Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

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  • Graff, Mariaelisa
    • ORCID: 0000-0001-6380-1735
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Scott, Robert A.
    • Other Affiliation: MRC Epidemiology Unit; Institute of Metabolic Science; University of Cambridge
  • Justice, Anne E.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Young, Kristin L.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
    • Other Affiliation: Carolina Population Center
  • Feitosa, Mary F.
    • Other Affiliation: Department of Genetics; Washington University School of Medicine
  • Barata, Llilda
    • Other Affiliation: Department of Genetics; Washington University School of Medicine
  • Winkler, Thomas W.
    • ORCID: 0000-0003-0292-5421
    • Other Affiliation: Department of Genetic Epidemiology; University of Regensburg
  • Chu, Audrey Y.
    • Other Affiliation: Division of Preventive Medicine; Brigham and Women's Hospital
  • Mahajan, Anubha
    • Other Affiliation: Wellcome Trust Centre for Human Genetics; University of Oxford
  • Hadley, David
    • Other Affiliation: Division of Population Health Sciences and Education; St. George's; University of London
  • Xue, Luting
    • Other Affiliation: Department of Biostatistics; Boston University School of Public Health
  • Workalemahu, Tsegaselassie
    • Other Affiliation: Department of Nutrition; Harvard T.H. Chan School of Public Health
  • Heard-Costa, Nancy L.
    • Other Affiliation: National Heart; Lung; and Blood Institute; Framingham Heart Study
  • den Hoed, Marcel
    • Other Affiliation: Department of Immunology; Genetics and Pathology and Science for Life Laboratory; Uppsala University
  • Ahluwalia, Tarunveer S.
    • Other Affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research; Section of Metabolic Genetics; Faculty of Health and Medical Sciences; University of Copenhagen
  • Qi, Qibin
    • Other Affiliation: Department of Epidemiology and Population Health; Albert Einstein College of Medicine
  • Ngwa, Julius S.
    • Other Affiliation: Howard University; Department of Internal Medicine
  • Renström, Frida
    • Other Affiliation: Department of Biobank Research; Umeå University
  • Quaye, Lydia
    • Other Affiliation: Department of Twin Research and Genetic Epidemiology; King's College London
  • Eicher, John D.
    • Other Affiliation: Population Sciences Branch; National Heart; Lung; and Blood Institute; National Institutes of Health; The Framingham Heart Study
  • Hayes, James E.
    • Other Affiliation: Cell and Developmental Biology Graduate Program; Weill Cornell Graduate School of Medical Sciences; Cornell University
  • Cornelis, Marilyn
    • Other Affiliation: Department of Preventive Medicine; Northwestern University Feinberg School of Medicine
  • Kutalik, Zoltan
    • Other Affiliation: Institute of Social and Preventive Medicine; Lausanne University Hospital
  • Lim, Elise
    • Other Affiliation: Department of Biostatistics; Boston University School of Public Health
  • Luan, Jian’an
    • Other Affiliation: MRC Epidemiology Unit; Institute of Metabolic Science; University of Cambridge
  • Huffman, Jennifer E.
    • Other Affiliation: MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine; University of Edinburgh; Western General Hospital
  • Zhang, Weihua
    • Other Affiliation: Department of Epidemiology and Biostatistics; School of Public Health; Imperial College London
  • Zhao, Wei
    • Other Affiliation: Department of Epidemiology; School of Public Health; University of Michigan
  • Griffin, Paula J.
    • Other Affiliation: Department of Biostatistics; Boston University School of Public Health
  • Haller, Toomas
    • Other Affiliation: Estonian Genome Center; University of Tartu
  • Ahmad, Shafqat
    • Other Affiliation: Department of Clinical Sciences; Genetic and Molecular Epidemiology Unit; Lund University
  • Marques-Vidal, Pedro M.
    • Other Affiliation: Department of Internal Medicine; Internal Medicine; Lausanne University Hospital
  • Bien, Stephanie
    • Other Affiliation: Division of Public Health Sciences; Fred Hutchinson Cancer Research Center
  • Yengo, Loic
    • Other Affiliation: University of Lille; CNRS; Institut Pasteur de Lille; UMR 8199 - EGID
  • Teumer, Alexander
    • Other Affiliation: Institute for Community Medicine; University Medicine Greifswald
  • Smith, Albert Vernon
    • Other Affiliation: Faculty of Medicine; University of Iceland
  • Kumari, Meena
    • Other Affiliation: ISER; University of Essex; Colchester
  • Harder, Marie Neergaard
    • Other Affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research; Section of Metabolic Genetics; Faculty of Health and Medical Sciences; University of Copenhagen
  • Justesen, Johanne Marie
    • Other Affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research; Section of Metabolic Genetics; Faculty of Health and Medical Sciences; University of Copenhagen
  • Kleber, Marcus E.
