutaneous endoscopic gastrostomy (PEG) placement were utilized systematically. Methods: Patients undergoing laparoscopic large PEH repair by a single surgeon between 1 January 2006 and 31 May 2021 were identified. Demographic data, hernia size, number of hiatal sutures used, use of mesh and/or PEG, fundoplication type, and complications were extracted by retrospective chart review. Hernia recurrence was assessed though postoperative radiographic and endoscopic studies or need for reoperation. Fisher’s exact, chi-square, Mood’s two-median and t-tests were used for between-group comparisons. Generalized linear models were used to assess associations between mesh and PEG placement and number of hiatal sutures and to compare risk differences for recurrence between treatment types (partial versus complete fundoplication; mesh versus no mesh; and PEG versus no PEG). Kaplan–Meier estimator with log-rank test was used to assess time to recurrence. Results: Overall, 413 patients (median age 66 years) underwent laparoscopic large PEH repair and fundoplication (51% partial and 49% complete fundoplications). Of these, 78% had overlay absorbable mesh and 51% had a PEG. With an average follow-up time of over 5 years, we found 19.9% had radiographic or endoscopic recurrence. Although cohort stratification based on mesh implementation and fundoplication type did not identify differences in recurrence rates, significantly lower recurrence rates were noted in patients with PEG compared to no-PEG (14.8% vs. 23.5%, p = 0.01). Notably, of five reoperations, all were in complete fundoplication patients, and one occurred in a patient with PEG placement at the index operation. Conclusions: PEG placement during laparoscopic PEH repair may lead to fewer recurrences in high-risk patients. Future prospective studies are warranted.
Resource type:: Article
Affiliation Label Tesim:: School of Medicine, Department of Surgery, Gillings School of Global Public Health, and Department of Epidemiology
Type:: http://purl.org/dc/dcmitype/Text
DOI:: https://doi.org/10.17615/03z3-g860
Edition:: Publisher
Identifier:: DOI: https://dx.doi.org/10.3390/jcm15072741, PMID: 41977042, and PMCID: PMC13072718
ISSN:: 2077-0383
Journal Issue:: 7
Journal Title:: Journal of Clinical Medicine
Journal Volume:: 15
Keyword:: inflammatory biomarker, rhizosphere, date palm, multivariate statistical analysis, tinea incognito, breed-specific regulatory elements, fused quinolines, transcriptional regulation, nanoparticles, SNVs, ozone, melanoma, lipid vesicles, mixture design, heavy metal, lymph node metastasis, UAV, permeation duration, thermal analysis, bioaccumulation, ANOVA, phytohormone, bio-polyols, protein content, GWAS, hybrid vigor, metabolic reprogramming, biorefinery, chlorhexidine, adsorbent pretreatment, improved YOLOv8, hydrogels, refrigerated quality, fish maw, single-cell protein, tooth extraction, electrochemical corrosion, random vibration, chemometrics, intracranial atherosclerosis, digital twin, Kolmogorov–Arnold network, POCUS, greenhouse agriculture, yeast-shell microcapsules, molecular modelling, object optimization, lightweight architecture, paraesophageal hernia repair, TAVI procedure, biomarkers, micro-CT, NMR spectroscopy, overweight/obesity, keratinocyte proliferation, surfactants and nanoparticles, inflammatory marker, Internet of Drones, heterogeneity, leaf area index, cell fate determination, structural variation, robotic, waterproof and breathable membrane, hydrate nucleation kinetics, peach landrace, electrospun nanofibers, reaction mechanism, industrial solid wastes, interstitial lung disease, exosome, liver metastases, grain size, ductile damage, milk yield, dysbiosis, copy number variations, microstructure, type VI secretion system (T6SS), sustainability, fetal vascular