PLoS Articles
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UNC-authored articles published by the Public Library of Science (PLoS)
Works (2127)
2041. Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies
- Title Tesim:
- Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies
- Creator:
- Tidwell, Richard R., Yeramian, Patrick D., Olson, Carol A., Merolle, Ada, Pohlig, Gabriele, Burri, Christian, Mpoto, Alfred Mpoo, Allen, James L., Blum, Johannes, Lutumba, Pascal, Lubaki, Jean-Pierre Fina, Mesu, Victor Kande Betu Ku, Bernhard, Sonja C., Josenando, Théophilo, Mpanya, Alain, Manuel, Francisco, Munungu, Blaise Fungula, Thompson, Mark, Bilenge, Constantin Miaka Mia, and Serge, Kazadi Kyanza
- Date of publication:
- 2016
- Abstract Tesim:
- BackgroundSleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death. We conducted two Phase 2 studies to determine the efficacy and safety of oral pafuramidine in African patients with first stage HAT.MethodsThe Phase 2a study was an open-label, non-controlled, proof-of-concept study where 32 patients were treated with 100 mg of pafuramidine orally twice a day (BID) for 5 days at two trypanosomiasis reference centers (Angola and the Democratic Republic of the Congo [DRC]) between August 2001 and November 2004. The Phase 2b study compared pafuramidine in 41 patients versus standard pentamidine therapy in 40 patients. The Phase 2b study was open-label, parallel-group, controlled, randomized, and conducted at two sites in the DRC between April 2003 and February 2007. The Phase 2b study was then amended to add an open-label sequence (Phase 2b-2), where 30 patients received pafuramidine for 10 days. The primary efficacy endpoint was parasitologic cure at 24 hours (Phase 2a) or 3 months (Phase 2b) after treatment completion. The primary safety outcome was the rate of occurrence of World Health Organization Toxicity Scale Grade 3 or higher adverse events. All subjects provided written informed consent.Findings/ConclusionPafuramidine for the treatment of first stage HAT was comparable in efficacy to pentamidine after 10 days of dosing. The cure rates 3 months post-treatment were 79% in the 5-day pafuramidine, 100% in the 7-day pentamidine, and 93% in the 10-day pafuramidine groups. In Phase 2b, the percentage of patients with at least 1 treatment-emergent adverse event was notably higher after pentamidine treatment (93%) than pafuramidine treatment for 5 days (25%) and 10 days (57%). These results support continuation of the development program for pafuramidine into Phase 3.Author SummarySleeping sickness (human African trypanosomiasis [HAT]) is caused by parasites, and has a chronic progressive course that may last from several months to several years before death occurs. The present studies were done to assess the effectiveness and safety of oral pafuramidine versus intramuscular pentamidine (the standard treatment), in patients with first stage HAT. The results indicated that, several months after treatment, pafuramidine administered for 10 days was as effective as pentamidine administered for 7 days, and it had a better safety profile than pentamidine. With further study, pafuramidine could be a promising alternative for patients with first stage HAT. In addition, the design of the studies can be used a guide for future studies for identification and delivery of treatment to affected individuals in rural Africa.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Pathology and Laboratory Medicine
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/yzy7-db89
- Identifier:
- Onescience id: a2640216c7862ce808d80c76ca76b0998b94b627, PMID: 26881924, Publisher DOI: https://doi.org/10.1371/journal.pntd.0004362, and PMCID: PMC4755713
- ISSN:
- 1935-2735 and 1935-2727
- Journal Issue:
- 2
- Journal Title:
- PLoS Neglected Tropical Diseases
- Journal Volume:
- 10
- Keyword:
- Middle Aged, Trypanosomiasis, African, Young Adult, Female, Pentamidine, Benzamidines, Antiprotozoal Agents, Adolescent, Drug-Related Side Effects and Adverse Reactions, Administration, Oral, Democratic Republic of the Congo, Adult, Male, Humans, pafuramidine, Treatment Outcome, and Angola
- Language Label:
- English
- ORCID:
- Other Affiliation:
- The Vaccine and Gene Therapy Institute of Florida, Infectious Diseases; Global Product Development; PPD, University of Basel, Swiss Tropical and Public Health Institute, Hôspital Evangélique de Vanga, Immtech Pharmaceuticals; Inc., Institut National de Recherche Biomédicale and Tropical Medicine Department; Kinshasa University, Programme des Maladies Tropicales Négligées; Ministère de la Santé Publique Kinshasa, Instituto de Combate e de Controlo das Tripanossomíases, Lisumbi Health Centre, Federally Qualified Community Health Center, Ministry of Health, and Médecins sans Frontières Suisse
- Page Start:
- e0004362
- Person:
