Evaluating the strength of genetic results: Risks and responsibilities Public Deposited

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Creator
  • Barsh, G.S.
    • Other Affiliation: HudsonAlpha Institute for Biotechnology
  • Cooper, G.M.
    • Other Affiliation: HudsonAlpha Institute for Biotechnology
  • Copenhaver, G.P.
    • Affiliation: College of Arts and Sciences, Department of Biology
  • Sirugo, G.
    • Other Affiliation: University of Pennsylvania Perelman School of Medicine
  • Tang, H.
    • Other Affiliation: Stanford University School of Medicine
  • Williams, S.M.
    • Other Affiliation: Case Western Reserve University
Abstract
  • In this issue, we are publishing an Editorial Expression of Concern in connection with a recent article on the genetics of multiple sclerosis (MS). In brief, the authors used exome sequencing of families with multiple individuals diagnosed with MS to identify 21 missense or nonsense mutations in 12 genes, and they then suggest that these 12 genes provide a platform for additional research. Following publication, concerns were raised about the validity of some of the statements made in the manuscript, leading us to a series of discussions, both internally and with the authors. The purpose of this editorial is to describe the sequence of events, the rationale for our eventual publication of the Editorial Expression of Concern, and, in doing so, comment and engender discussion more broadly on the role of scientists as editors in what can sometimes be a grey area: the causal relationship between genetic and phenotypic variation.
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Resource type
  • Article
Rights statement
  • In Copyright
License
  • Attribution 4.0 International
Journal title
  • PLoS Genetics
Journal volume
  • 15
Journal issue
  • 10
Language
  • English
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  • Publisher
ISSN
  • 1553-7390
Publisher
  • Public Library of Science
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