SGC-CAMKK2-1: A Chemical Probe for CAMKK2

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Creator
  • Wells, Carrow
    • Affiliation: Eshelman School of Pharmacy
  • Liang, Yi
    • Affiliation: Eshelman School of Pharmacy
  • Pulliam, Thomas L.
    • Other Affiliation: University of Texas MD Anderson Cancer Center
  • Lin, Chenchu
    • Other Affiliation: University of Texas MD Anderson Cancer Center
  • Awad, Dominik
    • Other Affiliation: University of Texas MD Anderson Cancer Center
  • Eduful, Benjamin
    • Affiliation: Eshelman School of Pharmacy
  • O’Byrne, Sean
    • Affiliation: Eshelman School of Pharmacy
  • Hossain, Mohammad Anwar
    • Affiliation: Eshelman School of Pharmacy
  • Catta-Preta, Carolina Moura Costa
    • Other Affiliation: Universidade Estadual de Campinas
  • Ramos, Priscila Zonzini
    • Other Affiliation: Universidade Estadual de Campinas
  • Gileadi, Opher
    • Other Affiliation: Universidade Estadual de Campinas
  • Gileadi, Carina
    • Other Affiliation: Universidade Estadual de Campinas
  • Couñago, Rafael M.
    • Other Affiliation: Universidade Estadual de Campinas
  • Stork, Brittany
    • Other Affiliation: Baylor College of Medicine
  • Langendorf, Christopher G.
    • Other Affiliation: St Vincent’s Institute of Medical Research
  • Nay, Kevin
    • Other Affiliation: St Vincent’s Institute of Medical Research
  • Oakhill, Jonathan S.
    • Other Affiliation: St Vincent’s Institute of Medical Research
  • Mukherjee, Debarati
    • Other Affiliation: Duke University School of Medicine
  • Racioppi, Luigi
    • Other Affiliation: Duke University School of Medicine
  • Means, Anthony R.
    • Other Affiliation: Baylor College of Medicine
  • York, Brian
    • Other Affiliation: Baylor College of Medicine
  • McDonnell, Donald P.
    • Other Affiliation: Duke University School of Medicine
  • Scott, John W.
    • Other Affiliation: St Vincent’s Institute of Medical Research
  • Frigo, Daniel E.
    • Other Affiliation: University of Texas MD Anderson Cancer Center
  • Drewry, David H.
    • Affiliation: Eshelman School of Pharmacy
Abstract
  • The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.
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Resource type
  • Article
Rights statement
  • In Copyright
License
  • Attribution 4.0 International
Journal title
  • Cells
Journal volume
  • 12
Journal issue
  • 2
Page start
  • 287
Language
  • English
Version
  • Publisher
ISSN
  • 2073-4409
Publisher
  • MDPI

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