PLoS Articles
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UNC-authored articles published by the Public Library of Science (PLoS)
Works (2111)
1811. Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
- Title Tesim:
- Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
- Creator:
- Snyder, Abraham Z., Styner, , Laufs, Helmut, Paterson, Sarah J., Pruett, , Styner, Martin A., Constantino, , Paterson, , Dager, Stephen, Piven, Joseph, Schultz, Robert T., Tagliazucchi, Enzo, Hazlett, Heather C., Shaw, , Wolff, Jason J., Chappell, , McKinstry, , Elison, Jed, Mitra, Anish, Raichle, Marcus, Gerig, Guido, Emerson, Robert W., Zwaigenbaum, Lonnie, Pruett, John R., Botteron, , Schlaggar, Bradley L., Estes, , Pike, , Evans, , Gu, , Botteron, Kelly N., Kostopoulos, , Estes, Annette M., Schultz, , Das, , Fonov, , Shen, Mark D., and Collins,
- Date of publication:
- 2017
- Abstract Tesim:
- Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Psychiatry
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/889h-pt06
- Identifier:
- Onescience id: 4628536e45aeb71d51c3a8143a6dc675cdf71af5, Publisher DOI: https://doi.org/10.1371/journal.pone.0188122, PMID: 29149191, and PMCID: PMC5693436
- ISSN:
- 1932-6203
- Journal Issue:
- 11
- Journal Title:
- PloS One
- Journal Volume:
- 12
- Keyword:
- Child, Preschool, Brain, Infant, Humans, Wakefulness, Magnetic Resonance Imaging, Principal Component Analysis, Sleep, Adult, Connectome, and Electroencephalography
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Department of Neurology; Washington University School of Medicine, Department of Radiology; Washington University School of Medicine, University of North Carolina, Department of Neurology; Christian-Albrechts-University, Department of Pediatrics; University of Pennsylvania, Washington University, Children’s Hospital of Philadelphia, University of Washington, Department of Radiology; University of Washington, Departamento de Fisica; Universidad de Buenos Aires, IBIS Network PI, Institute of Child Development; University of Minnesota, University of Minnesota, Department of Psychiatry; New York University, Image Processing Core; New York University, Department of Pediatrics; University of Alberta, University of Alberta, Department of Psychiatry; Washington University School of Medicine, Data Coordinating Center; Montreal Neurological Institute, Montreal Neurological Institute; McGill University, Statistical Analysis Core, and Department of Psychology; University of Washington
- Page Start:
- e0188122
- Person:
- Snyder, Abraham Z., Styner, , Laufs, Helmut, Paterson, Sarah J., Pruett, , Styner, Martin A., Constantino, , Paterson, , Dager, Stephen, Piven, Joseph, Schultz, Robert T., Tagliazucchi, Enzo, Hazlett, Heather C., Shaw, , Wolff, Jason J., Chappell, , McKinstry, , Elison, Jed, Mitra, Anish, Raichle, Marcus, Gerig, Guido, Emerson, Robert W., Zwaigenbaum, Lonnie, Pruett, John R., Botteron, , Schlaggar, Bradley L., Estes, , Pike, , Evans, , Gu, , Botteron, Kelly N., Kostopoulos, , Estes, Annette M., Schultz, , Das, , Fonov, , Shen, Mark D., and Collins,
- Rights Statement Label:
- In Copyright
- Source:
- df65vf26r
1812. Recreational Drug Use among Chinese MSM and Transgender Individuals: Results from a National Online Cross-Sectional Study
- Title Tesim:
- Recreational Drug Use among Chinese MSM and Transgender Individuals: Results from a National Online Cross-Sectional Study
- Creator:
- Zhao, Peizhen, Best, John, Tang, Songyuan, Wang, Cheng, Zhang, Ye, Tangthanasup, Thitikarn May, Wei, Chongyi, Tang, Weiming, Huang, Shujie, Yang, Bin, and Tucker, Joseph D.
