Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study
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Prins, Bram. P, et al. Investigating the Causal Relationship of C-reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-scale Cross-consortium Mendelian Randomization Study. 2016. https://doi.org/10.17615/946f-3p45APA
Prins, B., Abbasi, A., Wong, A., Vaez, A., Nolte, I., Franceschini, N., Stuart, P., Guterriez Achury, J., Mistry, V., Bradfield, J., Valdes, A., Bras, J., Shatunov, A., Lu, C., Han, B., Raychaudhuri, S., Bevan, S., Mayes, M., Tsoi, L., Evangelou, E., Nair, R., Grant, S., Polychronakos, C., Radstake, T., Van Heel, D., Dunstan, M., Wood, N., Al Chalabi, A., Dehghan, A., Hakonarson, H., Markus, H., Elder, J., Knight, J., Arking, D., Spector, T., Koeleman, B., Van Duijn, C., Martin, J., Morris, A., Weersma, R., Wijmenga, C., Munroe, P., Perry, J., Pouget, J., Jamshidi, Y., Snieder, H., & Alizadeh, B. (2016). Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. https://doi.org/10.17615/946f-3p45Chicago
Prins, Bram. P., Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart et al. 2016. Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. https://doi.org/10.17615/946f-3p45- Creator
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Prins, Bram. P.
- Other Affiliation: Department of Human Genetics; Wellcome Trust Sanger Institute
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Abbasi, Ali
- Other Affiliation: MRC Epidemiology Unit; University of Cambridge School of Clinical Medicine; Institute of Metabolic Science; Addenbrooke’s Hospital
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Wong, Anson
- Other Affiliation: Institute of Medical Sciences; University of Toronto
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Vaez, Ahmad
- Other Affiliation: School of Medicine; Isfahan University of Medical Sciences
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Nolte, Ilja
- Other Affiliation: Department of Epidemiology; University of Groningen; University Medical Center Groningen
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Franceschini, Nora
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Stuart, Philip E.
- ORCID: 0000-0002-9546-6529
- Other Affiliation: Department of Dermatology; Veterans Affairs Hospital; University of Michigan
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Guterriez Achury, Javier
- Other Affiliation: Department of Genetics; University of Groningen; University Medical Centre Groningen
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Mistry, Vanisha
- Other Affiliation: Metabolic Research Laboratories; Wellcome Trust–MRC Institute of Metabolic Science; Addenbrooke’s Hospital; University of Cambridge
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Bradfield, Jonathan P.
- Other Affiliation: Center for Applied Genomics; Division of Human Genetics; Children’s Hospital of Philadelphia
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Valdes, Ana M.
- Other Affiliation: Department of Academic Rheumatology; University of Nottingham
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Bras, Jose
- Other Affiliation: Department of Molecular Neuroscience; Institute of Neurology
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Shatunov, Aleksey
- Other Affiliation: Department of Basic and Clinical Neuroscience; Institute of Psychiatry; Psychology and Neuroscience; King’s College London
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Lu, Chen
- Other Affiliation: Department of Biostatistics; Boston University School of Public Health
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Han, Buhm
- Other Affiliation: Program in Medical and Population Genetics; Broad Institute of Harvard and MIT
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Raychaudhuri, Soumya
- Other Affiliation: Division of Rheumatology; Brigham and Women’s Hospital; Harvard Medical School
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Bevan, Steve
- Other Affiliation: Neurology Unit; Department of Clinical Neurosciences; University of Cambridge
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Mayes, Maureen D.
- Other Affiliation: Division of Rheumatology and Clinical Immunogenetics; University of Texas Health Science Center at Houston
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Tsoi, Lam C.
- Other Affiliation: Department of Biostatistics; University of Michigan
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Evangelou, Evangelos
- Other Affiliation: Department of Epidemiology and Biostatistics; School of Public Health; Imperial College London
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Nair, Rajan P.
- Other Affiliation: Department of Dermatology; Veterans Affairs Hospital; University of Michigan
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Grant, Struan F. A.
- Other Affiliation: Department of Pediatrics; Perelman School of Medicine; University of Pennsylvania
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Polychronakos, Constantin
- Other Affiliation: Endocrine Genetics Research Institute; McGill University Health Center
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Radstake, Timothy R. D.
- Other Affiliation: Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology; University Medical Center Utrecht
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van Heel, David A.
