The minipig intraoral dental implant model: A systematic review and meta-analysis Public Deposited

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  • Musskopf, Marta Liliana
    • Affiliation: School of Dentistry
  • Stadler, Amanda Finger
    • Affiliation: School of Dentistry
  • Wikesjö, Ulf ME
    • Affiliation: School of Dentistry
  • Susin, Cristiano
    • Affiliation: School of Dentistry
  • Objectives The objective of this report was to provide a review of the minipig intraoral dental implant model including a meta-analysis to estimate osseointegration and crestal bone remodeling. Methods A systematic review including PubMed and EMBASE databases through June 2021 was conducted. Two independent examiners screened titles/abstracts and selected full-text articles. Studies evaluating titanium dental implant osseointegration in native alveolar bone were included. A quality assessment of reporting was performed. Random-effects meta-analyses and meta-regressions were produced for bone-implant contact (BIC), first BIC, and crestal bone level. Results 125 out of 249 full-text articles were reviewed, 55 original studies were included. Quality of reporting was generally low, omissions included animal characteristics, examiner masking/calibration, and sample size calculation. The typical minipig model protocol included surgical extraction of the mandibular premolars and first molar, 12±4 wks post-extraction healing, placement of three narrow regular length dental implants per jaw quadrant, submerged implant healing and 8 wks of osseointegration. Approximately 90% of studies reported undecalcified incandescent light microscopy histometrics. Overall, mean BIC was 59.88% (95%CI: 57.43–62.33). BIC increased significantly over time (p<0.001): 40.93 (95%CI: 34.95–46.90) at 2 wks, 58.37% (95%CI: 54.38–62.36) at 4 wks, and 66.33% (95%CI: 63.45–69.21) beyond 4 wks. Variability among studies was mainly explained by differences in observation interval post-extraction and post-implant placement, and implant surface. Heterogeneity was high for all studies (I2 > 90%, p<0.001). Conclusions The minipig intraoral dental implant model appears to effectively demonstrate osseointegration and alveolar bone remodeling similar to that observed in humans and canine models.
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  • Article
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  • In Copyright
  • Attribution 4.0 International
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Journal volume
  • 17
Journal issue
  • 2
Page start
  • e0264475
  • English
  • Publisher
  • 1932-6203

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