PLoS Articles
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UNC-authored articles published by the Public Library of Science (PLoS)
Works (1980)
1811. Multi-Drug Resistance Transporters and a Mechanism-Based Strategy for Assessing Risks of Pesticide Combinations to Honey Bees
- Title Tesim:
- Multi-Drug Resistance Transporters and a Mechanism-Based Strategy for Assessing Risks of Pesticide Combinations to Honey Bees
- Creator:
- Pettis, Jeffrey S., Miller, Kaliah, Kunkle, Grace, Hawthorne, David J., Dively, Galen P., Guseman, Alex J., Evans, Jay D., and VanEngelsdorp, Dennis
- Date of publication:
- 2016
- Abstract Tesim:
- Annual losses of honey bee colonies remain high and pesticide exposure is one possible cause. Dangerous combinations of pesticides, plant-produced compounds and antibiotics added to hives may cause or contribute to losses, but it is very difficult to test the many combinations of those compounds that bees encounter. We propose a mechanism-based strategy for simplifying the assessment of combinations of compounds, focusing here on compounds that interact with xenobiotic handling ABC transporters. We evaluate the use of ivermectin as a model substrate for these transporters. Compounds that increase sensitivity of bees to ivermectin may be inhibiting key transporters. We show that several compounds commonly encountered by honey bees (fumagillin, Pristine, quercetin) significantly increased honey bee mortality due to ivermectin and significantly reduced the LC50 of ivermectin suggesting that they may interfere with transporter function. These inhibitors also significantly increased honey bees sensitivity to the neonicotinoid insecticide acetamiprid. This mechanism-based strategy may dramatically reduce the number of tests needed to assess the possibility of adverse combinations among pesticides. We also demonstrate an in vivo transporter assay that provides physical evidence of transporter inhibition by tracking the dynamics of a fluorescent substrate of these transporters (Rhodamine B) in bee tissues. Significantly more Rhodamine B remains in the head and hemolymph of bees pretreated with higher concentrations of the transporter inhibitor verapamil. Mechanism-based strategies for simplifying the assessment of adverse chemical interactions such as described here could improve our ability to identify those combinations that pose significantly greater risk to bees and perhaps improve the risk assessment protocols for honey bees and similar sensitive species.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Chemistry
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/p1vz-d444
- Identifier:
- PMID: 26840460, Publisher DOI: https://doi.org/10.1371/journal.pone.0148242, Onescience id: abbafd25df1917b702dfc806a35bf2f2b121da51, and PMCID: PMC4740413
- ISSN:
- 1932-6203
- Journal Issue:
- 2
- Journal Title:
- PloS One
- Journal Volume:
- 11
- Keyword:
- Drug Resistance, Multiple, Pyrazoles, Pyridines, Quercetin, Ivermectin, Animals, Rhodamines, ATP-Binding Cassette Transporters, Biological Transport, Carbamates, Fatty Acids, Unsaturated, Verapamil, Niacinamide, Cyclohexanes, Membrane Transport Proteins, Bees, Risk Assessment, Biphenyl Compounds, Insecticides, Sesquiterpenes, and Environmental Exposure
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Bee Research Laboratory; United States Department of Agriculture - Agricultural Research Service and Department of Entomology; University of Maryland
- Page Start:
- e0148242
- Person:
- Pettis, Jeffrey S., Miller, Kaliah, Kunkle, Grace, Hawthorne, David J., Dively, Galen P., Guseman, Alex J., Evans, Jay D., and VanEngelsdorp, Dennis
- Rights Statement Label:
- In Copyright
- Source:
- 6w924h89d
1812. Migration, Remittances and Nutrition Outcomes of Left-Behind Children: A National-Level Quantitative Assessment of Guatemala
- Title Tesim:
- Migration, Remittances and Nutrition Outcomes of Left-Behind Children: A National-Level Quantitative Assessment of Guatemala
- Creator:
- Davis, Jason and Brazil, Noli
- Date of publication:
- 2016
- Abstract Tesim:
- Historically, Guatemalans have suffered high rates of poverty and malnutrition while nearly ten percent of their population resides abroad. Many Guatemalan parents use economic migration, mainly international migration to the United States, as a means to improve the human capital prospects of their children. However, as this investigation shows, the timing of migration events in relation to left-behind children’s ages has important, often negative and likely permanent, repercussions on the physical development of their children. To illustrate these dynamics, this investigation uses an instrumental variables framework to disentangle the countervailing effects of Guatemalan fathers’ absences due to migration from concomitant remittances on left-behind children’s growth outcomes. Based on national-level data collected in 2000, the investigation reveals that the international migration of a father in the previous year is correlated with a 22.1% lower length/height-for-age z-score for the average left-behind child aged ≤ 3. In contrast, the receipt of remittance income has no influence on the physical stature of a child, which may indicate that migrant fathers with young children are not able to achieve economic success soon enough during their ventures abroad to fully ameliorate the harmful effects caused by their absences.