malperfusion, Cedrus atlantica, multiaxial, vitamin C, generative adversarial network, intelligent transportation systems, soil–plant transfer, white mulberry, salinity, secretion process, antioxidant activity, neurodegenerative diseases, nanotoxicology, image analysis, stiffened panels, erectile dysfunction, fused deposition modeling, ionic and osmotic adjustment, hub genes, ECOSAR, fenvalerate, neurovascular unit (NVU), medico-legal assessment, Herschel–Bulkley rheology, percutaneous drainage, self-healing, process parameter optimization, flurbiprofen, mortality, volatile metabolites, water use efficiency, composition optimization, thermoplastic starch, 1H-NMR, flexion–relaxation phenomenon, drug repurposing, labyrinth emitter, alternative therapies, isofuranodiene, new approach methodologies (NAMs), soy sauce, drug discovery, surgical site infection, phenylpropanoid metabolism, WES, multi-objective evolutionary algorithm, epigenetic landscape, single-sided deafness, thermal properties, pregnancy, peritoneum, neonatal encephalopathy, polyvinyl alcohol fibers, ANK2–MAVS–IL-8 axis, exosomes, refractory, oil synthesis, T cells, polyphenolic compounds, comment, arsenic, antimicrobial activity, large thickness flexible base layer, CNN, hardware acceleration, Doppler velocimetry, relapse, facial deformation, titanium alloys, OsWRKY53, antibiotic resistance, rumination time, sheep whey, UBQ gene family, multimodal prediction, Takayasu arteritis, microglia, molecular dynamics, cell segregation, skeletal muscle mass, Huntington’s disease, gripping motion, immunosuppression, corrosion, lung cancer surgery, apoptosis, referral, thyroid gland, drought, CNVs, graph-theoretical analysis, motility disorders, elevated blood pressure, α-linolenic acid, lipid oxidation, genetics, patient-derived organoids, ultrasound-assisted extraction, FT-IR spectroscopy, fruit ripeness, metabolomics, NAD metabolism, WGCNA, Raman spectroscopy, adaptive Kalman Filter, immune checkpoint inhibitor, functional food ingredients, melatonin, TALAM1, additives, heavy load, TLR4, enzyme inhibition, cricothyrotomy, HPLC, ultraviolet radiation, polysaccharide carriers for anticancer drugs, breast implant, light interception, small and medium-sized dairy companies, titanium dioxide photocatalyst, atrial fibrillation, topographic correction, transcription factors, lithium metal batteries, transferrin (Tf), orthopedics, load carriage, medullary thyroid carcinoma, #ENZIAN classification, progressive supranuclear palsy, atezolizumab, dual-tracer imaging, Cellina di Nardò (Olea europaea L., Oleaceae), albumin, nomogram, SHAP, breast neoplasms, viscosity, bitter taste receptors, diagnostic delay, drying methods, micro/nano-scale, tenderness, whey fermentation, NF-κB signaling, anisotropic gradient tensor, core–shell structure, near-infrared spectroscopy, PI3K-AKT signaling pathway, polyethylene terephthalate microplastics, targeted therapy, iron chelation, multi-scale CNN, monocytes, Ti–6Al–4V, yield stress, swelling capacity, VPg, early-onset colorectal cancer, avian pathogenic Escherichia coli (APEC), methanol content, unconfined compressive strength, multiple myeloma, clinicopathological features, eIF4E, case–control study, giraffe, review, clipping, gut–brain axis, trace elements, maternal vascular malperfusion, photosynthesis, traditional applications, wire and arc additive manufacturing, blood collection tourniquets, YOLOv11n, encapsulation of 5-Fluorouracil, CD39/CD73 ectonucleotidases, alternatives to antibiotics, cerebral atrophy, bamboo, generative AI, patient-reported outcomes, Triptophenolide, sulfated peptides, solid–liquid interface, Eph receptor, vitamin D, transcriptome sequencing, cancer drug discovery, vascular homeostasis, anticancer ruthenium complex, echocardiographic