Association between pregnancy and pregnancy loss with COPD in Chinese women: The China Kadoorie Biobank study

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  • Huang, Sha
    • Other Affiliation: Tsinghua University
  • Hee, Jia Yi
    • Other Affiliation: Tsinghua University
  • Zhang, Yuxun Oswald
    • Other Affiliation: Tsinghua University
  • Gongye, Ruofan
    • Affiliation: Gillings School of Global Public Health, Department of Maternal and Child Health
  • Zou, Siyu
    • Other Affiliation: Tsinghua University
  • Tang, Kun
    • Other Affiliation: Tsinghua University
Abstract
  • Background Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterized by airflow blockage. Pregnancy and pregnancy loss may be related to an elevated risk of COPD, although studies have yet to report on this association. Hence, this study aims to investigate the association between pregnancy and pregnancy loss with the risk of COPD among Chinese women. Methods Data on 302,510 female participants from the China Kadoorie Biobank were utilized for this study. Multivariable logistic regression, stratified by sociodemographic and lifestyle factors, was employed to obtain the odds ratio (ORs) and 95% confidence intervals (CIs) for the association between pregnancy and pregnancy loss with COPD. Results Pregnancy loss was significantly associated with increased risk of COPD (OR 1.19, 95% CI 1.13–1.25), specifically, spontaneous (OR 1.19, 95% CI 1.11–1.29) and induced abortion (OR 1.18, 95% CI 1.12–1.25). Stillbirth, however, was not significantly associated with the risk of COPD (OR 1.09, 95% CI 0.99–1.20). Increasing number of pregnancy losses was associated with increasing risk of COPD (one pregnancy loss: OR 1.14, 95% CI 1.07–1.21, two or more pregnancy loss: OR 1.25, 95% CI 1.17–1.32, and each additional pregnancy loss: OR 1.06, 95% CI 1.03–1.09). A single pregnancy was significantly associated with reduced risk of COPD (OR 0.75, 95% CI 0.59–0.97), although each additional pregnancy was significantly associated with increased risk of COPD (OR 1.03, 95% CI 1.01–1.04). Conclusion Pregnancy loss, in particular, spontaneous and induced abortions are associated with increased risk of COPD among Chinese women. A single pregnancy, however, demonstrated protective effects.
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  • Article
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  • Attribution 4.0 International
Journal title
  • Frontiers in Public Health
Journal volume
  • 10
Language
  • English
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  • Publisher
Funder
  • National Key Research and Development Program of China (2016YFC0900500, 2016YFC0900501, and 2016YFC0900504)
  • Kadoorie Charitable Foundation in Hong Kong
  • Wellcome Trust in the UK (088158/Z/09/Z and 104085/Z/14/Z)
ISSN
  • 2296-2565

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