Long COVID risk and pre-COVID vaccination in an EHR-based cohort study from the RECOVER program

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Brannock, M. Daniel
    • Other Affiliation: RTI International
  • Chew, Robert F.
    • Other Affiliation: RTI International
  • Preiss, Alexander J.
    • Other Affiliation: RTI International
  • Hadley, Emily C.
    • Other Affiliation: RTI International
  • Redfield, Signe
    • Other Affiliation: Patient-Led Research Collaborative
  • McMurry, Julie A.
    • Other Affiliation: University of Colorado AnschutzMedical Campus
  • Leese, Peter J.
    • Affiliation: University of North Carolina at Chapel Hill
  • Girvin, Andrew T.
    • Other Affiliation: Palantir Technologies
  • Crosskey, Miles
    • Other Affiliation: CoVar Applied Technologies
  • Zhou, Andrea G.
    • Other Affiliation: University of Virginia
  • Moffitt, Richard A.
    • Other Affiliation: Stony Brook University
  • Funk, Michele Jonsson
    • Affiliation: University of North Carolina at Chapel Hill
  • Pfaff, Emily R.
    • Affiliation: University of North Carolina at Chapel Hill
  • Haendel, Melissa A.
    • Other Affiliation: University of Colorado AnschutzMedical Campus
  • Chute, Christopher G.
    • Other Affiliation: Johns Hopkins University
Abstract
  • Long COVID, or complications arising from COVID-19 weeks after infection, has become a central concern for public health experts. The United States National Institutes of Health founded the RECOVER initiative to better understand long COVID. We used electronic health records available through the National COVID Cohort Collaborative to characterize the association between SARS-CoV-2 vaccination and long COVID diagnosis. Among patients with a COVID-19 infection between August 1, 2021 and January 31, 2022, we defined two cohorts using distinct definitions of long COVID—a clinical diagnosis (n = 47,404) or a previously described computational phenotype (n = 198,514)—to compare unvaccinated individuals to those with a complete vaccine series prior to infection. Evidence of long COVID was monitored through June or July of 2022, depending on patients’ data availability. We found that vaccination was consistently associated with lower odds and rates of long COVID clinical diagnosis and high-confidence computationally derived diagnosis after adjusting for sex, demographics, and medical history., The extent to which COVID-19 vaccination protects against long COVID is not well understood. Here, the authors use electronic health record data from the United States and find that, for people who received their vaccination prior to infection, vaccination was associated with lower incidence of long COVID.
Date of publication
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
License
  • Attribution 4.0 International
Journal title
  • Nature Communications
Journal volume
  • 14
Page start
  • 2914
Language
  • English
Version
  • Publisher
ISSN
  • 2041-1723

Relations

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details 41467_2023_Article_38388.pdf 2023-06-08 Public Download