gradient, magnetron sputtering, Hemangioma, B cells, fatigue characteristic, PIK3CA mutation, imiquimod, bioconjugate, high-value products, apple, food allergy, quality of care, ephrin ligands, colitis, FTIR, mechanotransduction, acidosis, hydroponics, transcriptomics, PC-12 cells, sesquiterpenes, seedling-stage weed detection, Aβ aggregation, laparoscopy, fluorescence imaging, topical therapy, macro–mesoscopic strength correlation model, radiation cooling, type I glandular trichomes, narrow passage, antimicrobial peptides (AMPs), turnaround time, gut–liver axis, array-CGH, Ht513 aggregates, path planning, drug resistance, growth-defense tradeoffs, therapy, membrane processes, airway management, amino acid profile, Moringa oleifera, egg, xenograft model, AZO, vegetable by-products, long-term physical activity, lymphoid development, type I collagen, cytomegalovirus, seasonality, leukocyte adhesion, biological activities, TiO2, regional anesthesia, disinfectant resistance, multidisciplinary team, pine wilt disease, Helichrysum italicum, implant, Alda-1, sulfur fumigation, chia flour, concentrated sulfuric acid, regioselective biotransformation, cognitive dysfunction, neohesperidin dihydrochalcone, child, photodynamic therapy, sickle cell disease, consumer acceptance, HALP score, mesh, tea plantation, functionalized suture, thoracotomy, mitragynine, total hip arthroplasty, Italian multicenter study, adversarial attacks, rapid access clinic, deep eutectic solvents, real-world data, vascular access, hepatoprotection, school feeding, RPL40, physiological sensing, rheumatoid arthritis, lupin, hepatotoxicity, rice (Oryza sativa L.), residual strength evaluation, plant growth-promoting rhizobacteria, tryptophan, motor neurons, vasospasm, pancreatic dysfunction, dissemination, candidacy, PTTG1, anesthetic technique, lumbar neuromuscular control, disease perception outcomes, anisotropy, durum wheat, endovascular treatment, ethylene, genipin, calcitonin, stillbirth, nerve-gut interactions, maturity classification, QSAR, mixed-effects modeling, recycled fine aggregate, molecular profiling, hemp flour, CUMT-1 lunar regolith simulant, nuclear lamins, non-conforming discretization, canopy texture, transvalvular gradient, NR2F1, polyelectrolytes, wearable devices, vascular inflammation, moonlight proteins, cancer surgery, cement concrete pavement, faba beans, genomic instability, IL-6, surgical suture, subarachnoid hemorrhage, BPS, Mott–Schottky, anaerobic digestion, proteomics, FAD-linked oxidoreductase protein, non-linear models, signet-ring cell, 13C NMR, supercritical CO2, extended Kalman filter, perioperative inflammation, adjuvant therapy, solid-state fermentation, C. elegans models, ulcerative colitis, date fruit by-products, COX-2, battle damage, resource management, biomarker, cutaneous T-cell lymphoma, pore water pressure, ear filling, traditional, angiogenesis, cetuximab, conservation, cinnamon essential oil, neuroblastoma, drip irrigation, uptake, pathophysiological mechanisms, immunosuppressive therapy, robotics, TAS2R43, dynamic penile Doppler ultrasound, proliferation, cucumber, flax, Cavutilide, DNA damage response, DySnakeConv, compressive strength, tapioca starch, the cascaded group attention mechanism, polydimethylsiloxane, laser shock peening, perturbation model, miR-92a, enzymatic treatment, SH-SY5Y, nicotinamide riboside, meat product, epigenetic regulation, chemical compositions, chitosan–vanillin oleogels, immune profile, esophageal motility disorder, panitumumab, insoluble dietary fibers, SEM, thrombin generation, infection control, bacterial load, penetrating disease, feature reduction, fetal growth restriction, Europe, exposure–response, non-transferrin bound iron (NTBI), soil amendments, additive manufacturing, SMOX, drug-eluting