    • Other Affiliation: Institute of Nutrition; Friedrich Schiller University Jena
  • Hollensted, Mette
    • Other Affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research; Section of Metabolic Genetics; Faculty of Health and Medical Sciences; University of Copenhagen
  • Lohman, Kurt
    • Other Affiliation: Department of Biostatistical Sciences; Division of Public Health Sciences; Wake Forest School of Medicine
  • Rivera, Natalia V.
    • Other Affiliation: Karolinska Institutet; Respiratory Unit; Department of Medicine Solna
  • Whitfield, John B.
    • Other Affiliation: Genetic Epidemiology; QIMR Berghofer Medical Research Institute
  • Zhao, Jing Hua
    • Other Affiliation: MRC Epidemiology Unit; Institute of Metabolic Science; University of Cambridge
  • Stringham, Heather M.
    • Other Affiliation: Center for Statistical Genetics; Department of Biostatistics; University of Michigan
  • Lyytikäinen, Leo-Pekka
    • Other Affiliation: Department of Clinical Chemistry; University of Tampere School of Medicine
  • Huppertz, Charlotte
    • Other Affiliation: Department of Biological Psychology; Vrije Universiteit
  • Willemsen, Gonneke
    • Other Affiliation: Department of Biological Psychology; Vrije Universiteit
  • Peyrot, Wouter J.
    • Other Affiliation: Department of Psychiatry; EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam; VU University Medical Center/GGZ InGeest
  • Wu, Ying
    • Affiliation: School of Medicine, Department of Genetics
  • Kristiansson, Kati
    • Other Affiliation: Institute for Molecular Medicine Finland; University of Helsinki
  • Demirkan, Ayse
    • Other Affiliation: Department of Human Genetics; Leiden University Medical Center
  • Fornage, Myriam
    • Other Affiliation: Division of Epidemiology; Human Genetics; and Environmental Sciences; University of Texas Health Science Center at Houston
  • Hassinen, Maija
    • Other Affiliation: Kuopio Research Institute of Exercise Medicine
  • Bielak, Lawrence F.
    • Other Affiliation: Department of Epidemiology; School of Public Health; University of Michigan
  • Cadby, Gemma
    • Other Affiliation: Centre for Genetic Origins of Health and Disease; University of Western Australia
  • Tanaka, Toshiko
    • Other Affiliation: Translational Gerontology Branch; National Institute on Aging
  • Mägi, Reedik
    • Other Affiliation: Estonian Genome Center; University of Tartu
  • van der Most, Peter J.
    • Other Affiliation: Department of Epidemiology; University of Groningen; University Medical Center Groningen
  • Jackson, Anne U.
    • Other Affiliation: Center for Statistical Genetics; Department of Biostatistics; University of Michigan
  • Bragg-Gresham, Jennifer L.
    • Other Affiliation: Center for Statistical Genetics; Department of Biostatistics; University of Michigan
  • Vitart, Veronique
    • Other Affiliation: MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine; University of Edinburgh; Western General Hospital
  • Marten, Jonathan
    • Other Affiliation: MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine; University of Edinburgh; Western General Hospital
  • Navarro, Pau
    • Other Affiliation: MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine; University of Edinburgh; Western General Hospital
  • Bellis, Claire
    • Other Affiliation: Genomics Research Centre; Institute of Health and Biomedical Innovation; Queensland University of Technology
  • Pasko, Dorota
    • Other Affiliation: Genetics of Complex Traits; University of Exeter Medical School; University of Exeter
  • Johansson, Åsa
    • Other Affiliation: Department of Immunology; Genetics and Pathology; Uppsala University
  • Snitker, Søren
    • Other Affiliation: Division of Endocrinology; Diabetes; and Nutrition; University of Maryland School of Medicine
  • Cheng, Yu-Ching
    • Other Affiliation: Veterans Affairs Maryland Health Care System; University of Maryland
  • Eriksson, Joel
    • Other Affiliation: Centre for Bone and Arthritis Research; Department of Internal Medicine and Clinical Nutrition; Institute of Medicine; Sahlgrenska Academy; University of Gothenburg
  • Lim, Unhee
    • Other Affiliation: Epidemiology Program; University of Hawaii Cancer Center
  • Aadahl, Mette
    • Other Affiliation: Department of Public Health; Faculty of Health and Medical Sciences; University of Copenhagen
  • Adair, Linda S.
