Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons. Public Deposited

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Creator
  • Traylor, Dennis
    • Affiliation: School of Medicine, Department of Pharmacology, Department of Psychiatry
  • Breese, George R.
    • ORCID: https://orcid.org/0000-0001-8579-9007
    • Affiliation: School of Medicine, Department of Pharmacology, Department of Psychiatry
Abstract
  • After the intracisternal administration of 6-hydroxydopamine, brain levels of norepinephrine were reduced significantly with or without pargyline pretreatment. Depletion of dopamine in the central nervous system was found to be enhanced markedly by pargyline administration at higher dose levels of 6-hydroxydopamine. Brain serotonin concentrations were not altered. The effects of 6-hydroxydopamine were long-lasting with the depletion of brain amines persisting at 78 days. After norepinephrine-H3 intracisternally to animals treated with 6-hydroxydopamine, labeled norepinephrine uptake was diminished with a corresponding reduction of deaminated catechols and a marked increased in methylated amines. Tyrosine hydroxylase activity was found to be reduced in brainstem, caudate nucleus and whole brain in 6-hydroxydopamine-treated animals. Conversion of tyrosine-H3 to labeled norepinephrine and dopamine was also markedly diminished. The results support the view that 6-hydroxydopamine produces a "central sympathectomy" when introduced into cerebrospinal fluid.
Date of publication
Identifier
  • 2-s2.0-0014848664
  • doi:n/a
Related resource URL
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Journal of Pharmacology and Experimental Therapeutics
Journal volume
  • 174
Journal issue
  • 3
Page start
  • 413
Page end
  • 420
Language
  • English
Version
  • Postprint
ISSN
  • 0022-3565
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