- Tidwell, Richard R., Yeramian, Patrick D., Olson, Carol A., Merolle, Ada, Pohlig, Gabriele, Burri, Christian, Mpoto, Alfred Mpoo, Allen, James L., Blum, Johannes, Lutumba, Pascal, Lubaki, Jean-Pierre Fina, Mesu, Victor Kande Betu Ku, Bernhard, Sonja C., Josenando, Théophilo, Mpanya, Alain, Manuel, Francisco, Munungu, Blaise Fungula, Thompson, Mark, Bilenge, Constantin Miaka Mia, and Serge, Kazadi Kyanza
- Rights Statement Label:
- In Copyright
- Source:
- m326m705s
2042. Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial
- Title Tesim:
- Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial
- Creator:
- Mesu, Victor Kande Betu Ku, Blum, Johannes, Mpanya, Alain, Deo, Gratias Kambau Manesa, Macharia, Stephen, Munungu, Blaise Fungula, Bilenge, Constantin Miaka Mia, Lubaki, Jean-Pierre Fina, Mutantu, Pierre Nsele, Franco, Jose Ramon, N’tombe, Patrick Mangoni, Mintwo, Alain Fukinsia, Bernhard, Sonja C., Pohlig, Gabriele, Tidwell, Richard R., Olson, Carol A., Burri, Christian, Kuikumbi, Florent Mbo, Mpoto, Alfred Mpoo, Munungi, Augustin Kayeye, Dituvanga, Ndinga Dieyi, and Dala, Amadeu
- Date of publication:
- 2016
- Abstract Tesim:
- BackgroundSleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration. In previous studies, orally administered pafuramidine was well tolerated in healthy patients (for up to 21 days) and stage 1 HAT patients (for up to 10 days), and demonstrated efficacy comparable to pentamidine.MethodsThis was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospitals in the Democratic Republic of the Congo between August 2005 and September 2009 to support the registration of pafuramidine for treatment of first stage HAT in collaboration with the United States Food and Drug Administration. Patients were treated with either 100 mg of pafuramidine orally twice a day for 10 days or 4 mg/kg pentamidine intramuscularly once daily for 7 days to assess the efficacy and safety of pafuramidine versus pentamidine. Pregnant and lactating women as well as adolescents were included.The primary efficacy endpoint was the combined rate of clinical and parasitological cure at 12 months. The primary safety outcome was the frequency and severity of adverse events. The study was registered on the International Clinical Trials Registry Platform at www.clinicaltrials.gov with the number ISRCTN85534673.Findings/ConclusionsThe overall cure rate at 12 months was 89% in the pafuramidine group and 95% in the pentamidine group; pafuramidine was non-inferior to pentamidine as the upper bound of the 95% confidence interval did not exceed 15%. The safety profile of pafuramidine was superior to pentamidine; however, 3 patients in the pafuramidine group had glomerulonephritis or nephropathy approximately 8 weeks post-treatment. Two of these events were judged as possibly related to pafuramidine. Despite good tolerability observed in preceding studies, the development program for pafuramidine was discontinued due to delayed post-treatment toxicity.Author SummarySleeping sickness, or human African trypanosomiasis (HAT), is a neglected tropical disease. Because only 2 treatment options are available to treat persons with stage 1 disease, and both require parenteral administration, oral drugs would be of great benefit to the affected population. In this Phase 3, multi-center, randomized, open-label, parallel-group study, we compared oral pafuramidine with intramuscular pentamidine in persons in sub-Sahara Africa with first stage HAT. At 12 months, the overall cure rates (combined clinical and parasitological cure) were similar: 89% in the pafuramidine group and 95% in the pentamidine group. At 24 months, the cure rates continued to be high: 84% and 89%, respectively. Pafuramidine’s safety profile was superior to the comparator drug, and it was consistent with the overall safety profile seen in previous Phase 2 studies. Upon further analysis, however, a renal safety issue was identified as being possibly related to pafuramidine and further clinical development was halted. Nevertheless, the clinical studies conducted in the pafuramidine development program provide a model for future studies in rural Africa.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Pathology and Laboratory Medicine
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/t9gg-2q43
- Identifier:
- PMID: 26882015, Publisher DOI: https://doi.org/10.1371/journal.pntd.0004363, Onescience id: dcb64c79402ba7670c92f1239cbf810a16d6a7ca, and PMCID: PMC4755561
- ISSN:
- 1935-2735 and 1935-2727
- Journal Issue:
- 2
- Journal Title:
- PLoS Neglected Tropical Diseases
- Journal Volume:
- 10
- Keyword:
- Aged, Trypanosoma brucei gambiense, Adult, Pentamidine, Benzamidines, Angola, Humans, Treatment Outcome, Drug-Related Side Effects and Adverse Reactions, Administration, Oral, Pregnancy, Democratic Republic of the Congo, Kidney Diseases, Trypanosomiasis, African, pafuramidine, Female, Injections, Intramuscular, Child, Sudan, Young Adult, Middle Aged, Adolescent, and Male
