Resolution of complex ends by Nonhomologous end joining - better to be lucky than good? Public Deposited

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Creator
  • Strande, Natasha Tiffany
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine, Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology
  • Waters, Crystal Ann
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine, Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology
  • Ramsden, Dale
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine, Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology
Abstract
  • Abstract The Nonhomologous end joining pathway is essential for efficient repair of chromosome double strand breaks. This pathway consequently plays a key role in cellular resistance to break-inducing exogenous agents, as well as in the developmentally-programmed recombinations that are required for adaptive immunity. Chromosome breaks often have complex or “dirty” end structures that can interfere with the critical ligation step in this pathway; we review here how Nonhomologous end joining resolves such breaks.
Date of publication
Identifier
  • 23276302
  • doi:10.1186/2041-9414-3-10
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Natasha Tiffany Strande et al.; licensee BioMed Central Ltd.
License
Journal title
  • Genome Integrity
Journal volume
  • 3
Journal issue
  • 1
Page start
  • 10
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 2041-9414
Bibliographic citation
  • Genome Integrity. 2012 Dec 31;3(1):10
Access
  • Open Access
Publisher
  • BioMed Central Ltd
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