- Resource type:
- Article
- Affiliation Label Tesim:
- Carolina Population Center
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/qdj6-r026
- Identifier:
- PMCID: PMC4803329, Onescience id: d578cef38ba029e9dbc495d1a0b20abdae47b8fb, PMID: 27002528, and Publisher DOI: https://doi.org/10.1371/journal.pone.0152089
- ISSN:
- 1932-6203
- Journal Issue:
- 3
- Journal Title:
- PloS One
- Journal Volume:
- 11
- Keyword:
- Female, Humans, Child, Socioeconomic Factors, Adult, Income, Male, Nutritional Status, United States, Emigration and Immigration, Body Height, Guatemala, Transients and Migrants, Infant, Parents, and Poverty
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Spatial Sciences Institute; University of Southern California
- Page Start:
- e0152089
- Person:
- Davis, Jason and Brazil, Noli
- Rights Statement Label:
- In Copyright
- Source:
- j098zh286
1813. Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis
- Title Tesim:
- Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis
- Creator:
- Mason, Philip J., Olson, Timothy S., Kamio, Takuya, Zhang, Yanping, Bessler, Monica, and Gu, Bai-Wei
- Date of publication:
- 2016
- Abstract Tesim:
- MDM2, an E3 ubiquitin ligase, is an important negative regulator of tumor suppressor p53. In turn the Mdm2 gene is a transcriptional target of p53, forming a negative feedback loop that is important in cell cycle control. It has recently become apparent that the ubiquitination of p53 by MDM2 can be inhibited when certain ribosomal proteins, including RPL5 and RPL11, bind to MDM2. This inhibition, and the resulting increase in p53 levels has been proposed to be responsible for the red cell aplasia seen in Diamond-Blackfan anemia (DBA) and in 5q- myelodysplastic syndrome (MDS). DBA and 5q- MDS are associated with inherited (DBA) or acquired (5q- MDS) haploinsufficiency of ribosomal proteins. A mutation in Mdm2 causing a C305F amino acid substitution blocks the binding of ribosomal proteins. Mice harboring this mutation (Mdm2C305F), retain a normal p53 response to DNA damage, but lack the p53 response to perturbations in ribosome biogenesis. While studying the interaction between RP haploinsufficiency and the Mdm2C305F mutation we noticed that Mdm2C305F homozygous mice had altered hematopoiesis. These mice developed a mild macrocytic anemia with reticulocytosis. In the bone marrow (BM), these mice showed a significant decrease in Ter119hi cells compared to wild type (WT) littermates, while no decrease in the number of mature erythroid cells (Ter119hiCD71low) was found in the spleen, which showed compensated bone marrow hematopoiesis. In methylcellulose cultures, BFU-E colonies from the mutant mice were slightly reduced in number and there was a significant reduction in CFU-E colony numbers in mutant mice compared with WT controls (p < 0.01). This erythropoietic defect was abrogated by concomitant p53 deficiency (Trp53ko/ko). Further investigation revealed that in Mdm2C305F animals, there was a decrease in Lin-Sca-1+c-Kit+ (LSK) cells, accompanied by significant decreases in multipotent progenitor (MPP) cells (p < 0.01). Competitive BM repopulation experiments showed that donor BM harboring the Mdm2C305F mutation possessed decreased repopulation capacity compared to WT BM, suggesting a functional stem cell deficit. These results suggest that there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 axis which is important in normal hematopoiesis.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Radiation Oncology
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/2sbf-xm24
- Identifier:
- PMID: 27042854, Onescience id: 34fb87c9671c36dc411a3cf0f51c655c2099feed, PMCID: PMC4820113, and Publisher DOI: https://doi.org/10.1371/journal.pone.0152263
- ISSN:
- 1932-6203
- Journal Issue:
- 4
- Journal Title:
- PloS One
- Journal Volume:
- 11
- Keyword:
- Research Article, Ribosomes, Cellular Types, R, Model Organisms, Red Blood Cells, Animal Models, Physiology, Spleen, Hematopoiesis, Spectrum Analysis Techniques, Mouse Models, Q, Cell Biology, Erythropoiesis, Blood Cells, Research and Analysis Methods, Flow Cytometry, Medicine, Cellular Structures and Organelles, Hematology, Medicine and Health Sciences, Immune Physiology, Science, Biochemistry, and Cytophotometry
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Department of Hematology; Children's Hospital of Philadelphia and
- Page Start:
- e0152263
- Person:
- Mason, Philip J., Olson, Timothy S., Kamio, Takuya, Zhang, Yanping, Bessler, Monica, and Gu, Bai-Wei
- Rights Statement Label:
- In Copyright
- Source:
- d791sn30k
1814. Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts
- Title Tesim:
- Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts
- Creator:
- Lipner, Matthew B., Raftery, Laura, Wang, Xianxi, Yeh, Jen Jen, O'Neil, Bert H., Deng, Yangmei, and Marayati, Raoud
- Date of publication:
- 2016
- Abstract Tesim:
- There is currently tremendous interest in developing anti-cancer therapeutics targeting cell signaling pathways important for both cancer cell metabolism and growth. Several epidemiological studies have shown that diabetic patients taking metformin have a decreased incidence of pancreatic cancer. This has prompted efforts to evaluate metformin, a drug with negligible toxicity, as a therapeutic modality in pancreatic cancer. Preclinical studies in cell line xenografts and one study in patient-derived xenograft (PDX) models were promising, while recently published clinical trials showed no benefit to adding metformin to combination therapy regimens for locally advanced and metastatic pancreatic cancer. PDX models in which patient tumors are directly engrafted into immunocompromised mice have been shown to be excellent preclinical models for biomarker discovery and therapeutic development. We evaluated the response of four PDX tumor lines to metformin treatment and found that all four of our PDX lines were resistant to metformin. We found that the mechanisms of resistance may occur through lack of sustained activation of adenosine monophosphate-activated protein kinase (AMPK) or downstream reactivation of the mammalian target of rapamycin (mTOR). Moreover, combined treatment with metformin and mTOR inhibitors failed to improve responses in cell lines, which further indicates that metformin alone or in combination with mTOR inhibitors will be ineffective in patients, and that resistance to metformin may occur through multiple pathways. Further studies are required to better understand these mechanisms of resistance and inform potential combination therapies with metformin and existing or novel therapeutics.
- Resource type:
- Article
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/0xyj-8t53
- Identifier:
- PMID: 26760500, Publisher DOI: https://doi.org/10.1371/journal.pone.0147113, Onescience id: 874ff77d1bbb52e6a614cd7b4f7ff48065922651, and PMCID: PMC4711922
- ISSN:
- 1932-6203
- Journal Issue:
- 1
- Journal Title:
- PloS One
- Journal Volume:
- 11
- Keyword:
- AMP-Activated Protein Kinases, Humans, Cell Line, Tumor, Disease Models, Animal, Metformin, Tumor Burden, TOR Serine-Threonine Kinases, Signal Transduction, Ribosomal Protein S6 Kinases, 70-kDa, Phosphorylation, Drug Synergism, Hypoglycemic Agents, Animals, Xenograft Model Antitumor Assays, Cell Proliferation, Pancreatic Neoplasms, Gene Expression, Mice, and Protein Kinase Inhibitors
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Department of Pharmacology; School of Medicine; University of North Carolina, Lineberger Comprehensive Cancer Center; University of North Carolina, ProHealth Care Regional Cancer Center, Department of Surgery; Division of Surgical Oncology and Endocrinology; University of North Carolina, and Department of Medicine; Division of Medical Oncology; University of Indiana
- Page Start:
- e0147113
- Person:
- Lipner, Matthew B., Raftery, Laura, Wang, Xianxi, Yeh, Jen Jen, O'Neil, Bert H., Deng, Yangmei, and Marayati, Raoud
- Rights Statement Label:
- In Copyright
- Source:
- 3x816s61f
1815. Meta-Analysis of Effect Sizes Reported at Multiple Time Points Using General Linear Mixed Model
- Title Tesim:
- Meta-Analysis of Effect Sizes Reported at Multiple Time Points Using General Linear Mixed Model
- Creator:
- Manda, Samuel O.M., Mwambi, Henry G., Musekiwa, Alfred, and Chen, Ding-Geng
- Date of publication:
- 2016
- Abstract Tesim:
- Meta-analysis of longitudinal studies combines effect sizes measured at pre-determined time points. The most common approach involves performing separate univariate meta-analyses at individual time points. This simplistic approach ignores dependence between longitudinal effect sizes, which might result in less precise parameter estimates. In this paper, we show how to conduct a meta-analysis of longitudinal effect sizes where we contrast different covariance structures for dependence between effect sizes, both within and between studies. We propose new combinations of covariance structures for the dependence between effect size and utilize a practical example involving meta-analysis of 17 trials comparing postoperative treatments for a type of cancer, where survival is measured at 6, 12, 18 and 24 months post randomization. Although the results from this particular data set show the benefit of accounting for within-study serial correlation between effect sizes, simulations are required to confirm these results.
