Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

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Creator
  • Hogan, Brigid L.M.
    • Other Affiliation: Duke Medicine
  • Barkauskas, Christina E.
    • Other Affiliation: Division of Pulmonary
  • Chapman, Harold A.
    • Other Affiliation: University of California, San Francisco
  • Epstein, Jonathan A.
    • Other Affiliation: University of Pennsylvania
  • Jain, Rajan
    • Other Affiliation: University of Pennsylvania
  • Hsia, Connie C.W.
    • Other Affiliation: UT Southwestern Medical School
  • Niklason, Laura
    • Other Affiliation: Yale University
  • Calle, Elizabeth
  • Le, Andrew
  • Randell, Scott H.
    • School of Medicine
  • Rock, Jason
    • Other Affiliation: University of California, San Francisco
  • Snitow, Melinda
    • Other Affiliation: University of Pennsylvania Perelman School of Medicine
  • Krummel, Matthew
    • Other Affiliation: University of California, San Francisco
  • Stripp, Barry R.
    • Other Affiliation: Cedars-Sinai Medical Center
  • Vu, Thiennu
    • Other Affiliation: University of California, San Francisco
  • White, Eric S.
    • Other Affiliation: University of Michigan, Ann Arbor
  • Whitsett, Jeffrey A.
    • Other Affiliation: University of Cincinnati College of Medicine
  • Morrisey, Edward E.
    • Other Affiliation: University of Pennsylvania
Abstract
  • Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive investigations. Recent studies have provided new information about the mechanisms driving lung development and differentiation. However, there is still much to learn about the ability of the adult respiratory system to undergo repair and to replace cells lost in response to injury and disease. This review highlights the multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair.
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  • Article
Rights statement
  • In Copyright
Journal title
  • Cell Stem Cell
Journal volume
  • 15
Journal issue
  • 2
Page start
  • 123
Page end
  • 138
Language
  • English
ISSN
  • 1875-9777
  • 1934-5909

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