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Programme des Maladies Tropicales Négligées; Ministère de la Santé Publique Kinshasa, Swiss Tropical and Public Health Institute; Medical Services and Diagnostic, Programme Nationale de Lutte contre la Trypanosomiase Humaine Africaine, Clinique Damas Aleka, Centre Hospitalier Lisungi BDOM, Ministry of Health, Institut National de Recherche Biomédicale, World Health Organisation Geneva; Department of Control of Neglected Diseases, Mission Hospital of Vanga, Swiss Tropical and Public Health Institute; Pharmaceutical Medicine Unit; Swiss Centre for International Health, Pharmacy & Clinical Pharmacology at the Division of Clinical Pharmacology; University of Basel, Sapphire Oak Consultants; LLC, Swiss Tropical and Public Health Institute; Department of Medicines Research, World Health Organization, and Instituto de Combate e de Controlo das Tripanossomíases
- Page Start:
- e0004363
- Person:
- Mesu, Victor Kande Betu Ku, Blum, Johannes, Mpanya, Alain, Deo, Gratias Kambau Manesa, Macharia, Stephen, Munungu, Blaise Fungula, Bilenge, Constantin Miaka Mia, Lubaki, Jean-Pierre Fina, Mutantu, Pierre Nsele, Franco, Jose Ramon, N’tombe, Patrick Mangoni, Mintwo, Alain Fukinsia, Bernhard, Sonja C., Pohlig, Gabriele, Tidwell, Richard R., Olson, Carol A., Burri, Christian, Kuikumbi, Florent Mbo, Mpoto, Alfred Mpoo, Munungi, Augustin Kayeye, Dituvanga, Ndinga Dieyi, and Dala, Amadeu
- Rights Statement Label:
- In Copyright
- Source:
- vh53x213z
2043. Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model
- Title Tesim:
- Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model
- Creator:
- Roche, James K., Kolling, Glynis L., Noronha, Francisco Jose, Cowardin, Carrie A., Buck, Gregory A., Zaenker, Edna I., Warren, Cirle A., Lara, Ana M., Turner, Jerrold R., Moore, John H., Guerrant, Richard L., Bolick, David T., and Bartelt, Luther A.
- Date of publication:
- 2016
- Abstract Tesim:
- Cryptosporidium is a major cause of severe diarrhea, especially in malnourished children. Using a murine model of C. parvum oocyst challenge that recapitulates clinical features of severe cryptosporidiosis during malnutrition, we interrogated the effect of protein malnutrition (PM) on primary and secondary responses to C. parvum challenge, and tested the differential ability of mucosal priming strategies to overcome the PM-induced susceptibility. We determined that while PM fundamentally alters systemic and mucosal primary immune responses to Cryptosporidium, priming with C. parvum (106 oocysts) provides robust protective immunity against re-challenge despite ongoing PM. C. parvum priming restores mucosal Th1-type effectors (CD3+CD8+CD103+ T-cells) and cytokines (IFNγ, and IL12p40) that otherwise decrease with ongoing PM. Vaccination strategies with Cryptosporidium antigens expressed in the S. Typhi vector 908htr, however, do not enhance Th1-type responses to C. parvum challenge during PM, even though vaccination strongly boosts immunity in challenged fully nourished hosts. Remote non-specific exposures to the attenuated S. Typhi vector alone or the TLR9 agonist CpG ODN-1668 can partially attenuate C. parvum severity during PM, but neither as effectively as viable C. parvum priming. We conclude that although PM interferes with basal and vaccine-boosted immune responses to C. parvum, sustained reductions in disease severity are possible through mucosal activators of host defenses, and specifically C. parvum priming can elicit impressively robust Th1-type protective immunity despite ongoing protein malnutrition. These findings add insight into potential correlates of Cryptosporidium immunity and future vaccine strategies in malnourished children.
- Resource type:
- Article
- Affiliation Label Tesim:
- Division of Infectious Diseases
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/xgwm-e598
- Identifier:
- Publisher DOI: https://doi.org/10.1371/journal.pntd.0004820, PMCID: PMC4965189, Onescience id: 5311bb0b178e59d2d98a1b2f4bd6855be0943dae, and PMID: 27467505
- ISSN:
- 1935-2735 and 1935-2727
- Journal Issue:
- 7
- Journal Title:
- PLoS Neglected Tropical Diseases
- Journal Volume:
- 10
- Keyword:
- Administration, Intranasal, Animals, Mice, Malnutrition, Cryptosporidiosis, Mice, Inbred C57BL, Dietary Proteins, Cryptosporidium, Protozoan Vaccines, and Female
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Division of Infectious Diseases and Center for Global Health; University of Virginia, Molecular Biology and Genetics; Virginia Commonwealth University, Departments of Pathology and Medicine—Gastroenterology; Brigham and Women’s Hospital, and Department of Pathology; The University of Chicago
- Page Start:
- e0004820
- Person:
- Roche, James K., Kolling, Glynis L., Noronha, Francisco Jose, Cowardin, Carrie A., Buck, Gregory A., Zaenker, Edna I., Warren, Cirle A., Lara, Ana M., Turner, Jerrold R., Moore, John H., Guerrant, Richard L., Bolick, David T., and Bartelt, Luther A.