    • Affiliation: Gillings School of Global Public Health, Department of Nutrition
  • Amin, Najaf
    • Other Affiliation: Genetic Epidemiology Unit; Department of Epidemiology; Erasmus MC
  • Balkau, Beverley
    • Other Affiliation: INSERM U-1018; CESP; Renal and Cardiovascular Epidemiology; UVSQ-UPS
  • Auvinen, Juha
    • Other Affiliation: Center for Life Course Health Research; Faculty of Medicine; University of Oulu
  • Beilby, John
    • Other Affiliation: PathWest Laboratory Medicine of WA; Sir Charles Gairdner Hospital
  • Bergman, Richard N.
    • Other Affiliation: Diabetes and Obesity Research Institute; Cedars-Sinai Medical Center
  • Bergmann, Sven
    • Other Affiliation: Department of Medical Genetics; University of Lausanne
  • Bertoni, Alain G.
    • Other Affiliation: Department of Internal Medicine; Wake Forest School of Medicine
  • Blangero, John
    • Other Affiliation: Texas Biomedical Research Institute; San Antonio
  • Bonnefond, Amélie
    • Other Affiliation: University of Lille; CNRS; Institut Pasteur de Lille; UMR 8199 - EGID
  • Bonnycastle, Lori L.
    • Other Affiliation: Medical Genomics and Metabolic Genetics Branch; National Human Genome Research Institute; NIH
  • Borja, Judith B.
    • Other Affiliation: Department of Nutrition and Dietetics; University of San Carlos
  • Brage, Søren
    • Other Affiliation: MRC Epidemiology Unit; Institute of Metabolic Science; University of Cambridge
  • Busonero, Fabio
    • Other Affiliation: Istituto di Ricerca Genetica e Biomedica (IRGB); Consiglio Nazionale Delle Ricerche (CNR); Cittadella Universitaria di Monserrato
  • Buyske, Steve
    • Other Affiliation: Department of Genetics; Rutgers University
  • Campbell, Harry
    • Other Affiliation: Centre for Global Health Research; Usher Institute for Population Health Sciences and Informatics
  • Chines, Peter S.
    • Other Affiliation: Medical Genomics and Metabolic Genetics Branch; National Human Genome Research Institute; NIH
  • Collins, Francis S.
    • Other Affiliation: Medical Genomics and Metabolic Genetics Branch; National Human Genome Research Institute; NIH
  • Corre, Tanguy
    • Other Affiliation: Department of Medical Genetics; University of Lausanne
  • Smith, George Davey
    • Other Affiliation: MRC Integrative Epidemiology Unit & School of Social and Community Medicine; University of Bristol
  • Delgado, Graciela E.
    • Other Affiliation: Vth Department of Medicine; Medical Faculty Mannheim; Heidelberg University
  • Dueker, Nicole
    • Other Affiliation: University of Maryland School of Medicine; Department of Epidemiology & Public Health
  • Dörr, Marcus
    • Other Affiliation: Department of Internal Medicine B; University Medicine Greifswald
  • Ebeling, Tapani
    • Other Affiliation: Institute of Clinical Medicine; Faculty of Medicine; University of Oulu
  • Eiriksdottir, Gudny
    • Other Affiliation: Icelandic Heart Association
  • Esko, Tõnu
    • Other Affiliation: Division of Endocrinology; Boston Children's Hospital
  • Faul, Jessica D.
    • Other Affiliation: Survey Research Center; Institute for Social Research; University of Michigan
  • Fu, Mao
    • Other Affiliation: Division of Endocrinology; Diabetes; and Nutrition; University of Maryland School of Medicine
  • Færch, Kristine
    • Other Affiliation: Steno Diabetes Center
  • Gieger, Christian
    • Other Affiliation: Institute of Genetic Epidemiology; Helmholtz Zentrum München; German Research Center for Environmental Health
  • Gläser, Sven
    • Other Affiliation: Department of Internal Medicine B; University Medicine Greifswald
  • Gong, Jian
    • Other Affiliation: Division of Public Health Sciences; Fred Hutchinson Cancer Research Center
  • Gordon-Larsen, Penny
    • Affiliation: Carolina Population Center
    • Other Affiliation: Department of Nutrition
  • Grallert, Harald
    • Other Affiliation: Research Unit of Molecular Epidemiology; Helmholtz Zentrum München - German Research Center for Environmental Health
  • Grammer, Tanja B.
