Rifaximin Exerts Beneficial Effects Independent of its Ability to Alter Microbiota Composition
Public Deposited- Creator
- Kang, Dae J
- Kakiyama, Genta
- Betrapally, Naga S
- Herzog, Jeremy
- Nittono, Hiroshi
- Hylemon, Phillip B
- Zhou, Huiping
- Carroll, Ian
- Yang, Jing
- Gillevet, Patrick M
- Jiao, Chunhua
- Takei, Hajime
- Pandak, William M
- Iida, Takashi
- Heuman, Douglas M
- Fan, Sili
- Fiehn, Oliver
- Kurosawa, Takao
- Sikaroodi, Masoumeh
- Sartor, R B
- Bajaj, Jasmohan S
- Abstract
- Rifaximin has clinical benefits in minimal hepatic encephalopathy (MHE) but the mechanism of action is unclear. The antibiotic-dependent and -independent effects of rifaximin need to be elucidated in the setting of MHE-associated microbiota. To assess the action of rifaximin on intestinal barrier, inflammatory milieu and ammonia generation independent of microbiota using rifaximin.
- Date of publication
- 2016
- DOI
- Identifier
- PMID: 27560928
- Onescience id: fcf8954f24fc3f8b194f606b85f6a2f423f15e99
- PMCID: PMC5543406
- Publisher DOI: https://doi.org/10.1038/ctg.2016.44
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Clinical and Translational Gastroenterology
- Journal volume
- 7
- Journal issue
- 8
- Page start
- e187
- Page end
- e187
- Language
- English
- ISSN
- 2155-384X
Relations
- Parents:
This work has no parents.
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