SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
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Wahl, A, et al. Sars-cov-2 Infection Is Effectively Treated and Prevented by Eidd-2801. Nature Research, 2021. https://doi.org/10.17615/0604-mv57APA
Wahl, A., Gralinski, L., Johnson, C., Yao, W., Kovarova, M., Dinnon, I., Liu, H., Madden, V., Krzystek, H., De, C., White, K., Gully, K., Schäfer, A., Zaman, T., Leist, S., Grant, P., Bluemling, G., Kolykhalov, A., Natchus, M., Askin, F., Painter, G., Browne, E., Jones, C., Pickles, R., Baric, R., & Garcia, J. (2021). SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801. Nature Research. https://doi.org/10.17615/0604-mv57Chicago
Wahl, A., L.E Gralinski, C.E Johnson, W Yao, M Kovarova, Iii Dinnon, H Liu et al. 2021. Sars-Cov-2 Infection Is Effectively Treated and Prevented by Eidd-2801. Nature Research. https://doi.org/10.17615/0604-mv57- Creator
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Wahl, A.
- Affiliation: School of Medicine, Division of Infectious Diseases
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Gralinski, L.E.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Johnson, C.E.
- Affiliation: School of Medicine, Division of Infectious Diseases
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Yao, W.
- Affiliation: School of Medicine, Division of Infectious Diseases
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Kovarova, M.
- Affiliation: School of Medicine, Division of Infectious Diseases
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Dinnon, K.H., III
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Liu, H.
- Affiliation: College of Arts and Sciences, Department of Biology
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Madden, V.J.
- Affiliation: School of Medicine
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Krzystek, H.M.
- Affiliation: College of Arts and Sciences, Department of Biology
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De, C.
- Affiliation: School of Medicine, Division of Infectious Diseases
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White, K.K.
- Affiliation: School of Medicine
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Gully, K.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Schäfer, A.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Zaman, T.
- Affiliation: College of Arts and Sciences, Department of Biology
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Leist, S.R.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Grant, P.O.
- Affiliation: College of Arts and Sciences, Department of Biology
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Bluemling, G.R.
- Other Affiliation: Emory University
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Kolykhalov, A.A.
- Other Affiliation: Emory University
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Natchus, M.G.
- Other Affiliation: Drug Innovation Ventures at Emory (DRIVE)
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Askin, F.B.
- Affiliation: School of Medicine, Department of Pathology and Laboratory Medicine
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Painter, G.
- Other Affiliation: Emory University
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Browne, E.P.
- Affiliation: School of Medicine, Division of Infectious Diseases
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Jones, C.D.
- Affiliation: College of Arts and Sciences, Department of Biology
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Pickles, R.J.
- Affiliation: School of Medicine, Department of Microbiology and Immunology
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Baric, R.S.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Garcia, J.V.
- Affiliation: School of Medicine, Division of Infectious Diseases
- Abstract
- All known recently emerged human coronaviruses probably originated in bats1. Here we used a single experimental platform based on human lung-only mice (LoM) to demonstrate efficient in vivo replication of all recently emerged human coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) and two highly relevant endogenous pre-pandemic SARS-like bat coronaviruses. Virus replication in this model occurs in bona fide human lung tissue and does not require any type of adaptation of the virus or the host. Our results indicate that bats harbour endogenous coronaviruses capable of direct transmission into humans. Further detailed analysis of pandemic SARS-CoV-2 in vivo infection of LoM human lung tissue showed predominant infection of human lung epithelial cells, including type II pneumocytes present in alveoli and ciliated airway cells. Acute SARS-CoV-2 infection was highly cytopathic and induced a robust and sustained type I interferon and inflammatory cytokine/chemokine response. Finally, we evaluated a therapeutic and pre-exposure prophylaxis strategy for coronavirus infection. Our results show that therapeutic and prophylactic administration of EIDD-2801, an oral broad spectrum antiviral currently in phase II–III clinical trials, dramatically inhibited SARS-CoV-2 replication in vivo and thus has significant potential for the prevention and treatment of COVID-19.
- Date of publication
- 2021
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Nature
- Language
- English
- Version
- Postprint
- ISSN
- 0028-0836
- Publisher
- Nature Research
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