- Date of publication:
- 2017
- Abstract Tesim:
- Recreational drug use has increased considerably among Chinese men who have sex with men (MSM). The phenomenon has the potentially to increase HIV transmission among Chinese MSM. The aims of this study were: 1) to investigate the prevalence of recreational drug use among Chinese MSM, and 2) to explore the correlation between gay smartphone based sex-seeking applications (gay apps), HIV/STIs testing, group sex, commercial sex, sexual roles and poppers use among Chinese MSM.
- Resource type:
- Article
- Affiliation Label Tesim:
- UNC Project-China
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/mcb3-8t40
- Identifier:
- Onescience id: 82ec657006bf15c2d4ea2d98bda1bd0f8ee8a4bd, Publisher DOI: https://doi.org/10.1371/journal.pone.0170024, PMCID: PMC5249205, and PMID: 28107391
- ISSN:
- 1932-6203
- Journal Issue:
- 1
- Journal Title:
- PloS One
- Journal Volume:
- 12
- Keyword:
- Humans, Male, China, Homosexuality, Male, Female, Transgender Persons, Young Adult, Sexually Transmitted Diseases, Adult, Adolescent, Cross-Sectional Studies, and Substance-Related Disorders
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Guangdong Center for Skin Diseases and STI Control, School of Medicine; University of California; San Francisco, Kunming Medical University, UNC Project-China, and School of Medicine
- Page Start:
- e0170024
- Person:
- Zhao, Peizhen, Best, John, Tang, Songyuan, Wang, Cheng, Zhang, Ye, Tangthanasup, Thitikarn May, Wei, Chongyi, Tang, Weiming, Huang, Shujie, Yang, Bin, and Tucker, Joseph D.
- Rights Statement Label:
- In Copyright
- Source:
- 3484zp320
1813. Public attitudes toward larger cigarette pack warnings: Results from a nationally representative U.S. sample
- Title Tesim:
- Public attitudes toward larger cigarette pack warnings: Results from a nationally representative U.S. sample
- Creator:
- Kowitt, Sarah D., Ranney, Leah M., Goldstein, Adam O., and Noar, Seth M.
- Date of publication:
- 2017
- Abstract Tesim:
- A large body of evidence supports the effectiveness of larger health warnings on cigarette packages. However, there is limited research examining attitudes toward such warning labels, which has potential implications for implementation of larger warning labels. The purpose of the current study was to examine attitudes toward larger warning sizes on cigarette packages and examine variables associated with more favorable attitudes. In a nationally representative survey of U.S. adults (N = 5,014), participants were randomized to different warning size conditions, assessing attitude toward “a health warning that covered (25, 50, 75) % of a cigarette pack.” SAS logistic regression survey procedures were used to account for the complex survey design and sampling weights. Across experimental groups, nearly three-quarters (72%) of adults had attitudes supportive of larger warning labels on cigarette packs. Among the full sample and smokers only (N = 1,511), most adults had favorable attitudes toward labels that covered 25% (78.2% and 75.2%, respectively), 50% (70% and 58.4%, respectively), and 75% (67.9% and 61%, respectively) of a cigarette pack. Young adults, females, racial/ethnic minorities, and non-smokers were more likely to have favorable attitudes toward larger warning sizes. Among smokers only, females and those with higher quit intentions held more favorable attitudes toward larger warning sizes. Widespread support exists for larger warning labels on cigarette packages among U.S. adults, including among smokers. Our findings support the implementation of larger health warnings on cigarette packs in the U.S. as required by the 2009 Tobacco Control Act.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Health Behavior, Department of Family Medicine, University of North Carolina at Chapel Hill, and School of Media and Journalism
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/j9pq-xn91
- Identifier:
- Onescience id: 12578390aa3ea9358eccba0283ec19f3679d279c, Publisher DOI: https://doi.org/10.1371/journal.pone.0171496, PMID: 28253257, and PMCID: PMC5333827
- ISSN:
- 1932-6203
- Journal Issue:
- 3
- Journal Title:
- PloS One
- Journal Volume:
- 12
- Keyword:
- Product Labeling, Young Adult, Adult, Male, Humans, United States, Female, Surveys and Questionnaires, Tobacco Products, and Public Opinion
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Department of Family Medicine and University of North Carolina at Chapel Hill
- Page Start:
- e0171496
- Person:
- Kowitt, Sarah D., Ranney, Leah M., Goldstein, Adam O., and Noar, Seth M.