    • Other Affiliation: Vth Department of Medicine; Medical Faculty Mannheim; Heidelberg University
  • Grarup, Niels
    • Other Affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research; Section of Metabolic Genetics; Faculty of Health and Medical Sciences; University of Copenhagen
  • van Grootheest, Gerard
    • Other Affiliation: Department of Psychiatry; EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam; VU University Medical Center/GGZ InGeest
  • Harald, Kennet
    • Other Affiliation: National Institute for Health and Welfare; Department of Health
  • Hastie, Nicholas D.
    • Other Affiliation: MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine; University of Edinburgh; Western General Hospital
  • Havulinna, Aki S.
    • Other Affiliation: National Institute for Health and Welfare; Department of Health
  • Hernandez, Dena
    • Other Affiliation: Laboratory of Neurogenetics; National Institute on Aging
  • Hindorff, Lucia
    • Other Affiliation: Division of Genomic Medicine; National Human Genome Research Institute; National Institutes of Health
  • Hocking, Lynne J.
    • Other Affiliation: Musculoskeletal Research Programme; Division of Applied Medicine; University of Aberdeen; Foresterhill
  • Holmens, Oddgeir L.
    • Other Affiliation: St. Olav Hospital; Trondheim University Hospital
  • Holzapfel, Christina
    • Other Affiliation: Research Unit of Molecular Epidemiology; Helmholtz Zentrum München - German Research Center for Environmental Health
  • Hottenga, Jouke Jan
    • Other Affiliation: Department of Biological Psychology; Vrije Universiteit
  • Huang, Jie
    • Other Affiliation: Department of Human Genetics; Wellcome Trust Sanger Institute; Hinxton
  • Huang, Tao
    • Other Affiliation: Department of Nutrition; Harvard T.H. Chan School of Public Health
  • Hui, Jennie
    • Other Affiliation: PathWest Laboratory Medicine of WA; Sir Charles Gairdner Hospital
  • Huth, Cornelia
    • Other Affiliation: German Center for Diabetes Research (DZD)
  • Hutri-Kähönen, Nina
    • Other Affiliation: Department of Pediatrics; University of Tampere School of Medicine
  • James, Alan L.
    • Other Affiliation: School of Medicine and Pharmacology; The University of Western Australia
  • Jansson, John-Olov
    • Other Affiliation: Department of Physiology; Institute of Neuroscience and Physiology; Sahlgrenska Academy; University of Gothenburg
  • Jhun, Min A.
    • Other Affiliation: Department of Epidemiology; School of Public Health; University of Michigan
  • Juonala, Markus
    • Other Affiliation: Department of Medicine; University of Turku
  • Kinnunen, Leena
    • Other Affiliation: National Institute for Health and Welfare; Department of Health
  • Koistinen, Heikki A.
    • Other Affiliation: Minerva Foundation Institute for Medical Research
  • Kolcic, Ivana
    • Other Affiliation: Department of Public Health; Faculty of Medicine; University of Split
  • Komulainen, Pirjo
    • Other Affiliation: Kuopio Research Institute of Exercise Medicine
  • Kuusisto, Johanna
    • Other Affiliation: Department of Medicine; University of Eastern Finland and Kuopio University Hospital
  • Kvaløy, Kirsti
    • Other Affiliation: HUNT Research Centre; Department of Public Health and General Practice; Norwegian University of Science and Technology
  • Kähönen, Mika
    • Other Affiliation: Department of Clinical Physiology; University of Tampere School of Medicine
  • Lakka, Timo A.
    • Other Affiliation: Institute of Biomedicine; Physiology; University of Eastern Finland
  • Launer, Lenore J.
    • Other Affiliation: Neuroepidemiology Section; National Institute on Aging; National Institutes of Health
  • Lehne, Benjamin
    • Other Affiliation: Department of Epidemiology and Biostatistics; School of Public Health; Imperial College London
  • Lindgren, Cecilia M.
    • Other Affiliation: The Big Data Institute; University of Oxford
  • Lorentzon, Mattias
    • Other Affiliation: Geriatric Medicine; Sahlgrenska University Hospital
  • Luben, Robert
    • Other Affiliation: Department of Public Health and Primary Care; University of Cambridge
  • Marre, Michel
    • Other Affiliation: INSERM U-1138; Équipe 2: Pathophysiology and Therapeutics of Vascular and Renal diseases Related to Diabetes; Centre de Recherche des Cordeliers
  • Milaneschi, Yuri
    • Other Affiliation: Department of Psychiatry; EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam; VU University Medical Center/GGZ InGeest
  • Monda, Keri L.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
    • Other Affiliation: Center for Observational Research; Amgen Inc.
