Nanotechnology: a promising method for oral cancer detection and diagnosis

Creator

Chen, Xiao-Jie
- Other Affiliation: Wuhan University
Zhang, Xue-Qiong
- Other Affiliation: Wuhan University of Technology
Liu, Qi
- Affiliation: Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics
Zhang, Jing
- Other Affiliation: Wuhan University
Zhou, Gang
- Other Affiliation: Wuhan University

Abstract

Abstract Oral cancer is a common and aggressive cancer with high morbidity, mortality, and recurrence rate globally. Early detection is of utmost importance for cancer prevention and disease management. Currently, tissue biopsy remains the gold standard for oral cancer diagnosis, but it is invasive, which may cause patient discomfort. The application of traditional noninvasive methods-such as vital staining, exfoliative cytology, and molecular imaging-is limited by insufficient sensitivity and specificity. Thus, there is an urgent need for exploring noninvasive, highly sensitive, and specific diagnostic techniques. Nano detection systems are known as new emerging noninvasive strategies that bring the detection sensitivity of biomarkers to nano-scale. Moreover, compared to current imaging contrast agents, nanoparticles are more biocompatible, easier to synthesize, and able to target specific surface molecules. Nanoparticles generate localized surface plasmon resonances at near-infrared wavelengths, providing higher image contrast and resolution. Therefore, using nano-based techniques can help clinicians to detect and better monitor diseases during different phases of oral malignancy. Here, we review the progress of nanotechnology-based methods in oral cancer detection and diagnosis.

Date of publication

DOI

Identifier

Resource type

Rights statement

Rights holder

Journal title

Journal volume

Journal issue

Language

Bibliographic citation

Publisher

Relations

Thumbnail	Title	Date Uploaded	Visibility	Actions
	12951_2018_article_378.pdf	2019-05-06	Public	Download