suture, phytochemicals, phenolic compounds, dual drug-eluting suture, glucose, hydraulic pressure, abdominal abscess, antiresorptive therapy, calcium–magnesium ratio, public health, nanotechnology, human–infrastructure interaction, TNF-α, leaf economic spectrum, essential oil, combination therapy, diagnostic yield, QRISK3, endometriosis, prediction, Laves phase, taste signalling, children, Angelica dahurica, advanced AI, thermal stability, drug release system, optimization study, lipidomics, papillary thyroid carcinoma, rASRM classification, incremental technique, germplasm resources, resin composite, conductive composites, confocal microscopy, sleep quality, cytokines, Penicillium janthinellum, episodic cluster headache, electrochemical activity, powder metallurgy, molten salt synthesis, pomalidomide, coordinated care, bursa-derived cells, systemic gene expression, high-resolution computed tomography, perturbation, UPLC-Q-TOF-MS/MS, chromosomal abnormalities, Caenorhabditis elegans, non-traditional, amyloid-β, intravenous steroid therapy, morcellation risk, cold plasma, high throughput cell phenotyping, low geostatic stress, endothelial cells, perioperative oncology, fatigue assessment, resistance, risk assessment, reactive oxygen species, processing and extraction, neurodevelopmental disorder, C-reactive protein, lily bulbs, hemodialysis, kidney transplantation, raspberry (Rubus idaeus L.), drought tolerance, sentinel lymph node biopsy, meta-analysis, pharmacological cardioversion, safflower, GC-MS, colorectal carcinoma, femoral rotation angle, hemophagocytic lymphohistiocytosis, headache-related disability, soil type, calcium carbonate precipitation, lung transplantation outcomes, extracellular matrix, leiomyoma, delayed diagnosis, pulmonary embolism, neohesperidin dihydrochalcone-L-arginine complex, explantation, acceleration, gastropexy, biocompatibility, artificial intelligence, pembrolizumab, alkali-activated geopolymers, heavy metal stress, road cycling, precision agriculture, fulvestrant, TGFB1, 2D materials, ELSD-LCMS, mean weight 100 grains, rheological properties, JAK–STAT signaling, vacuum-microwave drying, tensile fracture tests, colon, RNA therapeutics, infrared emissivity, nutraceutical, optimal stem anteversion, Ti2AlC, rotator cuff, surgical stress response, fracture width estimation, macro- and trace elements, kombucha, jaw cyst, environmental exposure, myopia, uterine sarcoma, derivatization, apigenin, non-small cell lung cancer, permeation property, signaling pathways, immunometabolism, cisplatin resistance, tissue expander, Comet assay, overall survival, Warner–Bratzler shear force, biopolymers, hormonal priming, stemness, immune checkpoint inhibitors, tannic acid, Fukui functions, uterine malignancy, multiple system atrophy, liver, gluten-free bread, antioxidant, polyphenols, adaptive activation functions, divalent metal transporter 1 (DMT1), environmental exposome, HIV-1, immuno-oncology, Anisakis, CADES, solid waste, inhibition zone test, anterior iliac approach, neuronal morphogenesis, psoriasis, immunotherapy resistance, lncRNAs, peptidomimetics, molecular docking, preservation, cell ultrastructure, surface electromyography, solvothermal method, liquid biopsy, nutritional components, Alnus glutinosa (L.) 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License Label:: Attribution 4.0 International
ORCID:: https://orcid.org/0009-0009-5522-7337, https://orcid.org/0009-0007-9130-2715, https://orcid.org/0000-0001-7157-814X, https://orcid.org/0000-0001-9850-3869, https://orcid.org/0000-0002-9439-6530, , and https://orcid.org/0000-0001-9528-2087
Other Affiliation:
Person:: Kessel, Julia, Higgins, Madeleine, Agala, Chris B., Hsu, Justin, Varvoglis, Dimitrios N., Hodges, Maggie M., Cook, Lauren M., Feeney, Timothy, and Farrell, Timothy M.
