Understanding Regulatory Mechanisms of Brain Function and Disease through 3D Genome Organization

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Creator
  • Liu, Weifang
    • Gillings School of Global Public Health, Department of Biostatistics
  • Zhong, Wujuan
    • Other Affiliation: Merck & Co.
  • Chen, Jiawen
    • Gillings School of Global Public Health, Department of Biostatistics
  • Huang, Bo
    • Other Affiliation: University of California, San Francisco
  • Hu, Ming
    • Other Affiliation: Cleveland Clinic Foundation
  • Li, Yun
    • Gillings School of Global Public Health, Department of Biostatistics
Abstract
  • The human genome has a complex and dynamic three-dimensional (3D) organization, which plays a critical role for gene regulation and genome function. The importance of 3D genome organization in brain development and function has been well characterized in a region- and cell-type-specific fashion. Recent technological advances in chromosome conformation capture (3C)-based techniques, imaging approaches, and ligation-free methods, along with computational methods to analyze the data generated, have revealed 3D genome features at different scales in the brain that contribute to our understanding of genetic mechanisms underlying neuropsychiatric diseases and other brain-related traits. In this review, we discuss how these advances aid in the genetic dissection of brain-related traits.
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  • Article
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  • In Copyright
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  • Attribution 3.0 United States
Journal title
  • Genes
Journal volume
  • 13
Journal issue
  • 4
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  • 586
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  • English
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  • Publisher
ISSN
  • 2073-4425

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