Nanotechnology: a promising method for oral cancer detection and diagnosis Public Deposited

Downloadable Content

Download PDF
Creator
  • Liu, Qi
    • Affiliation: Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics
  • Zhang, Jing
    • Other Affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, People’s Republic of China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, People’s Republic of China
  • Zhang, Xue-Qiong
    • Other Affiliation: School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, People’s Republic of China
  • Chen, Xiao-Jie
    • Other Affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, People’s Republic of China
  • Zhou, Gang
    • Other Affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, People’s Republic of China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, People’s Republic of China
Abstract
  • Abstract Oral cancer is a common and aggressive cancer with high morbidity, mortality, and recurrence rate globally. Early detection is of utmost importance for cancer prevention and disease management. Currently, tissue biopsy remains the gold standard for oral cancer diagnosis, but it is invasive, which may cause patient discomfort. The application of traditional noninvasive methods-such as vital staining, exfoliative cytology, and molecular imaging-is limited by insufficient sensitivity and specificity. Thus, there is an urgent need for exploring noninvasive, highly sensitive, and specific diagnostic techniques. Nano detection systems are known as new emerging noninvasive strategies that bring the detection sensitivity of biomarkers to nano-scale. Moreover, compared to current imaging contrast agents, nanoparticles are more biocompatible, easier to synthesize, and able to target specific surface molecules. Nanoparticles generate localized surface plasmon resonances at near-infrared wavelengths, providing higher image contrast and resolution. Therefore, using nano-based techniques can help clinicians to detect and better monitor diseases during different phases of oral malignancy. Here, we review the progress of nanotechnology-based methods in oral cancer detection and diagnosis.
Date of publication
Identifier
  • doi:10.1186/s12951-018-0378-6
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • The Author(s)
Language
  • English
Bibliographic citation
  • Journal of Nanobiotechnology. 2018 Jun 11;16(1):52
Publisher
  • BioMed Central
Parents:

This work has no parents.

Items