Publisher:: Multidisciplinary Digital Publishing Institute (MDPI)
Rights Statement Label:: In Copyright

30. Twelve Weeks of In-Season Strength Training at Moderate Intensities Improve Strength and Body Composition Without Increasing Muscle Damage or Inflammation in Elite Young Female Soccer Players

Title Tesim:: Twelve Weeks of In-Season Strength Training at Moderate Intensities Improve Strength and Body Composition Without Increasing Muscle Damage or Inflammation in Elite Young Female Soccer Players
Creator:: Zouhal, Hassane, Hmid, Ahlem Ben, Granacher, Urs, Karamti, Houssem M., Del Coso, Juan, Hackney, Anthony C., Bousselmi, Mariem, Darragi, Manel, Zouita, Sghaeir, and Zouita, Amira Ben Moussa
Date of publication:: 2026
Abstract Tesim:: Strength training (ST) is commonly implemented to enhance soccer-related fitness qualities such as sprinting, jumping, and changes-of-direction while also contributing to injury risk reduction. It is traditionally emphasized in the pre-season period. In-season ST may confer these benefits, but it can also induce muscle damage and inflammation. To examine the effects of a 12-week in-season ST program on maximal dynamic strength, muscle damage biomarkers, and inflammatory biomarkers, 24 elite young female soccer players (Tier 4 according to the McKay et al. classification) aged 14.9 ± 0.8 years and a maturity offset of +2.6 ± 1.1 years were randomly allocated to an ST group (STG, n = 12) or an active control group (CG, n = 12). Both groups followed the same soccer training program. However, in the STG, two weekly soccer sessions were replaced with ST. Overall training volume was comparable between groups. Maximal dynamic strength (1-RM tests for bench press, lat pull-down, and leg press), blood biomarkers of muscle damage (creatine phosphokinase [CPK], lactate dehydrogenase [LDH]), and inflammation (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α]) were assessed before (T1) and after (T2) the interventions. Analyses showed significant increases for STG for the 1-RM bench press, the 1-RM lat pull-down, and the 1-RM leg press (p < 0.001). No significant interactions were detected for any blood marker of muscle damage (LDH and CPK) or inflammation (IL-6 and TNF-α) (all p > 0.05). Results support a 12-week in-season ST program improved maximal dynamic strength in elite young female soccer players without altering resting levels of muscle damage or inflammatory markers measured 48 h after training compared to regular soccer training. These findings suggest that ST can be safely implemented during the competitive season in young female soccer players without overreaching or overtraining.
Resource type:: Article
Affiliation Label Tesim:: College of Arts and Sciences and Department of Exercise and Sport Science
Type:: http://purl.org/dc/dcmitype/Text
DOI:: https://doi.org/10.17615/3dmj-jr29
Edition:: Publisher
Identifier:: PMID: 42043068, DOI: https://dx.doi.org/10.3390/sports14040136, and PMCID: PMC13120612
ISSN:: 2075-4663
Journal Issue:: 4
Journal Title:: Sports
Journal Volume:: 14
Keyword:: trigeminal neuralgia, cellulose nanomaterials, low-income countries, validation study, hepatocyte–macrophage crosstalk, Bellman–Gronwall inequality, pleiotropy, stigma, PEG, radiofrequency wire, anthropometric characteristics, type 2 diabetes mellitus, Anxiety, dietary interventions, GPI-anchored proteins, prostate biopsy, nested PCR, biomedicine, biopolymers, arbovirus, tick, amplitude modulation, anionic polysaccharide, executive control network, iron, neural complexity, therapeutic target, exercise training, immunoinformatics, transitional care, stochastic stability, radiopharmaceutical, virtual reality, CYP polymorphisms, sex pheromones, cutinase, antiseizure medications, RO, muscle fibers, MVA, metavirome, paraspeckle, Kölliker’s organ, aquaculture, genotyping, Gabor filters, fock representation, breastfeeding, proton exchange membrane, capillary ceramic-membrane contactors, small molecule bioactive peptide-mediated antioxidant system, real-world study, auditory development, slow-twitch, clinical, psychological tests, dynamic model, executive functions, motor inhibition, cell therapy, epigenetic therapy, mitochondria metabolism, psychometric validation, IHNV, dendritic cells, methotrexate, electrochemical energy storage, FOXA3, Particle Image Velocimetry, exchange symmetry, vaccinology, quantum thermodynamics, psoriasis, Caregiver Preparedness Scale, supplement safety, contamination indices, appetite suppression, signaling