- Resource type:
- Article
- Affiliation Label Tesim:
- School of Social Work
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/wfny-tt98
- Identifier:
- Publisher DOI: https://doi.org/10.1371/journal.pone.0164898, PMID: 27798661, Onescience id: 8e36e12c2896d591721dc8aeb50af8e9b27732d4, and PMCID: PMC5087886
- ISSN:
- 1932-6203
- Journal Issue:
- 10
- Journal Title:
- PloS One
- Journal Volume:
- 11
- Keyword:
- Combined Modality Therapy, Neoplasms, Research Design, Algorithms, Likelihood Functions, Postoperative Care, Odds Ratio, Models, Statistical, Longitudinal Studies, Meta-Analysis as Topic, Linear Models, Sample Size, and Humans
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Biostatistics Unit; South African Medical Research Council, School of Mathematics; Statistics; and Computer Science; University of KwaZulu-Natal, and Department of Statistics; University of Pretoria
- Page Start:
- e0164898
- Person:
- Manda, Samuel O.M., Mwambi, Henry G., Musekiwa, Alfred, and Chen, Ding-Geng
- Rights Statement Label:
- In Copyright
- Source:
- x633f5787
1816. MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme
- Title Tesim:
- MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme
- Creator:
- Lee-Sherick, Alisa B., Keating, Amy K., Kowalski, Jeanne, Frye, Stephen V., Sufit, Alexandra, Earp, H. Shelton, Graham, Douglas K., Varella-Garcia, Marileila, Deryckere, Deborah, Dwivedi, Bhakti, Wang, Xiaodong, Rupji, Manali, and Pierce, Angela M.
- Date of publication:
- 2016
- Abstract Tesim:
- MER receptor tyrosine kinase (MERTK) is expressed in a variety of malignancies, including glioblastoma multiforme (GBM). Our previous work demonstrated that inhibition of MERTK using RNA interference induced cell death and chemosensitivity in GBM cells, implicating MERTK as a potential therapeutic target. Here we investigate whether a novel MERTK-selective small molecule tyrosine kinase inhibitor, UNC2025, has similar anti-tumor effects in GBM cell lines.
- Resource type:
- Article
- Affiliation Label Tesim:
- Center for Integrative Chemical Biology and Drug Discovery and Department of Medicine
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/smpz-dr69
- Identifier:
- PMID: 27783662, Onescience id: 131339a10bc406b8b71c9da88bc326497a9382bd, PMCID: PMC5081168, and Publisher DOI: https://doi.org/10.1371/journal.pone.0165107
- ISSN:
- 1932-6203
- Journal Issue:
- 10
- Journal Title:
- PloS One
- Journal Volume:
- 11
- Keyword:
- Glioblastoma, Neural Stem Cells, Protein Kinase Inhibitors, Gene Expression Regulation, Neoplastic, Antineoplastic Agents, Prognosis, Piperazines, Polyploidy, Cell Proliferation, Cell Aging, Cell Death, Adenine, Cell Line, Tumor, Enzyme Activation, Humans, Intercellular Signaling Peptides and Proteins, Proto-Oncogene Proteins, and Receptor Protein-Tyrosine Kinases
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Children's Hospital Colorado, University of Colorado; Anschutz Medical Campus, Winship Cancer Institute; Emory University, Department of Biostatistics and Bioinformatics; Rollins School of Public Health; Emory University, Department of Medicine, and Aflac Cancer and Blood Disorders Center; Children's Healthcare of Atlanta; Emory University; Department of Pediatrics
- Page Start:
- e0165107
- Person:
- Lee-Sherick, Alisa B., Keating, Amy K., Kowalski, Jeanne, Frye, Stephen V., Sufit, Alexandra, Earp, H. Shelton, Graham, Douglas K., Varella-Garcia, Marileila, Deryckere, Deborah, Dwivedi, Bhakti, Wang, Xiaodong, Rupji, Manali, and Pierce, Angela M.
