SARS-like WIV1-CoV poised for human emergence
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Menachery, Vineet D, et al. Sars-like Wiv1-cov Poised for Human Emergence. 2016. https://doi.org/10.17615/9tgz-an32APA
Menachery, V., Yount, B., Sims, A., Debbink, K., Agnihothram, S., Gralinski, L., Graham, R., Scobey, T., Plante, J., Royal, S., Swanstrom, J., Sheahan, T., Pickles, R., Corti, D., Randell, S., Lanzavecchia, A., Marasco, W., & Baric, R. (2016). SARS-like WIV1-CoV poised for human emergence. https://doi.org/10.17615/9tgz-an32Chicago
Menachery, Vineet D., Boyd L Yount, Amy C Sims, Kari Debbink, Sudhakar S Agnihothram, Lisa E Gralinski, Rachel L Graham et al. 2016. Sars-Like Wiv1-Cov Poised for Human Emergence. https://doi.org/10.17615/9tgz-an32- Creator
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Menachery, Vineet D.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Yount, Boyd L.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Sims, Amy C.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Debbink, Kari
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
- Other Affiliation: Department of Microbiology and Immunology
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Agnihothram, Sudhakar S.
- Other Affiliation: Division of Microbiology; National Center for Toxicological Research; Food and Drug Administration
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Gralinski, Lisa E.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Graham, Rachel L.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Scobey, Trevor
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Plante, Jessica A.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Royal, Scott R.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Swanstrom, Jesica
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Sheahan, Timothy P.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Pickles, Raymond J.
- Affiliation: School of Medicine, Department of Cell Biology and Physiology
- Other Affiliation: Division of Microbiology; National Center for Toxicological Research; Food and Drug Administration
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Corti, Davide
- Other Affiliation: Institute for Research in Biomedicine
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Randell, Scott H.
- Affiliation: School of Medicine, Department of Cell Biology and Physiology
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Lanzavecchia, Antonio
- Other Affiliation: Institute for Research in Biomedicine
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Marasco, Wayne A.
- Other Affiliation: Department of Cancer Immunology and AIDS; Dana-Farber Cancer Institute-Department of Medicine; Harvard Medical School
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Baric, Ralph S.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
- Other Affiliation: Division of Microbiology; National Center for Toxicological Research; Food and Drug Administration
- Abstract
- The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV highlights the continued risk of cross-species transmission leading to epidemic disease. This manuscript describes efforts to extend surveillance beyond sequence analysis, constructing chimeric and full-length zoonotic coronaviruses to evaluate emergence potential. Focusing on SARS-like virus sequences isolated from Chinese horseshoe bats, the results indicate a significant threat posed by WIV1-CoV. Both full-length and chimeric WIV1-CoV readily replicated efficiently in human airway cultures and in vivo, suggesting capability of direct transmission to humans. In addition, while monoclonal antibody treatments prove effective, the SARS-based vaccine approach failed to confer protection. Together, the study indicates an ongoing threat posed by WIV1-related viruses and the need for continued study and surveillance.
- Date of publication
- 2016
- Keyword
- Animals
- Cercopithecus aethiops
- Coronaviridae Infections
- Cross Reactions
- Antibodies, Viral
- Host Specificity
- Mice
- Cells, Cultured
- Epithelial Cells
- Encephalitis, Viral
- SARS
- Mice, Transgenic
- CoV
- Lung
- Models, Molecular
- emergence
- Chiroptera
- Coronaviridae
- Communicable Diseases, Emerging
- Antibodies, Neutralizing
- Spike
- Mice, Inbred BALB C
- WIV1
- Antibodies, Monoclonal
- Humans
- DOI
- Identifier
- Publisher DOI: https://doi.org/10.1073/pnas.1517719113
- PMID: 26976607
- PMCID: PMC4801244
- Onescience id: e895925e5226b1e51094173360f463f0117e471a
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Proceedings of the National Academy of Sciences of the United States of America
- Journal volume
- 113
- Journal issue
- 11
- Language
- English
- ISSN
- 1091-6490
- 0027-8424
- 0744-2831
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