Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia Public Deposited

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  • Sheffler, Douglas J.
    • Other Affiliation: Department of Biochemistry, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
  • Kroeze, Wesley K.
    • Other Affiliation: Department of Biochemistry, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
  • Roth, Bryan L.
    • ORCID: https://orcid.org/0000-0002-0561-6531
    • Other Affiliation: Department of Biochemistry, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
Abstract
  • Most common central nervous system disorders — such as depression, bipolar disorder and schizophrenia — seem to be polygenic in origin, and the most effective medications have exceedingly complex pharmacologies. Attempts to develop more effective treatments for diseases such as schizophrenia and depression by discovering drugs selective for single molecular targets (that is, 'magic bullets') have, not surprisingly, been largely unsuccessful. Here we propose that designing selectively non-selective drugs (that is, 'magic shotguns') that interact with several molecular targets will lead to new and more effective medications for a variety of central nervous system disorders.
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  • Journal Item
Rights statement
  • In Copyright
Journal title
  • Nature Reviews Drug Discovery
Journal volume
  • 3
Journal issue
  • 4
Page start
  • 353
Page end
  • 359
Language
  • English
Version
  • Postprint
ISSN
  • 1474-1776
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