Driving force of COVID-19 among people living with HIV in Wuhan, China

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  • Guo W.
    • Other Affiliation: Zhongnan Hospital of Wuhan University
  • Ming F.
    • Other Affiliation: Wuchang District Center for Disease Control and Prevention
  • Dong Y.
    • Other Affiliation: Zhongnan Hospital of Wuhan University
  • Zhang Q.
    • Other Affiliation: Qingshan District Center for Disease Control and Prevention
  • Liu L.
    • Other Affiliation: Caidian District Center for Disease Control and Prevention
  • Gao M.
    • Other Affiliation: Xinzhou District Center for Disease Control and Prevention
  • Zhang X.
    • Other Affiliation: Zhongnan Hospital of Wuhan University
  • Mo P.
    • Other Affiliation: Zhongnan Hospital of Wuhan University
  • Feng Y.
    • Other Affiliation: Wuhan University
  • Tang W.
    • Affiliation: School of Medicine, UNC Project-China
  • Liang K.
    • Other Affiliation: Zhongnan Hospital of Wuhan University
Abstract
  • Background: Although people living with HIV (PLWH) were considered to be at increased risk of SARS-CoV-2 infection, the driving force among this group of individuals is still not clear. Methods: We investigated 1,709 PLWH through a telephone interview and identified 11 COVID-19 patients in four districts of Wuhan, China. The demographic features and major clinical characteristics of these patients were retrieved from the information management systems for COVID-19 patients of the four districts’ CDC. Statistical analysis was performed to find out the driving force of COVID-19 among PLWH. Results: The prevalence of COVID-19 in PLWH is 0.6% (95% CI: 0.2% - 1.0%), which is comparable to the overall population prevalence in Wuhan city (0.6%). Nine out of the 11 COVID-19 patients had relatively high CD4+ T lymphocyte count (>200/μl) and undetectable HIV viral load (<20 copies/ml), and ten of them were on antiretroviral therapy. Older PLWH with low CD4 + count, got HIV infected through homosexual activity, and had been diagnosed with HIV for a long time, were more likely to develop COVID-19. Conclusions: COVID-19 related morbidity rates were comparable between PLWH and the general population. Older age with low CD4 count, an extended period of HIV diagnosis, and treatment-naivety were potential driving forces of COVID-19 prevalence among PLWH. Strategies for preventing SARS-CoV-2 infection among PLWH with weak immune responses are required.
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  • Article
Rights statement
  • In Copyright
Journal title
  • AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Journal volume
  • 34
Journal issue
  • 11
Page start
  • 1364
Page end
  • 1371
Language
  • English
Funder
  • Wuhan University, WHU, (PTXM2020008)
  • National Natural Science Foundation of China, NSFC, (81903371)
  • Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences, (2020-PT320-004)
  • National Major Science and Technology Projects of China, (2018ZX10101-001-001-003)
  • Special Found on Prevention and Control of New Coronary Pneumonia in Guangdong Universities, (2020KZDZX1047)
  • National Key Research and Development Program of China, NKRDPC, (2017YFE0103800)
  • National Institute of Mental Health, NIMH, (R34MH119963)
  • Science and Technology Innovation Cultivation Fund of Zhongnan Hospital, (TFJC2018004, cxpy2017043)
ISSN
  • 0954-0121
Publisher
  • Routledge

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