Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes

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Creator
  • Granados, Hector M.
    • Other Affiliation: Department of Pediatrics; Texas Tech Health Science Center
  • Draghi, Andrew
    • Other Affiliation: Department of Immunology; University of Connecticut Health Center
  • Tsurutani, Naomi
    • Other Affiliation: Department of Immunology; University of Connecticut Health Center
  • Wright, Kyle
    • Other Affiliation: Department of Immunology; University of Connecticut Health Center
  • Fernandez, Marina L.
    • Other Affiliation: Department of Pediatrics; Connecticut Children’s Medical Center
  • Sylvester, Francisco A.
    • Affiliation: School of Medicine, Department of Pediatrics
  • Vella, Anthony T.
    • Other Affiliation: Department of Immunology; University of Connecticut Health Center
Abstract
  • Programmed death cell 1 (PD-1) is an inhibitor of T cell activation and is also functionally linked to glycolysis. We hypothesized that PD-1 expression is defective in activated T cells from children with type 1 diabetes (T1D), resulting in abnormal T cell glucose metabolism.
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  • Article
Rights statement
  • In Copyright
Journal title
  • PloS One
Journal volume
  • 12
Journal issue
  • 9
Page start
  • e0183887
Language
  • English
ISSN
  • 1932-6203

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