  • Montgomery, Grant W.
    • Other Affiliation: Genetic Epidemiology; QIMR Berghofer Medical Research Institute
  • De Moor, Marleen H. M.
    • Other Affiliation: Section of Clinical Child and Family Studies; Department of Educational and Family Studies; Vrije Universiteit
  • Mulas, Antonella
    • Other Affiliation: Dipartimento di Scienze Biomediche; Università degli Studi di Sassari
  • Müller-Nurasyid, Martina
    • Other Affiliation: Institute of Genetic Epidemiology; Helmholtz Zentrum München; German Research Center for Environmental Health
  • Musk,
    • Other Affiliation: Department of Respiratory Medicine; Sir Charles Gairdner Hospital
  • Männikkö, Reija
    • Other Affiliation: Kuopio Research Institute of Exercise Medicine
  • Männistö, Satu
    • Other Affiliation: National Institute for Health and Welfare; Department of Health
  • Narisu, Narisu
    • Other Affiliation: Medical Genomics and Metabolic Genetics Branch; National Human Genome Research Institute; NIH
  • Nauck, Matthias
    • Other Affiliation: Institute of Clinical Chemistry and Laboratory Medicine; University Medicine Greifswald
  • Nettleton, Jennifer A.
    • Other Affiliation: Division of Epidemiology; Human Genetics; and Environmental Sciences; University of Texas Health Science Center at Houston
  • Nolte, Ilja M.
    • Other Affiliation: Department of Epidemiology; University of Groningen; University Medical Center Groningen
  • Oldehinkel, Albertine J.
    • Other Affiliation: Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE); University of Groningen; University Medical Center Groningen
  • Olden, Matthias
    • Other Affiliation: Department of Genetic Epidemiology; University of Regensburg
  • Ong, Ken K.
    • Other Affiliation: MRC Epidemiology Unit; Institute of Metabolic Science; University of Cambridge
  • Padmanabhan, Sandosh
    • Other Affiliation: Institute of Cardiovascular and Medical Sciences; BHF Glasgow Cardiovascular Research Centre; University of Glasgow
  • Paternoster, Lavinia
    • Other Affiliation: MRC Integrative Epidemiology Unit & School of Social and Community Medicine; University of Bristol
  • Perez, Jeremiah
    • Other Affiliation: Department of Biostatistics; Boston University School of Public Health
  • Perola, Markus
    • Other Affiliation: Institute for Molecular Medicine Finland; University of Helsinki
  • Peters, Annette
    • Other Affiliation: German Center for Diabetes Research (DZD)
  • Peters, Ulrike
    • Other Affiliation: Division of Public Health Sciences; Fred Hutchinson Cancer Research Center
  • Peyser, Patricia A.
    • Other Affiliation: Department of Epidemiology; School of Public Health; University of Michigan
  • Prokopenko, Inga
    • Other Affiliation: Genomics of Common Disease; Imperial College London
  • Puolijoki, Hannu
    • Other Affiliation: South Ostrobothnia Central Hospital
  • Raitakari, Olli T.
    • Other Affiliation: Department of Clinical Physiology and Nuclear Medicine; Turku University Hospital
  • Rankinen, Tuomo
    • Other Affiliation: Human Genomics Laboratory; Pennington Biomedical Research Center
  • Rasmussen-Torvik, Laura J.
    • Other Affiliation: Department of Preventive Medicine; Northwestern University Feinberg School of Medicine
  • Rawal, Rajesh
    • Other Affiliation: Institute of Genetic Epidemiology; Helmholtz Zentrum München; German Research Center for Environmental Health
  • Ridker, Paul M.
    • Other Affiliation: Division of Preventive Medicine; Brigham and Women's Hospital
  • Rose, Lynda M.
    • Other Affiliation: Division of Preventive Medicine; Brigham and Women's Hospital
  • Rudan, Igor
    • Other Affiliation: Centre for Global Health Research; Usher Institute for Population Health Sciences and Informatics
  • Sarti, Cinzia
    • Other Affiliation: Social Services and Health Care Department; City of Helsinki
  • Sarzynski, Mark A.
    • Other Affiliation: Human Genomics Laboratory; Pennington Biomedical Research Center
  • Savonen, Kai
    • Other Affiliation: Kuopio Research Institute of Exercise Medicine
  • Scott, William R.