- Rights Statement Label:
- In Copyright
- Source:
- 8336h697j
2044. Tuberculosis detection and the challenges of integrated care in rural China: A cross-sectional standardized patient study
- Title Tesim:
- Tuberculosis detection and the challenges of integrated care in rural China: A cross-sectional standardized patient study
- Creator:
- Zhou, Chengchao, Yi, Hongmei, Shi, Yaojiang, Sylvia, Sean, Das, Jishnu, Pai, Madhukar, Xue, Hao, Rozelle, Scott, and Zhou, Huan
- Date of publication:
- 2017
- Abstract Tesim:
- Despite recent reductions in prevalence, China still faces a substantial tuberculosis (TB) burden, with future progress dependent on the ability of rural providers to appropriately detect and refer TB patients for further care. This study (a) provides a baseline assessment of the ability of rural providers to correctly manage presumptive TB cases; (b) measures the gap between provider knowledge and practice and; (c) evaluates how ongoing reforms of China’s health system—characterized by a movement toward “integrated care” and promotion of initial contact with grassroots providers—will affect the care of TB patients.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Health Policy and Management
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/kv5z-8a93
- Identifier:
- PMCID: PMC5644979, Publisher DOI: https://doi.org/10.1371/journal.pmed.1002405, PMID: 29040263, and Onescience id: 703cde03d15f63719e4b74b97f9ffab33ece9558
- ISSN:
- 1549-1676 and 1549-1277
- Journal Issue:
- 10
- Journal Title:
- PLoS Medicine
- Journal Volume:
- 14
- Keyword:
- Health Care, Pharmacology, Research Article, Microbiology, Medical Doctors, Antimicrobials, Infectious Diseases, Geographical Locations, Asia, Medicine and Health Sciences, Population Groupings, Tuberculosis, Professions, Diagnostic Medicine, China, Bacterial Diseases, Antibiotics, Tuberculosis Diagnosis and Management, People and Places, Physicians, Biology and Life Sciences, Health Care Providers, Tropical Diseases, Medical Personnel, and Drugs
- Language Label:
- English
- ORCID:
- 0000-0002-9364-3579, 0000-0002-6934-0498, , and 0000-0002-9508-247X
- Other Affiliation:
- Institute of Social Medicine and Health Administration; School of Public Health; Shandong University, School of Advanced Agricultural Sciences; Peking University, Center for Experimental Economics in Education; Shaanxi Normal University, Development Research Group; The World Bank, McGill International TB Centre & Department of Epidemiology; Biostatistics and Occupational Health; McGill University, Freeman Spogli Institute for International Studies; Stanford University, and Department of Health and Social Behavior; West China School of Public Health; Sichuan University
- Page Start:
- e1002405
- Person:
- Zhou, Chengchao, Yi, Hongmei, Shi, Yaojiang, Sylvia, Sean, Das, Jishnu, Pai, Madhukar, Xue, Hao, Rozelle, Scott, and Zhou, Huan
- Rights Statement Label:
- In Copyright
- Source:
- pc289q00n
2045. The US President’s Malaria Initiative and under-5 child mortality in sub-Saharan Africa: A difference-in-differences analysis
- Title Tesim:
- The US President’s Malaria Initiative and under-5 child mortality in sub-Saharan Africa: A difference-in-differences analysis
- Creator:
- Thirumurthy, Harsha, Stearns, Sally C., Kruk, Margaret E., Jakubowski, Aleksandra, and Angeles, Gustavo
- Date of publication:
- 2017
- Abstract Tesim:
- Despite substantial financial contributions by the United States President’s Malaria Initiative (PMI) since 2006, no studies have carefully assessed how this program may have affected important population-level health outcomes. We utilized multiple publicly available data sources to evaluate the association between introduction of PMI and child mortality rates in sub-Saharan Africa (SSA).
