Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.
Public Deposited- Creator
- Smith, M S
- Kessler, J A
- Rankin, C D
- Pagano, J S
- Kurtzberg, J
- Carter, S G
- Abstract
- 3'-Azido-2',3'-deoxythymidine and carbovir [racemic and (-) enantiomer] were evaluated individually and in combination for antiviral activity against human immunodeficiency virus type 1 replication and cytotoxicity in vitro. The combination of these drugs synergistically inhibited human immunodeficiency virus type 1 replication in C3 and Jurkat cells and in human peripheral blood mononuclear cells, although the same combination also produced synergistic cytotoxicity in human peripheral blood mononuclear cells.
- Date of publication
- 1993
- Keyword
- Virus HIV1
- Infected cell
- Cellule infectée
- Lentivirinae
- Microorganism culture
- Retroviridae
- Virus
- Culture microorganisme
- Carbovir
- Virus immunodéficience humaine
- Zidovudine
- Réplication
- Célula infectada
- HIV-1 virus
- Asociación medicamentosa
- Human immunodeficiency virus
- In vitro
- Antiviral
- Drug combination
- Cytotoxicity
- Citotoxicidad
- Cytotoxicité
- Replication
- Cultivo microorganismo
- Association médicamenteuse
- DOI
- Identifier
- PMCID: PMC187624
- Onescience id: 6cfb698ba3a15a8534450427021bb2f8ff4264a7
- Publisher DOI: https://doi.org/10.1128/AAC.37.1.144
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Antimicrobial Agents and Chemotherapy
- Journal volume
- 37
- Journal issue
- 1
- Page start
- 144
- Page end
- 147
- Language
- English
- ISSN
- 1098-6596
- 0066-4804
Relations
- Parents:
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