A population-based study of prevalence and risk factors of chronic kidney disease in León, Nicaragua Public Deposited

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  • Colindres, Romulo E.
    • Affiliation: School of Medicine, UNC Kidney Center
  • Lebov, Jill F.
    • Affiliation: School of Medicine, UNC Kidney Center
  • Hogan, Susan
    • Affiliation: School of Medicine, UNC Kidney Center
  • Peña, Edgar M.
    • Other Affiliation: Centro de Salud Torre Ramona, Unidad Docente de Medicina Familiar y Comunitaria, Sector II, Zaragoza, España
  • Peña, Rodolfo
    • Other Affiliation: Centro de Investigaciones e Intervenciones en Salud, León, Nicaragua
  • Cisneros, Efren C.
    • Other Affiliation: Department of Physiological Sciences, UNAN-León, Nicaragua
  • Sanoff, Scott L.
    • Other Affiliation: Duke University, Durham, NC
  • Valladares, Eliette
    • Other Affiliation: Centro de Investigaciones e Intervenciones en Salud, León, Nicaragua
  • Morgan, Douglas R.
    • Affiliation: School of Medicine, Department of Medicine
    • Other Affiliation: Department of Medicine, Vanderbilt University, Nashville, TN, USA
  • Abstract Background Recent studies have shown an excess of chronic kidney disease (CKD) among younger adult males in the Pacific coastal region of Nicaragua and suggest a non-conventional CKD etiology in this region. These studies have been conducted in small, non-representative populations. Objectives We conducted a large population-based cross-sectional study to estimate CKD prevalence in León, Nicaragua, and to evaluate the association between previously investigated risk factors and CKD. Methods Estimated glomerular filtration rate, derived using the MDRD equation, was assessed to determine CKD status of 2275 León residents. Multivariable logistic regression was used to estimate adjusted prevalence odds ratios. León CKD prevalence was also standardized to the demographic distributions of the León Health and Demographic Surveillance System and the León 2005 Census. Results CKD prevalence was 9.1%; twice as high for males (13.8%) than females (5.8%). In addition to gender, older age, rural zone, lower education level, and self-reported high blood pressure, more years of agricultural work, lija (unregulated alcohol) consumption, and higher levels of daily water consumption were significantly associated with CKD. Notably, self-reported diabetes was associated with CKD in adjusted models for females but not males. Conclusions Our findings are comparable to those found in regional studies and further support the hypothesis of a Mesoamerican Nephropathy.
Date of publication
  • doi:10.1186/s40697-015-0041-1
Resource type
  • Article
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  • In Copyright
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  • Lebov et al.; licensee BioMed Central.
  • English
Bibliographic citation
  • Canadian Journal of Kidney Health and Disease. 2015 Feb 24;2(1):6
  • BioMed Central

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