- Rights Statement Label:
- In Copyright
- Source:
- dz010w21m
1814. Progress towards a public chemogenomic set for protein kinases and a call for contributions
- Title Tesim:
- Progress towards a public chemogenomic set for protein kinases and a call for contributions
- Creator:
- Angell, Richard, Frederiksen, Mathias, Al-Ali, Hassan, Hooper, Alice, Zuercher, William J., Denny, R. Aldrin, Gray, Nathanael, Gileadi, Opher, Ettmayer, Peter, Wells, Carrow I., Drewry, David H., Capuzzi, Stephen J., Andrews, David M., Müller, Susanne, Luecking, Ulrich, Axtman, Alison D., Knapp, Stefan, Muratov, Eugene, Willson, Timothy M., Laufer, Stefan, Saikatendu, Kumar S., Treiber, Daniel K., Michaelides, Michael, and Elkins, Jonathan M.
- Date of publication:
- 2017
- Abstract Tesim:
- Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small molecule inhibitors, which we call chemogenomic sets, that are designed to inhibit the catalytic function of almost half the human protein kinases. In this manuscript we share our progress towards generation of a comprehensive kinase chemogenomic set (KCGS), release kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outline a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases.
- Resource type:
- Article
- Affiliation Label Tesim:
- Eshelman School of Pharmacy
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/7aj6-5547
- Identifier:
- PMCID: PMC5540273, Publisher DOI: https://doi.org/10.1371/journal.pone.0181585, PMID: 28767711, and Onescience id: f207222afe7d1a993dc4a4138ea389ffd83f9ebc
- ISSN:
- 1932-6203
- Journal Issue:
- 8
- Journal Title:
- PloS One
- Journal Volume:
- 12
- Keyword:
- Consortia, Biology and Life Sciences, Enzymology, Commerce, Entropy, Chemical Compounds, Enzyme Inhibitors, Social Sciences, Thermodynamics, Medicine and Health Sciences, Physics, Small Molecules, Kinase Inhibitors, Enzymes, Economics, Sociology, Biotechnology, Organic Compounds, Chemistry, Physical Sciences, Proteins, Organic Chemistry, Vendors, Protein Kinases, Pharmacology, and Biochemistry
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Drug Discovery Group; University College London School of Pharmacy, Novartis Institutes for BioMedical Research; Novartis Campus, Peggy and Harold Katz Family Drug Discovery Center; University of Miami Miller School of Medicine, Miami Project to Cure Paralysis; University of Miami Miller School of Medicine, Worldwide Medicinal Chemistry; Pfizer Inc., Harvard Department of Biological Chemistry and Molecular Pharmacology; Harvard Medical School, Department of Cancer Biology; Dana−Farber Cancer Institute, Structural Genomics Consortium; Target Discovery Institute; Nuffield Department of Clinical Medicine; University of Oxford, Boehringer Ingelheim RCV GmbH and Co. KG, AstraZeneca, Structural Genomics Consortium; Buchmann Institute for Molecular Life Sciences; Institute of Pharmaceutical Chemistry; Goethe University Frankfurt, Bayer Pharma AG; Drug Discovery, Department of Pharmaceutical Chemistry; Institute of Pharmaceutical Sciences; Eberhard Karls Universität Tübingen, Global Research Externalization; Takeda California; Inc., DiscoverX Corporation, Oncology Chemistry; AbbVie, and Structural Genomics Consortium; Universidade Estadual de Campinas—UNICAMP
- Page Start:
- e0181585
- Person:
- Angell, Richard, Frederiksen, Mathias, Al-Ali, Hassan, Hooper, Alice, Zuercher, William J., Denny, R. Aldrin, Gray, Nathanael, Gileadi, Opher, Ettmayer, Peter, Wells, Carrow I., Drewry, David H., Capuzzi, Stephen J., Andrews, David M., Müller, Susanne, Luecking, Ulrich, Axtman, Alison D., Knapp, Stefan, Muratov, Eugene, Willson, Timothy M., Laufer, Stefan, Saikatendu, Kumar S., Treiber, Daniel K., Michaelides, Michael, and Elkins, Jonathan M.
