Cell Migration: Integrating Signals from Front to Back Public Deposited

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Creator
  • Parsons, J. Thomas
    • Other Affiliation: Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
  • Schwartz, Martin A.
    • Other Affiliation: Departments of Microbiology and Biomedical Engineering, Cardiovascular Research Center and Mellon Prostate Cancer Research Institute; University of Virginia School of Medicine, Charlottesville, VA 22908, USA
  • Firtel, Richard A.
    • Other Affiliation: Section of Cell and Developmental Biology, Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0634, USA
  • Horwitz, Alan Rick
    • Other Affiliation: Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
  • Ridley, Anne J.
    • Other Affiliation: Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
  • Ginsberg, Mark H.
    • Other Affiliation: Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
  • Burridge, Keith
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine, Department of Cell Biology and Physiology
  • Borisy, Gary
    • Other Affiliation: Department of Cellular and Molecular Biology, Northwestern University, School of Medicine, Chicago, IL 60611, USA
Abstract
  • Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.
Date of publication
Identifier
  • doi:10.1126/science.1092053
  • 2-s2.0-0344305784
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Resource type
  • Journal Item
Rights statement
  • In Copyright
Journal title
  • Science
Journal volume
  • 302
Journal issue
  • 5651
Page start
  • 1704
Page end
  • 1709
Language
  • English
Version
  • Postprint
ISSN
  • 0036-8075
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