Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study Public Deposited

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  • Prins, Bram. P.
    • Other Affiliation: Department of Human Genetics; Wellcome Trust Sanger Institute
  • Abbasi, Ali
    • Other Affiliation: MRC Epidemiology Unit; University of Cambridge School of Clinical Medicine; Institute of Metabolic Science; Addenbrooke’s Hospital
  • Wong, Anson
    • Other Affiliation: Institute of Medical Sciences; University of Toronto
  • Vaez, Ahmad
    • Other Affiliation: School of Medicine; Isfahan University of Medical Sciences
  • Nolte, Ilja
    • Other Affiliation: Department of Epidemiology; University of Groningen; University Medical Center Groningen
  • Franceschini, Nora
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Stuart, Philip E.
    • ORCID: 0000-0002-9546-6529
    • Other Affiliation: Department of Dermatology; Veterans Affairs Hospital; University of Michigan
  • Guterriez Achury, Javier
    • Other Affiliation: Department of Genetics; University of Groningen; University Medical Centre Groningen
  • Mistry, Vanisha
    • Other Affiliation: Metabolic Research Laboratories; Wellcome Trust–MRC Institute of Metabolic Science; Addenbrooke’s Hospital; University of Cambridge
  • Bradfield, Jonathan P.
    • Other Affiliation: Center for Applied Genomics; Division of Human Genetics; Children’s Hospital of Philadelphia
  • Valdes, Ana M.
    • Other Affiliation: Department of Academic Rheumatology; University of Nottingham
  • Bras, Jose
    • Other Affiliation: Department of Molecular Neuroscience; Institute of Neurology
  • Shatunov, Aleksey
    • Other Affiliation: Department of Basic and Clinical Neuroscience; Institute of Psychiatry; Psychology and Neuroscience; King’s College London
  • Lu, Chen
    • Other Affiliation: Department of Biostatistics; Boston University School of Public Health
  • Han, Buhm
    • Other Affiliation: Program in Medical and Population Genetics; Broad Institute of Harvard and MIT
  • Raychaudhuri, Soumya
    • Other Affiliation: Division of Rheumatology; Brigham and Women’s Hospital; Harvard Medical School
  • Bevan, Steve
    • Other Affiliation: Neurology Unit; Department of Clinical Neurosciences; University of Cambridge
  • Mayes, Maureen D.
    • Other Affiliation: Division of Rheumatology and Clinical Immunogenetics; University of Texas Health Science Center at Houston
  • Tsoi, Lam C.
    • Other Affiliation: Department of Biostatistics; University of Michigan
  • Evangelou, Evangelos
    • Other Affiliation: Department of Epidemiology and Biostatistics; School of Public Health; Imperial College London
  • Nair, Rajan P.
    • Other Affiliation: Department of Dermatology; Veterans Affairs Hospital; University of Michigan
  • Grant, Struan F. A.
    • Other Affiliation: Department of Pediatrics; Perelman School of Medicine; University of Pennsylvania
  • Polychronakos, Constantin
    • Other Affiliation: Endocrine Genetics Research Institute; McGill University Health Center
  • Radstake, Timothy R. D.
    • Other Affiliation: Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology; University Medical Center Utrecht
  • van Heel, David A.
    • Other Affiliation: Blizard Institute; Barts and The London School of Medicine and Dentistry; Queen Mary University of London
  • Dunstan, Melanie L.
    • ORCID: 0000-0003-3817-2142
    • Other Affiliation: Institute of Psychological Medicine and Clinical Neurosciences; School of Medicine; Cardiff University
  • Wood, Nicholas W.
    • Other Affiliation: Department of Molecular Neuroscience; UCL Institute of Neurology
  • Al-Chalabi, Ammar
    • Other Affiliation: Complex Disease Genetics; Cold Spring Harbor Laboratory
  • Dehghan, Abbas
    • Other Affiliation: Department of Epidemiology; Erasmus University Rotterdam; University Medical Centre Rotterdam; Rotterdam
  • Hakonarson, Hakon
    • Other Affiliation: Department of Pediatrics; Perelman School of Medicine; University of Pennsylvania
  • Markus, Hugh S.
    • Other Affiliation: Neurology Unit; Department of Clinical Neurosciences; University of Cambridge
  • Elder, James T.
    • Other Affiliation: Department of Dermatology; Veterans Affairs Hospital; University of Michigan
  • Knight, Jo
    • Other Affiliation: Institute of Medical Sciences; University of Toronto
  • Arking, Dan E.
    • Other Affiliation: McKusick-Nathans Institute of Genetic Medicine and Department of Medicine; Division of Cardiology; Johns Hopkins University School of Medicine
  • Spector, Timothy D.
    • Other Affiliation: Department of Twin Research and Genetic Epidemiology; King’s College London
  • Koeleman, Bobby P. C.
    • Other Affiliation: Complex Genetic Section; Department of Medical Genetics; University Medical Center Utrecht
  • van Duijn, Cornelia M.
    • Other Affiliation: Department of Epidemiology; Erasmus University Rotterdam; University Medical Centre Rotterdam; Rotterdam
  • Martin, Javier
    • Other Affiliation: Instituto de Parasitologia y Biomedicina Lopez-Neyra; Consejo Superior de Investigaciones Científicas
  • Morris, Andrew P.
    • Other Affiliation: Wellcome Trust Centre for Human Genetics; University of Oxford
  • Weersma, Rinse K.
    • Other Affiliation: Department of Gastroenterology and Hepatology; University of Groningen; University Medical Center Groningen
  • Wijmenga, Cisca
    • Other Affiliation: Department of Genetics; University of Groningen; University Medical Centre Groningen
  • Munroe, Patricia B.
    • Other Affiliation: Clinical Pharmacology; William Harvey Research Institute; Barts and the London School of Medicine; Queen Mary University of London
  • Perry, John R. B.
    • Other Affiliation: MRC Epidemiology Unit; University of Cambridge School of Clinical Medicine; Institute of Metabolic Science; Addenbrooke’s Hospital
  • Pouget, Jennie G.
    • Other Affiliation: Institute of Medical Sciences; University of Toronto
  • Jamshidi, Yalda
    • Other Affiliation: Cardiogenetics Lab; Cardiovascular and Cell Sciences Institute; St George’s Hospital Medical School
  • Snieder, Harold
    • Other Affiliation: Department of Epidemiology; University of Groningen; University Medical Center Groningen
  • Alizadeh, Behrooz Z.
    • Other Affiliation: Department of Gastroenterology and Hepatology; University of Groningen; University Medical Center Groningen
Abstract
  • C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • PLoS Medicine
Journal volume
  • 13
Journal issue
  • 6
Page start
  • e1001976
Language
  • English
ISSN
  • 1549-1277
  • 1549-1676
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