- Rights Statement Label:
- In Copyright
- Source:
- 0p096c903
1815. Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes
- Title Tesim:
- Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes
- Creator:
- Tsurutani, Naomi, Draghi, Andrew, Granados, Hector M., Wright, Kyle, Sylvester, Francisco A., Vella, Anthony T., and Fernandez, Marina L.
- Date of publication:
- 2017
- Abstract Tesim:
- Programmed death cell 1 (PD-1) is an inhibitor of T cell activation and is also functionally linked to glycolysis. We hypothesized that PD-1 expression is defective in activated T cells from children with type 1 diabetes (T1D), resulting in abnormal T cell glucose metabolism.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Pediatrics
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/bdbm-7298
- Identifier:
- Onescience id: c2f1a2911d3caa3a65f167a41fc11f02e0c0f18b, Publisher DOI: https://doi.org/10.1371/journal.pone.0183887, PMCID: PMC5587274, and PMID: 28877189
- ISSN:
- 1932-6203
- Journal Issue:
- 9
- Journal Title:
- PloS One
- Journal Volume:
- 12
- Keyword:
- Cytokines, Child, Adolescent, Pilot Projects, Humans, Case-Control Studies, Flow Cytometry, Leukocytes, Mononuclear, Diabetes Mellitus, Type 1, Female, Enzyme-Linked Immunosorbent Assay, Male, T-Lymphocytes, Glycolysis, Cell Death, and Programmed Cell Death 1 Receptor
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Department of Immunology; University of Connecticut Health Center, Department of Pediatrics; Texas Tech Health Science Center, and Department of Pediatrics; Connecticut Children’s Medical Center
- Page Start:
- e0183887
- Person:
- Tsurutani, Naomi, Draghi, Andrew, Granados, Hector M., Wright, Kyle, Sylvester, Francisco A., Vella, Anthony T., and Fernandez, Marina L.
- Rights Statement Label:
- In Copyright
- Source:
- 1z40kz95n
1816. Principal component analysis identifies patterns of cytokine expression in non-small cell lung cancer patients undergoing definitive radiation therapy
- Title Tesim:
- Principal component analysis identifies patterns of cytokine expression in non-small cell lung cancer patients undergoing definitive radiation therapy
- Creator:
- Zhao, Jing, Chen, Jie, Wang, Weili, Ellsworth, Susannah G., Miller, Amy, Campbell, Jeffrey, Kong, Feng-Ming, Stanton, Paul, Jolly, Shruti, Matuszak, Martha, Pi, Wenhu, and Rabatic, Bryan M.
- Date of publication:
- 2017
- Abstract Tesim:
- Radiation treatment (RT) stimulates the release of many immunohumoral factors, complicating the identification of clinically significant cytokine expression patterns. This study used principal component analysis (PCA) to analyze cytokines in non-small cell lung cancer (NSCLC) patients undergoing RT and explore differences in changes after hypofractionated stereotactic body radiation therapy (SBRT) and conventionally fractionated RT (CFRT) without or with chemotherapy.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Radiation Oncology
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/p82j-dv23
- Identifier:
- Publisher DOI: https://doi.org/10.1371/journal.pone.0183239, PMCID: PMC5608186, PMID: 28934231, and Onescience id: 77935b7c56f24a6318ab3f71cca8888b8edcf148
- ISSN:
- 1932-6203
- Journal Issue:
- 9
- Journal Title:
- PloS One
- Journal Volume:
- 12
- Keyword:
- Case-Control Studies, Female, Gene Expression Profiling, Male, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Humans, Adult, Cytokines, Principal Component Analysis, Aged, 80 and over, Aged, and Middle Aged
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Department of Radiation Oncology; Augusta University, Department of Biostatistics and Epidemiology; Augusta University, Department of Radiation Oncology; Indiana University School of Medicine, and Department of Radiation Oncology; University of Michigan School of Medicine
- Page Start:
- e0183239
- Person:
- Zhao, Jing, Chen, Jie, Wang, Weili, Ellsworth, Susannah G., Miller, Amy, Campbell, Jeffrey, Kong, Feng-Ming, Stanton, Paul, Jolly, Shruti, Matuszak, Martha, Pi, Wenhu, and Rabatic, Bryan M.
