Editorial: Epigenetic insights into diagnostic and therapeutic applications

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Creator
  • Fratta E.
    • Other Affiliation: IRCCS
  • Jerónimo C.
    • Other Affiliation: University of Porto
  • Perry A.S.
    • Other Affiliation: University College Dublin
  • Pattenden S.G.
    • Affiliation: Eshelman School of Pharmacy, Division of Chemical Biology and Medicinal Chemistry
Abstract
  • Studies of the heredity and variation in DNA sequence that directs normal development of all living organisms has fundamentally reshaped our understanding of human disease. However, a greater focus on an additional layer of information that does not depend on the underlying DNA sequence referred to as “epigenetics”, has emerged. Epigenetic processes have been recognized as critical for refining DNA-encoded instructions that direct cellular function, and there is increasing evidence that epigenetic dysregulation plays a central role in human disease. In contrast to irreversible genetic mutations, alterations to epigenetic pathways are dynamic, making them attractive therapeutic targets.
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  • Article
License
  • Attribution 4.0 International
Journal title
  • Frontiers in Oncology
Journal volume
  • 13
Language
  • English
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  • Publisher
ISSN
  • 2234943X
Publisher
  • Frontiers Media SA

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