    • Other Affiliation: Department of Epidemiology and Biostatistics; School of Public Health; Imperial College London
  • Sanna, Serena
    • Other Affiliation: Istituto di Ricerca Genetica e Biomedica (IRGB); Consiglio Nazionale Delle Ricerche (CNR); Cittadella Universitaria di Monserrato
  • Shuldiner, Alan R.
    • Other Affiliation: Veterans Affairs Maryland Health Care System; University of Maryland
  • Sidney, Steve
    • Other Affiliation: Division of Research; Kaiser Permanente Northern California
  • Silbernagel, Günther
    • Other Affiliation: Division of Angiology; Department of Internal Medicine; Medical University Graz
  • Smith, Blair H.
    • Other Affiliation: School of Medicine; University of Dundee; Ninewells Hospital and Medical School
  • Smith, Jennifer A.
    • Other Affiliation: Department of Epidemiology; School of Public Health; University of Michigan
  • Snieder, Harold
    • Other Affiliation: Department of Epidemiology; University of Groningen; University Medical Center Groningen
  • Stančáková, Alena
    • Other Affiliation: Department of Medicine; University of Eastern Finland and Kuopio University Hospital
  • Sternfeld, Barbara
    • Other Affiliation: Division of Research; Kaiser Permanente Northern California
  • Swift, Amy J.
    • Other Affiliation: Medical Genomics and Metabolic Genetics Branch; National Human Genome Research Institute; NIH
  • Tammelin, Tuija
    • Other Affiliation: LIKES Research Center for Sport and Health Sciences
  • Tan, Sian-Tsung
    • Other Affiliation: National Heart and Lung Institute; Imperial College London
  • Thorand, Barbara
    • Other Affiliation: German Center for Diabetes Research (DZD)
  • Thuillier, Dorothée
    • Other Affiliation: University of Lille; CNRS; Institut Pasteur de Lille; UMR 8199 - EGID
  • Vandenput, Liesbeth
    • Other Affiliation: Centre for Bone and Arthritis Research; Department of Internal Medicine and Clinical Nutrition; Institute of Medicine; Sahlgrenska Academy; University of Gothenburg
  • Vestergaard, Henrik
    • Other Affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research; Section of Metabolic Genetics; Faculty of Health and Medical Sciences; University of Copenhagen
  • van Vliet-Ostaptchouk, Jana V.
    • Other Affiliation: Department of Endocrinology; University of Groningen; University Medical Center Groningen
  • Vohl, Marie-Claude
    • Other Affiliation: School of Nutrition; Laval University
  • Völker, Uwe
    • Other Affiliation: Interfaculty Institute for Genetics and Functional Genomics; University Medicine Greifswald
  • Waeber, Gérard
    • Other Affiliation: Department of Internal Medicine; Internal Medicine; Lausanne University Hospital
  • Walker, Mark
    • Other Affiliation: Institute of Cellular Medicine; Newcastle University
  • Wild, Sarah
    • Other Affiliation: Centre for Population Health Sciences; Usher Institute for Population Health Sciences and Informatics; Teviot Place
  • Wong, Andrew
    • Other Affiliation: MRC Unit for Lifelong Health and Ageing at UCL
  • Wright, Alan F.
    • Other Affiliation: MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine; University of Edinburgh; Western General Hospital
  • Zillikens, M. Carola
    • Other Affiliation: Department of Internal Medicine; Erasmus MC
  • Zubair, Niha
    • Other Affiliation: Division of Public Health Sciences; Fred Hutchinson Cancer Research Center
  • Haiman, Christopher A.
    • Other Affiliation: Department of Preventive Medicine; Norris Comprehensive Cancer Center; Keck School of Medicine; University of Southern California
  • Lemarchand, Loic
    • Other Affiliation: Epidemiology Program; University of Hawaii Cancer Center
  • Gyllensten, Ulf
    • Other Affiliation: Department of Immunology; Genetics and Pathology; Uppsala University
  • Ohlsson, Claes
    • Other Affiliation: Centre for Bone and Arthritis Research; Department of Internal Medicine and Clinical Nutrition; Institute of Medicine; Sahlgrenska Academy; University of Gothenburg
  • Hofman, Albert
    • Other Affiliation: Department of Epidemiology; Erasmus MC
  • Rivadeneira, Fernando
    • Other Affiliation: Department of Epidemiology; Erasmus MC
  • Uitterlinden, André G.
    • Other Affiliation: Department of Epidemiology; Erasmus MC
  • Pérusse, Louis
    • Other Affiliation: Department of Kinesiology; Laval University
  • Wilson, James F.