- Rights Statement Label:
- In Copyright
- Source:
- cv43p2675
1817. Prevalence of Atrial Fibrillation and Antithrombotic Therapy in Hemodialysis Patients: Cross-Sectional Results of the Vienna InVestigation of AtriaL Fibrillation and Thromboembolism in Patients on HemoDIalysis (VIVALDI)
- Title Tesim:
- Prevalence of Atrial Fibrillation and Antithrombotic Therapy in Hemodialysis Patients: Cross-Sectional Results of the Vienna InVestigation of AtriaL Fibrillation and Thromboembolism in Patients on HemoDIalysis (VIVALDI)
- Creator:
- Pabinger, Ingrid, Stampfel, Gerald, Königsbrügge, Oliver, Zuntner, Günther, Steiner, Stefan, Kletzmayr, Josef, Säemann, Marcus, Schmaldienst, Sabine, Klauser-Braun, Renate, Ay, Cihan, Grilz, Ella, Posch, Florian, Antlanger, Marlies, Auinger, Martin, Kovarik, Josef, and Lorenz, Matthias
- Date of publication:
- 2017
- Abstract Tesim:
- Atrial fibrillation (AF) adds significant risk of stroke and thromboembolism in patients on hemodialysis (HD). The aim of this study was to investigate the prevalence of AF in a population-based cohort of HD patients and practice patterns of antithrombotic therapy for stroke prevention in AF.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Medicine
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/fj8s-6g84
- Identifier:
- PMID: 28052124, Publisher DOI: https://doi.org/10.1371/journal.pone.0169400, PMCID: PMC5213813, and Onescience id: cb9c517009584b50eb6ed97ba18417b7f429b53c
- ISSN:
- 1932-6203
- Journal Issue:
- 1
- Journal Title:
- PloS One
- Journal Volume:
- 12
- Keyword:
- Prevalence, Austria, Age Factors, Aged, Cross-Sectional Studies, Male, Female, Middle Aged, Time Factors, Renal Dialysis, Anticoagulants, Atrial Fibrillation, Humans, and Thromboembolism
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Clinical Division of Hematology and Hemostaseology; Department of Medicine i; Medical University of Vienna, Department of Medicine i; Rudolfstiftung Hospital, Department of Medicine III; Donauspital, Clinical Division of Nephrology; Department of Medicine III; Medical University of Vienna, Department of Medicine i; Kaiser-Franz-Josef-Spital, Department of Medicine; Clinical Division of Oncology; Medical University of Graz, Department of Medicine III; Hietzing Hospital, Department of Medicine VI; Wilhelminenspital, and Vienna Dialysis Center
- Page Start:
- e0169400
- Person:
- Pabinger, Ingrid, Stampfel, Gerald, Königsbrügge, Oliver, Zuntner, Günther, Steiner, Stefan, Kletzmayr, Josef, Säemann, Marcus, Schmaldienst, Sabine, Klauser-Braun, Renate, Ay, Cihan, Grilz, Ella, Posch, Florian, Antlanger, Marlies, Auinger, Martin, Kovarik, Josef, and Lorenz, Matthias
- Rights Statement Label:
- In Copyright
- Source:
- rb68xj072
1818. Prevalence of and risk for gastrointestinal bleeding and peptic ulcerative disorders in a cohort of HIV patients from a U.S. healthcare claims database
- Title Tesim:
- Prevalence of and risk for gastrointestinal bleeding and peptic ulcerative disorders in a cohort of HIV patients from a U.S. healthcare claims database
- Creator:
- Bratton, Emily, Vannappagari, Vani, and Kobayashi, Monica G.