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Health Policy and Management and Carolina Population Center
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/0343-pd48
- Identifier:
- PMID: 28609442, Publisher DOI: https://doi.org/10.1371/journal.pmed.1002319, Onescience id: d86bb73d91663dfd9c02e9cbedc4971bbdc0912c, and PMCID: PMC5469567
- ISSN:
- 1549-1277 and 1549-1676
- Journal Issue:
- 6
- Journal Title:
- PLoS Medicine
- Journal Volume:
- 14
- Keyword:
- Humans, Child Mortality, Female, Infant, United States, Male, International Cooperation, Infant, Newborn, Child, Preschool, Malaria, Africa South of the Sahara, and Infant Mortality
- Language Label:
- English
- ORCID:
- , 0000-0002-1129-0838, 0000-0002-9549-8432, and 0000-0001-7698-1392
- Other Affiliation:
- Carolina Population Center, Department of Global Health and Population; Harvard T.H. Chan School of Public Health; Harvard University, and Department of Maternal and Child Health
- Page Start:
- e1002319
- Person:
- Thirumurthy, Harsha, Stearns, Sally C., Kruk, Margaret E., Jakubowski, Aleksandra, and Angeles, Gustavo
- Rights Statement Label:
- In Copyright
- Source:
- x920g279r
2046. malERA: An updated research agenda for characterising the reservoir and measuring transmission in malaria elimination and eradication
- Title Tesim:
- malERA: An updated research agenda for characterising the reservoir and measuring transmission in malaria elimination and eradication
- Creator:
- The malERA Refresh Consultative Panel on Characterising the Reservoir and Measuring Transmission
- Date of publication:
- 2017
- Abstract Tesim:
- This paper summarises key advances in defining the infectious reservoir for malaria and the measurement of transmission for research and programmatic use since the Malaria Eradication Research Agenda (malERA) publication in 2011. Rapid and effective progress towards elimination requires an improved understanding of the sources of transmission as well as those at risk of infection. Characterising the transmission reservoir in different settings will enable the most appropriate choice, delivery, and evaluation of interventions. Since 2011, progress has been made in a number of areas. The extent of submicroscopic and asymptomatic infections is better understood, as are the biological parameters governing transmission of sexual stage parasites. Limitations of existing transmission measures have been documented, and proof-of-concept has been established for new innovative serological and molecular methods to better characterise transmission. Finally, there now exists a concerted effort towards the use of ensemble datasets across the spectrum of metrics, from passive and active sources, to develop more accurate risk maps of transmission. These can be used to better target interventions and effectively monitor progress toward elimination. The success of interventions depends not only on the level of endemicity but also on how rapidly or recently an area has undergone changes in transmission. Improved understanding of the biology of mosquito–human and human–mosquito transmission is needed particularly in low-endemic settings, where heterogeneity of infection is pronounced and local vector ecology is variable. New and improved measures of transmission need to be operationally feasible for the malaria programmes. Outputs from these research priorities should allow the development of a set of approaches (applicable to both research and control programmes) that address the unique challenges of measuring and monitoring transmission in near-elimination settings and defining the absence of transmission.
- Resource type:
- Article
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/v2mk-fg36
- Identifier:
- Publisher DOI: https://doi.org/10.1371/journal.pmed.1002452, PMCID: PMC5708619, PMID: 29190279, and Onescience id: 23c844bbbf305b25ef49cc1f5fa4dc6541f9aea9
- ISSN:
- 1549-1676 and 1549-1277
- Journal Issue:
- 11
- Journal Title:
- PLoS Medicine
- Journal Volume:
- 14
- Keyword:
- Apicomplexa, Cellular Types, Invertebrates, Parasitic Diseases, Insect Vectors, Collection Review, Biology and Life Sciences, Disease Vectors, Animal Cells, Infectious Diseases, Parasite Groups, Malarial Parasites, Parasitology, Plasmodium, Cell Biology, Insects, Species Interactions, Germ Cells, Parasitic Protozoans, Organisms, Malaria, Tropical Diseases, Protozoans, Gametocytes, Arthropoda, Diagnostic Medicine, Medicine and Health Sciences, Infectious Disease Control, Animals, Mosquitoes, and Eukaryota
- Language Label:
- English
- ORCID:
- Other Affiliation:
- Page Start:
- e1002452
- Person:
- The malERA Refresh Consultative Panel on Characterising the Reservoir and Measuring Transmission
- Rights Statement Label:
- In Copyright
- Source:
- 0p096c84z
2047. Malaria, malnutrition, and birthweight: A meta-analysis using individual participant data
- Title Tesim:
- Malaria, malnutrition, and birthweight: A meta-analysis using individual participant data
- Creator:
- Gutman, Julie, Schmiegelow, Christentze, Rogerson, Stephen, Valea, Innocent, Maleta, Kenneth, Ashorn, Per, Terlouw, Dianne J., Dellicour, Stephanie, Stanisic, Danielle, Ouma, Peter, Oneko, Martina, Fievet, Nadine, Dewey, Kathryn G., Lusingu, John P. A., Landis, Sarah H., Bauserman, Melissa, Meshnick, Steven, Slutsker, Laurence, Adair, Linda, Desai, Meghna, Unger, Holger W., Ayisi, John, Cole, Stephen R., Madanitsa, Mwayiwawo, Adu-Afarwuah, Seth, Mueller, Ivo, Westreich, Daniel, Mwapasa, Victor, Cates, Jordan E., Briand, Valerie, van Eijk, Anna Maria, Kariuki, Simon, ter Kuile, Feiko O., D’Alessandro, Umberto, and Tinto, Halidou
- Date of publication:
- 2017
- Abstract Tesim:
- Four studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight (LBW; <2,500 g) may depend upon maternal nutritional status. We investigated this dependence further using a large, diverse study population.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Pediatrics, Department of Epidemiology, and Department of Nutrition
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/99a5-h416
- Identifier:
- PMID: 28792500, Onescience id: dd74987bcaab8d466a8b8705e088dae167d3d159, Publisher DOI: https://doi.org/10.1371/journal.pmed.1002373, and PMCID: PMC5549702
- ISSN:
- 1549-1277 and 1549-1676
- Journal Issue:
- 8
- Journal Title:
- PLoS Medicine
- Journal Volume:
- 14
- Keyword:
- Anemia, Body Weight, Physiology, Hema, ws_115, Research Article, Tropical Diseases, Medicine, Pregnancy, /dk/atira/pure/researchoutput/pubmedpublicationtype/D017418, wa_310, qu_145, Birth, Labor and Delivery, Physical Sciences, Statistics (Mathematics), Malnutrition, Research and Analysis Methods, Birth Weight, Nutrition, Mathematical and Statistical Techniques, Maternal Health, Meta-Analysis, Biology and Life Sciences, Mathematics, wq_256, Malaria, ws_420, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, and wc_750
- Language Label:
- English
- ORCID:
- , 0000-0002-9360-9741, 0000-0003-4287-1982, 0000-0002-2536-3938, 0000-0002-2981-242X, 0000-0003-4300-7416, and 0000-0001-6341-5009
- Other Affiliation:
- Malaria Branch; Division of Parasitic Diseases and Malaria; Center for Global Health; Centers for Disease Control and Prevention, Centre for Medical Parasitology; Depart. Of Immunology and Microbiology; Faculty of Health Science; University of Copenhagen, Department of Medicine at the Doherty Institute; The University of Melbourne, Departement de Recherche Clinique, Unite de Recherche Clinique de Nanoro; Institut de Recherche en Sciences de la Santé-DRO, School of Public Health and Family Medicine; College of Medicine; University of Malawi, Center for Child Health Research University of Tampere School of Medicine and Tampere University Hospital, Department of Clinical Sciences; Liverpool School of Tropical Medicine, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Institute for Glycomics; Griffith University, Kenya Medical Research Institute (KEMRI)/ Centre for Global Health Research, UMR216-MERIT; French National Research Institute for Sustainable Development (IRD); Paris Descartes University, Department of Nutrition; University of California, National Institute for Medical Research; Tanga Centre, Worldwide Epidemiology; GlaxoSmithKline, Department of Nutrition, Malaria and Neglected Tropical Diseases; Center for Malaria Control and Elimination; PATH, Department of Obstetrics and Gynaecology; Edinburgh Royal Infirmary, Department of Nutrition and Food Science; University of Ghana, Walter and Eliza Hall Institute, London School of Hygiene and Tropical Medicine, and Medical Research Council Unit
- Page Start:
- e1002373
- Person:
- Gutman, Julie, Schmiegelow, Christentze, Rogerson, Stephen, Valea, Innocent, Maleta, Kenneth, Ashorn, Per, Terlouw, Dianne J., Dellicour, Stephanie, Stanisic, Danielle, Ouma, Peter, Oneko, Martina, Fievet, Nadine, Dewey, Kathryn G., Lusingu, John P. A., Landis, Sarah H., Bauserman, Melissa, Meshnick, Steven, Slutsker, Laurence, Adair, Linda, Desai, Meghna, Unger, Holger W., Ayisi, John, Cole, Stephen R., Madanitsa, Mwayiwawo, Adu-Afarwuah, Seth, Mueller, Ivo, Westreich, Daniel, Mwapasa, Victor, Cates, Jordan E., Briand, Valerie, van Eijk, Anna Maria, Kariuki, Simon, ter Kuile, Feiko O., D’Alessandro, Umberto, and Tinto, Halidou
- Rights Statement Label:
- In Copyright
- Source:
- g732dg07f
2048. Changes in prices, sales, consumer spending, and beverage consumption one year after a tax on sugar-sweetened beverages in Berkeley, California, US: A before-and-after study
- Title Tesim:
- Changes in prices, sales, consumer spending, and beverage consumption one year after a tax on sugar-sweetened beverages in Berkeley, California, US: A before-and-after study
- Creator:
- Silver, Lynn D., Induni, Marta, Miles, Donna R., Popkin, Barry M., Taillie, Lindsey Smith, Ng, Shu Wen, Ryan-Ibarra, Suzanne, and Poti, Jennifer M.
- Date of publication:
- 2017
- Abstract Tesim:
- Taxes on sugar-sweetened beverages (SSBs) meant to improve health and raise revenue are being adopted, yet evaluation is scarce. This study examines the association of the first penny per ounce SSB excise tax in the United States, in Berkeley, California, with beverage prices, sales, store revenue/consumer spending, and usual beverage intake.
