Diminished physical function in older HIV-infected adults in the Southeastern U.S. despite successful antiretroviral therapy

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Khoury, Audrey L.
- Affiliation: School of Medicine
Morey, Miriam C.
- Other Affiliation: Claude D Pepper Older Americans Independence Center; Department of Medicine; Duke University School of Medicine
Wong, Tammy C.
- Affiliation: School of Medicine
McNeil, Donna Lynn
- Other Affiliation: Office of Research Support; Duke Cancer Institute
Humphries, Barlett
- Other Affiliation: Center for Applied Genomics and Precision Medicine; Duke University Medical Center
Frankey, Katherine
- Other Affiliation: Center for Applied Genomics and Precision Medicine; Duke University Medical Center
Pieper, Carl F.
- Other Affiliation: Duke Department of Biostatistics and Bioinformatics
Hicks, Charles B.
- Other Affiliation: Division of Infectious Diseases; University of California; San Diego School of Medicine
Huffman, Kim
- Other Affiliation: Duke Molecular Physiology Institute; Duke University School of Medicine
McKellar, Mehri S.
- Other Affiliation: Division of Infectious Disease; Duke University Medical Center

Abstract

As antiretroviral therapy efficacy improves, HIV is gradually being recognized more as a chronic disease within the aging HIV-infected population. While these individuals are surviving into old age, they may, however, be experiencing “accelerated aging” with greater declines in physical function than that observed among comparably matched individuals free of HIV. This decline is not well understood and it remains unclear if physical decline correlates with the degree of immunosuppression based on CD4 lymphocyte nadir.

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