Emergence of a Highly Fit SARS-CoV-2 Variant

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Creator
  • Baric, Ralph S.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
Abstract
  • Sarbecoviruses have emerged twice in the 21st century, causing a worldwide epidemic and pandemic. The ongoing pandemic of coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused unprecedented disruption of human society. Since its emergence in December 2019, SARS-CoV-2 has spread worldwide, infecting more than 70 million persons and causing more than 1.6 million deaths as of early December 2020. Previous studies have clearly shown that epidemic and pandemic RNA virus spread may select for mutations that alter RNA virus pathogenesis, virulence, transmissibility, or a combination of these, yet this process remains poorly studied among emerging coronaviruses in animals and humans.
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  • Article
Rights statement
  • In Copyright
Journal title
  • New England Journal of Medicine
Journal volume
  • 383
Page start
  • 2684
Page end
  • 2686
Language
  • English
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  • Publisher
ISSN
  • 0028-4793
Publisher
  • Massachussetts Medical Society

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