MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme
Public Deposited- Creator
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Sufit, Alexandra
- Other Affiliation: University of Colorado; Anschutz Medical Campus
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Lee-Sherick, Alisa B.
- Other Affiliation: Children's Hospital Colorado
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Deryckere, Deborah
- Other Affiliation: Aflac Cancer and Blood Disorders Center; Children's Healthcare of Atlanta; Emory University; Department of Pediatrics
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Rupji, Manali
- Other Affiliation: Winship Cancer Institute; Emory University
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Dwivedi, Bhakti
- Other Affiliation: Winship Cancer Institute; Emory University
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Varella-Garcia, Marileila
- Other Affiliation: University of Colorado; Anschutz Medical Campus
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Pierce, Angela M.
- Other Affiliation: University of Colorado; Anschutz Medical Campus
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Kowalski, Jeanne
- Other Affiliation: Winship Cancer Institute; Emory University
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Wang, Xiaodong
- Affiliation: Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery
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Frye, Stephen V.
- Affiliation: Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery
- Other Affiliation: Department of Medicine
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Earp, H. Shelton
- Affiliation: School of Medicine, Department of Medicine
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Keating, Amy K.
- Other Affiliation: Children's Hospital Colorado
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Graham, Douglas K.
- Affiliation: Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery
- Other Affiliation: Aflac Cancer and Blood Disorders Center; Children's Healthcare of Atlanta; Emory University; Department of Pediatrics
- Abstract
- MER receptor tyrosine kinase (MERTK) is expressed in a variety of malignancies, including glioblastoma multiforme (GBM). Our previous work demonstrated that inhibition of MERTK using RNA interference induced cell death and chemosensitivity in GBM cells, implicating MERTK as a potential therapeutic target. Here we investigate whether a novel MERTK-selective small molecule tyrosine kinase inhibitor, UNC2025, has similar anti-tumor effects in GBM cell lines.
- Date of publication
- 2016
- Keyword
- Glioblastoma
- Neural Stem Cells
- Protein Kinase Inhibitors
- Gene Expression Regulation, Neoplastic
- Antineoplastic Agents
- Prognosis
- Piperazines
- Polyploidy
- Cell Proliferation
- Cell Aging
- Cell Death
- Adenine
- Cell Line, Tumor
- Enzyme Activation
- Humans
- Intercellular Signaling Peptides and Proteins
- Proto-Oncogene Proteins
- Receptor Protein-Tyrosine Kinases
- DOI
- Identifier
- PMID: 27783662
- Onescience id: 131339a10bc406b8b71c9da88bc326497a9382bd
- PMCID: PMC5081168
- Publisher DOI: https://doi.org/10.1371/journal.pone.0165107
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- PloS One
- Journal volume
- 11
- Journal issue
- 10
- Page start
- e0165107
- Language
- English
- ISSN
- 1932-6203
Relations
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