- Other Affiliation: Blizard Institute; Barts and The London School of Medicine and Dentistry; Queen Mary University of London
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Dunstan, Melanie L.
- ORCID: 0000-0003-3817-2142
- Other Affiliation: Institute of Psychological Medicine and Clinical Neurosciences; School of Medicine; Cardiff University
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Wood, Nicholas W.
- Other Affiliation: Department of Molecular Neuroscience; UCL Institute of Neurology
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Al-Chalabi, Ammar
- Other Affiliation: Complex Disease Genetics; Cold Spring Harbor Laboratory
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Dehghan, Abbas
- Other Affiliation: Department of Epidemiology; Erasmus University Rotterdam; University Medical Centre Rotterdam; Rotterdam
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Hakonarson, Hakon
- Other Affiliation: Department of Pediatrics; Perelman School of Medicine; University of Pennsylvania
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Markus, Hugh S.
- Other Affiliation: Neurology Unit; Department of Clinical Neurosciences; University of Cambridge
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Elder, James T.
- Other Affiliation: Department of Dermatology; Veterans Affairs Hospital; University of Michigan
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Knight, Jo
- Other Affiliation: Institute of Medical Sciences; University of Toronto
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Arking, Dan E.
- Other Affiliation: McKusick-Nathans Institute of Genetic Medicine and Department of Medicine; Division of Cardiology; Johns Hopkins University School of Medicine
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Spector, Timothy D.
- Other Affiliation: Department of Twin Research and Genetic Epidemiology; King’s College London
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Koeleman, Bobby P. C.
- Other Affiliation: Complex Genetic Section; Department of Medical Genetics; University Medical Center Utrecht
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van Duijn, Cornelia M.
- Other Affiliation: Department of Epidemiology; Erasmus University Rotterdam; University Medical Centre Rotterdam; Rotterdam
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Martin, Javier
- Other Affiliation: Instituto de Parasitologia y Biomedicina Lopez-Neyra; Consejo Superior de Investigaciones Científicas
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Morris, Andrew P.
- Other Affiliation: Wellcome Trust Centre for Human Genetics; University of Oxford
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Weersma, Rinse K.
- Other Affiliation: Department of Gastroenterology and Hepatology; University of Groningen; University Medical Center Groningen
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Wijmenga, Cisca
- Other Affiliation: Department of Genetics; University of Groningen; University Medical Centre Groningen
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Munroe, Patricia B.
- Other Affiliation: Clinical Pharmacology; William Harvey Research Institute; Barts and the London School of Medicine; Queen Mary University of London
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Perry, John R. B.
- Other Affiliation: MRC Epidemiology Unit; University of Cambridge School of Clinical Medicine; Institute of Metabolic Science; Addenbrooke’s Hospital
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Pouget, Jennie G.
- Other Affiliation: Institute of Medical Sciences; University of Toronto
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Jamshidi, Yalda
- Other Affiliation: Cardiogenetics Lab; Cardiovascular and Cell Sciences Institute; St George’s Hospital Medical School
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Snieder, Harold
- Other Affiliation: Department of Epidemiology; University of Groningen; University Medical Center Groningen
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Alizadeh, Behrooz Z.
- Other Affiliation: Department of Gastroenterology and Hepatology; University of Groningen; University Medical Center Groningen
- Abstract
- C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal.
- Date of publication
- 2016
- Keyword
- Genome Analysis
- Biology and Life Sciences
- Osteoarthritis
- Vascular Medicine
- Mood Disorders
- Medicine and Health Sciences
- Rheumatology
- Sociology
- Bipolar Disorder
- Blood Pressure
- Genome-Wide Association Studies
- Social Sciences
- Schizophrenia
- Arthritis
- Mental Health and Psychiatry
- Anatomy
- Computational Biology
- Legs
- Genetics of Disease
- Human Genetics
- Consortia
- Limbs (Anatomy)
- Musculoskeletal System
- Genomics
- Genetics
- DOI
- Identifier
- Publisher DOI: https://doi.org/10.1371/journal.pmed.1001976
- Onescience id: d07411f33a9e6bfbdf17eec61159a7a84901d677
- PMCID: PMC4915710
- PMID: 27327646
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- PLoS Medicine
- Journal volume
- 13
- Journal issue
- 6
- Page start
- e1001976
- Language
- English
- ISSN
- 1549-1277
- 1549-1676
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