- Rights Statement Label:
- In Copyright
- Source:
- 3r075097j
1817. Mechanical Ventilation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Retrospective Observational Study
- Title Tesim:
- Mechanical Ventilation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Retrospective Observational Study
- Creator:
- Katz, Marcelo, Barbas, Carmen Sílvia Valente, Serrano, Carlos V., Katz, Jason N., Franken, Marcelo, Makdisse, Marcia R., Correa, Alessandra G., Pereira, Carolina, Pesaro, Antonio Eduardo P., and Lopes, Renato D.
- Date of publication:
- 2016
- Abstract Tesim:
- Patients with acute myocardial infarction (AMI) and respiratory impairment may be treated with either invasive or non-invasive mechanical ventilation (MV). However, there has been little testing of non-invasive MV in the setting of AMI. Our objective was to evaluate the incidence and associated clinical outcomes of patients with AMI who were treated with non-invasive or invasive MV.
- Resource type:
- Article
- Affiliation Label Tesim:
- Division of Cardiology
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/zcya-s190
- Identifier:
- Publisher DOI: https://doi.org/10.1371/journal.pone.0151302, Onescience id: 738ae3aa9d50559d57ac0d42109108d08c7c3374, PMCID: PMC4792462, and PMID: 26977804
- ISSN:
- 1932-6203
- Journal Issue:
- 3
- Journal Title:
- PloS One
- Journal Volume:
- 11
- Keyword:
- Aged, 80 and over, Prognosis, Male, Aged, Respiration, Artificial, Respiratory Insufficiency, Middle Aged, Female, Retrospective Studies, Myocardial Infarction, Humans, Length of Stay, Hospital Mortality, and Treatment Outcome
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Hospital Israelita Albert Einstein, Pulmonary Department; Heart Institute (INCOR); University of São Paulo Medical School, Heart Institute (INCOR); University of Sao Paulo Medical School, Duke University Medical Center; Duke Clinical Research Institute, and Federal University of São Paulo; Paulista School of Medicine
- Page Start:
- e0151302
- Person:
- Katz, Marcelo, Barbas, Carmen Sílvia Valente, Serrano, Carlos V., Katz, Jason N., Franken, Marcelo, Makdisse, Marcia R., Correa, Alessandra G., Pereira, Carolina, Pesaro, Antonio Eduardo P., and Lopes, Renato D.
- Rights Statement Label:
- In Copyright
- Source:
- pg15bk982
1818. Measuring Concurrency Attitudes: Development and Validation of a Vignette-Based Scale
- Title Tesim:
- Measuring Concurrency Attitudes: Development and Validation of a Vignette-Based Scale
- Creator:
- Ramirez, Catalina, DeVellis, Robert F., Adimora, Adaora A., Cope, Anna B., Schoenbach, Victor J., and Agans, Robert
- Date of publication:
- 2016
- Abstract Tesim:
- Concurrent sexual partnerships (partnerships that overlap in time) may contribute to higher rates of HIV transmission in African Americans. Attitudes toward a behavior constitute an important component of most models of health-related behavior and behavioral change. We have developed a scale, employing realistic vignettes that appear to reliably measure attitudes about concurrency in young African American adults.