- Date of publication:
- 2017
- Abstract Tesim:
- The primary study objectives were to estimate the frequencies and rates of gastrointestinal bleeding and peptic ulcerative disorder in HIV-positive patients compared with age- and sex-matched HIV-negative subjects. Data from a US insurance claims database was used for this analysis. Among 89,207 patients with HIV, 9.0% had a GI bleed, 1.0% had an upper gastrointestinal bleed, 5.6% had a lower gastrointestinal bleed, 1.9% had a peptic ulcerative disorder diagnosis, and 0.6% had both gastrointestinal/peptic ulcerative disorder. Among 267,615 HIV-negative subjects, the respective frequencies were 6.9%, 0.6%, 4.3%, 1.4%, and 0.4% (p<0.0001 for each diagnosis subcategory). After combining effect measure modifiers into comedication and comorbidity strata, gastrointestinal bleeding hazard ratios (HRs) were higher for HIV-positive patients without comedication/comorbidity, and those with comedication alone (HR, 2.73; 95% confidence interval [CI], 2.62–2.84; HR, 1.59; 95% CI, 1.47–1.71). The rate of peptic ulcerative disorder among those without a history of ulcers and no comorbidity/comedication was also elevated (HR, 2.72; 95% CI, 2.48–2.99). Hazard ratios of gastrointestinal bleeding, and peptic ulcerative disorder without a history of ulcers were lower among patients infected with HIV with comedication/comorbidity (HR, 0.64; 95% CI, 0.56–0.73; HR, 0.46; 95% CI, 0.33–0.65). Rates of gastrointestinal bleeding plus peptic ulcerative disorder followed a similar pattern. In summary, the rates of gastrointestinal/peptic ulcerative disorder events comparing HIV-infected subjects to non–HIV-infected subjects were differential based on comorbidity and comedication status.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/7nqm-gw24
- Identifier:
- Onescience id: bc707b60f9fd908d10ba71f363e90c018e13768a, Publisher DOI: https://doi.org/10.1371/journal.pone.0180612, PMCID: PMC5493421, and PMID: 28666006
- ISSN:
- 1932-6203
- Journal Issue:
- 6
- Journal Title:
- PloS One
- Journal Volume:
- 12
- Keyword:
- Gastrointestinal Hemorrhage, Insurance Claim Reporting, Adult, Young Adult, Aged, Prevalence, Male, Female, HIV Infections, Risk Factors, Humans, Peptic Ulcer, Retrospective Studies, Middle Aged, and Adolescent
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Real World Evidence Solutions; QuintilesIMS, Epidemiology and Real World Evidence; ViiV Healthcare Ltd; Research Triangle Park, and PAREXEL Access Consulting; PAREXEL International
- Page Start:
- e0180612
- Person:
- Bratton, Emily, Vannappagari, Vani, and Kobayashi, Monica G.
- Rights Statement Label:
- In Copyright
- Source:
- xw42nf05r
1819. Prevalence and risk factors of chlamydia infection in Hong Kong: A population-based geospatial household survey and testing
- Title Tesim:
- Prevalence and risk factors of chlamydia infection in Hong Kong: A population-based geospatial household survey and testing
- Creator:
- Ho, King Man, Fong, Francois Yeung, Emch, Michael, Wong, William Chi Wai, Miu, Heidi Yin Hai, Wong, Ngai Sze, Tucker, Joseph D., Zhao, Yanping, Yang, Li-Gang, and Parish, William L.