- Resource type:
- Article
- Affiliation Label Tesim:
- Carolina Population Center and Department of Nutrition
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/s7sf-zp74
- Identifier:
- PMCID: PMC5395172, PMID: 28419108, Publisher DOI: https://doi.org/10.1371/journal.pmed.1002283, and Onescience id: 80024a47cd5c45870e8b67355d39d23bf873cae7
- ISSN:
- 1549-1676 and 1549-1277
- Journal Issue:
- 4
- Journal Title:
- PLoS Medicine
- Journal Volume:
- 14
- Keyword:
- Feeding Behavior, California, Beverages, Follow-Up Studies, Nutrition Surveys, Commerce, Humans, Drinking Behavior, Sweetening Agents, Taxes, and Dietary Sucrose
- Language Label:
- English
- ORCID:
- 0000-0002-2680-7393, , 0000-0001-9490-2096, and 0000-0002-7651-3625
- Other Affiliation:
- Public Health Institute and Carolina Population Center
- Page Start:
- e1002283
- Person:
- Silver, Lynn D., Induni, Marta, Miles, Donna R., Popkin, Barry M., Taillie, Lindsey Smith, Ng, Shu Wen, Ryan-Ibarra, Suzanne, and Poti, Jennifer M.
- Rights Statement Label:
- In Copyright
- Source:
- dn39x661w
2049. Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach
- Title Tesim:
- Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach
- Creator:
- Fox, Caroline, Willinger, Christine, Cohain, Ariella, Pankow, James S., Lipovich, Leonard, Liu, Chunyu, Multhaup, Michael, Joehanes, Roby, Irvin, Marguerite R., Krauss, Ronald M., Deary, Ian J., Arnett, Donna K., Ingelsson, Erik, Mendelson, Michael M., Boerwinkle, Eric, Yao, Chen, Huan, Tianxiao, Corley, Janie, Courchesne, Paul, North, Kari, Schadt, Eric E., Marioni, Riccardo E., Liang, Liming, Kleinbrink, Erica, Gustafsson, Stefan, Shah, Sonia, Redmond, Paul, Zhi, Degui, Guan, Weihua, Fallin, Daniele, Wray, Naomi R., Gibson, Jude, Fornage, Myriam, Sundström, Johan, Demerath, Ellen W., McRae, Allan F., Absher, Devin M., Bressler, Jan, Hedman, Åsa K., Lind, Lars, Chen, Brian, Harris, Sarah E., Visscher, Peter M., Murphy, Lee, Starr, John M., Aslibekyan, Stella, Feinberg, Andrew, Levy, Daniel, and Grove, Megan L.
- Date of publication:
- 2017
- Abstract Tesim:
- The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/9kkt-zw63
- Identifier:
- Onescience id: da20a17b5d1b2f3945a15547c2ac00942b3cd3fa, PMCID: PMC5240936, PMID: 28095459, and Publisher DOI: https://doi.org/10.1371/journal.pmed.1002215
- ISSN:
- 1549-1676 and 1549-1277
- Journal Issue:
- 1
- Journal Title:
- PLoS Medicine
- Journal Volume:
- 14
- Keyword:
- Cell biology, DNA methylation, Anatomy, Body Fluids, Epigenetics, DNA, Body Weight, Hematology, Gene Expression, Physiological Parameters, Medicine and Health Sciences, Chromatin, Nucleic acids, DNA modification, Biochemistry, Body Mass Index, Biology and life sciences, Obesity, Chromatin modification, Blood, Gene expression, Chromosome biology, Genetics, Biology and Life Sciences, Physiology, and Genetic Loci
- Language Label:
- English
- ORCID:
- , 0000-0003-2375-0683, 0000-0002-0531-3570, 0000-0002-8565-207X, 0000-0002-9948-3908, 0000-0003-4405-1646, 0000-0001-5413-204X, 0000-0001-9065-3301, 0000-0001-6467-7449, and 0000-0001-6764-2508
- Other Affiliation:
- Population Sciences Branch; National Heart; Lung; and Blood Institute; National Institutes of Health, Framingham Heart Study, Icahn Institute for Genomics and Multiscale Biology and Department of Genetics and Genomic Sciences; Icahn School of Medicine at Mount Sinai, Division of Epidemiology and Community Health; School of Public Health; University of Minnesota, Center for Molecular Medicine and Genetics and Department of Neurology; Wayne State University, Department of Biostatistics; Boston University, Center for Epigenetics; Johns Hopkins University School of Medicine, Hebrew SeniorLife; Harvard Medical School, Department of Epidemiology; School of Public Health; University of Alabama at Birmingham, Children’s Hospital Oakland Research Institute, Department of Psychology; University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology; University of Edinburgh, College of Public Health; University of Kentucky, Department of Medicine; Division of Cardiovascular Medicine; Stanford University School of Medicine, Molecular Epidemiology and Science for Life Laboratory; Department of Medical Sciences; Uppsala University, Department of Cardiology; Boston Children’s Hospital, Boston University School of Medicine, Human Genetics Center; School of Public Health; University of Texas Health Science Center at Houston, Human Genome Sequencing Center; Baylor College of Medicine, Medical Genetics