- Resource type:
- Article
- Affiliation Label Tesim:
- Division of Infectious Diseases, Department of Health Behavior, Department of Epidemiology, and Department of Biostatistics
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/8p8e-gr89
- Identifier:
- Onescience id: 15a97ab21cfe8336818e2d4d25cfd0f2b7e60e43, PMCID: PMC5072680, Publisher DOI: https://doi.org/10.1371/journal.pone.0163947, and PMID: 27764104
- ISSN:
- 1932-6203
- Journal Issue:
- 10
- Journal Title:
- PloS One
- Journal Volume:
- 11
- Keyword:
- Substance-Related Disorders, Adult, Age Factors, Female, Sexual Behavior, Sex Factors, Alcohol Drinking, Interviews as Topic, African Americans, Focus Groups, HIV Infections, Attitude, Self Efficacy, Factor Analysis, Statistical, Male, Humans, Adolescent, and Sexual Partners
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Department of Epidemiology
- Page Start:
- e0163947
- Person:
- Ramirez, Catalina, DeVellis, Robert F., Adimora, Adaora A., Cope, Anna B., Schoenbach, Victor J., and Agans, Robert
- Rights Statement Label:
- In Copyright
- Source:
- 2j62s978s
1819. Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060
- Title Tesim:
- Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060
- Creator:
- Gabriel, Erin E., Palumbo, Paul, Nonde, Thikazi, Phakati, Severiano, Philippe, Patrick Jean, Kafulafula, George, Tegha, Gerald, Shingalili, Ellen, Borkowsky, William, Mbewe, Felistas, Simbeye, Darius, Elbireer, Ali, Kafufu, Bosco, Balamusani, David, Kamthunzi, Portia, Kirmse, Brian, Chintu, Namwinga, Sambo, Pauline, Ilmet, Tiina, Kabugho, Enid, Barlow-Mosha, Linda, Tauzie, Jean, Prescott, William, Mofenson, Lynne, Chen, Jingyang, Petzold, Elizabeth, Musoke, Philippa, Mwale, John, Duffy, Patrick E., Neal, Jillian, Li, Yonghua, Hobbs, Charlotte V., Deygoo, Nagamah, Chi, Benjamin H., Nunkwe, Esnart Mwaba, and Parikh, Sunil
- Date of publication:
- 2016
- Abstract Tesim:
- HIV and malaria geographically overlap. HIV protease inhibitors kill malaria parasites in vitro and in vivo, but further evaluation in clinical studies is needed.
- Resource type:
- Article
- Affiliation Label Tesim:
- UNC Project-Malawi and Department of Obstetrics and Gynecology
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/72mc-9j68
- Identifier:
- Publisher DOI: https://doi.org/10.1371/journal.pone.0165140, PMID: 27936233, PMCID: PMC5147802, and Onescience id: 5f1877a9eb016f17d15ca76892c3e61ab65db8a0
- ISSN:
- 1932-6203
- Journal Issue:
- 12
- Journal Title:
- PloS One
- Journal Volume:
- 11
- Keyword:
- Lopinavir, Zidovudine, Malaria, Incidence, Protease Inhibitors, Human immunodeficiency virus 1, Ritonavir, In Vitro Techniques, Reverse Transcriptase Inhibitors, HIV Protease Inhibitors, Blood, Risk, Microscopy, Lamivudine, Nevirapine, Therapeutics, Homo sapiens, Antimalarials, Art Therapy, and Nucleosides
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Biostatistics Research Branch; National Institute of Allergy and Infectious Diseases; National Institutes of Health, Division of Infectious Diseases and International Health; Geisel School of Medicine at Dartmouth, HJF-DAIDS; Division of the Henry M. Jackson Foundation for the Advancement of Military Medicine; Inc.; NIAID; NIH; DHHS, Department of Pediatrics; Division of Infectious Disease and Immunology; New York University School of Medicine, Makerere University-Johns Hopkins University Research Collaboration, Department of Pediatrics; Division of Medical Genetics; University of Mississippi Medical Center; Batson Children's Hospital, Cornell Clinical Trials Unit; Weill Cornell Medicine, HYDAS World Health; Inc., Elizabeth Glaser Pediatric AIDS Foundation, Ben Towne Center for Childhood Cancer Research; Seattle Children's Research Institute; University of Washington; Fred Hutchinson Cancer Research Center, Laboratory of Malaria Immunology and Vaccinology; National Institute of Allergy and Infectious Diseases; National Institutes of Health, Duke Clinical Research Institute, Department of Pediatrics and Child Health; Makerere University, Batson Children's Hospital; Department of Pediatrics; Division of Infectious Diseases; Department of Microbiology; University of Mississippi Medical Center, and Yale Schools of Public Health and Medicine
