Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D1 Receptor
Public Deposited- Creator
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Ma, Zhong Ze
- Other Affiliation: McLean Hospital
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Xu, Wei
- Other Affiliation: Temple University
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Jensen, Niels H.
- School of Medicine
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Roth, Bryan L.
- School of Medicine
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Liu-Chen, Lee Yuan
- Other Affiliation: Temple University
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Lee, David Y.W.
- Other Affiliation: McLean Hospital
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Ma, Zhong Ze
- Abstract
- Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and dehydrocorybulbine. The tertiary alkaloids were further analyzed by chiral HPLC to determine the ratios of d-and l-isomers. The isolated compounds were screened for their binding affinities at the dopamine D(1) receptor. Isocorypalmine had the highest affinity (K(i) = 83 nM). The structure-affinity relationships of these alkaloids are discussed.
- Date of publication
- 2008
- Keyword
- DOI
- Identifier
- Onescience id: eeb3f4c7fbaf2414250362d56499a73fcc6ac2d8
- Publisher DOI: https://doi.org/10.3390/molecules13092303
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Molecules (Basel, Switzerland)
- Journal volume
- 13
- Journal issue
- 9
- Page start
- 2303
- Page end
- 2312
- Language
- English
- ISSN
- 1420-3049
- 1431-5157
Relations
- Parents:
- In Collection:
This work has no parents.
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