Detection and quantitation of HPV in anogenital and oral tissues and fluids of HIV-positive individuals by real-time PCR

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  • Seaman, William T
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
  • Andrews, Elizabeth
    • Affiliation: School of Medicine, Division of Infectious Diseases, School of Dentistry, Department of Dental Ecology
  • Couch, Marion
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
  • Kojic, Erna
    • Other Affiliation: Division of Biology and Medicine, Brown University, Providence, RI, USA
  • Cu-Uvin, Susan
    • Other Affiliation: Division of Biology and Medicine, Brown University, Providence, RI, USA
  • Deal, Allison M
    • Affiliation: School of Dentistry, Department of Dental Ecology
  • Quinlavin, Byrd
    • Other Affiliation: Division of Biology and Medicine, Brown University, Providence, RI, USA
  • Seay, Julia
    • Other Affiliation: Division of Biology and Medicine, Brown University, Providence, RI, USA
  • Webster-Cyriaque, Jennifer
    • Affiliation: School of Medicine, Department of Microbiology and Immunology, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
Abstract
  • Human papillomaviruses (HPV) remain a serious world health problem due to their association with anogenital and oral cancers and warts. While over 100 HPV types have been identified, only a subset is associated with malignancy. HPV16 and 18 are the most common oncogenic types, while HPV6 and 11 are the most common types responsible for anogenital warts. These four types cause up to 90% of HPV-associated disease. While other quantitative PCR (qPCR) assays can be used to detect oncogenic HPV, there is no single tube assay that distinguishes the most frequent oncogenic types and the most common types found in warts. A qPCR assay was developed that allowed for detection and quantitation of these 4 HPV types.
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  • Article
Rights statement
  • In Copyright
Rights holder
  • William T Seaman et al.; licensee BioMed Central Ltd.
Journal title
  • Infectious Agents and Cancer
Journal volume
  • 5
Journal issue
  • Suppl 1
Page start
  • A17
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1750-9378
Bibliographic citation
  • Infectious Agents and Cancer. 2010 Oct 11;5(Suppl 1):A17
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • August 23, 2012

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