pathway, HDAC, whole genome sequencing, artificial intelligence, antibiotic degradation, vector surveillance, placental malaria, lipid metabolism, network clustering, electromagnetic therapy, in vitro disease model, nitric oxide synthase, herpes simplex stromal keratitis, IL-1β, dopamine, KAT, biomarker discovery, mushroom alcohol, individualised anaesthesia, ARMS, covariance matrix, ferroptosis, Nrf2, surgical time, temporal KD quasiprobability distribution, hyaluronidases, MARTINI force field, prior expectations, microvascular decompression, MAT, electrochemical evaluation, diet, delayed onset muscle soreness, soil remediation, synthetic microbial communities, financial market uncertainty and risk assessment, long-term control, lysine acetylation, epidemiology, pathogenesis, energy harvesting system, Ising model, fascial plane hydrodissection, alcohol dependence, linear Hamiltonian systems, Malawi, thiocyanate transport, β-elimination lyases, breast neoplasms, Deep Learning, tribo-corrosion, susceptibility source separation, type 1 diabetes, redox homeostasis, HIV, ethics, medial ganglionic eminence, supported membranes, neurovascular compression syndrome, DMLS, orthokeratology, CMSM pillaring, gas separation, casting, anti-reflux mucosal ablation, intellectual profile, performance, cardiovascular disease, replicative stress, Acanthamoeba, microbubble, nonclassicality measure, health risk, PVDF, immunotherapy, urinary tract infection, high-intensity interval training, pneumococcal vaccination, heat damage analysis, default mode network, dialysis fluids, steatosis, healthspan, informal caregivers, histamine-2 receptor antagonists, phytoremediation, dynamic traits, cutaneous immunity, prototype learning, fructooligosaccharides, powder Co–Cr, therapeutic options, immobilization mechanisms, workload, oocyte quality, microalgae harvesting, hemorrhagic stroke, recovery, mitochondria, fermented milk, arsenate transport, CYP2D6, Lactococcus lactis, ceramides, life cycle assessment, generalized stochastic averaging method, multiclass models, cross-modal alignment, retirement, pharmacy practice, developmental pathways, potable water, Mori Fructus polysaccharide (MFP-1), reciprocating wear, multi-view learning, electrolyte disturbances, genetic covariance, chemotherapy, lipidomic, adenocarcinoma, PMF model, motivation, neuromuscular adaptations, amyloid‐related imaging abnormalities, drug-to-antibody ratio, radioactive wastewater, water treatment, early pregnancy loss, enteric neurons, pain control, learning curve, organizational culture, neuronal blockade, alcoholic liver disease, Mannich reaction, humoral response, lysosome, Aliquat 336, ORAC, breast cancer, interstitial lung disease, stable isotopes, short‐term spatial memory, real-world, vaccine hesitancy, biomarker, excitatory–inhibitory balance, proteomics, GERD, collagen, chronic arthritis, N-lactoyl-phenylalanine, mRNA virus-like particle, Fusarium tricinctum, electrocoagulation, cardiorespiratory fitness, Bayesian analyses, precision nutrition, collapse models, flexible blade, nurse managers, Brewster Angle Microscopy (BAM), matrix-free co-culture, motile cilia, fluid biomarkers, maximum likelihood estimator, college football players, sex pheromone receptors, cellular response, cost-effectiveness, cognitive function, biological control, Atlantic salmon, potential ecological risk index (RI), immunopathogenesis, mental health of students, developing countries, MAPK signaling, rapid access clinic, mental 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QEVO, TNF-α, Wigner’s Friend, inclusion, atomic force microscopy (AFM), ovarian transcriptomics, psychometrics, health policy, PTEs, anti-CGRP monoclonal antibodies, pathogens, quantum spin chains, pregnancy, precision medicine, polypyrrole, molecular dynamics simulation, lipidomics, diffusion magnetic resonance imaging, immune, ethics in research, ergogenic aids, fast fading channel, vaccination, neurodegeneration, functional verification, mRNA vaccine, heavy metal ions removal, AI-driven crude oil price forecasting, serum metabolomics, ammonia recovery, electron paramagnetic resonance (EPR), order restriction, community pharmacy, reconstruction algorithms, molecular dynamics (MD) simulations, bioinformatics, budget impact, Mawashi Geri Jodan, stirred-tank bioreactor, CAD/CAM, PVDF-HFP, stroke, liposome structure change with temperature, female karate athletes, berries, synthetic polysaccharide, 3D printing SLM, body composition, hepatocellular carcinoma, mast cell