    • Other Affiliation: Centre for Global Health Research; Usher Institute for Population Health Sciences and Informatics
  • Hayward, Caroline
    • Other Affiliation: MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine; University of Edinburgh; Western General Hospital
  • Polasek, Ozren
    • Other Affiliation: Department of Public Health; Faculty of Medicine; University of Split
  • Cucca, Francesco
    • Other Affiliation: Dipartimento di Scienze Biomediche; Università degli Studi di Sassari
  • Hveem, Kristian
    • Other Affiliation: HUNT Research Centre; Department of Public Health and General Practice; Norwegian University of Science and Technology
  • Hartman, Catharina A.
    • Other Affiliation: Department of Psychiatry; University of Groningen; University Medical Center Groningen
  • Tönjes, Anke
    • Other Affiliation: University of Leipzig; Medical Department
  • Bandinelli, Stefania
    • Other Affiliation: Geriatric Unit; Azienda Sanitaria Firenze
  • Palmer, Lyle J.
    • Other Affiliation: School of Public Health; University of Adelaide; Adelaide
  • Kardia, Sharon L. R.
    • Other Affiliation: Department of Epidemiology; School of Public Health; University of Michigan
  • Rauramaa, Rainer
    • Other Affiliation: Department of Clinical Physiology and Nuclear Medicine; Kuopio University Hospital
  • Sørensen, Thorkild I. A.
    • Other Affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research; Section of Metabolic Genetics; Faculty of Health and Medical Sciences; University of Copenhagen
  • Tuomilehto, Jaakko
    • Other Affiliation: Diabetes Research Group; King Abdulaziz University
  • Salomaa, Veikko
    • Other Affiliation: National Institute for Health and Welfare; Department of Health
  • Penninx, Brenda W. J. H.
    • Other Affiliation: Department of Psychiatry; EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam; VU University Medical Center/GGZ InGeest
  • de Geus, Eco J. C.
    • Other Affiliation: Department of Biological Psychology; Vrije Universiteit
  • Boomsma, Dorret I.
    • Other Affiliation: Department of Biological Psychology; Vrije Universiteit
  • Lehtimäki, Terho
    • Other Affiliation: Department of Clinical Chemistry; University of Tampere School of Medicine
  • Mangino, Massimo
    • Other Affiliation: Department of Twin Research and Genetic Epidemiology; King's College London
  • Laakso, Markku
    • Other Affiliation: Department of Medicine; University of Eastern Finland and Kuopio University Hospital
  • Bouchard, Claude
    • Other Affiliation: Human Genomics Laboratory; Pennington Biomedical Research Center
  • Martin, Nicholas G.
    • Other Affiliation: Genetic Epidemiology; QIMR Berghofer Medical Research Institute
  • Kuh, Diana
    • Other Affiliation: MRC Unit for Lifelong Health and Ageing at UCL
  • Liu, Yongmei
    • Other Affiliation: Department of Epidemiology and Prevention; Division of Public Health Sciences; Wake Forest School of Medicine
  • Linneberg, Allan
    • Other Affiliation: Department of Clinical Experimental Research; Rigshospitalet
  • März, Winfried
    • Other Affiliation: Synlab Academy; Synlab Services LLC
  • Strauch, Konstantin
    • Other Affiliation: Institute of Genetic Epidemiology; Helmholtz Zentrum München; German Research Center for Environmental Health
  • Kivimäki, Mika
    • Other Affiliation: Department of Epidemiology and Public Health; University College London
  • Harris, Tamara B.
    • Other Affiliation: Laboratory of Epidemiology and Population Science; National Institute on Aging
  • Gudnason, Vilmundur
    • Other Affiliation: Faculty of Medicine; University of Iceland
  • Völzke, Henry
    • Other Affiliation: Institute for Community Medicine; University Medicine Greifswald
  • Qi, Lu
    • Other Affiliation: Department of Nutrition; Harvard T.H. Chan School of Public Health
  • Järvelin, Marjo-Riitta
    • Other Affiliation: Biocenter Oulu; University of Oulu
  • Chambers, John C.
    • Other Affiliation: Department of Epidemiology and Biostatistics; School of Public Health; Imperial College London
  • Kooner, Jaspal S.