- Date of publication:
- 2017
- Abstract Tesim:
- Chlamydia causes infertility and increases risk of HIV infection, and population-based studies provide essential information for effective infection control and prevention. This study examined Chlamydia trachomatis prevalence and risk factors among a representative sample of 18-49-year-old residents in Hong Kong.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Geography and Institute for Global Health and Infectious Diseases
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/d68c-wv55
- Identifier:
- Onescience id: b08bd6a31fa86062c7f2d0cdee6df36c6905ca67, PMID: 28225805, PMCID: PMC5321413, and Publisher DOI: https://doi.org/10.1371/journal.pone.0172561
- ISSN:
- 1932-6203
- Journal Issue:
- 2
- Journal Title:
- PloS One
- Journal Volume:
- 12
- Keyword:
- Chlamydia trachomatis, Sex Factors, Health Surveys, Hong Kong, Age Factors, Male, Adult, Mass Screening, Prevalence, Female, Risk Factors, Middle Aged, Humans, Adolescent, Young Adult, and Chlamydia Infections
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Social Hygiene Service; Department of Health; Hong Kong Government, Hong Kong Sexual Health Centre, , Department of Family Medicine and Primary Care; Li Ka Shing Faculty of Medicine; University of Hong Kong, University of North Carolina Project-China, London School of Hygiene and Tropical Medicine, Guangdong Provincial Centers for Skin Diseases and STI Control, and Sociology Department; University of Chicago
- Page Start:
- e0172561
- Person:
- Ho, King Man, Fong, Francois Yeung, Emch, Michael, Wong, William Chi Wai, Miu, Heidi Yin Hai, Wong, Ngai Sze, Tucker, Joseph D., Zhao, Yanping, Yang, Li-Gang, and Parish, William L.
- Rights Statement Label:
- In Copyright
- Source:
- cc08hm87d
1820. Prenatal care and child growth and schooling in four low- and medium-income countries
- Title Tesim:
- Prenatal care and child growth and schooling in four low- and medium-income countries
- Creator:
- Sachdev, Harshpal S., Da Silveira, Mariangela Freitas, Behrman, Jere R., Adair, Linda S., Borja, Judith B., Bhargava, Santosh K., Richter, Linda M., Stein, Aryeh D., Horta, Bernardo L., Martorell, Reynaldo, Norris, Shane A., and Liu, Xiaoying
- Date of publication:
- 2017
- Abstract Tesim:
- The effectiveness of prenatal care for improving birth and subsequent child outcomes in low-income countries remains controversial, with much of the evidence to date coming from high-income countries and focused on early-life outcomes. We examined associations between prenatal care visits and birth weight, height-for-age at 24 months and attained schooling in four low- and middle-income countries.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Nutrition
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/ftyn-xp35
- Identifier:
- Publisher DOI: https://doi.org/10.1371/journal.pone.0171299, PMCID: PMC5291430, Onescience id: ef47282ce44fad5512cfa93c131a62333a15e3c9, and PMID: 28158229
- ISSN:
- 1932-6203
- Journal Issue:
- 2
- Journal Title:
- PloS One
- Journal Volume:
- 12
- Keyword:
- Humans, Income, Male, Developing Countries, Schools, Pregnancy, Patient Acceptance of Health Care, Child Development, Child, Female, Education, and Prenatal Care
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Department of Pediatrics and Clinical Epidemiology; Sitaram Bhartia Institute of Science and Research, Postgraduation Program in Epidemiology; Faculty of Medicine; Federal University of Pelotas, Population Studies Center; University of Pennsylvania, USC-Office of Population Studies Foundation; Inc.; Department of Nutrition and Dietetics; University of San Carlos, Department of Pediatrics; S.L. Jain Hospital, University of the Witwatersrand; DST-NRF Centre of Excellence in Human Development, Medical Research Council Developmental Pathways to Health Research Unit; University of the Witwatersrand, and Hubert Department of Global Health; Rollins School of Public Health; Emory University
- Page Start:
- e0171299
- Person:
- Sachdev, Harshpal S., Da Silveira, Mariangela Freitas, Behrman, Jere R., Adair, Linda S., Borja, Judith B., Bhargava, Santosh K., Richter, Linda M., Stein, Aryeh D., Horta, Bernardo L., Martorell, Reynaldo, Norris, Shane A., and Liu, Xiaoying
- Rights Statement Label:
- In Copyright
- Source:
- 9880vx17r
Collection Details
- Total items
-
2111
- Size
-
unknown
- Date created
-
February 2, 2022