disorders, 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symptoms checklist, mechanical ventilation, intestinal ultrasound, diseases, substance-related disorders, myocardial fibrosis, mitochondrial dysfunction, MASLD, sepsis, glycolysis, TIF, quantum communication, core-periphery structure, graph states, nanofibers, polymer inclusion membrane, surface electromyography, molecular dynamics, FNDC5, thermodynamic refinement, GnRH pulsatility, alcohol-associated liver disease (ALD), predictive analytics, molecular dynamics simulations, implementation, urinary incontinence, dietetic fiber, confinment diffusion, anti-angiogenic therapy, adverse drug reactions, glioma, sciatic nerve, SiO2 mixture, ATG5, deoxynivalenol, age-related changes, cognitive performance, volatile organic compounds, neurogenic detrusor overactivity, long head of the biceps tendon, cellulose filter paper, discrete phase model, autoimmune hemolytic anemia, breast conserving therapy, geometric quantization, gastro-esophageal reflux disease, tendon loading, odor activity, flux 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compatibility, powder CoCr, LC-HRMS, volatile formulation, COVID-19, basal serum tryptase, reagent-efficient membrane fabrication, transoral incisionless fundoplication, dengue virus, microfiltration, CAKUT, botulinum toxin, global exponential stability, transcranial magneto-acoustic stimulation (TMAS), postoperative pain, irisin, Nrf2/HO-1 pathway, perinatal, real-time PCR-HRM, informal caregiver, Thessaloniki, aesthetic, multiplex PCR, hand injury, bladder administration, Genetically Modified Organisms (GMOs), MUSE, tensor-valued diffusion MRI, polymers of intrinsic microporosity (PIMs), alkaline cleaning, nano zero-valent iron, satellite cells, NORMs, single-cell RNA-seq, leadership, depression, chronic pain, motor impairment, deep brain stimulation, electroencephalography (EEG), mechanical properties, supported lipid bilayers (SLBs), hydrophobic coating, sex differences, placenta, ceramic membranes, biofouling, ethanol consumption, multiple sclerosis, adenosine A2A receptor, lung injury, Romania, post-traumatic stress, prognosis, nutrient metabolism, cerebral amyloid angiopathy, obesity, enthesopathy, down syndrome, exerkine, glucose, glucose uptake, muscle regeneration, potentially toxic elements, hepatitis delta virus, symplectic geometry, suicide, endoluminal anti-reflux therapy, polymer inclusion membranes, Bayesian modelling, miR-21, gut–liver axis, Escherichia coli BL21(DE3), Sargassum, SARS-CoV-2, Durapore® PVDF membranes, animal model, microbes, CV-QKD, liposomes, autoantibodies, extracellular polymeric substances, GLP-1-based therapies, attention, intravenous contamination, co‐design, occupational health, forward flushing, nano TiO2, FO, superdense coding, human metabolic reconstruction, RSV, tirzepatide, membrane fouling, myopia management, fast-twitch, phenolic compounds, glutaraldehyde, LDLR, HKDC1, systematic review, directed graphs, thyroid carcinoma, mast cell activation syndrome, side-effect profile, layer by layer self assembly, importance 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medicine, viral infection, position, membrane aging, H2 separation, social media, IBD, insects, nursing, and low frequency pulsed magnetic fields
License Label:: Attribution 4.0 International
ORCID:: https://orcid.org/0000-0001-6743-6464, , https://orcid.org/0000-0002-7095-813X, https://orcid.org/0000-0002-5785-984X, https://orcid.org/0000-0002-7437-6225, https://orcid.org/0009-0004-7427-1118, and https://orcid.org/0000-0002-2266-9472
Other Affiliation:: International Institute of Sport Sciences (2I2S), Rennes, France, Laboratory of Transmission, Control and Immunobiology of Infections (LR11IPT02), Pasteur Institute of Tunis, Tunis, Tunisia, Department of Sport and Sport Science, Exercise and Human Movement Science, University of Freiburg, Freiburg, Germany, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia, Sport Sciences Research Centre, Rey Juan Carlos University, Madrid, Spain, , Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Manouba, Tunisia, and Research Laboratory (LR23JS01) “Sports Performance, Health & Society”, University of Manouba, Manouba, Tunisia
Person:: Zouhal, Hassane, Hmid, Ahlem Ben, Granacher, Urs, Karamti, Houssem M., Del Coso, Juan, Hackney, Anthony C., Bousselmi, Mariem, Darragi, Manel, Zouita, Sghaeir, and Zouita, Amira Ben Moussa
Publisher:: Multidisciplinary Digital Publishing Institute (MDPI)
Rights Statement Label:: In Copyright