- Page Start:
- e0165140
- Person:
- Gabriel, Erin E., Palumbo, Paul, Nonde, Thikazi, Phakati, Severiano, Philippe, Patrick Jean, Kafulafula, George, Tegha, Gerald, Shingalili, Ellen, Borkowsky, William, Mbewe, Felistas, Simbeye, Darius, Elbireer, Ali, Kafufu, Bosco, Balamusani, David, Kamthunzi, Portia, Kirmse, Brian, Chintu, Namwinga, Sambo, Pauline, Ilmet, Tiina, Kabugho, Enid, Barlow-Mosha, Linda, Tauzie, Jean, Prescott, William, Mofenson, Lynne, Chen, Jingyang, Petzold, Elizabeth, Musoke, Philippa, Mwale, John, Duffy, Patrick E., Neal, Jillian, Li, Yonghua, Hobbs, Charlotte V., Deygoo, Nagamah, Chi, Benjamin H., Nunkwe, Esnart Mwaba, and Parikh, Sunil
- Rights Statement Label:
- In Copyright
- Source:
- th83m436d
1820. Low Heart Rate Variability in a 2-Minute Electrocardiogram Recording Is Associated with an Increased Risk of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities Study
- Title Tesim:
- Low Heart Rate Variability in a 2-Minute Electrocardiogram Recording Is Associated with an Increased Risk of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities Study
- Creator:
- Norby, Faye L., Soliman, Elsayed Z., Alonso, Alvaro, Maheshwari, Ankit, Chen, Lin Y., Whitse, Eric A., and Adabag, Selcuk
- Date of publication:
- 2016
- Abstract Tesim:
- Low heart rate variability (HRV) has been linked to increased total mortality in the general population; however, the relationship between low HRV and sudden cardiac death (SCD) is less well-characterized. The goal of this study was to evaluate the relationship between low HRV and SCD in a community-based cohort. Our cohort consisted of 12,543 participants from the Atherosclerosis Risk in Communities (ARIC) study. HRV measures were derived from 2-minute electrocardiogram recordings obtained during the baseline exam (1987–89). Time domain measurements included the standard deviation of all normal RR intervals (SDNN) and the root mean squared successive difference (r-MSSD). Frequency domain measurements included low frequency power (LF) and high frequency (HF) power. During a median follow-up of 13 years, 215 SCDs were identified from physician adjudication of all coronary heart disease deaths through 2001. In multivariable adjusted Cox proportional hazards models, each standard deviation decrement in SDNN, LF, and HF were associated with 24%, 27% and 16% increase in SCD risk, respectively. Low HRV is independently associated with increased risk of SCD in the general population.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/8g7k-n768
- Identifier:
- PMCID: PMC4995012, Publisher DOI: https://doi.org/10.1371/journal.pone.0161648, Onescience id: 3c69308fcc7ee2bc50a69506d7c4bf55ba46d2ac, and PMID: 27551828
- ISSN:
- 1932-6203
- Journal Issue:
- 8
- Journal Title:
- PloS One
- Journal Volume:
- 11
- Keyword:
- Atherosclerosis, Proportional Hazards Models, Risk Factors, Death, Sudden, Cardiac, Middle Aged, Prospective Studies, Population Surveillance, Comorbidity, Humans, Female, Electrocardiography, Heart Rate, Male, Follow-Up Studies, and Risk Assessment
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Division of Epidemiology and Community Health; School of Public Health; University of Minnesota, Epidemiological Cardiology Research Center (EPICARE); Wake Forest School of Medicine, Department of Epidemiology; Rollins School of Public Health; Emory University, Cardiovascular Division; Department of Medicine; University of Minnesota; Medical School, and Division of Cardiology; Veteran Affairs Medical Center
- Page Start:
- e0161648
- Person:
- Norby, Faye L., Soliman, Elsayed Z., Alonso, Alvaro, Maheshwari, Ankit, Chen, Lin Y., Whitse, Eric A., and Adabag, Selcuk
- Rights Statement Label:
- In Copyright
- Source:
- c821gr05m
Collection Details
- Total items
-
1980
- Size
-
unknown
- Date created
-
February 2, 2022