Section; Centre for Genomic and Experimental Medicine; Institute of Genetics and Molecular Medicine; University of Edinburgh, Queensland Brain Institute; University of Queensland, Departments of Epidemiology and Biostatistics; School of Public Health; Harvard University, Institute for Molecular Bioscience; University of Queensland, Department of Biostatistics; School of Public Health; University of Alabama at Birmingham, Division of Biostatistics; School of Public Health; University of Minnesota, Wellcome Trust Clinical Research Facility; Western General Hospital; University of Edinburgh, Brown Foundation Institute of Molecular Medicine; University of Texas, Cardiovascular Epidemiology; Department of Medical Sciences; Uppsala University, HudsonAlpha Institute for Biotechnology, and Alzheimer Scotland Dementia Research Centre; University of Edinburgh
- Page Start:
- e1002215
- Person:
- Fox, Caroline, Willinger, Christine, Cohain, Ariella, Pankow, James S., Lipovich, Leonard, Liu, Chunyu, Multhaup, Michael, Joehanes, Roby, Irvin, Marguerite R., Krauss, Ronald M., Deary, Ian J., Arnett, Donna K., Ingelsson, Erik, Mendelson, Michael M., Boerwinkle, Eric, Yao, Chen, Huan, Tianxiao, Corley, Janie, Courchesne, Paul, North, Kari, Schadt, Eric E., Marioni, Riccardo E., Liang, Liming, Kleinbrink, Erica, Gustafsson, Stefan, Shah, Sonia, Redmond, Paul, Zhi, Degui, Guan, Weihua, Fallin, Daniele, Wray, Naomi R., Gibson, Jude, Fornage, Myriam, Sundström, Johan, Demerath, Ellen W., McRae, Allan F., Absher, Devin M., Bressler, Jan, Hedman, Åsa K., Lind, Lars, Chen, Brian, Harris, Sarah E., Visscher, Peter M., Murphy, Lee, Starr, John M., Aslibekyan, Stella, Feinberg, Andrew, Levy, Daniel, and Grove, Megan L.
- Rights Statement Label:
- In Copyright
- Source:
- ns064c02k
2050. A comparison of Selective Aortic Arch Perfusion and Resuscitative Endovascular Balloon Occlusion of the Aorta for the management of hemorrhage-induced traumatic cardiac arrest: A translational model in large swine
- Title Tesim:
- A comparison of Selective Aortic Arch Perfusion and Resuscitative Endovascular Balloon Occlusion of the Aorta for the management of hemorrhage-induced traumatic cardiac arrest: A translational model in large swine
- Creator:
- Cox, Jennifer M., Barnard, Ed B. G., Rall, Jason M., Ross, James D., Smith, Jason E., and Manning, James E.
- Date of publication:
- 2017
- Abstract Tesim:
- Survival rates remain low after hemorrhage-induced traumatic cardiac arrest (TCA). Noncompressible torso hemorrhage (NCTH) is a major cause of potentially survivable trauma death. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) at the thoracic aorta (Zone 1) can limit subdiaphragmatic blood loss and allow for IV fluid resuscitation when intrinsic cardiac activity is still present. Selective Aortic Arch Perfusion (SAAP) combines thoracic aortic balloon hemorrhage control with intra-aortic oxygenated perfusion to achieve return of spontaneous circulation (ROSC) when cardiac arrest has occurred.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Emergency Medicine
- Deposit Record:
- http://windsor.libint.unc.edu:8181/fcrepo/rest/prod/e2/82/bb/5c/e282bb5c-ecfc-4dd2-8603-2a46b5cc8e4b
- Type:
- http://purl.org/dc/dcmitype/Text
- DOI:
- https://doi.org/10.17615/ak2n-w721
- Identifier:
- Publisher DOI: https://doi.org/10.1371/journal.pmed.1002349, PMID: 28742797, PMCID: PMC5526509, and Onescience id: 970440ba08d99fc05fa3ee9897bdb3ac6dae6b6a
- ISSN:
- 1549-1277 and 1549-1676
- Journal Issue:
- 7
- Journal Title:
- PLoS Medicine
- Journal Volume:
- 14
- Keyword:
- Animals, Aorta, Swine, Balloon Occlusion, Perfusion, Disease Models, Animal, Translational Medical Research, Resuscitation, Heart Arrest, Hemorrhage, Aorta, Thoracic, and Male
- Language Label:
- English
- ORCID:
- and 0000-0001-7538-2099
- Other Affiliation:
- Air Force Trauma and Resuscitation Research Program; Joint Base San Antonio-Lackland, Institute of Naval Medicine, Academic Department of Military Emergency Medicine; Royal Centre for Defence Medicine (Research & Academia); Medical Directorate, Division of Trauma; Critical Care & Acute Care Surgery; Oregon Health & Science University, and Emergency Department; Derriford Hospital
- Page Start:
- e1002349
- Person:
- Cox, Jennifer M., Barnard, Ed B. G., Rall, Jason M., Ross, James D., Smith, Jason E., and Manning, James E.
- Rights Statement Label:
- In Copyright
- Source:
- 79408328z
Collection Details
- Total items
-
2127
- Size
-
unknown
- Date created
-
February 2, 2022