    • Other Affiliation: Department of Cardiology; Ealing Hospital HNS Trust
  • Froguel, Philippe
    • Other Affiliation: University of Lille; CNRS; Institut Pasteur de Lille; UMR 8199 - EGID
  • Kooperberg, Charles
    • Other Affiliation: Division of Public Health Sciences; Fred Hutchinson Cancer Research Center
  • Vollenweider, Peter
    • Other Affiliation: Department of Internal Medicine; Internal Medicine; Lausanne University Hospital
  • Hallmans, Göran
    • Other Affiliation: Department of Biobank Research; Umeå University
  • Hansen, Torben
    • Other Affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research; Section of Metabolic Genetics; Faculty of Health and Medical Sciences; University of Copenhagen
  • Pedersen, Oluf
    • Other Affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research; Section of Metabolic Genetics; Faculty of Health and Medical Sciences; University of Copenhagen
  • Metspalu, Andres
    • Other Affiliation: Estonian Genome Center; University of Tartu
  • Wareham, Nicholas J.
    • Other Affiliation: MRC Epidemiology Unit; Institute of Metabolic Science; University of Cambridge
  • Langenberg, Claudia
    • Other Affiliation: MRC Epidemiology Unit; Institute of Metabolic Science; University of Cambridge
  • Weir, David R.
    • Other Affiliation: Survey Research Center; Institute for Social Research; University of Michigan
  • Porteous, David J.
    • Other Affiliation: Generation Scotland; Centre for Genomic and Experimental Medicine; University of Edinburgh
  • Boerwinkle, Eric
    • Other Affiliation: Division of Epidemiology; Human Genetics; and Environmental Sciences; University of Texas Health Science Center at Houston
  • Chasman, Daniel I.
    • Other Affiliation: Division of Preventive Medicine; Brigham and Women's Hospital
  • Abecasis, Gonçalo R.
    • Other Affiliation: Center for Statistical Genetics; Department of Biostatistics; University of Michigan
  • Barroso, Inês
    • Other Affiliation: The University of Cambridge Metabolic Research Laboratories; Wellcome Trust-MRC Institute of Metabolic Science
  • McCarthy, Mark I.
    • Other Affiliation: Oxford NIHR Biomedical Research Centre
  • Frayling, Timothy M.
    • Other Affiliation: Genetics of Complex Traits; University of Exeter Medical School; University of Exeter
  • O’Connell, Jeffrey R.
    • Other Affiliation: Division of Endocrinology; Diabetes; and Nutrition; University of Maryland School of Medicine
  • van Duijn, Cornelia M.
    • Other Affiliation: Center of Medical Systems Biology
  • Boehnke, Michael
    • Other Affiliation: Center for Statistical Genetics; Department of Biostatistics; University of Michigan
  • Heid, Iris M.
    • Other Affiliation: Department of Genetic Epidemiology; University of Regensburg
  • Mohlke, Karen L.
    • Affiliation: School of Medicine, Department of Genetics
  • Strachan, David P.
    • ORCID: 0000-0001-7854-1366
    • Other Affiliation: Population Health Research Institute; St. George's University of London
  • Fox, Caroline S.
    • Other Affiliation: Population Sciences Branch; National Heart; Lung; and Blood Institute; National Institutes of Health; The Framingham Heart Study
  • Liu, Ching-Ti
    • ORCID: 0000-0002-0703-0742
    • Other Affiliation: Department of Biostatistics; Boston University School of Public Health
  • Hirschhorn, Joel N.
    • Other Affiliation: Broad Institute of the Massachusetts Institute of Technology and Harvard University
  • Klein, Robert J.
    • ORCID: 0000-0003-3539-5391
    • Other Affiliation: Icahn Institute for Genomics and Multiscale Biology; Icahn School of Medicine at Mount Sinai
  • Johnson, Andrew D.
    • Other Affiliation: Population Sciences Branch; National Heart; Lung; and Blood Institute; National Institutes of Health; The Framingham Heart Study
  • Borecki, Ingrid B.
    • Other Affiliation: Department of Genetics; Washington University School of Medicine
  • Franks, Paul W.
    • Other Affiliation: Department of Public Health & Clinical Medicine; Umeå University
  • North, Kari E.
    • Affiliation: School of Medicine, Carolina Center for Genome Sciences
  • Cupples, L. Adrienne
    • Other Affiliation: Department of Biostatistics; Boston University School of Public Health
  • Loos, Ruth J. F.
    • Other Affiliation: The Department of Preventive Medicine; The Icahn School of Medicine at Mount Sinai
  • Kilpeläinen, Tuomas O.
    • Other Affiliation: The Department of Preventive Medicine; The Icahn School of Medicine at Mount Sinai
Abstract
  • Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • PLoS Genetics
Journal volume
  • 13
Journal issue
  • 8
Page start
  • e1006972
Language
  • English
ISSN
  • 1553-7404
  • 1553-7390

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