Research on HIV cure: Mapping the ethics landscape

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Creator
  • Dube, Karine
    • Affiliation: Gillings School of Global Public Health
  • Sylla, Laurie
    • Other Affiliation: defeatHIV Community Advisory Board
  • Dee, Lynda
    • Other Affiliation: amfAR Institute for HIV Cure Research Community Advisory Board
  • Taylor, Jeff
    • Other Affiliation: amfAR Institute for HIV Cure Research Community Advisory Board
  • Evans, David
    • Other Affiliation: Delaney AIDS Research Enterprise Community Advisory Board
  • Bruton, Carl Dean
    • Other Affiliation: Collaboratory of AIDS Researchers for Eradication Community Advisory Board
  • Gilbertson, Adam
    • Affiliation: School of Medicine, Department of Social Medicine
  • Gralinski, Lisa
    • Affiliation: Gillings School of Global Public Health
  • Brown, Brandon
    • Other Affiliation: University of California Riverside
  • Skinner, Asheley
    • Affiliation: Gillings School of Global Public Health
  • Weiner, Bryan J.
    • Affiliation: Gillings School of Global Public Health
  • Greene, Sandra B.
    • Affiliation: Gillings School of Global Public Health
  • Corneli, Amy
    • Other Affiliation: Duke Clinical Research Institute
  • Adimora, Adaora
    • Affiliation: School of Medicine, Institute for Global Health and Infectious Diseases
  • Tucker, Joseph D.
    • Affiliation: School of Medicine, Institute for Global Health and Infectious Diseases
  • Rennie, Stuart
    • Affiliation: School of Medicine, Department of Social Medicine
Abstract
  • According to current estimates, 36.7 million people are infected with HIV worldwide. Despite large-scale and growing programs to prevent and treat HIV infection, possible approaches to achieve a cure for HIV infection are of strong interest. In the development of candidate approaches to achieve an HIV cure, issues of future translation to human study participants, evidence-based practice, clinical care, diverse populations, and populations in low- and middle-income countries should all be considered. An HIV cure should be effective, safe, simple, affordable, and scalable. Acceptability research is a critical adjunct to ongoing biomedical HIV cure research efforts. Anticipating some of the ethical and implementation challenges related to HIV cure strategies is necessary before the availability of effective interventions. Ongoing engagement of stakeholders is needed to resolve ethical, logistical, social, cultural, policy, regulatory, and implementation challenges at all stages of the HIV cure research development process.
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Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • PLoS Medicine
Journal volume
  • 14
Journal issue
  • 12
Language
  • English
ISSN
  • 15491277

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