Genome-wide asociation analysis identifies three psoriasis susceptibility loci

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Stuart, P.E.
    • Other Affiliation: University of Michigan
  • Nair, R.P.
    • Other Affiliation: University of Michigan
  • Elinghaus, E.
    • Other Affiliation: University of Kiel
  • Ding, J.
    • Other Affiliation: University of Michigan
  • Tejasvi, T.
    • Other Affiliation: University of Michigan
  • Gudjonson, J.E.
    • Other Affiliation: University of Michigan
  • Li, Y.
    • Affiliation: Gillings School of Global Public Health, Department of Biostatistics
    • Other Affiliation: University of Michigan
  • Weidinger, S.
    • Other Affiliation: Technical University Munich
  • Eberlein, B.
    • Other Affiliation: Technical University Munich
  • Gieger, C.
    • Other Affiliation: Ludwig-Maximilians-University
  • Wichman, H.E.
    • Other Affiliation: Ludwig-Maximilians-University
  • Kunz, M.
    • Other Affiliation: University of Lübeck
  • Ike, R.
    • Other Affiliation: University of Michigan
  • Krueger, G.G.
    • Other Affiliation: University of Utah
  • Bowcock, A.M.
    • Other Affiliation: Washington University at St. Louis
  • Mrowietz, U.
    • Other Affiliation: University of Kiel
  • Lim, H.W.
    • Other Affiliation: Henry Ford Hospital
  • Vorhes, J.J.
    • Other Affiliation: University of Michigan
  • Abecasis, G.R.
    • Other Affiliation: University of Michigan
  • Weichenthal, M.
    • Other Affiliation: University of Kiel
  • Franke, A.
    • Other Affiliation: University of Kiel
  • Rahman, P.
    • Other Affiliation: Memorial University
  • Gladman, D.D.
    • Other Affiliation: University of Toronto
  • Elder, J.T.
    • Other Affiliation: University of Michigan
Abstract
  • We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10-11), one at FBXL19 (rs10782001, combined P = 9-10-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10-5; rs10782001, combined P = 4-10-8; and rs12586317, combined P = 6-10-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10-8; rs10782001, combined P = 2-10-6; and rs12586317, combined P = 1-10-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10-7).
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Nature Genetics
Journal volume
  • 42
Journal issue
  • 11
Page start
  • 1000
Page end
  • 1004
Language
  • English
Version
  • Postprint
ISSN
  • 1061-4036

Relations

Parents:

This work has no parents.

Items

Thumbnail Title Date Uploaded Visibility Actions
file details nihms-238920.pdf 2021-11-11 Public Download