A population of G2-arrested cells are selected as sensory organ precursors for the interommatidial bristles of the Drosophila eye Public Deposited

Downloadable Content

Download PDF
  • Meserve, Joy H.
    • Affiliation: School of Medicine, Curriculum in Genetics and Molecular Biology
  • Duronio, Robert
    • ORCID: https://orcid.org/0000-0001-6469-6965
    • Affiliation: School of Medicine, Department of Genetics, College of Arts and Sciences, Department of Biology, Integrative Program for Biological and Genome Sciences, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology
  • Cell cycle progression and differentiation are highly coordinated during the development of multicellular organisms. The mechanisms by which these processes are coordinated and how their coordination contributes to normal development are not fully understood. Here, we determine the developmental fate of a population of precursor cells in the developing Drosophila melanogaster retina that arrest in G2 phase of the cell cycle and investigate whether cell cycle phase-specific arrest influences the fate of these cells. We demonstrate that retinal precursor cells that arrest in G2 during larval development are selected as sensory organ precursors (SOPs) during pupal development and undergo two cell divisions to generate the four-cell interommatidial mechanosensory bristles. While G2 arrest is not required for bristle development, preventing G2 arrest results in incorrect bristle positioning in the adult eye. We conclude that G2-arrested cells provide a positional cue during development to ensure proper spacing of bristles in the eye. Our results suggest that the control of cell cycle progression refines cell fate decisions and that the relationship between these two processes is not necessarily deterministic.
Date of publication
  • doi:10.1016/j.ydbio.2017.06.023
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Developmental Biology
Journal volume
  • 430
Journal issue
  • 2
Page start
  • 374
Page end
  • 384
  • English
  • Publisher
  • National Institutes of Health

This work has no parents.