Roles for the IKK-related kinases TBK1 and IKKε in cancer
Public Deposited- Creator
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Durand, J.K.
- Affiliation: School of Medicine, Curriculum in Genetics and Molecular Biology
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Zhang, Q.
- Affiliation: School of Medicine, Department of Pathology and Laboratory Medicine
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Baldwin, A.S.
- Affiliation: School of Medicine, Curriculum in Genetics and Molecular Biology
- Abstract
- While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of these kinases control proliferation, autophagy, cell survival, and cancer immune responses. Here we review the involvement of TBK1 and IKKε in controlling different cancers and in regulating responses to cancer immunotherapy.
- Date of publication
- 2018
- Keyword
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- License
- Attribution 4.0 International
- Journal title
- Cells
- Journal volume
- 7
- Journal issue
- 9
- Language
- English
- Version
- Publisher
- ISSN
- 2073-4409
- Publisher
- MDPI
Relations
- Parents:
- In Collection:
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