Real-world treatment patterns and clinical outcomes for inpatients with COVID-19 in the US from September 2020 to February 2021
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Ayodele, O, et al. Real-world Treatment Patterns and Clinical Outcomes for Inpatients with Covid-19 In the Us From September 2020 to February 2021. Public Library of Science, 2021. https://doi.org/10.17615/tsvj-5x10APA
Ayodele, O., Ren, K., Zhao, J., Signorovitch, J., Funk, M., Zhu, J., Bao, Y., Gondek, K., & Keenan, H. (2021). Real-world treatment patterns and clinical outcomes for inpatients with COVID-19 in the US from September 2020 to February 2021. Public Library of Science. https://doi.org/10.17615/tsvj-5x10Chicago
Ayodele, O, K Ren, J Zhao, J Signorovitch, M.J Funk, J Zhu, Y Bao et al. 2021. Real-World Treatment Patterns and Clinical Outcomes for Inpatients with Covid-19 In the Us From September 2020 to February 2021. Public Library of Science. https://doi.org/10.17615/tsvj-5x10- Creator
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Ayodele, O
- Other Affiliation: Data Sciences Institute, Takeda Pharmaceutical Company Limited, Cambridge, MA, United States
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Ren, K
- Other Affiliation: Data Sciences Institute, Takeda Pharmaceutical Company Limited, Cambridge, MA, United States
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Zhao, J
- Other Affiliation: Analysis Group, Data Sciences Institute, Boston, MA, United States
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Signorovitch, J
- Other Affiliation: Analysis Group, Data Sciences Institute, Boston, MA, United States
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Funk, M.J
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Zhu, J
- Other Affiliation: Center for Observational Research and Data Science, Bristol-Myers Squibb, Princeton, NJ, United States
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Bao, Y
- Other Affiliation: Center for Observational Research and Data Science, Bristol-Myers Squibb, Princeton, NJ, United States
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Gondek, K
- Other Affiliation: Data Sciences Institute, Takeda Pharmaceutical Company Limited, Cambridge, MA, United States
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Keenan, H
- Other Affiliation: Data Sciences Institute, Takeda Pharmaceutical Company Limited, Cambridge, MA, United States
- Abstract
- The objective of this retrospective cohort study was to describe pre-treatment characteristics, treatment patterns, health resource use, and clinical outcomes among adults hospitalized with COVID-19 in the United States (US) who initiated common treatments for COVID-19. The Optum® COVID-19 electronic health records database was used to identify patients >18 years, diagnosed with COVID-19, who were admitted to an inpatient setting and received treatments of interest for COVID-19 between September 2020 and January 2021. Patients were stratified into cohorts based on index treatment use. Patient demographics, medical history, care setting, medical procedures, subsequent treatment use, patient disposition, clinical improvement, and outcomes were summarized descriptively. Among a total of 26,192 patients identified, the most prevalent treatments initiated were dexamethasone (35.4%) and dexamethasone + remdesivir (14.9%), and dexamethasone was the most common subsequent treatment. At day 14 post-index, <10% of patients received any treatments of interest. Mean (standard deviation [SD]) patient age was 65.6 (15.6) years, and the most prevalent comorbidities included hypertension (44.8%), obesity (35.4%), and diabetes (25.7%). At the end of follow-up, patients had a mean (SD) 8.1 (6.6) inpatient days and 1.4 (4.1) days with ICU care. Oxygen supplementation, non-invasive, or invasive ventilation was required by 4.5%, 3.0%, and 3.1% of patients, respectively. At the end of follow-up, 84.2% of patients had evidence of clinical improvement, 3.1% remained hospitalized, 83.8% were discharged, 4% died in hospital, and 9.1% died after discharge. Although the majority of patients were discharged alive, no treatments appeared to alleviate the inpatient morbidity and mortality associated with COVID-19. This highlights an unmet need for effective treatment options for patients hospitalized with COVID-19.
- Date of publication
- 2021
- Keyword
- health care utilization
- antiinflammatory agent
- genetics
- treatment pattern
- Adenosine Monophosphate
- combination drug therapy
- Alanine
- middle aged
- major clinical study
- Patient Discharge
- Hypertension
- COVID-19
- azithromycin
- Young Adult
- disease severity
- remdesivir
- invasive ventilation
- follow up
- hospital patient
- comorbidity
- Comorbidity
- Article
- young adult
- aged
- virus RNA
- alanine
- practice guideline
- clinical outcome
- Male
- United States
- Follow-Up Studies
- in-hospital mortality
- treatment outcome
- coronavirus disease 2019
- adolescent
- unmet medical need
- obesity
- intensive care unit
- Retrospective Studies
- Female
- diagnosis
- human
- dexamethasone
- Antiviral Agents
- Aged, 80 and over
- very elderly
- RNA, Viral
- Aged
- tocilizumab
- retrospective study
- controlled study
- virology
- immunology
- antivirus agent
- Middle Aged
- adenosine phosphate
- drug therapy
- Treatment Outcome
- hospital discharge
- SARS-CoV-2
- Humans
- oxygen therapy
- Dexamethasone
- hospitalization
- procedures
- Obesity
- diabetes mellitus
- hypertension
- Drug Therapy, Combination
- adult
- noninvasive ventilation
- cohort analysis
- Adolescent
- female
- Anti-Inflammatory Agents
- health care quality
- Adult
- hydroxychloroquine
- convalescent plasma
- clinical feature
- male
- DOI
- Identifier
- Resource type
- Article
- License
- Attribution 4.0 International
- Journal title
- PLoS ONE
- Journal volume
- 16
- Journal issue
- 12-Dec
- Language
- English
- Version
- Publisher
- ISSN
- 1932-6203
- Publisher
- Public Library of Science
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